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Blast Method:


Homo sapiens ets variant 6 (ETV6), mRNA.

Clone ID Definition Vector Stock Status Price *Turnaround time Select
OHu25525D Homo sapiens ets variant 6 (ETV6), mRNA. pcDNA3.1-C-(k)DYK In-stock Starting from $99 5-7
OHu25525C Homo sapiens ets variant 6 (ETV6), mRNA. Your vector of choice In-stock Starting from $99 5-7
OHu25525M Mutant Clone for Homo sapiens ets variant 6 (ETV6), mRNA. pcDNA3.1-C-(k)DYK In-stock Starting from $149 Additional 5 days
OHu25525CM Mutant Clone for Homo sapiens ets variant 6 (ETV6), mRNA. Your vector of choice In-stock Starting from $149 Additional 5 days

*Business Day

Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_001987.4, 153267458
Length 1359 bp
Structure linear
Update Date 18-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens ets variant 6 (ETV6), mRNA.
Product transcription factor ETV6

Summary: This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008].

RefSeq NP_001978.1
CDS 275..1633
Misc Feature(1)269..271
Misc Feature(2)278..280
Misc Feature(3)278..280
Misc Feature(4)305..310
Misc Feature(5)305..307
Misc Feature(6)320..322
Misc Feature(7)323..325
Misc Feature(8)326..328
Misc Feature(9)326..328
Misc Feature(10)338..340
Misc Feature(11)434..439
Misc Feature(12)437..442
Misc Feature(13)440..643
Misc Feature(14)order(461..463,527..529,536..544,548..553,560..562,
Misc Feature(15)order(497..514,593..601,605..610,617..622)
Misc Feature(16)911..913
Misc Feature(17)1043..1045
Misc Feature(18)1178..1180
Misc Feature(19)1280..1285
Misc Feature(20)1286..1540
Exon (1)1..307
Gene Synonym:TEL; TEL/ABL
Exon (2)308..437
Gene Synonym:TEL; TEL/ABL
Exon (3)438..602
Gene Synonym:TEL; TEL/ABL
Exon (4)603..737
Gene Synonym:TEL; TEL/ABL
Exon (5)738..1283
Gene Synonym:TEL; TEL/ABL
Exon (6)1284..1426
Gene Synonym:TEL; TEL/ABL
Exon (7)1427..1527
Gene Synonym:TEL; TEL/ABL
Exon (8)1528..5989
Gene Synonym:TEL; TEL/ABL
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Position Chain Variation Link
136+a, gdbSNP:374449699
201+a, gdbSNP:182620920
254+a, tdbSNP:375945066
255+c, gdbSNP:200485978
301+a, cdbSNP:372541278
325+c, tdbSNP:144055004
331+c, tdbSNP:147305258
336+a, gdbSNP:139212214
340+c, tdbSNP:373836023
346+a, gdbSNP:143194205
351+c, gdbSNP:150858928
356+a, gdbSNP:34966596
366+c, tdbSNP:149994836
367+a, g, tdbSNP:201801905
370+a, cdbSNP:201002416
390+a, gdbSNP:144209028
398+a, gdbSNP:199863871
470+a, gdbSNP:139975161
475+c, gdbSNP:143451658
478+c, gdbSNP:202004830
488+g, tdbSNP:72550776
500+g, tdbSNP:121434637
518+a, gdbSNP:202244621
532+a, gdbSNP:11611479
613+a, cdbSNP:72550784
654+a, gdbSNP:140357643
676+c, tdbSNP:368516584
678+a, gdbSNP:201130440
695+c, tdbSNP:146150601
770+a, gdbSNP:142603082
778+c, tdbSNP:372140891
809+c, tdbSNP:140772322
815+c, tdbSNP:149660037
816+a, gdbSNP:150089916
830+a, gdbSNP:372716250
835+a, gdbSNP:375865123
846+g, tdbSNP:201820837
