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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


Homo sapiens laminin, beta 3 (LAMB3), transcript variant 3, mRNA.


RefSeq Accession Definition Services Price Order
NM_001127641 Homo sapiens laminin, beta 3 (LAMB3), transcript variant 3, mRNA. ORF Sequence $1231.65
Peptide Services
Antibody Services
Protein Services


RefSeq Version NM_001127641.1, 189083718
Length 4067 bp
Structure linear
Update Date 17-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens laminin, beta 3 (LAMB3), transcript variant 3, mRNA.
Product laminin subunit beta-3 precursor
Comment

Summary: The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008].


Transcript Variant: This variant (3, also known as B3B) has an alternate 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.


Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

RefSeq NP_001121113.1
CDS 119..3637
Misc Feature(1)50..52
Misc Feature(2)50..52
Misc Feature(3)176..862
Misc Feature(4)863..1030
Misc Feature(5)866..1039
Misc Feature(6)order(866..868,872..874,932..934,953..955,959..961,
Misc Feature(7)1061..1225
Misc Feature(8)1064..1225
Misc Feature(9)order(1064..1066,1070..1072,1091..1093,1145..1147,
Misc Feature(10)1250..1405
Misc Feature(11)1253..1402
Misc Feature(12)order(1253..1255,1259..1261,1292..1294,1313..1315,
Misc Feature(13)1406..1555
Misc Feature(14)1409..1552
Misc Feature(15)order(1409..1411,1415..1417,1448..1450,1469..1471,
Misc Feature(16)1556..1714
Misc Feature(17)1559..1720
Misc Feature(18)order(1559..1561,1565..1567,1595..1597,1616..1618,
Misc Feature(19)1715..1864
Misc Feature(20)1718..1831
Misc Feature(21)order(1718..1720,1724..1726,1754..1756,1775..1777,
Misc Feature(22)1853..2473
Misc Feature(23)2474..2566
Misc Feature(24)2567..3628
Misc Feature(25)<3140..3493
Exon (1)1..81
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (2)82..146
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (3)147..301
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (4)302..416
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (5)417..490
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (6)491..682
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (7)683..746
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (8)747..940
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (9)941..1061
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (10)1062..1250
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (11)1251..1406
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (12)1407..1603
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (13)1604..1715
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (14)1716..2094
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (15)2095..2255
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (16)2256..2476
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (17)2477..2674
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (18)2675..2819
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (19)2820..3027
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (20)3028..3169
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (21)3170..3346
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (22)3347..3500
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Exon (23)3501..4038
Gene:LAMB3
Gene Synonym:BM600-125KDA; LAM5; LAMNB1
Translation MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYG EWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVM MEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRP NARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYA VSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNR PWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQL HYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEP CACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRG TEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFG RLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRR TLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLST AYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDL TPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLT DPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARAR RLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQ VLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFER IKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAI MLRSADLTGLEKRVEQIRDHINGRVLYYATCK
