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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


Homo sapiens dynein, cytoplasmic 1, heavy chain 1 (DYNC1H1), mRNA.


RefSeq Accession Definition Services Price Order
NM_001376 Homo sapiens dynein, cytoplasmic 1, heavy chain 1 (DYNC1H1), mRNA. ORF Sequence Quote
Peptide Services
Antibody Services
Protein Services


RefSeq Version NM_001376.4, 209413718
Length 14361 bp
Structure linear
Update Date 17-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens dynein, cytoplasmic 1, heavy chain 1 (DYNC1H1), mRNA.
Product cytoplasmic dynein 1 heavy chain 1
Comment

Summary: Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008].

RefSeq NP_001367.2
CDS 165..14105
Misc Feature(1)114..116
Misc Feature(2)321..5765
Misc Feature(3)321..5765
Misc Feature(4)876..2666
Misc Feature(5)1506..2273
Misc Feature(6)2115..2570
Misc Feature(7)3537..3539
Misc Feature(8)3729..4085
Misc Feature(9)4119..5339
Misc Feature(10)5766..6473
Misc Feature(11)5766..6461
Misc Feature(12)6702..7520
Misc Feature(13)6819..7241
Misc Feature(14)7392..7394
Misc Feature(15)7791..8771
Misc Feature(16)7830..8579
Misc Feature(17)7872..8363
Misc Feature(18)7947..7970
Misc Feature(19)order(7950..7973,8154..8156,8301..8303)
Misc Feature(20)8142..8159
Misc Feature(21)8340..8342
Misc Feature(22)8859..9668
Misc Feature(23)8928..>9200
Misc Feature(24)8973..8996
Misc Feature(25)order(8976..8999,9147..9149)
Misc Feature(26)9135..9152
Misc Feature(27)9729..10664
Misc Feature(28)9765..10748
Misc Feature(29)10602..10604
Misc Feature(30)10821..11510
Misc Feature(31)10848..11504
Misc Feature(32)11907..14099
Misc Feature(33)12177..12827
Misc Feature(34)13011..13013
Misc Feature(35)13266..13268
Misc Feature(36)13266..13268
Exon (1)1..420
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (2)421..508
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (3)509..682
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (4)683..938
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (5)939..1125
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (6)1126..1397
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (7)1398..1625
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (8)1626..2702
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (9)2703..2882
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (10)2883..3032
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (11)3033..3179
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (12)3180..3320
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (13)3321..3497
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (14)3498..3608
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (15)3609..3728
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (16)3729..3968
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (17)3969..4124
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (18)4125..4238
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (19)4239..4349
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (20)4350..4559
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (21)4560..4706
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (22)4707..4873
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (23)4874..5047
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (24)5048..5213
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (25)5214..5402
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (26)5403..5597
