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Homo sapiens engrailed homeobox 2 (EN2), mRNA.

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001427 Homo sapiens engrailed homeobox 2 (EN2), mRNA. GenEZ ORF Cloning On-demand $TBD TBD

*Business Day

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RefSeq Version NM_001427.3, 126090912
Length 3405 bp
Structure linear
Update Date 17-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens engrailed homeobox 2 (EN2), mRNA.
Product homeobox protein engrailed-2

Summary: Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008].

RefSeq NP_001418.2
CDS 250..1251
Misc Feature(1)97..99
Misc Feature(2)97..99
Misc Feature(3)976..1155
Misc Feature(4)976..1155
Misc Feature(5)994..1152
Misc Feature(6)order(994..996,1000..1002,1051..1053,1069..1071,
Misc Feature(7)order(997..999,1117..1119,1126..1131,1138..1140)
Misc Feature(8)1075..1077
Misc Feature(9)1153..1248
Exon (1)935..3395
Gene Synonym:EN2
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Position Chain Variation Link
277+c, gdbSNP:193264681
360+a, gdbSNP:77846527
420+c, gdbSNP:199573836
610+a, gdbSNP:3735653
653+g, tdbSNP:112029171
849+c, gdbSNP:80239010
969+a, gdbSNP:145749730
986+g, tdbSNP:148967146
987+g, tdbSNP:144197066
990+a, gdbSNP:138007513
1006+g, tdbSNP:75103128
1059+a, gdbSNP:112687347
1083+a, gdbSNP:146535449
1125+c, gdbSNP:141222652
1137+c, tdbSNP:145531356
1149+a, gdbSNP:34614453
1158+a, gdbSNP:148064651
1173+a, gdbSNP:140822188
1179+c, g, tdbSNP:56008230
1201+c, tdbSNP:2361689
1209+c, tdbSNP:142774508
1245+c, tdbSNP:149481945
1254+c, tdbSNP:12674067
1285+a, gdbSNP:192274449
1318+g, tdbSNP:184624346
1506+a, gdbSNP:73734533
1634+c, tdbSNP:189436701
1660+c, tdbSNP:181376144
1670+c, gdbSNP:207468873
1770+c, gdbSNP:185936495
1851+, gdbSNP:144219267
1861+a, gdbSNP:56651365
1874+g, tdbSNP:143878581
1876+a, gdbSNP:3808330
1955+c, tdbSNP:3808329
1964+c, tdbSNP:189617846
1981+a, gdbSNP:3808328
2001+c, tdbSNP:10234087
2019..2022+, ctttdbSNP:111556743
2060+c, tdbSNP:139789685
2069+a, gdbSNP:3808327
2075+c, tdbSNP:55729502
2076+a, gdbSNP:3808326
2131+a, tdbSNP:57599144
2186+, cdbSNP:113000817
2217+c, tdbSNP:143914514
2244+c, tdbSNP:4716597
2266+c, tdbSNP:181828936
2380+g, tdbSNP:114134796
2446+a, tdbSNP:67027007
2530+a, gdbSNP:186374442
2549+c, tdbSNP:10949811
2559..2560+, acdbSNP:113684257
2560..2563+, acacdbSNP:144874127
2577+, cacdbSNP:72575652
2578..2579+, acadbSNP:147466369
2581+a, cdbSNP:77385528
2582..2583+, acadbSNP:72022210
2583..2584+, a, acdbSNP:35869460
2583..2584+, acdbSNP:200496623
2584+a, cdbSNP:200149777
2711+c, tdbSNP:190966205
2733+c, tdbSNP:117213382
2925+c, tdbSNP:182759274
3044+c, tdbSNP:118079538
3124+c, tdbSNP:146402842
3238..3239+, cdbSNP:34901594
3264+c, tdbSNP:139745969
3276+g, tdbSNP:186998101
3299+c, tdbSNP:115156116
3381+c, tdbSNP:56178493
Gene SymbolEN2
Gene SynonymEN2
Locus Map7q36
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_001427 Homo sapiens engrailed homeobox 2 (EN2), mRNA. On-demand TBD TBD
Title The WNT2 gene polymorphism associated with speech delay inherent to autism .
Author Lin,P.I., Chien,Y.L., Wu,Y.Y., Chen,C.H., Gau,S.S., Huang,Y.S., Liu,S.K., Tsai,W.C. and Chiu,Y.N.
Journal Res Dev Disabil 33 (5), 1533-1540 (2012)
Title Cut-like homeobox 1 and nuclear factor I/B mediate ENGRAILED2 autism spectrum disorder-associated haplotype function .
Author Choi,J., Ababon,M.R., Matteson,P.G. and Millonig,J.H.
Journal Hum. Mol. Genet. 21 (7), 1566-1580 (2012)
Title Engrailed-2 (EN2): a tumor specific urinary biomarker for the early diagnosis of prostate cancer .
Author Morgan,R., Boxall,A., Bhatt,A., Bailey,M., Hindley,R., Langley,S., Whitaker,H.C., Neal,D.E., Ismail,M., Whitaker,H., Annels,N., Michael,A. and Pandha,H.
Journal Clin. Cancer Res. 17 (5), 1090-1098 (2011)
Title Family-based studies indicate association of Engrailed 2 gene with autism in an Indian population .
Author Sen,B., Singh,A.S., Sinha,S., Chatterjee,A., Ahmed,S., Ghosh,S. and Usha,R.
Journal Genes Brain Behav. 9 (2), 248-255 (2010)
Title Intronic single nucleotide polymorphisms of engrailed homeobox 2 modulate the disease vulnerability of autism in a han chinese population .
Author Yang,P., Shu,B.C., Hallmayer,J.F. and Lung,F.W.
Journal Neuropsychobiology 62 (2), 104-115 (2010)
Title Deregulated expression of PAX5 in medulloblastoma .
Author Kozmik,Z., Sure,U., Ruedi,D., Busslinger,M. and Aguzzi,A.
Journal Proc. Natl. Acad. Sci. U.S.A. 92 (12), 5709-5713 (1995)
Title Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions .
Author Logan,C., Hanks,M.C., Noble-Topham,S., Nallainathan,D., Provart,N.J. and Joyner,A.L.
Journal Dev. Genet. 13 (5), 345-358 (1992)
Title Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox .
Author Joyner,A.L., Herrup,K., Auerbach,B.A., Davis,C.A. and Rossant,J.
Journal Science 251 (4998), 1239-1243 (1991)
Title Isolation and chromosomal localization of the human En-2 gene .
Author Poole,S.J., Law,M.L., Kao,F.T. and Lau,Y.F.
Journal Genomics 4 (3), 225-231 (1989)
Title Chromosomal localization of the human homeo box-containing genes, EN1 and EN2 .
Author Logan,C., Willard,H.F., Rommens,J.M. and Joyner,A.L.
Journal Genomics 4 (2), 206-209 (1989)

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