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Homo sapiens insulin-like growth factor 2 (somatomedin A) (IGF2), transcript variant 3, mRNA.

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001127598 Homo sapiens insulin-like growth factor 2 (somatomedin A) (IGF2), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $399.00 14

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RefSeq Version NM_001127598.1, 189083845
Length 4856 bp
Structure linear
Update Date 29-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens insulin-like growth factor 2 (somatomedin A) (IGF2), transcript variant 3, mRNA.
Product insulin-like growth factor II isoform 2

Summary: This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].

Transcript Variant: This variant (3) contains two alternate exons at the 5' end, one non-coding and another coding, compared to variant 1. This results in the use of an upstream AUG (not found in variants 1 and 2) and a longer isoform (2) with a distinct N-terminus compared to isoform 1.

Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.

RefSeq NP_001121070.1
CDS 259..969
Misc Feature(1)214..216
Misc Feature(2)<268..411
Misc Feature(3)<268..411
Misc Feature(4)406..411
Misc Feature(5)508..699
Misc Feature(6)order(514..516,541..543,565..579)
Misc Feature(7)order(568..570,574..579,625..627)
Misc Feature(8)order(640..648,658..663)
Misc Feature(9)760..924
Exon (1)1..255
Gene Synonym:C11orf43; IGF-II; PP9974
Exon (2)256..420
Gene Synonym:C11orf43; IGF-II; PP9974
Exon (3)421..583
Gene Synonym:C11orf43; IGF-II; PP9974
Exon (4)584..732
Gene Synonym:C11orf43; IGF-II; PP9974
Exon (5)733..4839
Gene Synonym:C11orf43; IGF-II; PP9974
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Position Chain Variation Link
complement(68)-t, gdbSNP:114780445
complement(90)-g, cdbSNP:182133033
complement(297)-g, cdbSNP:80080270
complement(348)-g, adbSNP:74050127
complement(355)-g, adbSNP:200441006
complement(424)-g, adbSNP:201281696
complement(447)-c, adbSNP:146334276
complement(485)-g, adbSNP:142012621
complement(486)-t, cdbSNP:200510687
complement(490)-g, adbSNP:112276039
complement(520)-g, adbSNP:202212014
complement(555)-g, adbSNP:140032633
complement(591)-g, adbSNP:199968864
complement(620)-t, cdbSNP:150610908
complement(660)-g, cdbSNP:1803647
complement(666)-t, cdbSNP:148165917
complement(714)-g, adbSNP:202163388
complement(719)-g, adbSNP:143785521
complement(786)-t, gdbSNP:14367
complement(807)-c, adbSNP:1065443
complement(853)-t, cdbSNP:200836416
complement(865)-t, cdbSNP:150866176
complement(867)-t, cdbSNP:139194127
complement(887)-t, cdbSNP:146962483
complement(893)-t, cdbSNP:61732764
complement(915)-g, adbSNP:199646294
complement(930)-g, adbSNP:200036157
complement(936)-g, adbSNP:138399775
complement(943)-t, cdbSNP:11545014
complement(944)-c, adbSNP:1050342
complement(966)-t, gdbSNP:12993
complement(983)-g, adbSNP:9282726
complement(995)-t, cdbSNP:3741214
complement(998)-t, cdbSNP:2230949
complement(999)-t, cdbSNP:200131466
complement(1029)-g, adbSNP:3213234
complement(1079)-, gdbSNP:34337549
complement(1149)-g, adbSNP:6223
complement(1176)-t, adbSNP:11510
complement(1208)-c, adbSNP:1803648
complement(1291..1292)-, acdbSNP:11564731
complement(1297..1298)-, ggdbSNP:199644459
complement(1297)-g, adbSNP:200385877
complement(1298)-, gdbSNP:71805698
complement(1475)-g, cdbSNP:74050125