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (27)5598..5880
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (28)5881..5981
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (29)5982..6141
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (30)6142..6385
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (31)6386..6569
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (32)6570..6782
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (33)6783..7021
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (34)7022..7178
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (35)7179..7406
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (36)7407..7637
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (37)7638..7778
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (38)7779..8012
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (39)8013..8219
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (40)8220..8341
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (41)8342..8507
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (42)8508..8671
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (43)8672..8801
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (44)8802..8935
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (45)8936..9050
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (46)9051..9212
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (47)9213..9427
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (48)9428..9632
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (49)9633..9806
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (50)9807..9926
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (51)9927..10047
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (52)10048..10243
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (53)10244..10361
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (54)10362..10577
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (55)10578..10790
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (56)10791..10918
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (57)10919..11072
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (58)11073..11219
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (59)11220..11370
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (60)11371..11624
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (61)11625..11759
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (62)11760..11854
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (63)11855..12029
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (64)12030..12105
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (65)12106..12266
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (66)12267..12378
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (67)12379..12439
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (68)12440..12563
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (69)12564..12677
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (70)12678..12848
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (71)12849..13066
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (72)13067..13170
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (73)13171..13382
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (74)13383..13536
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (75)13537..13679
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (76)13680..13848
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (77)13849..13976
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Exon (78)13977..14340
Gene:DYNC1H1
Gene Synonym:DHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Translation MSEPGGGGGEDGSAGLEVSAVQNVADVSVLQKHLRKLVPLLLEDGGEAPAALEAALEEKS ALEQMRKFLSDPQVHTVLVERSTLKEDVGDEGEEEKEFISYNINIDIHYGVKSNSLAFIK RTPVIDADKPVSSQLRVLTLSEDSPYETLHSFISNAVAPFFKSYIRESGKADRDGDKMAP SVEKKIAELEMGLLHLQQNIEIPEISLPIHPMITNVAKQCYERGEKPKVTDFGDKVEDPT FLNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLT LDILKHGKRFHATVSFDTDTGLKQALETVNDYNPLMKDFPLNDLLSATELDKIRQALVAI FTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKVLGTRKLMHVAYEEFEKVMVACFEVF QTWDDEYEKLQVLLRDIVKRKREENLKMVWRINPAHRKLQARLDQMRKFRRQHEQLRAVI VRVLRPQVTAVAQQNQGEVPEPQDMKVAEVLFDAADANAIEEVNLAYENVKEVDGLDVSK EGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGA IREYQTQLIQRVKDDIESLHDKFKVQYPQSQACKMSHVRDLPPVSGSIIWAKQIDRQLTA YMKRVEDVLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFDDWARKVQQRNLGVSGRIFTI ESTRVRGRTGNVLKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKAHQANQLYPFAIS LIESVRTYERTCEKVEERNTISLLVAGLKKEVQALIAEGIALVWESYKLDPYVQRLAETV FNFQEKVDDLLIIEEKIDLEVRSLETCMYDHKTFSEILNRVQKAVDDLNLHSYSNLPIWV NKLDMEIERILGVRLQAGLRAWTQVLLGQAEDKAEVDMDTDAPQVSHKPGGEPKIKNVVH ELRITNQVIYLNPPIEECRYKLYQEMFAWKMVVLSLPRIQSQRYQVGVHYELTEEEKFYR NALTRMPDGPVALEESYSAVMGIVSEVEQYVKVWLQYQCLWDMQAENIYNRLGEDLNKWQ ALLVQIRKARGTFDNAETKKEFGPVVIDYGKVQSKVNLKYDSWHKEVLSKFGQMLGSNMT EFHSQISKSRQELEQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQ RFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKIVQEDRAVESRTTDLLTD WEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKAKEALELTDTGLLSGSEERVQ VALEELQDLKGVWSELSKVWEQIDQMKEQPWVSVQPRKLRQNLDALLNQLKSFPARLRQY ASYEFVQRLLKGYMKINMLVIELKSEALKDRHWKQLMKRLHVNWVVSELTLGQIWDVDLQ KNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCRLIRGWDDLFNKVKEH INSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGIFTGSADIKHL LPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSLERLADLLGKIQKALGEYLE RERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSIILNEDNSVVLGISSRE GEEVMFKTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPNTYIT WIDKYQAQLVVLSAQIAWSENVETALSSMGGGGDAAPLHSVLSNVEVTLNVLADSVLMEQ PPLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQ MANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALG HQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQE ALREHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLA MTKPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSA GNVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSVCETMVPKLVAEDIPLLFSL LSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEEVGGMWVEKVLQLYQITQINHGL MMVGPSGSGKSMAWRVLLKALERLEGVEGVAHIIDPKAISKDHLYGTLDPNTREWTDGLF THVLRKIIDSVRGELQKRQWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVR IMFEVQDLKYATLATVSRCGMVWFSEDVLSTDMIFNNFLARLRSIPLDEGEDEAQRRRKG KEDEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHAFQLEHIMDLTRLRCLGSLFS MLHQACRNVAQYNANHPDFPMQIEQLERYIQRYLVYAILWSLSGDSRLKMRAELGEYIRR ITTVPLPTAPNIPIIDYEVSISGEWSPWQAKVPQIEVETHKVAAPDVVVPTLDTVRHEAL LYTWLAEHKPLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCE YRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFYRTSDQTW VKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGTFNRAMLRLIP SLRTYAEPLTAAMVEFYTMSQERFTQDTQPHYIYSPREMTRWVRGIFEALRPLETLPVEG LIRIWAHEALRLFQDRLVEDEERRWTDENIDTVALKHFPNIDREKAMSRPILYSNWLSKD