• THAT   AND

Sequence in raw or FASTA format:


Blast Method:


Homo sapiens insulin-like growth factor 2 (somatomedin A) (IGF2), transcript variant 3, mRNA.

Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu28283 Homo sapiens insulin-like growth factor 2 (somatomedin A) (IGF2), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand $159.00 7-9
OHu28283C Homo sapiens insulin-like growth factor 2 (somatomedin A) (IGF2), transcript variant 3, mRNA. Customized vector On-demand $209.00 7-9

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Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_001127598.1, 189083845
Length 711 bp
Update Date 19-JUN-2014
Organism Homo sapiens (human)
Definition Homo sapiens insulin-like growth factor 2 (somatomedin A) (IGF2), transcript variant 3, mRNA.
Product insulin-like growth factor II isoform 2

Summary: This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].

Transcript Variant: This variant (3) contains two alternate exons at the 5' end, one non-coding and another coding, compared to variant 1. This results in the use of an upstream AUG (not found in variants 1 and 2) and a longer isoform (2) with a distinct N-terminus compared to isoform 1.

Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.

RefSeq NP_001121070.1
CDS 259..969
Misc Feature(1)214..216
Misc Feature(2)<268..411
Misc Feature(3)<268..411
Misc Feature(4)406..411
Misc Feature(5)508..699
Misc Feature(6)order(514..516,541..543,565..579)
Misc Feature(7)order(568..570,574..579,625..627)
Misc Feature(8)order(640..648,658..663)
Misc Feature(9)760..924
Exon (1)1..255
Gene Synonym:C11orf43; IGF-II; PP9974
Exon (2)256..420
Gene Synonym:C11orf43; IGF-II; PP9974
Exon (3)421..583
Gene Synonym:C11orf43; IGF-II; PP9974
Exon (4)584..732
Gene Synonym:C11orf43; IGF-II; PP9974
Exon (5)733..4839
Gene Synonym:C11orf43; IGF-II; PP9974
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Position Chain Variation Link
complement(68)-t, gdbSNP:114780445
complement(90)-g, cdbSNP:182133033
complement(100)-g, adbSNP:376456871
complement(286)-g, cdbSNP:373288584
complement(297)-g, cdbSNP:80080270
complement(335)-t, cdbSNP:376196753
complement(348)-g, adbSNP:74050127
complement(355)-g, adbSNP:200441006
complement(401)-g, cdbSNP:376757645
complement(420)-g, cdbSNP:371300605
complement(424)-g, adbSNP:201281696
complement(447)-c, adbSNP:146334276
complement(450)-t, cdbSNP:374362537
complement(485)-g, adbSNP:142012621
complement(486)-t, cdbSNP:200510687
complement(490)-g, adbSNP:112276039
complement(520)-g, adbSNP:202212014
complement(555)-g, adbSNP:140032633
complement(591)-g, adbSNP:199968864
complement(617)-t, cdbSNP:369844466
complement(620)-t, cdbSNP:150610908
complement(624)-g, adbSNP:377034431
complement(660)-g, cdbSNP:1803647
complement(666)-t, cdbSNP:148165917
complement(696)-g, adbSNP:373036890
complement(714)-g, adbSNP:202163388
complement(719)-g, adbSNP:143785521
complement(731)-g, adbSNP:369122420
complement(754)-t, cdbSNP:376878619
786+g, tdbSNP:14367
807+a, c, tdbSNP:1065443
complement(838)-g, adbSNP:371682005
complement(842)-c, adbSNP:369452652
complement(847)-t, cdbSNP:375129654
complement(852)-g, adbSNP:372036269
complement(853)-t, cdbSNP:200836416
complement(865)-t, cdbSNP:150866176
complement(867)-t, cdbSNP:139194127
complement(869)-g, adbSNP:368814253
complement(887)-g, cdbSNP:146962483
complement(893)-t, cdbSNP:61732764
complement(915)-g, adbSNP:199646294
complement(925)-c, adbSNP:377316111
complement(930)-g, adbSNP:200036157
complement(936)-g, adbSNP:138399775
943+c, tdbSNP:11545014
944+a, cdbSNP:1050342
966+g, tdbSNP:12993
complement(983)-g, adbSNP:9282726