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Position Chain Variation Link
complement(128)-g, adbSNP:116218572
complement(133)-g, adbSNP:140470350
complement(134)-g, adbSNP:113185295
complement(148)-dbSNP:
complement(148)-g, adbSNP:114304155
complement(173)-t, gdbSNP:200672750
complement(183)-g, adbSNP:147620922
complement(185)-g, adbSNP:115191959
complement(186)-t, cdbSNP:139480015
complement(207)-g, adbSNP:116643086
complement(234)-t, cdbSNP:146125956
complement(242)-t, cdbSNP:80356680
complement(256)-t, cdbSNP:2228339
complement(298)-g, adbSNP:114295238
complement(309)-dbSNP:
complement(309)-t, adbSNP:201830202
complement(385)-g, adbSNP:143833060
complement(409)-t, gdbSNP:2076356
complement(425)-dbSNP:
complement(425)-g, cdbSNP:200105150
complement(450)-t, cdbSNP:55824996
complement(457)-t, adbSNP:199599061
complement(497)-dbSNP:
complement(497)-t, gdbSNP:202025705
complement(502)-t, cdbSNP:1130667
complement(520)-t, cdbSNP:183509078
complement(522)-t, cdbSNP:148603717
complement(535)-g, adbSNP:201554705
complement(562)-g, adbSNP:200607251
complement(593)-g, adbSNP:116472735
complement(597)-c, adbSNP:192538322
complement(614)-t, cdbSNP:121912483
complement(659)-t, cdbSNP:2235542
complement(665)-g, adbSNP:116124880
complement(666)-t, cdbSNP:150895872
complement(675)-c, adbSNP:200501999
complement(700)-dbSNP:
complement(700)-c, adbSNP:75876132
complement(714)-g, cdbSNP:121912486
complement(737)-c, adbSNP:121912487
complement(746)-g, adbSNP:121912482
complement(787)-dbSNP:
complement(787)-t, cdbSNP:200235429
complement(789)-g, adbSNP:138986366
complement(807)-g, cdbSNP:61734502
complement(810)-c, adbSNP:143725782
complement(845)-t, cdbSNP:80356681
complement(852)-t, cdbSNP:114886812
complement(890)-g, adbSNP:145575474
complement(895)-g, adbSNP:146529524
complement(896)-t, cdbSNP:113063967
complement(930)-t, gdbSNP:115812503
complement(931)-g, adbSNP:146690433
complement(935)-g, cdbSNP:201231089
complement(946)-dbSNP:
complement(946)-g, cdbSNP:182105392
complement(976)-t, gdbSNP:200006309
complement(977)-t, cdbSNP:144788254
complement(980)-g, adbSNP:149420629
complement(985)-g, adbSNP:115579649
complement(993)-t, c, adbSNP:12091253
complement(1029)-g, adbSNP:114394307
complement(1045)-t, g, adbSNP:141059189
complement(1046)-t, cdbSNP:140216548
complement(1047)-g, adbSNP:199755124
complement(1086)-dbSNP:
complement(1086)-t, cdbSNP:185105348
complement(1096)-g, adbSNP:145473444
complement(1126)-t, cdbSNP:114404740
complement(1133)-g, adbSNP:52814161
complement(1168)-g, adbSNP:76690225
complement(1169)-t, cdbSNP:114875539
complement(1188)-c, adbSNP:149360787
complement(1198)-t, cdbSNP:116607807
complement(1214)-g, adbSNP:142542174
complement(1217)-g, adbSNP:140336145
complement(1267)-dbSNP:
complement(1267)-t, cdbSNP:2076351
complement(1269)-t, cdbSNP:115433823
complement(1295)-t, cdbSNP:189196778
complement(1306)-g, adbSNP:115883756
complement(1312)-t, cdbSNP:116602483
complement(1340)-g, cdbSNP:145170416
complement(1354)-t, cdbSNP:202113091
complement(1380)-g, adbSNP:147719781
complement(1385)-t, cdbSNP:139404117
complement(1392)-g, adbSNP:150917125
complement(1393)-t, cdbSNP:148726330
complement(1402)-g, adbSNP:142876683
complement(1430)-dbSNP:
complement(1430)-t, adbSNP:2229468
complement(1446)-g, adbSNP:202096620
complement(1448)-g, adbSNP:199952752
complement(1466)-g, adbSNP:200895463
complement(1491)-g, adbSNP:201559735
complement(1531)-t, cdbSNP:112316651
complement(1541)-t, cdbSNP:147986178
complement(1557)-g, adbSNP:61734494
complement(1602)-t, cdbSNP:114315478
complement(1626)-dbSNP:
complement(1626)-t, cdbSNP:202095584
complement(1634)-t, adbSNP:145548817
complement(1664)-t, cdbSNP:148988085
complement(1667)-g, adbSNP:78788119
