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Homo sapiens transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2), transcript variant 4, mRNA.


Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu21127 Homo sapiens transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand $219.00 7-9
OHu21127C Homo sapiens transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2), transcript variant 4, mRNA. Customized vector On-demand $269.00 7-9

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Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_001146284.1, 226371622
Length 1368 bp
Structure linear
Update Date 05-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2), transcript variant 4, mRNA.
Product transcription factor 7-like 2 isoform 4
Comment

Summary: This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010].


Transcript Variant: This variant (4) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 4) has a distinct C-terminus and is shorter than isoform 1.


Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

RefSeq NP_001139756.1
CDS 508..1875
Misc Feature(1)100..102
Misc Feature(2)508..1215
Misc Feature(3)508..1215
Misc Feature(4)1483..1686
Misc Feature(5)order(1486..1491,1495..1500,1507..1512,1519..1521,
Exon (1)1..696
Gene:TCF7L2
Gene Synonym:TCF-4; TCF4
Exon (2)697..763
Gene:TCF7L2
Gene Synonym:TCF-4; TCF4
Exon (3)764..888
Gene:TCF7L2
Gene Synonym:TCF-4; TCF4
Exon (4)889..990
Gene:TCF7L2
Gene Synonym:TCF-4; TCF4
Exon (5)991..1123
Gene:TCF7L2
Gene Synonym:TCF-4; TCF4
Exon (6)1124..1214
Gene:TCF7L2
Gene Synonym:TCF-4; TCF4
Exon (7)1215..1301
Gene:TCF7L2
Gene Synonym:TCF-4; TCF4
Exon (8)1302..1427
Gene:TCF7L2
Gene Synonym:TCF-4; TCF4
Exon (9)1428..1587
Gene:TCF7L2
Gene Synonym:TCF-4; TCF4
Exon (10)1588..1695
Gene:TCF7L2
Gene Synonym:TCF-4; TCF4
Exon (11)1696..1744
Gene:TCF7L2
Gene Synonym:TCF-4; TCF4
Exon (12)1745..1795
Gene:TCF7L2
Gene Synonym:TCF-4; TCF4
Exon (13)1796..3919
Gene:TCF7L2
Gene Synonym:TCF-4; TCF4
Translation MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS LSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPL ITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWQGQP VYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSD VGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRR WHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLN PCLSLPPITGEKKSAFATYKVKAAASAHPLQMEAY
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Position Chain Variation Link
11+dbSNP:
11+g, tdbSNP:77172590
50+g, tdbSNP:185303710
95+c, tdbSNP:190495490
155+, cdbSNP:113102683
163+c, tdbSNP:113409023
213..214+, ttdbSNP:74804400
315+a, cdbSNP:372649758
352+a, gdbSNP:377107790
416..417+, gdbSNP:200139921
499..500+, adbSNP:373426839
517+c, tdbSNP:182211983
522+c, tdbSNP:369343242
531+a, gdbSNP:113219338
complement(536)-g, adbSNP:188153157
552+c, tdbSNP:76088094
573+a, gdbSNP:369358979
591+a, gdbSNP:373425129
complement(597)-g, adbSNP:192341583
605+a, gdbSNP:148876270
656+a, cdbSNP:79274995
657+c, tdbSNP:199669957