YIPVDQEELRDYVKARLKVFYEEELDVPLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSG AGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVL DSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEELYKWFTSQVIR NLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDLEKPNY IVPDYMPVVYDKLPQPPSHREAIVNSCVFVHQTLHQANARLAKRGGRTMAITPRHYLDFI NHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKL KKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIK KQHLVEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIMRENFIPTIVNFSAEEIS DAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPLRNELQKLE DDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLK SLSAERERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQAN IQFRTDIARTEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFI MNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDPVLNPVLNREVRRTGGRV LITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAE RPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEV TRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQIHFLYQYSLQFFLDIYHNVL YENPNLKGVTDHTQRLSIITKDLFQVAFNRVARGMLHQDHITFAMLLARIKLKGTVGEPT YDAEFQHFLRGNEIVLSAGSTPRIQGLTVEQAEAVVRLSCLPAFKDLIAKVQADEQFGIW LDSSSPEQTVPYLWSEETPATPIGQAIHRLLLIQAFRPDRLLAMAHMFVSTNLGESFMSI MEQPLDLTHIVGTEVKPNTPVLMCSVPGYDASGHVEDLAAEQNTQITSIAIGSAEGFNQA DKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSLQPHACFRLFLTMEINPKVPVNLLR AGRIFVFEPPPGVKANMLRTFSSIPVSRICKSPNERARLYFLLAWFHAIIQERLRYAPLG WSKKYEFGESDLRSACDTVDTWLDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEF DQRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWVELLPDTQTPSW LGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTDSTSDGRPAWMRTL HTTASNWLHLIPQTLSHLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEG KKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNISLAAASGG AKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVTTSQGATLDACSFGV TGLKLQGATCNNNKLSLSNAISTALPLTQLRWVKQTNTEKKASVVTLPVYLNFTRADLIF TVDFEIATKEDPRSFYERGVAVLCTE
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Position Chain Variation Link
72+dbSNP:
72+a, cdbSNP:17540561
112+a, gdbSNP:2273436
118+a, tdbSNP:17511851
160+a, gdbSNP:17511858
210+c, tdbSNP:2273437
425+dbSNP:
425+a, c, tdbSNP:75113705
439+g, tdbSNP:11544083
446+a, gdbSNP:147788966
470+c, tdbSNP:17540624
526+dbSNP:
526+a, gdbSNP:201746558
554+c, tdbSNP:2273439
573+a, gdbSNP:143421325
620+c, tdbSNP:148062994
621+a, gdbSNP:140905741
731+dbSNP:
731+c, tdbSNP:200918195
749+c, tdbSNP:144882836
760+a, gdbSNP:77216005
773+a, gdbSNP:138702876
788+a, gdbSNP:3818188
789+a, gdbSNP:146338899
798+a, gdbSNP:138182529
902+a, gdbSNP:117189734
1016+dbSNP:
1016+a, gdbSNP:199534174
1049+a, gdbSNP:34287672
1078+a, gdbSNP:112558840
1208+dbSNP:
1208+a, gdbSNP:144254264
1209+g, tdbSNP:7157623
1250+a, gdbSNP:17540728
1337+a, gdbSNP:17540735
1380+c, tdbSNP:201446486
1460+dbSNP:
1460+a, gdbSNP:144954782
1472+c, tdbSNP:147531912
1549+a, gdbSNP:202204063
1638+dbSNP:
1638+g, tdbSNP:75648834
1658+c, gdbSNP:140744226
1709+a, gdbSNP:145784659
1751+c, tdbSNP:138418906
1805+a, gdbSNP:187807797
1868+c, tdbSNP:192959810
1970+c, tdbSNP:145526188
2141+a, gdbSNP:151170554
2189+c, tdbSNP:140154194
2341+a, gdbSNP:199986472
2375+a, tdbSNP:149902566
2399+a, gdbSNP:200165575
2400+c, tdbSNP:200705447
2447+a, gdbSNP:202008601
2492+a, gdbSNP:144921184
2516+c, tdbSNP:149028205
2540+c, tdbSNP:35092963
2564+c, gdbSNP:146746729
2605+c, gdbSNP:140342004
2612+c, tdbSNP:145405293
2621+c, tdbSNP:148030949
2675+a, gdbSNP:17512054
