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Homo sapiens apolipoprotein A-V (APOA5), transcript variant 2, mRNA.


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001166598 Homo sapiens apolipoprotein A-V (APOA5), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $549.00 14

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RefSeq Version NM_001166598.1, 262231736
Length 1930 bp
Structure linear
Update Date 17-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens apolipoprotein A-V (APOA5), transcript variant 2, mRNA.
Product apolipoprotein A-V precursor
Comment

Summary: The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009].


Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

RefSeq NP_001160070.1
CDS 50..1150
Misc Feature(1)35..37
Misc Feature(2)221..820
Exon (1)1..41
Gene:APOA5
Gene Synonym:APOAV; RAP3
Exon (2)42..98
Gene:APOA5
Gene Synonym:APOAV; RAP3
Exon (3)99..210
Gene:APOA5
Gene Synonym:APOAV; RAP3
Exon (4)211..1908
Gene:APOA5
Gene Synonym:APOAV; RAP3
Translation MASMAAVLTWALALLSAFSATQARKGFWDYFSQTSGDKGRVEQIHQQKMAREPATLKDSL EQDLNNMNKFLEKLRPLSGSEAPRLPQDPVGMRRQLQEELEEVKARLQPYMAEAHELVGW NLEGLRQQLKPYTMDLMEQVALRVQELQEQLRVVGEDTKAQLLGGVDEAWALLQGLQSRV VHHTGRFKELFHPYAESLVSGIGRHVQELHRSVAPHAPASPARLSRCVQVLSRKLTLKAK ALHARIQQNLDQLREELSRAFAGTGTEEGAGPDPQMLSEEVRQRLQAFRQDTYLQIAAFT RAIDQETEEVQQQLAPPPPGHSAFAPEFQQTDSGKVLSKLQARLDDLWEDITHSLHDQGH SHLGDP
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Position Chain Variation Link
complement(9)-dbSNP:
complement(9)-t, cdbSNP:45611741
complement(22)-g, adbSNP:186726407
complement(47)-dbSNP:
complement(47)-t, cdbSNP:651821
complement(67)-g, adbSNP:199724136
complement(105)-dbSNP:
complement(105)-g, cdbSNP:3135506
complement(119)-t, gdbSNP:144178633
complement(134)-t, cdbSNP:139630081
complement(153)-t, cdbSNP:184390502
complement(155)-g, cdbSNP:146323308
complement(160)-t, gdbSNP:34282181
complement(168)-c, adbSNP:148778842
complement(181)-t, gdbSNP:12287066
complement(202)-t, gdbSNP:149652056
complement(214)-dbSNP:
complement(214)-g, cdbSNP:138300114
complement(217)-t, cdbSNP:147142271
complement(329)-g, adbSNP:201686049
complement(338)-g, adbSNP:201079485
complement(343)-g, cdbSNP:143382500
complement(344)-t, cdbSNP:138033117
complement(345)-t, cdbSNP:201115317
complement(362)-c, adbSNP:146964666
complement(425)-t, gdbSNP:140178861
complement(434)-t, gdbSNP:199974844
complement(464)-t, cdbSNP:121917821
complement(506)-t, cdbSNP:3135507
complement(549)-t, cdbSNP:143130285
complement(568)-t, cdbSNP:149112933
complement(588)-g, adbSNP:34543602
complement(600)-g, cdbSNP:201229911
complement(602)-t, gdbSNP:2075291
complement(603)-t, cdbSNP:144211639
complement(655)-g, adbSNP:140482460
complement(693)-g, adbSNP:76753536
complement(702..703)-, gdbSNP:71469115
complement(745)-t, g, cdbSNP:146781249
complement(872)-g, adbSNP:149808404
complement(874..875)-, tdbSNP:34767938
complement(883)-g, cdbSNP:139770186
complement(886)-c, adbSNP:150667142
complement(890)-t, cdbSNP:142901239
complement(897)-t, cdbSNP:140206085
complement(924)-g, adbSNP:34832733
complement(931)-t, cdbSNP:113986025
complement(935)-t, cdbSNP:199689773
complement(986)-g, adbSNP:147528707
complement(993)-g, adbSNP:143292359
complement(994)-t, cdbSNP:200738033
complement(1011)-t, adbSNP:201201147
complement(1024)-g, adbSNP:137942813
complement(1049)-t, cdbSNP:61743807
complement(1050)-c, adbSNP:147349873
complement(1072)-g, cdbSNP:7120555
complement(1162)-g, adbSNP:185060854