664+a, gdbSNP:184454375
707+dbSNP:
707+a, gdbSNP:373536721
790+dbSNP:
790+c, tdbSNP:201733753
855+c, tdbSNP:143305771
870+c, tdbSNP:370746069
932+dbSNP:
932+a, gdbSNP:139127477
940+a, gdbSNP:370021688
966+a, gdbSNP:140603697
971+a, cdbSNP:13458
985+a, gdbSNP:143077353
1017+dbSNP:
1017+c, tdbSNP:146872546
1043+a, cdbSNP:3197486
1073+c, tdbSNP:368592547
1108+a, gdbSNP:190966900
1140+dbSNP:
1140+a, gdbSNP:369811726
complement(1171)-t, cdbSNP:187396733
1185+c, tdbSNP:200396486
1186+a, gdbSNP:375223335
1197+a, cdbSNP:375642398
1206+g, tdbSNP:369602107
1234+dbSNP:
1234+a, cdbSNP:148523217
1242+a, gdbSNP:367884505
1281+c, tdbSNP:145083306
1291+c, tdbSNP:376667743
1295+a, tdbSNP:199917787
1347+dbSNP:
1347+a, gdbSNP:150706998
1356+a, gdbSNP:113767743
1362+a, gdbSNP:142028588
1374+a, gdbSNP:201875922
1452+dbSNP:
1452+a, gdbSNP:140535977
complement(1464)-c, adbSNP:2757884
1470+c, gdbSNP:150691578
1560+a, gdbSNP:375748811
1561+a, gdbSNP:111888905
1593+dbSNP:
1593+c, tdbSNP:142903496
1671+c, tdbSNP:149820593
1739+dbSNP:
1739+a, cdbSNP:372105926
1743+c, tdbSNP:146352267
1812+dbSNP:
1812+a, gdbSNP:368331428
1846+a, gdbSNP:191844653
1851+a, cdbSNP:77961654
1887+c, gdbSNP:201257936
1888+a, c, gdbSNP:77673441
1889+c, gdbSNP:149031135
1891+c, tdbSNP:202133956
1913+g, tdbSNP:201460379
1916+c, gdbSNP:151216935
1917+c, gdbSNP:375657594
1922+c, tdbSNP:372584799
1923+a, c, gdbSNP:138649767
1929+c, tdbSNP:58719567
1949+g, tdbSNP:375237374
1958+c, gdbSNP:368142604
1971+c, tdbSNP:185631836
1973+c, tdbSNP:76249005
2008+c, tdbSNP:371338610
2014+c, tdbSNP:201155099
2033+c, tdbSNP:375945855
2064+a, gdbSNP:368560561
2067+a, gdbSNP:372869035
2087+c, tdbSNP:150354863
2090+g, tdbSNP:191419844
2097+a, cdbSNP:147601829
2102+c, tdbSNP:73362229
2104+c, tdbSNP:369554727
2108..2644+c, g, tdbSNP:66702705
2110+c, gdbSNP:147059345
2144+a, gdbSNP:113907149
2155+c, gdbSNP:138340674
2156+c, tdbSNP:199967681
2157+c, tdbSNP:147841431
2164+c, gdbSNP:371235565
2166+c, gdbSNP:375473698
2188+c, tdbSNP:149556542
2192+c, tdbSNP:143411121
2204+c, tdbSNP:200948170
2208+a, gdbSNP:188333249
2217+c, tdbSNP:200117101
2220+c, tdbSNP:368555957
2223+c, tdbSNP:202158086
2232..2233+, adbSNP:141448155
2232+a, cdbSNP:201172396
2240+c, tdbSNP:1056877
2245+a, gdbSNP:368024370
2277+c, tdbSNP:114631541
2484..2485+, atdbSNP:369882395
2502+a, cdbSNP:71483172
2672+c, tdbSNP:140330059
2692..2693+, tdbSNP:5787989
2693..2694+, tdbSNP:11378467
2707..2708+, tdbSNP:10665742
2708+a, gdbSNP:200049258
2768+a, gdbSNP:368580149
2793+g, tdbSNP:192217246
2815+c, gdbSNP:7099964
2843+c, tdbSNP:184002338
2855+c, gdbSNP:3793883
2898+a, gdbSNP:186775783
2927+a, gdbSNP:191579091
2937+c, tdbSNP:56386996
3021+a, gdbSNP:3167853
3073+c, tdbSNP:78052345
3074+c, tdbSNP:143046274
3107+c, tdbSNP:55699322
3122..3123+, gdbSNP:35361397
3123..3124+, gdbSNP:397845504
3129+, tdbSNP:34227984
3201+a, gdbSNP:182519552
3234+a, gdbSNP:200066265
3272+a, gdbSNP:386517467
3272+c, tdbSNP:11196251
3273+a, gdbSNP:150438785
3284+c, tdbSNP:187178316