2726+dbSNP:
2726+a, gdbSNP:150213445
2788+c, tdbSNP:184868637
2789+a, gdbSNP:17512082
2834+g, tdbSNP:142961295
2880..2881+, cdbSNP:35678416
2885+dbSNP:
2885+c, tdbSNP:114021657
2900+c, tdbSNP:201391933
2944+c, tdbSNP:199663361
3038+dbSNP:
3038+c, tdbSNP:150783632
3039+a, gdbSNP:140141126
3128+c, tdbSNP:192263501
3176+c, tdbSNP:139087346
3200+dbSNP:
3200+a, gdbSNP:200641486
3560+dbSNP:
3560+a, gdbSNP:202121407
3584+a, gdbSNP:144002471
3643+dbSNP:
3643+c, tdbSNP:200290958
3659+c, tdbSNP:144359313
3764+dbSNP:
3764+a, gdbSNP:12893215
3840+a, cdbSNP:142580174
3929+c, tdbSNP:150953878
4013+dbSNP:
4013+c, tdbSNP:201658297
4037+a, gdbSNP:138014752
4041+a, gdbSNP:201107645
4073+a, gdbSNP:34690489
4111+a, gdbSNP:80342281
4117+a, gdbSNP:143114300
4157+dbSNP:
4157+c, tdbSNP:17540957
4191+a, gdbSNP:111306376
4340+dbSNP:
4340+c, tdbSNP:112261870
4460+dbSNP:
4460+c, gdbSNP:150374820
4489+a, cdbSNP:79375714
4495+c, tdbSNP:141561289
4673+dbSNP:
4673+c, tdbSNP:116089522
4679+a, gdbSNP:186932188
4697+a, gdbSNP:150900416
4727+dbSNP:
4727+a, cdbSNP:199653737
4798+g, tdbSNP:78499581
4896+dbSNP:
4896+c, tdbSNP:143297786
4932+c, gdbSNP:200700087
5018+c, tdbSNP:75094258
5075+dbSNP:
5075+a, gdbSNP:181705516
5150+a, gdbSNP:113210905
5165+c, tdbSNP:117199211
5333+dbSNP:
5333+a, gdbSNP:147025658
5346+g, tdbSNP:77319596
5361+a, gdbSNP:138287354
5412+dbSNP:
5412+a, gdbSNP:199740595
5418+c, tdbSNP:200839329
5457+a, gdbSNP:144147463
5458+c, tdbSNP:150687712
5459+a, gdbSNP:139919955
5462+g, tdbSNP:149395439
5474+c, tdbSNP:34013442
5475+a, gdbSNP:139842853
5490+a, gdbSNP:200722698
5491+c, tdbSNP:201902137
5492+a, gdbSNP:143258359
5510+a, gdbSNP:111244988
5524+c, tdbSNP:183510947
5661+dbSNP:
5661+a, gdbSNP:150846332
5732+a, gdbSNP:200001375
5758+a, gdbSNP:146678667
5816+c, tdbSNP:17512313
5882+dbSNP:
5882+a, cdbSNP:139070737
6038+dbSNP:
6038+c, tdbSNP:142726284
6046+a, cdbSNP:76714579
6089+a, gdbSNP:113962837
6112+a, gdbSNP:200934709
6135+a, gdbSNP:151001016
6149+dbSNP:
6149+c, tdbSNP:140841480
6194+a, gdbSNP:202004938
6392+dbSNP:
6392+c, tdbSNP:201113072
6398+a, gdbSNP:202202428
6650+dbSNP:
6650+a, gdbSNP:149707073
6699+a, cdbSNP:147905977
6842+dbSNP:
6842+g, tdbSNP:141898156
6926+c, tdbSNP:150603103
6959+c, tdbSNP:200339812
7022+dbSNP:
7022+a, gdbSNP:147061741
7073+c, tdbSNP:138326082
7150+a, gdbSNP:142335110
7154+a, gdbSNP:143403214
7232+dbSNP:
7232+a, gdbSNP:188714917
7241+c, tdbSNP:200885538
7301+a, gdbSNP:17512439
7352+a, gdbSNP:199686352
7356+c, tdbSNP:141525226
7367+a, cdbSNP:150888094
7403+g, tdbSNP:138407720
7427+dbSNP:
7427+a, gdbSNP:201651726
7439+a, gdbSNP:141665695
7454+c, tdbSNP:112811548
7481+c, tdbSNP:200197781
7535+a, gdbSNP:186858721
7571+a, gdbSNP:113450243
7574+a, gdbSNP:139109090
7578+c, tdbSNP:201407474
7583+c, tdbSNP:111459275
7613+c, tdbSNP:17541158
7614+a, gdbSNP:200144084
7620+c, tdbSNP:111562779
7622+g, tdbSNP:17541165
7627+a, gdbSNP:149581331
7688+dbSNP:
7688+a, gdbSNP:17541179
7734+a, gdbSNP:147836678
7751+a, gdbSNP:201720217
7790+dbSNP:
7790+c, tdbSNP:200589320
7796+a, gdbSNP:17512460
7901+c, tdbSNP:140096332
7922+c, tdbSNP:145487328
7923+a, gdbSNP:147684971
7936+c, tdbSNP:111483497
8060+dbSNP:
8060+a, gdbSNP:17512467
8084+a, gdbSNP:140949915
8143+g, tdbSNP:201272954
8231+dbSNP:
8231+c, tdbSNP:201369840
8309+c, tdbSNP:200413541
8339+c, tdbSNP:150181583
8366+dbSNP:
8366+a, gdbSNP:202023896
8381+a, gdbSNP:138710201
8387+c, tdbSNP:149018711
8394+c, gdbSNP:145876293
8468+a, gdbSNP:77113510
8536+dbSNP:
8536+a, tdbSNP:190094426
8642+a, gdbSNP:117846737
8666+a, gdbSNP:146220233
8675+dbSNP:
8675+c, tdbSNP:137911066
8694+c, tdbSNP:141634210
8695+a, gdbSNP:150520534
8711+c, tdbSNP:149526821
8729+a, gdbSNP:2749899
8748+a, gdbSNP:139461837
8876+dbSNP:
8876+a, gdbSNP:141827899
8948+dbSNP:
8948+a, gdbSNP:149753029
9002+a, gdbSNP:147427595
9011+c, tdbSNP:200720335
9092+dbSNP:
9092+a, g, tdbSNP:8010870
9152+a, gdbSNP:149327058
9183+a, cdbSNP:181567525
9257+dbSNP:
9257+a, gdbSNP:145208135
9302+g, tdbSNP:34338935
9335+a, gdbSNP:201041097
9374+a, gdbSNP:201817995
9464+dbSNP:
9464+a, gdbSNP:148753855
9488+a, gdbSNP:142338762
9566+a, gdbSNP:145095254
9635+dbSNP:
9635+a, gdbSNP:151255069
9728+c, tdbSNP:202053613
9767+a, gdbSNP:140436909
9800+c, gdbSNP:2295445
9867+dbSNP:
9867+c, gdbSNP:199966256
10028+dbSNP:
10028+c, tdbSNP:200512100
10043+a, gdbSNP:184853838
10223+dbSNP:
10223+c, tdbSNP:145903700
10229+c, tdbSNP:80096622
10248+dbSNP:
10248+a, gdbSNP:113879661
10457+dbSNP:
10457+c, tdbSNP:75075497
10496+c, tdbSNP:145087182
10565+a, tdbSNP:184264124
10604+dbSNP:
10604+a, gdbSNP:138887857
10637+a, gdbSNP:201109134
10686+a, cdbSNP:149496322
10814+dbSNP:
10814+a, gdbSNP:143068719
10867+c, tdbSNP:148203153
10871+c, tdbSNP:111732439
10902+c, gdbSNP:200525912
10916+c, tdbSNP:181445947
10966+dbSNP:
10966+c, tdbSNP:199735285
10997+c, gdbSNP:35143882
11051+c, tdbSNP:141133453
11060+a, cdbSNP:200903643
11114+dbSNP:
11114+c, tdbSNP:17541505
11151+a, gdbSNP:200204286
11180+a, gdbSNP:199679500
11186+a, gdbSNP:139719984
11303+dbSNP:
11303+a, gdbSNP:143642514
11426+dbSNP:
11426+c, tdbSNP:147204277
11503+g, tdbSNP:75855880
11525+a, gdbSNP:145320071
11552+c, tdbSNP:149806996
11564+a, gdbSNP:182767009
11573+a, gdbSNP:17512783
11577+a, gdbSNP:201692735
11661+dbSNP:
11661+c, tdbSNP:200735835
11667+a, gdbSNP:148513391
11798+dbSNP:
11798+c, gdbSNP:144177631
11849+c, tdbSNP:17541519
11868+dbSNP:
11868+a, gdbSNP:17512818
11913+a, cdbSNP:201024297
11915+g, tdbSNP:141469535
11929+c, tdbSNP:141696238
11939+a, gdbSNP:11544085
11966+c, gdbSNP:151307859
11978+c, gdbSNP:200524253
11985+c, tdbSNP:187563446
12026+c, tdbSNP:140543419
12037+dbSNP:
12037+g, tdbSNP:150118849
12077+c, gdbSNP:201174299
12106+dbSNP:
12106+c, gdbSNP:138428684
12109+c, gdbSNP:200449441
12129+c, tdbSNP:142701168
12221+c, gdbSNP:201290175
12251+a, cdbSNP:10129889
12323+dbSNP:
12323+a, tdbSNP:115992196
12327+a, gdbSNP:143757179
12350+c, gdbSNP:144124371
12356+g, tdbSNP:114906811
12422+dbSNP:
12422+c, tdbSNP:141242095
12467+dbSNP:
12467+a, gdbSNP:150851798
12494+a, gdbSNP:182070792
12518+g, tdbSNP:143574214
12519+a, cdbSNP:139284699
12561+a, cdbSNP:112050355
12576+dbSNP:
12576+c, gdbSNP:144282707
12599+c, tdbSNP:11544084
12605+c, tdbSNP:146075696
12617+a, tdbSNP:200375220
12660+a, gdbSNP:202107738
12748+dbSNP:
12748+a, gdbSNP:140013253
12758+a, tdbSNP:143936619
12827+a, gdbSNP:145849008
12869+dbSNP:
12869+a, gdbSNP:199792795
12938+c, tdbSNP:17512877
12964+c, tdbSNP:1043455
12998+c, tdbSNP:201126154
12999+a, gdbSNP:142900209
13103+dbSNP:
13103+c, tdbSNP:151172467
13115+a, gdbSNP:141273501
13142+c, tdbSNP:146950724
13178+dbSNP:
13178+c, tdbSNP:200400317
13226+c, tdbSNP:181697853
13241+a, gdbSNP:186804068
13244+c, tdbSNP:13749
13252+a, cdbSNP:141925609
13301+a, tdbSNP:150172431
13315+c, tdbSNP:201971718
13321+a, gdbSNP:201575292
13325+g, tdbSNP:138618346
13345+c, tdbSNP:149300055
13356+c, tdbSNP:144570049
13367+c, gdbSNP:138022242
13479+dbSNP:
13479+a, gdbSNP:142883042