complement(1181)-t, cdbSNP:619054
complement(1209)-t, gdbSNP:192708363
complement(1226)-t, cdbSNP:34089864
complement(1273)-g, cdbSNP:112650726
complement(1295)-t, cdbSNP:45459507
complement(1308)-t, cdbSNP:2266788
complement(1322)-g, adbSNP:114627122
complement(1341)-g, adbSNP:188133936
complement(1434..1435)-, tcdbSNP:45596738
complement(1437..1438)-, tcdbSNP:72525532
complement(1439..1440)-, ctdbSNP:148759216
complement(1455)-t, cdbSNP:76463524
complement(1544)-t, cdbSNP:33984246
complement(1708)-t, cdbSNP:182378073
complement(1792)-t, adbSNP:35009896
complement(1841)-g, adbSNP:35822632
complement(1863)-g, cdbSNP:146109377
Gene SymbolAPOA5
Gene SynonymAPOAV; RAP3
Chromosome11
Locus Map11q23
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_001166598 Homo sapiens apolipoprotein A-V (APOA5), transcript variant 2, mRNA. On-demand $549.00 14
NM_052968 Homo sapiens apolipoprotein A-V (APOA5), transcript variant 1, mRNA. On-demand $549.00 14
Title The polymorphism -1131T>C in apolipoprotein A5 gene is associated with dyslipidemia in Brazilian subjects .
Author Ferreira,C.N., Carvalho,M.G., Fernandes,A.P., Santos,I.R., Rodrigues,K.F., Lana,A.M., Almeida,C.R., Loures-Vale,A.A., Gomes,K.B. and Sousa,M.O.
Journal Gene 516 (1), 171-175 (2013)
Title Gene transfer of apolipoprotein A-V improves the hypertriglyceridemic phenotype of apoa5 (-/-) mice .
Author Sharma,V., Beckstead,J.A., Simonsen,J.B., Nelbach,L., Watson,G., Forte,T.M. and Ryan,R.O.
Journal Arterioscler. Thromb. Vasc. Biol. 33 (3), 474-480 (2013)
Title Apolipoprotein A5 polymorphisms in Turkish population: association with serum lipid profile and risk of ischemic stroke .
Author Can Demirdogen,B., Sahin,E., Turkanoglu Ozcelik,A., Bek,S., Demirkaya,S. and Adali,O.
Journal Mol. Biol. Rep. 39 (12), 10459-10468 (2012)
Title Influence of apolipoprotein A-V on hepatocyte lipid droplet formation .
Author Gao,X., Forte,T.M. and Ryan,R.O.
Journal Biochem. Biophys. Res. Commun. 427 (2), 361-365 (2012)
Title Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis .
Author Inouye,M., Ripatti,S., Kettunen,J., Lyytikainen,L.P., Oksala,N., Laurila,P.P., Kangas,A.J., Soininen,P., Savolainen,M.J., Viikari,J., Kahonen,M., Perola,M., Salomaa,V., Raitakari,O., Lehtimaki,T., Taskinen,M.R., Jarvelin,M.R., Ala-Korpela,M., Palotie,A. and de Bakker,P.I.
Journal PLoS Genet. 8 (8), E1002907 (2012)
Title Definitive N-terminal protein sequence and further characterization of the novel apolipoprotein A5 in human serum .
Author Alborn,W.E., Johnson,M.G., Prince,M.J. and Konrad,R.J.
Journal Clin. Chem. 52 (3), 514-517 (2006)
Title The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese .
Author Nabika,T., Nasreen,S., Kobayashi,S. and Masuda,J.
Journal Atherosclerosis 165 (2), 201-204 (2002)
Title Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels .
Author Pennacchio,L.A., Olivier,M., Hubacek,J.A., Krauss,R.M., Rubin,E.M. and Cohen,J.C.
Journal Hum. Mol. Genet. 11 (24), 3031-3038 (2002)
Title Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration .
Author van der Vliet,H.N., Sammels,M.G., Leegwater,A.C., Levels,J.H., Reitsma,P.H., Boers,W. and Chamuleau,R.A.
Journal J. Biol. Chem. 276 (48), 44512-44520 (2001)
Title An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing .
Author Pennacchio,L.A., Olivier,M., Hubacek,J.A., Cohen,J.C., Cox,D.R., Fruchart,J.C., Krauss,R.M. and Rubin,E.M.
Journal Science 294 (5540), 169-173 (2001)


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