995+c, tdbSNP:3741214
complement(998)-t, cdbSNP:2230949
complement(998)-g, adbSNP:386561794
complement(999)-t, cdbSNP:200131466
1029+a, gdbSNP:3213234
complement(1078)-t, gdbSNP:376978352
complement(1079)-, gdbSNP:34337549
1149+a, gdbSNP:6223
1176+a, tdbSNP:11510
1208+a, cdbSNP:1803648
1291..1292+, acdbSNP:11564731
complement(1297..1298)-, ggdbSNP:199644459
complement(1297)-g, adbSNP:200385877
complement(1421)-t, cdbSNP:372089802
complement(1475)-g, cdbSNP:74050125
complement(1483)-g, adbSNP:15737
1552+a, c, gdbSNP:680
complement(1575)-g, adbSNP:74050124
1582+c, gdbSNP:1065685
complement(1587)-g, adbSNP:190844832
complement(1633)-t, cdbSNP:137976914
complement(1656)-c, adbSNP:146936885
complement(1699)-t, gdbSNP:187623619
complement(1702)-g, cdbSNP:142713948
complement(1875)-t, cdbSNP:56731553
complement(1881)-t, cdbSNP:56154171
complement(1887..1888)-, tgdbSNP:372409298
complement(1899..1900)-, atgctcgtgtgtgtgctgt, at, tadbSNP:59198946
complement(1900..1901)-, tadbSNP:113750887
complement(1912..1913)-, gtgtgtgtgctgtatgctcdbSNP:138254272
complement(1913..1918)-gcgttt, atgctcdbSNP:386749759
complement(1913)-t, cdbSNP:61872709
complement(1914)-t, cdbSNP:112372828
complement(1915)-t, cdbSNP:61872708
complement(1916)-g, adbSNP:113064670
complement(1917)-t, cdbSNP:78158653
complement(1918)-g, adbSNP:80242682
complement(1926..1927)-, cgtttgtgtgdbSNP:376418013
complement(1946)-g, adbSNP:201857559
complement(1964)-t, cdbSNP:184016711
complement(1972..1979)-, cgtgtgtgdbSNP:374501941
complement(1980..1981)-, tgdbSNP:375635884
complement(1983)-t, cdbSNP:371884035
complement(2023)-t, cdbSNP:185336081
complement(2032)-g, adbSNP:61872707
complement(2038)-g, adbSNP:61872706
complement(2045..2061)-, ctgtgcgtttgtgtgtgdbSNP:374335327
complement(2050)-t, cdbSNP:11042774
complement(2050)-t, cdbSNP:111064298
complement(2051..2052)-, tgdbSNP:372745821
complement(2073)-t, cdbSNP:199625419
complement(2103..2104)-, gtdbSNP:200421505
complement(2110)-g, adbSNP:111218600
complement(2134)-g, adbSNP:201271948
complement(2135)-t, cdbSNP:111164747
complement(2135)-t, cdbSNP:116037594
complement(2159..2162)-, tgtgdbSNP:59630895
complement(2160..2163)-, gtgtdbSNP:141005898
complement(2184)-t, gdbSNP:193063121
complement(2219)-t, cdbSNP:375588366
complement(2221)-t, cdbSNP:7111331
complement(2261)-t, gdbSNP:11042767
complement(2263..2264)-, tgdbSNP:377138336
complement(2265)-t, gdbSNP:188024661
complement(2266..2267)-, tcdbSNP:202059019
complement(2278..2279)-, tgdbSNP:141204597
complement(2293)-g, adbSNP:7129583
complement(2293)-g, adbSNP:62650856
complement(2293)-g, adbSNP:111064297
complement(2293)-g, adbSNP:111163770
complement(2295)-t, gdbSNP:28462050
complement(2301..2302)-, tgdbSNP:200119028
complement(2328..2329)-, tgdbSNP:369407323
complement(2333)-t, cdbSNP:28472590
complement(2344..2345)-, tgdbSNP:58312807
complement(2354)-t, cdbSNP:372916351
complement(2387..2388)-, tgdbSNP:60649995
complement(2387)-, tgdbSNP:398114950
complement(2389)-t, gdbSNP:199699118
complement(2395..2396)-, tgdbSNP:142373942
complement(2405..2406)-, atdbSNP:200933432
complement(2414..2415)-, tgdbSNP:200018341
complement(2417..2420)-, tgtgdbSNP:374582945
complement(2422..2425)-, gtgtdbSNP:201879085
complement(2431)-g, adbSNP:58562468
complement(2495)-t, cdbSNP:143209706
complement(2515..2516)-, tgdbSNP:200159614
complement(2529)-t, cdbSNP:374392622
complement(2542)-t, gdbSNP:79531557
2547+a, gdbSNP:1065687
2595+a, cdbSNP:3208122
complement(2609)-t, cdbSNP:117486875
2645+c, gdbSNP:3168310
complement(2768)-g, adbSNP:149099319
complement(2851)-, tdbSNP:58527086
complement(2860)-t, cdbSNP:181654351