complement(1679)-c, adbSNP:149855893
complement(1683)-t, cdbSNP:144249951
complement(1697)-t, cdbSNP:2076349
complement(1721)-dbSNP:
complement(1721)-t, cdbSNP:141723352
complement(1733)-g, adbSNP:200300715
complement(1773)-t, cdbSNP:201154610
complement(1795)-c, adbSNP:114274965
complement(1823)-g, adbSNP:201551805
complement(1827)-c, adbSNP:200027100
complement(1834)-g, adbSNP:2179402
complement(1845)-g, cdbSNP:202063530
complement(1852)-g, adbSNP:138710333
complement(1879)-t, gdbSNP:185451408
complement(1882)-t, cdbSNP:2229465
complement(1887)-g, adbSNP:143370006
complement(1888)-t, cdbSNP:143594988
complement(1895)-g, adbSNP:146647886
complement(1910)-g, adbSNP:139547896
complement(1911)-t, cdbSNP:139555809
complement(1914..1915)-, adbSNP:35794952
complement(1926)-t, cdbSNP:114651102
complement(1937)-t, cdbSNP:150564174
complement(1948)-g, adbSNP:121912484
complement(1955)-g, adbSNP:147438032
complement(1970)-g, adbSNP:200108885
complement(1980)-g, adbSNP:142689095
complement(1986)-t, cdbSNP:145841733
complement(2006)-t, cdbSNP:138869997
complement(2021)-t, cdbSNP:80356682
complement(2086)-g, adbSNP:140478941
complement(2096)-dbSNP:
complement(2096)-g, adbSNP:146794392
complement(2124)-t, adbSNP:3180385
complement(2131)-t, cdbSNP:147801427
complement(2154)-g, adbSNP:201223111
complement(2184)-g, adbSNP:149161589
complement(2187)-g, adbSNP:2229466
complement(2189)-t, cdbSNP:144538210
complement(2194)-g, adbSNP:140248040
complement(2201)-t, cdbSNP:113725466
complement(2212)-t, cdbSNP:115704192
complement(2242)-g, adbSNP:2072937
complement(2243)-c, adbSNP:184108671
complement(2251)-c, adbSNP:192846348
complement(2265)-dbSNP:
complement(2265)-t, cdbSNP:114174766
complement(2271)-g, adbSNP:199517693
complement(2320)-g, adbSNP:140720448
complement(2354)-g, adbSNP:150191600
complement(2359)-t, gdbSNP:199758152
complement(2368)-t, cdbSNP:151058440
complement(2374)-t, cdbSNP:151334148
complement(2376)-c, adbSNP:202068754
complement(2378)-g, c, adbSNP:62637710
complement(2404)-t, cdbSNP:11555726
complement(2416)-t, cdbSNP:113745536
complement(2446)-t, cdbSNP:139058862
complement(2467)-t, gdbSNP:150736643
complement(2515)-dbSNP:
complement(2515)-t, cdbSNP:114544692
complement(2521)-g, adbSNP:115279528
complement(2550)-t, cdbSNP:144275374
complement(2575)-t, cdbSNP:61734500
complement(2633)-g, cdbSNP:35310684
complement(2637)-t, cdbSNP:142191279
complement(2660)-g, adbSNP:59260335
complement(2672)-t, adbSNP:12748250
complement(2682)-dbSNP:
complement(2682)-g, c, adbSNP:151006337
complement(2686)-g, adbSNP:148395967
complement(2700)-g, adbSNP:145464247
complement(2723)-t, cdbSNP:11555728
complement(2724)-g, cdbSNP:145977001
complement(2750)-g, adbSNP:199946321
complement(2758)-t, g, cdbSNP:200322380
complement(2778)-t, cdbSNP:183045589
complement(2783)-g, cdbSNP:201003237
complement(2784)-t, cdbSNP:139896242
complement(2791)-g, adbSNP:3179860
complement(2805)-t, cdbSNP:147033674
complement(2815)-t, cdbSNP:115431256
complement(2841)-dbSNP:
complement(2841)-g, adbSNP:61753424
complement(2863)-g, adbSNP:200462390
complement(2864)-t, cdbSNP:145014090
complement(2871)-g, cdbSNP:201460793
complement(2895)-t, gdbSNP:2076222
complement(2913)-g, adbSNP:139829784
complement(2924)-t, cdbSNP:121912485
complement(2945)-g, cdbSNP:146443318
complement(2950)-g, adbSNP:112109122
complement(2959)-t, cdbSNP:144342691
complement(2982)-t, adbSNP:199691851
complement(2988)-g, adbSNP:149625153
complement(2989)-t, cdbSNP:143164025
complement(2991)-t, cdbSNP:142984572
complement(2996)-g, adbSNP:146501772
complement(2997)-t, cdbSNP:141894965
complement(2999)-g, adbSNP:78303595
complement(3015)-g, adbSNP:201582241
complement(3030)-dbSNP:
complement(3030)-t, cdbSNP:201448367
complement(3033)-t, cdbSNP:143547447
complement(3051)-g, cdbSNP:138748613
complement(3063)-t, cdbSNP:140769823
complement(3080)-t, c, adbSNP:2229467
complement(3081)-t, cdbSNP:142912342
complement(3128)-t, gdbSNP:201207044
complement(3160)-g, cdbSNP:199715844
complement(3169)-g, cdbSNP:200270332
complement(3185)-dbSNP:
complement(3185)-g, adbSNP:199980014
