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Homo sapiens centromere protein C 1 (CENPC1), mRNA.


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001812 Homo sapiens centromere protein C 1 (CENPC1), mRNA. GenEZ ORF Cloning On-demand $899.00 20

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RefSeq Version NM_001812.2, 68508960
Length 3349 bp
Structure linear
Update Date 17-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens centromere protein C 1 (CENPC1), mRNA.
Product centromere protein C 1
Comment

Summary: Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008].

RefSeq NP_001803.2
CDS 184..3015
Misc Feature(1)55..57
Misc Feature(2)469..471
Misc Feature(3)469..471
Misc Feature(4)571..573
Misc Feature(5)619..621
Misc Feature(6)682..684
Misc Feature(7)691..693
Misc Feature(8)712..714
Misc Feature(9)730..732
Misc Feature(10)748..750
Misc Feature(11)856..858
Misc Feature(12)856..858
Misc Feature(13)958..1002
Misc Feature(14)964..966
Misc Feature(15)1129..1131
Misc Feature(16)1129..1131
Misc Feature(17)1180..1182
Misc Feature(18)1498..1500
Misc Feature(19)1633..1680
Misc Feature(20)1741..1743
Misc Feature(21)1753..1755
Misc Feature(22)1783..1785
Misc Feature(23)1795..1797
Misc Feature(24)1795..1797
Misc Feature(25)1855..1905
Misc Feature(26)2308..2310
Misc Feature(27)2311..2313
Misc Feature(28)2344..2346
Misc Feature(29)2383..2385
Misc Feature(30)2392..2460
Misc Feature(31)2419..2421
Misc Feature(32)2470..2472
Misc Feature(33)2500..2502
Misc Feature(34)2521..2577
Misc Feature(35)2749..3003
Misc Feature(36)2851..3012
Exon (1)1..201
Gene:CENPC1
Gene Synonym:CENP-C; CENPC; hcp-4; MIF2
Exon (2)202..248
Gene:CENPC1
Gene Synonym:CENP-C; CENPC; hcp-4; MIF2
Exon (3)249..319
Gene:CENPC1
Gene Synonym:CENP-C; CENPC; hcp-4; MIF2
Exon (4)320..414
Gene:CENPC1
Gene Synonym:CENP-C; CENPC; hcp-4; MIF2
Exon (5)415..514
Gene:CENPC1
Gene Synonym:CENP-C; CENPC; hcp-4; MIF2
Exon (6)515..800
Gene:CENPC1
Gene Synonym:CENP-C; CENPC; hcp-4; MIF2
Exon (7)801..1013
Gene:CENPC1
Gene Synonym:CENP-C; CENPC; hcp-4; MIF2
Exon (8)1014..1627
Gene:CENPC1
Gene Synonym:CENP-C; CENPC; hcp-4; MIF2
Exon (9)1628..1795
Gene:CENPC1
Gene Synonym:CENP-C; CENPC; hcp-4; MIF2
Exon (10)1796..2087
Gene:CENPC1
Gene Synonym:CENP-C; CENPC; hcp-4; MIF2
Exon (11)2088..2234
Gene:CENPC1
Gene Synonym:CENP-C; CENPC; hcp-4; MIF2
Exon (12)2235..2314
Gene:CENPC1
Gene Synonym:CENP-C; CENPC; hcp-4; MIF2
Exon (13)2315..2368
Gene:CENPC1
Gene Synonym:CENP-C; CENPC; hcp-4; MIF2
Exon (14)2369..2473
Gene:CENPC1
Gene Synonym:CENP-C; CENPC; hcp-4; MIF2
Exon (15)2474..2602
Gene:CENPC1
Gene Synonym:CENP-C; CENPC; hcp-4; MIF2
Exon (16)2603..2698
Gene:CENPC1
Gene Synonym:CENP-C; CENPC; hcp-4; MIF2
Exon (17)2699..2853
Gene:CENPC1
Gene Synonym:CENP-C; CENPC; hcp-4; MIF2
Exon (18)2854..2944
Gene:CENPC1
Gene Synonym:CENP-C; CENPC; hcp-4; MIF2
Exon (19)2945..3349
Gene:CENPC1
Gene Synonym:CENP-C; CENPC; hcp-4; MIF2