13513+c, tdbSNP:146087540
13515+c, tdbSNP:1127284
13523+c, tdbSNP:140033479
13568+dbSNP:
13568+a, gdbSNP:17541692
13572+c, tdbSNP:150906249
13578+a, gdbSNP:199692678
13604+c, tdbSNP:150286673
13613+c, tdbSNP:112444677
13721+dbSNP:
13721+a, gdbSNP:35546990
13815+a, gdbSNP:145366078
13831+a, gdbSNP:142519155
13847+a, gdbSNP:192742245
13871+dbSNP:
13871+a, gdbSNP:138571942
13889+a, gdbSNP:200002869
13898+a, cdbSNP:201665825
13927+c, tdbSNP:200971499
13928+a, gdbSNP:35079638
13946+a, gdbSNP:147580834
13972+g, tdbSNP:200731839
14018+c, tdbSNP:112650569
14037+a, gdbSNP:200149883
14051+a, gdbSNP:141961494
14076+c, tdbSNP:200224597
14111+c, tdbSNP:201172648
14131+a, gdbSNP:192484803
14198+a, gdbSNP:1043826
14246..14247+, gdbSNP:35480752
14295+a, gdbSNP:13901
14337+c, tdbSNP:17512996
Gene SymbolDYNC1H1
Gene SynonymDHC1; DHC1a; DNCH1; Dnchc1; DNCL; DNECL; DYHC; HL-3; p22
Chromosome14
Locus Map14q32
All Transcripts
RefSeq Accession Definition Sequence Price Select
NM_001376 Homo sapiens dynein, cytoplasmic 1, heavy chain 1 (DYNC1H1), mRNA. Full Length Quote
ORF Sequence Quote
Title Reconstitution of the human cytoplasmic dynein complex .
Author Trokter,M., Mucke,N. and Surrey,T.
Journal Proc. Natl. Acad. Sci. U.S.A. 109 (51), 20895-20900 (2012)
Title BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures .
Author Splinter,D., Razafsky,D.S., Schlager,M.A., Serra-Marques,A., Grigoriev,I., Demmers,J., Keijzer,N., Jiang,K., Poser,I., Hyman,A.A., Hoogenraad,C.C., King,S.J. and Akhmanova,A.
Journal Mol. Biol. Cell 23 (21), 4226-4241 (2012)
Title A DYNC1H1 mutation causes a dominant spinal muscular atrophy with lower extremity predominance .
Author Tsurusaki,Y., Saitoh,S., Tomizawa,K., Sudo,A., Asahina,N., Shiraishi,H., Ito,J., Tanaka,H., Doi,H., Saitsu,H., Miyake,N. and Matsumoto,N.
Journal Neurogenetics 13 (4), 327-332 (2012)
Title Mutations in the tail domain of DYNC1H1 cause dominant spinal muscular atrophy .
Author Harms,M.B., Ori-McKenney,K.M., Scoto,M., Tuck,E.P., Bell,S., Ma,D., Masi,S., Allred,P., Al-Lozi,M., Reilly,M.M., Miller,L.J., Jani-Acsadi,A., Pestronk,A., Shy,M.E., Muntoni,F., Vallee,R.B. and Baloh,R.H.
Journal Neurology 78 (22), 1714-1720 (2012)
Title Multiple modes of cytoplasmic dynein regulation .
Author Vallee,R.B., McKenney,R.J. and Ori-McKenney,K.M.
Journal Nat. Cell Biol. 14 (3), 224-230 (2012)
Title Multiple mouse chromosomal loci for dynein-based motility .
Author Vaughan,K.T., Mikami,A., Paschal,B.M., Holzbaur,E.L., Hughes,S.M., Echeverri,C.J., Moore,K.J., Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Vallee,R.B.
Journal Genomics 36 (1), 29-38 (1996)
Title Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles .
Author Vaisberg,E.A., Grissom,P.M. and McIntosh,J.R.
Journal J. Cell Biol. 133 (4), 831-842 (1996)
Title Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function .
Author Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
Journal J. Cell Biol. 129 (6), 1617-1628 (1995)
Title Localization of the human cytoplasmic dynein heavy chain (DNECL) to 14qter by fluorescence in situ hybridization .
Author Narayan,D., Desai,T., Banks,A., Patanjali,S.R., Ravikumar,T.S. and Ward,D.C.
Journal Genomics 22 (3), 660-661 (1994)
Title Cytoplasmic dynein plays a role in mammalian mitotic spindle formation .
Author Vaisberg,E.A., Koonce,M.P. and McIntosh,J.R.
Journal J. Cell Biol. 123 (4), 849-858 (1993)

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