complement(1483)-g, adbSNP:15737
complement(1552)-g, c, adbSNP:680
complement(1575)-g, adbSNP:74050124
complement(1582)-g, cdbSNP:1065685
complement(1587)-g, adbSNP:190844832
complement(1633)-t, cdbSNP:137976914
complement(1656)-c, adbSNP:146936885
complement(1699)-t, gdbSNP:187623619
complement(1702)-g, cdbSNP:142713948
complement(1875)-t, cdbSNP:56731553
complement(1881)-t, cdbSNP:56154171
complement(1899..1900)-, atgctcgtgtgtgtgctgt, atdbSNP:59198946
complement(1900..1901)-, tadbSNP:113750887
complement(1912..1913)-, gtgtgtgtgctgtatgctcdbSNP:138254272
complement(1913)-t, cdbSNP:61872709
complement(1914)-t, cdbSNP:112372828
complement(1915)-t, cdbSNP:61872708
complement(1916)-g, adbSNP:113064670
complement(1917)-t, cdbSNP:78158653
complement(1918)-g, adbSNP:80242682
complement(1946)-g, adbSNP:201857559
complement(1964)-t, cdbSNP:184016711
complement(2023)-t, cdbSNP:185336081
complement(2032)-g, adbSNP:61872707
complement(2038)-g, adbSNP:61872706
complement(2050)-t, cdbSNP:11042774
complement(2073)-t, cdbSNP:199625419
complement(2103..2104)-, gtdbSNP:200421505
complement(2134)-g, adbSNP:201271948
complement(2135)-t, cdbSNP:116037594
complement(2159..2162)-, tgtgdbSNP:59630895
complement(2160..2163)-, gtgtdbSNP:141005898
complement(2184)-t, gdbSNP:193063121
complement(2221)-t, cdbSNP:7111331
complement(2261)-t, gdbSNP:11042767
complement(2265)-t, gdbSNP:188024661
complement(2266..2267)-, tcdbSNP:202059019
complement(2278..2279)-, tgdbSNP:141204597
complement(2293)-g, adbSNP:7129583
complement(2295)-t, gdbSNP:28462050
complement(2301..2302)-, tgdbSNP:200119028
complement(2333)-t, cdbSNP:28472590
complement(2344..2345)-, tgdbSNP:58312807
complement(2387..2388)-, tgdbSNP:60649995
complement(2389)-t, gdbSNP:199699118
complement(2395..2396)-, tgdbSNP:142373942
complement(2405..2406)-, atdbSNP:200933432
complement(2414..2415)-, tgdbSNP:200018341
complement(2422..2425)-, gtgtdbSNP:201879085
complement(2431)-g, adbSNP:58562468
complement(2495)-t, cdbSNP:143209706
complement(2515..2516)-, tgdbSNP:200159614
complement(2542)-t, gdbSNP:79531557
complement(2547)-g, adbSNP:1065687
complement(2595)-c, adbSNP:3208122
complement(2609)-t, cdbSNP:117486875
complement(2645)-g, cdbSNP:3168310
complement(2768)-g, adbSNP:149099319
complement(2851)-, tdbSNP:58527086
complement(2860)-t, cdbSNP:181654351
complement(2919)-g, adbSNP:59196953
complement(2927)-g, c, adbSNP:79275529
complement(3080)-t, cdbSNP:57156844
complement(3134)-t, cdbSNP:3802971
complement(3223)-t, cdbSNP:112863993
complement(3345)-c, adbSNP:117403190
complement(3367)-t, gdbSNP:3180700
complement(3368)-c, adbSNP:72851054
complement(3373..3374)-, gdbSNP:143773245
complement(3417)-, tdbSNP:148117489
complement(3417)-t, g, adbSNP:113798050
complement(3426..3427)-, ggdbSNP:57423851
complement(3474)-t, gdbSNP:35818489
complement(3791)-t, cdbSNP:11825733
complement(3844)-t, cdbSNP:150340979
complement(3853)-g, adbSNP:11541377
complement(3862)-g, cdbSNP:11541375
complement(3889)-t, cdbSNP:186411823
complement(3900)-t, cdbSNP:11541373
complement(3915)-g, adbSNP:11541372
complement(4007)-t, gdbSNP:11541374
complement(4059)-t, cdbSNP:140620676
complement(4094)-t, cdbSNP:181296097
complement(4160)-c, adbSNP:3189464
complement(4174)-t, cdbSNP:189306072
complement(4290)-g, adbSNP:61745040
complement(4291)-g, adbSNP:11564732
complement(4293)-g, adbSNP:182285016