Translation MAASGLDHLKNGYRRRFCRPSRARDINTEQGQNVLEILQDCFEEKSLANDFSTNSTKSVP NSTRKIKDTCIQSPSKECQKSHPKSVPVSSKKKEASLQFVVEPSEATNRSVQAHEVHQKI LATDVSSKNTPDSKKISSRNINDHHSEADEEFYLSVGSPSVLLDAKTSVSQNVIPSSAQK RETYTFENSVNMLPSSTEVSVKTKKRLNFDDKVMLKKIEIDNKVSDEEDKTSEGQERKPS GSSQNRIRDSEYEIQRQAKKSFSTLFLETVKRKSESSPIVRHAATAPPHSCPPDDTKLIE DEFIIDESDQSFASRSWITIPRKAGSLKQRTISPAESTALLQGRKSREKHHNILPKTLAN DKHSHKPHPVETSQPSDKTVLDTSYALIGETVNNYRSTKYEMYSKNAEKPSRSKRTIKQK QRRKFMAKPAEEQLDVGQSKDENIHTSHITQDEFQRNSDRNMEEHEEMGNDCVSKKQMPP VGSKKSSTRKDKEESKKKRFSSESKNKLVPEEVTSTVTKSRRISRRPSDWWVVKSEESPV YSNSSVRNELPMHHNSSRKSTKKTNQSSKNIRKKTIPLKRQKTATKGNQRVQKFLNAEGS GGIVGHDEISRCSLSEPLESDEADLAKKKNLDCSRSTRSSKNEDNIMTAQNVPLKPQTSG YTCNIPTESNLDSGEHKTSVLEESGPSRLNNNYLMSGKNDVDDEEVHGSSDDSKQSKVIP KNRIHHKLVLPSNTPNVRRTKRTRLKPLEYWRGERIDYQGRPSGGFVISGVLSPDTISSK RKAKENIGKVNKKSNKKRICLDNDERKTNLMVNLGIPLGDPLQPTRVKDPETREIILMDL VRPQDTYQFFVKHGELKVYKTLDTPFFSTGKLILGPQEEKGKQHVGQDILVFYVNFGDLL CTLHETPYILSTGDSFYVPSGNYYNIKNLRNEESVLLFTQIKR
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Position Chain Variation Link
complement(29)-dbSNP:
complement(29)-t, cdbSNP:35108540
complement(46)-t, cdbSNP:145363683
complement(72)-t, cdbSNP:150026106
complement(275)-dbSNP:
complement(275)-t, cdbSNP:141072717
complement(373)-dbSNP:
complement(373)-g, adbSNP:201575627
complement(403)-g, cdbSNP:60820404
complement(463)-dbSNP:
complement(463)-t, cdbSNP:76729386
complement(524)-dbSNP:
complement(524)-t, cdbSNP:183104004
complement(589)-t, gdbSNP:138967637
complement(612)-g, adbSNP:199649803
complement(756)-g, adbSNP:190926374
complement(879)-dbSNP:
complement(879)-g, adbSNP:355510
complement(950)-t, cdbSNP:201103062
complement(1181)-dbSNP:
complement(1181)-g, adbSNP:200888615
complement(1193)-t, cdbSNP:200220629
complement(1204)-t, cdbSNP:11250
complement(1285)-g, adbSNP:150498437
complement(1349)-g, adbSNP:1056787
complement(1432)-t, cdbSNP:142565656
complement(1501)-t, cdbSNP:190294402
complement(1548)-t, cdbSNP:185918036
complement(1554)-t, adbSNP:201443057
complement(1577)-t, cdbSNP:181597128
complement(1628)-dbSNP:
complement(1628)-c, adbSNP:141379239
complement(1639)-t, cdbSNP:199691875
complement(1679)-c, adbSNP:184128058
complement(1709)-g, adbSNP:200847573
complement(1797)-dbSNP:
complement(1797)-g, adbSNP:201681976
complement(1838)-g, adbSNP:192751329
complement(1857)-t, gdbSNP:202179070
complement(1978)-t, cdbSNP:200110790
complement(1993)-t, cdbSNP:114326582
complement(2022)-g, adbSNP:1056789
complement(2081)-t, cdbSNP:200998915
complement(2095)-dbSNP:
complement(2095)-t, cdbSNP:199972728
complement(2122)-t, cdbSNP:61750808
complement(2152)-g, adbSNP:186769176
complement(2197)-t, cdbSNP:183418720
complement(2203)-t, cdbSNP:199856009
complement(2247)-dbSNP:
complement(2247)-g, cdbSNP:189594633
complement(2260)-t, adbSNP:201011714
complement(2403)-dbSNP:
complement(2403)-g, adbSNP:187437348
complement(2458)-g, cdbSNP:140146155
complement(2460)-t, cdbSNP:17854081
complement(2517)-dbSNP:
complement(2517)-t, cdbSNP:112599674
complement(2566)-t, cdbSNP:201718172
complement(2665)-dbSNP:
complement(2665)-t, cdbSNP:199998234
complement(2766)-dbSNP:
complement(2766)-t, cdbSNP:112493476
complement(2796..2797)-, tdbSNP:35453375
complement(2927)-dbSNP:
complement(2927)-g, adbSNP:200509560