3285+c, tdbSNP:375337885
complement(3287)-g, cdbSNP:138209264
3315+c, gdbSNP:731788
3419+a, gdbSNP:192852951
3436..3437+, adbSNP:149548874
3509+c, tdbSNP:137902798
3510+a, gdbSNP:185357908
3549+c, tdbSNP:190131632
3689+a, gdbSNP:149574944
3697+c, tdbSNP:149044108
3729+, adbSNP:373786915
3730+c, tdbSNP:143071937
3763+a, gdbSNP:184873075
3780+a, tdbSNP:79963628
3804+c, tdbSNP:3635
3804+c, tdbSNP:386584535
3914+a, gdbSNP:3208480
Gene SymbolTCF7L2
Gene SynonymTCF-4; TCF4
Chromosome10
Locus Map10q25.3
Title Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality .
Author Seppala I, Kleber ME, Lyytikainen LP, Hernesniemi JA, Makela KM, Oksala N, Laaksonen R, Pilz S, Tomaschitz A, Silbernagel G, Boehm BO, Grammer TB, Koskinen T, Juonala M, Hutri-Kahonen N, Alfthan G, Viikari JS, Kahonen M, Raitakari OT, Marz W, Meinitzer A and Lehtimaki T.
Journal Eur. Heart J. 35 (8), 524-531 (2014)
Title Polymorphisms of transcription factor-7-like 2 (TCF7L2) gene in Tunisian women with polycystic ovary syndrome (PCOS) .
Author Ben-Salem A, Ajina M, Suissi M, Daher HS, Almawi WY and Mahjoub T.
Journal Gene 533 (2), 554-557 (2014)
Title Genome-wide association study identifies three novel loci for type 2 diabetes .
Author Hara K, Fujita H, Johnson TA, Yamauchi T, Yasuda K, Horikoshi M, Peng C, Hu C, Ma RC, Imamura M, Iwata M, Tsunoda T, Morizono T, Shojima N, So WY, Leung TF, Kwan P, Zhang R, Wang J, Yu W, Maegawa H, Hirose H, Kaku K, Ito C, Watada H, Tanaka Y, Tobe K, Kashiwagi A, Kawamori R, Jia W, Chan JC, Teo YY, Shyong TE, Kamatani N, Kubo M, Maeda S and Kadowaki T.
Journal Hum. Mol. Genet. 23 (1), 239-246 (2014)
Title Association between TCF7L2 gene polymorphism and cancer risk: a meta-analysis .
Author Chen J, Yuan T, Liu M and Chen P.
Journal PLoS ONE 8 (8), E71730 (2013)
Title The TCF7L2 rs7903146 (T) allele is associated with type 2 diabetes in urban Ghana: a hospital-based case-control study .
Author Danquah I, Othmer T, Frank LK, Bedu-Addo G, Schulze MB and Mockenhaupt FP.
Journal BMC Med. Genet. 14, 96 (2013)
Title Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium .
Author Barker N, Huls G, Korinek V and Clevers H.
Journal Am. J. Pathol. 154 (1), 29-35 (1999)
Title Identification of c-MYC as a target of the APC pathway .
Author He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B and Kinzler KW.
Journal Science 281 (5382), 1509-1512 (1998)
Title Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC .
Author Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B and Kinzler KW.
Journal Science 275 (5307), 1787-1790 (1997)
Title Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma .
Author Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW, Vogelstein B and Clevers H.
Journal Science 275 (5307), 1784-1787 (1997)
Title A gene family of HMG-box transcription factors with homology to TCF-1 .
Author Castrop J, van Norren K and Clevers H.
Journal Nucleic Acids Res. 20 (3), 611 (1992)

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