complement(4310)-g, cdbSNP:11541376
complement(4489)-g, adbSNP:7873
complement(4499)-t, cdbSNP:61745039
complement(4611)-t, cdbSNP:143676947
complement(4615)-t, cdbSNP:3177805
complement(4627)-g, cdbSNP:1065715
complement(4628)-g, cdbSNP:11541371
complement(4634)-t, cdbSNP:1049926
complement(4649)-t, cdbSNP:3177946
complement(4703)-t, cdbSNP:184965397
complement(4713)-c, adbSNP:1050035
complement(4735)-g, adbSNP:11541370
complement(4742)-t, cdbSNP:2585
complement(4805)-g, adbSNP:79148793
complement(4807)-g, cdbSNP:1050141
complement(4837)-t, adbSNP:112372484
Gene SymbolIGF2
Gene SynonymC11orf43; IGF-II; PP9974
Locus Map11p15.5
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_000612 Homo sapiens insulin-like growth factor 2 (somatomedin A) (IGF2), transcript variant 1, mRNA. On-demand $399.00 14
NM_001007139 Homo sapiens insulin-like growth factor 2 (somatomedin A) (IGF2), transcript variant 2, mRNA. On-demand $399.00 14
NM_001127598 Homo sapiens insulin-like growth factor 2 (somatomedin A) (IGF2), transcript variant 3, mRNA. On-demand $399.00 14
Title Biochemical characterization of individual human glycosylated pro-insulin-like growth factor (IGF)-II and big-IGF-II isoforms associated with cancer .
Author Greenall,S.A., Bentley,J.D., Pearce,L.A., Scoble,J.A., Sparrow,L.G., Bartone,N.A., Xiao,X., Baxter,R.C., Cosgrove,L.J. and Adams,T.E.
Journal J. Biol. Chem. 288 (1), 59-68 (2013)
Title Folate in pregnancy and imprinted gene and repeat element methylation in the offspring .
Author Haggarty,P., Hoad,G., Campbell,D.M., Horgan,G.W., Piyathilake,C. and McNeill,G.
Journal Am. J. Clin. Nutr. 97 (1), 94-99 (2013)
Title Investigation of PAX3/7-FKHR fusion genes and IGF2 gene expression in rhabdomyosarcoma tumors .
Author de Souza,R.R., Oliveira,I.D., Caran,E.M., Alves,M.T., Abib,S. and Toledo,S.R.
Journal Growth Horm. IGF Res. 22 (6), 245-249 (2012)
Title The production and regulation of IGF and IGFBPs in human adipose tissue cultures .
Author Gude,M.F., Frystyk,J., Flyvbjerg,A., Bruun,J.M., Richelsen,B. and Pedersen,S.B.
Journal Growth Horm. IGF Res. 22 (6), 200-205 (2012)
Title [Correlation between epigenetic alterations in the insulin growth factor-II gene and hepatocellular carcinoma] .
Author Dong,Z.Z., Yao,D.F., Wu,W., Qiu,L.W., Yao,N.H., Yan,X.D., Yu,D.D. and Chen,J.
Journal Zhonghua Gan Zang Bing Za Zhi 20 (8), 593-597 (2012)
Title Relaxation of imprinted genes in human cancer .
Author Rainier,S., Johnson,L.A., Dobry,C.J., Ping,A.J., Grundy,P.E. and Feinberg,A.P.
Journal Nature 362 (6422), 747-749 (1993)
Title The identification of O-glycosylated precursors of insulin-like growth factor II .
Author Hudgins,W.R., Hampton,B., Burgess,W.H. and Perdue,J.F.
Journal J. Biol. Chem. 267 (12), 8153-8160 (1992)
Title Polymerase chain reaction (PCR) for detection of ApaI polymorphism at the insulin like growth factor II gene (IGF2) .
Author Tadokoro,K., Fujii,H., Inoue,T. and Yamada,M.
Journal Nucleic Acids Res. 19 (24), 6967 (1991)
Title Specific endonucleolytic cleavage of IGF-II mRNAs .
Author Meinsma,D., Holthuizen,P.E., Van den Brande,J.L. and Sussenbach,J.S.
Journal Biochem. Biophys. Res. Commun. 179 (3), 1509-1516 (1991)
Title Primary structure of human insulin-like growth factor II .
Author Rinderknecht,E. and Humbel,R.E.
Journal FEBS Lett. 89 (2), 283-286 (1978)

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