complement(2928)-t, cdbSNP:201433526
complement(3028)-dbSNP:
complement(3028)-t, gdbSNP:11544339
complement(3040)-t, cdbSNP:144515314
complement(3054)-t, cdbSNP:149259908
complement(3091)-t, gdbSNP:116290223
complement(3136)-g, adbSNP:186886346
complement(3139)-g, cdbSNP:7662513
complement(3171)-t, adbSNP:201579401
complement(3173..3174)-, tgdbSNP:74311223
complement(3173)-t, adbSNP:200336031
complement(3174..3175)-, tgdbSNP:55872090
complement(3175..3176)-, atdbSNP:199926074
complement(3175)-t, cdbSNP:201227524
complement(3259..3260)-, cdbSNP:35085170
complement(3302)-g, adbSNP:200306120
complement(3314)-g, cdbSNP:138272228
complement(3329)-t, gdbSNP:7692496
Gene SymbolCENPC1
Gene SynonymCENP-C; CENPC; hcp-4; MIF2
Chromosome4
Locus Map4q13.2
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_001812 Homo sapiens centromere protein C 1 (CENPC1), mRNA. On-demand $899.00 20
Title CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin .
Author Dambacher,S., Deng,W., Hahn,M., Sadic,D., Frohlich,J., Nuber,A., Hoischen,C., Diekmann,S., Leonhardt,H. and Schotta,G.
Journal Nucleus 3 (1), 101-110 (2012)
Title Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore .
Author Screpanti,E., De Antoni,A., Alushin,G.M., Petrovic,A., Melis,T., Nogales,E. and Musacchio,A.
Journal Curr. Biol. 21 (5), 391-398 (2011)
Title DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions .
Author Gopalakrishnan,S., Sullivan,B.A., Trazzi,S., Della Valle,G. and Robertson,K.D.
Journal Hum. Mol. Genet. 18 (17), 3178-3193 (2009)
Title Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population .
Author Yosifova,A., Mushiroda,T., Stoianov,D., Vazharova,R., Dimova,I., Karachanak,S., Zaharieva,I., Milanova,V., Madjirova,N., Gerdjikov,I., Tolev,T., Velkova,S., Kirov,G., Owen,M.J., O'Donovan,M.C., Toncheva,D. and Nakamura,Y.
Journal J Affect Disord 117 (1-2), 87-97 (2009)
Title The C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation .
Author Trazzi,S., Perini,G., Bernardoni,R., Zoli,M., Reese,J.C., Musacchio,A. and Della Valle,G.
Journal PLoS ONE 4 (6), E5832 (2009)
Title Human chromosome pellicle antibody recognizing centromere protein-C (CENP-C), the main component of the kinetochore .
Author Xie,Y., Ni,Z.M., Gu,J.R., Wong,P., Wu,W.Q. and Xu,G.W.
Journal Cell Res. 7 (1), 13-19 (1997)
Title Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator .
Author Pluta,A.F. and Earnshaw,W.C.
Journal J. Biol. Chem. 271 (31), 18767-18774 (1996)
Title FISH mapping of centromere protein C (CENPC) on human chromosome 4q31-->q21 .
Author Xie,Y. and Heng,H.H.
Journal Cytogenet. Cell Genet. 74 (3), 192-193 (1996)
Title Sequence homologies and linkage group conservation of the human and mouse Cenpc genes .
Author McKay,S., Thomson,E. and Cooke,H.
Journal Genomics 22 (1), 36-40 (1994)
Title CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate .
Author Saitoh,H., Tomkiel,J., Cooke,C.A., Ratrie,H. III, Maurer,M., Rothfield,N.F. and Earnshaw,W.C.
Journal Cell 70 (1), 115-125 (1992)


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