complement(3186)-t, cdbSNP:147527725
complement(3242)-g, adbSNP:114040223
complement(3310)-t, cdbSNP:115239928
complement(3390)-dbSNP:
complement(3390)-t, cdbSNP:186130143
complement(3411)-g, adbSNP:116580440
complement(3429)-t, cdbSNP:149573831
complement(3441)-c, adbSNP:150859715
complement(3446)-t, cdbSNP:200585982
complement(3469)-t, cdbSNP:114560498
complement(3486)-t, adbSNP:78483218
complement(3522)-dbSNP:
complement(3522)-t, cdbSNP:115712132
complement(3550)-g, adbSNP:1049607
complement(3553)-t, cdbSNP:200469035
complement(3554)-c, adbSNP:148831499
complement(3566)-t, cdbSNP:2228342
complement(3597)-t, cdbSNP:147931502
complement(3667)-g, adbSNP:201971267
complement(3739)-t, cdbSNP:2566
complement(3761)-g, adbSNP:185362831
complement(3841)-t, cdbSNP:145792505
complement(3875)-c, adbSNP:193069291
complement(3912)-g, adbSNP:188120955
complement(3929)-g, adbSNP:12033066
complement(3942)-g, adbSNP:11555727
complement(4006)-g, adbSNP:111402627
Gene SymbolLAMB3
Gene SynonymBM600-125KDA; LAM5; LAMNB1
Chromosome1
Locus Map1q32
All Transcripts
RefSeq Accession Definition Sequence Price Select
NM_000228 Homo sapiens laminin, beta 3 (LAMB3), transcript variant 1, mRNA. Full Length $1432.55
ORF Sequence $1231.65
NM_001017402 Homo sapiens laminin, beta 3 (LAMB3), transcript variant 2, mRNA. Full Length $1518.65
ORF Sequence $1231.65
NM_001127641 Homo sapiens laminin, beta 3 (LAMB3), transcript variant 3, mRNA. Full Length $1423.45
ORF Sequence $1231.65
Title Invasive breast cancer induces laminin-332 upregulation and integrin beta4 neoexpression in myofibroblasts to confer an anoikis-resistant phenotype during tissue remodeling .
Author Kim,B.G., Gao,M.Q., Choi,Y.P., Kang,S., Park,H.R., Kang,K.S. and Cho,N.H.
Journal Breast Cancer Res. 14 (3), R88 (2012)
Title Polymerized laminin-332 matrix supports rapid and tight adhesion of keratinocytes, suppressing cell migration .
Author Kariya,Y., Sato,H., Katou,N., Kariya,Y. and Miyazaki,K.
Journal PLoS ONE 7 (5), E35546 (2012)
Title Aberrant up-regulation of LAMB3 and LAMC2 by promoter demethylation in gastric cancer .
Author Kwon,O.H., Park,J.L., Kim,M., Kim,J.H., Lee,H.C., Kim,H.J., Noh,S.M., Song,K.S., Yoo,H.S., Paik,S.G., Kim,S.Y. and Kim,Y.S.
Journal Biochem. Biophys. Res. Commun. 406 (4), 539-545 (2011)
Title Type XVII collagen (BP180) can function as a cell-matrix adhesion molecule via binding to laminin 332 .
Author Van den Bergh,F., Eliason,S.L. and Giudice,G.J.
Journal Matrix Biol. 30 (2), 100-108 (2011)
Title Polymorphisms involved in the miR-218-LAMB3 pathway and susceptibility of cervical cancer, a case-control study in Chinese women .
Author Zhou,X., Chen,X., Hu,L., Han,S., Qiang,F., Wu,Y., Pan,L., Shen,H., Li,Y. and Hu,Z.
Journal Gynecol. Oncol. 117 (2), 287-290 (2010)
Title Altered laminin 5 expression due to mutations in the gene encoding the beta 3 chain (LAMB3) in generalized atrophic benign epidermolysis bullosa .
Author McGrath,J.A., Pulkkinen,L., Christiano,A.M., Leigh,I.M., Eady,R.A. and Uitto,J.
Journal J. Invest. Dermatol. 104 (4), 467-474 (1995)
Title Cloning of the beta 3 chain gene (LAMB3) of human laminin 5, a candidate gene in junctional epidermolysis bullosa .
Author Pulkkinen,L., Gerecke,D.R., Christiano,A.M., Wagman,D.W., Burgeson,R.E. and Uitto,J.
Journal Genomics 25 (1), 192-198 (1995)
Title Detection of sequence variants in the gene encoding the beta 3 chain of laminin 5 (LAMB3) .
Author Pulkkinen,L., McGrath,J.A., Christiano,A.M. and Uitto,J.
Journal Hum. Mutat. 6 (1), 77-84 (1995)
Title A homozygous nonsense mutation in the beta 3 chain gene of laminin 5 (LAMB3) in Herlitz junctional epidermolysis bullosa .
Author Pulkkinen,L., Christiano,A.M., Gerecke,D., Wagman,D.W., Burgeson,R.E., Pittelkow,M.R. and Uitto,J.
Journal Genomics 24 (2), 357-360 (1994)
Title The complete primary structure for a novel laminin chain, the laminin B1k chain .
Author Gerecke,D.R., Wagman,D.W., Champliaud,M.F. and Burgeson,R.E.
Journal J. Biol. Chem. 269 (15), 11073-11080 (1994)

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