complement(2865)-t, cdbSNP:369965474
complement(2919)-g, adbSNP:59196953
complement(2927)-g, c, adbSNP:79275529
complement(3080)-t, cdbSNP:57156844
3134+c, tdbSNP:3802971
complement(3223)-t, cdbSNP:112863993
complement(3345)-c, adbSNP:117403190
3367+g, tdbSNP:3180700
complement(3367)-c, adbSNP:386580567
complement(3368)-, cdbSNP:370546130
complement(3368)-c, adbSNP:72851054
complement(3373..3374)-, gdbSNP:143773245
complement(3417..3418)-, ggdbSNP:57423851
complement(3417)-, tdbSNP:148117489
complement(3417)-t, g, adbSNP:113798050
complement(3427..3428)-, gdbSNP:368927765
complement(3460)-g, adbSNP:375769044
complement(3474)-t, gdbSNP:35818489
complement(3791)-t, cdbSNP:11825733
3844+c, tdbSNP:150340979
3853+a, gdbSNP:11541377
3862+c, gdbSNP:11541375
complement(3889)-t, cdbSNP:186411823
3900+c, tdbSNP:11541373
3915+a, gdbSNP:11541372
4007+g, tdbSNP:11541374
complement(4059)-t, cdbSNP:140620676
complement(4094)-t, cdbSNP:181296097
4160+a, cdbSNP:3189464
complement(4174)-t, cdbSNP:189306072
complement(4247)-t, cdbSNP:367940335
complement(4290)-g, adbSNP:61745040
complement(4291)-g, adbSNP:11564732
complement(4293)-g, adbSNP:182285016
4310+c, gdbSNP:11541376
4489+a, gdbSNP:7873
complement(4489)-g, adbSNP:386613755
complement(4499)-t, cdbSNP:61745039
complement(4610)-t, adbSNP:377720187
4611+c, tdbSNP:143676947
4615+c, tdbSNP:3177805
4627+c, gdbSNP:1065715
complement(4628)-g, cdbSNP:11541371
4634+c, tdbSNP:1049926
4649+c, tdbSNP:3177946
complement(4703)-t, cdbSNP:184965397
complement(4708)-t, cdbSNP:374278108
4713+a, cdbSNP:1050035
complement(4735)-g, adbSNP:11541370
complement(4742)-t, cdbSNP:2585
complement(4742)-t, cdbSNP:386569988
complement(4805)-g, adbSNP:79148793
4807+c, gdbSNP:1050141
complement(4837)-t, adbSNP:112372484
Gene SymbolIGF2
Gene SynonymC11orf43; IGF-II; PP9974
Locus Map11p15.5
Title Insulin-like growth factor II peptide fusion enables uptake and lysosomal delivery of alpha-N-acetylglucosaminidase to mucopolysaccharidosis type IIIB fibroblasts .
Author Kan SH, Troitskaya LA, Sinow CS, Haitz K, Todd AK, Di Stefano A, Le SQ, Dickson PI and Tippin BL.
Journal Biochem. J. 458 (2), 281-289 (2014)
Title CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism .
Author Ellis BC, Graham LD and Molloy PL.
Journal Biochim. Biophys. Acta 1843 (2), 372-386 (2014)
Title Insulin like growth factor 2 regulation of aryl hydrocarbon receptor in MCF-7 breast cancer cells .
Author Tomblin JK and Salisbury TB.
Journal Biochem. Biophys. Res. Commun. 443 (3), 1092-1096 (2014)
Title Relaxation of imprinted genes in human cancer .
Author Rainier S, Johnson LA, Dobry CJ, Ping AJ, Grundy PE and Feinberg AP.
Journal Nature 362 (6422), 747-749 (1993)
Title Beckwith-Wiedemann Syndrome .
Author Shuman,C., Beckwith,J.B., Smith,A.C. and Weksberg,R.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Title Russell-Silver Syndrome .
Author Saal,H.M.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Title Wilms Tumor Overview .
Author Dome,J.S. and Huff,V.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Title The third IGF-II promoter specifies transcription of three transcripts out of five in human placenta .
Author Daimon M, Johnson TR, Ilan J and Ilan J.
Journal Mol. Reprod. Dev. 33 (4), 413-417 (1992)
Title Structure and expression of the human insulin-like growth factor genes .
Author Sussenbach JS, Steenbergh PH and Holthuizen P.
Journal Growth Regul. 2 (1), 1-9 (1992)
Title Primary structure of human insulin-like growth factor II .
Author Rinderknecht,E. and Humbel,R.E.
Journal FEBS Lett. 89 (2), 283-286 (1978)

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