847+g, tdbSNP:35030220
855+c, tdbSNP:192765271
861+c, tdbSNP:138600719
862+c, tdbSNP:142652732
869+c, tdbSNP:373494708
876+c, tdbSNP:145477191
879+a, gdbSNP:200351280
901+c, tdbSNP:376163010
903+a, gdbSNP:201298740
906+a, gdbSNP:111871763
916+a, gdbSNP:72550786
942+c, tdbSNP:373315577
973+c, tdbSNP:149416707
997+a, gdbSNP:199557618
1014+c, tdbSNP:144782370
1021+c, tdbSNP:376620291
1022+a, gdbSNP:370744157
1027+c, tdbSNP:138208833
1032+c, tdbSNP:200525003
1033+a, gdbSNP:371171278
1039+a, tdbSNP:148116823
1048+c, tdbSNP:2071149
1049+c, tdbSNP:141868934
1065+a, gdbSNP:150621299
1127+a, gdbSNP:376242225
1146+a, gdbSNP:72550787
1159+c, tdbSNP:140005721
1179+a, gdbSNP:372530736
1255+a, gdbSNP:374744954
1259+a, gdbSNP:184240587
1306+c, tdbSNP:372141414
1326+g, tdbSNP:199735381
1336+c, tdbSNP:374829210
1349+a, cdbSNP:141938078
1369+c, tdbSNP:369012954
1371+a, gdbSNP:202119450
1407+a, gdbSNP:146280653
1561+c, tdbSNP:201517292
1594+a, g, tdbSNP:12231057
1650+c, gdbSNP:183579990
1651+c, tdbSNP:373407006
1656+c, tdbSNP:72550782
1695+c, tdbSNP:72550783
1706+a, tdbSNP:116163696
1781+a, gdbSNP:188643374
1848+a, c, g, tdbSNP:1058028
1926+c, tdbSNP:114439497
1927+a, gdbSNP:114995773
1992+c, tdbSNP:73281367
2046..2047+, tadbSNP:71435871
2047..2048+, at, tadbSNP:34166149
2056..2057+, atdbSNP:148938293
2057..2058+, atdbSNP:67600135
2058+a, tdbSNP:79663578
complement(2128..2129)-c, adbSNP:1801071
2134+c, tdbSNP:140010615
2147+c, tdbSNP:113420500
2188+, adbSNP:372555234
2317+a, gdbSNP:72552352
2379+a, cdbSNP:372192477
2414..2415+a, gdbSNP:72552354
2414+c, gdbSNP:72552353
2438..2439+, tcdbSNP:373327285
2507+a, gdbSNP:375299707
2537+c, tdbSNP:12822376
2556+c, tdbSNP:374847526
2581+a, cdbSNP:72552355
2610..2614+, agcgcdbSNP:72552341
2616..2619+, gcgcdbSNP:199697595
2617+c, tdbSNP:201545799
2656+a, gdbSNP:72552356
2748+c, tdbSNP:71457109
2760+a, gdbSNP:191387762
2798..2799+, tdbSNP:35812814
complement(2838)-g, adbSNP:2710278
2907+c, gdbSNP:139887205
2917+g, tdbSNP:1062298
3041+a, gdbSNP:369706711
3091+, tdbSNP:371083937
3092+a, tdbSNP:78623999
3209+a, cdbSNP:112659697
3226..3227+, ctdbSNP:371751484
3243+c, tdbSNP:147273403
3269+a, gdbSNP:183305984
complement(3302)-g, adbSNP:148444634
3320+c, tdbSNP:115533446
3367+c, tdbSNP:186881078
3400+g, tdbSNP:72550770
3516+c, tdbSNP:72550771
3526+c, gdbSNP:142637277
3586+g, tdbSNP:72550772
3603+c, tdbSNP:11552161
3610+c, tdbSNP:72550773
3629+a, gdbSNP:151008926
3680+, gdbSNP:369218546
3692+c, tdbSNP:72550774
3728+c, tdbSNP:72550775
complement(3785)-t, gdbSNP:143501237
3917+c, tdbSNP:183543088
3942..3943+, aaagdbSNP:10649660
3943..3944+, aaagdbSNP:67900047
3945..3946+, gaaadbSNP:3050331
3948..3949+, agaadbSNP:199690814
3950+a, cdbSNP:187884342
3976+c, tdbSNP:146656971
3994+a, gdbSNP:2855748
complement(4031)-g, adbSNP:9870
4082+a, gdbSNP:2855749
4134+c, tdbSNP:1044919
4258+g, tdbSNP:374682883
4311+c, tdbSNP:2855750
4379..4380+, ttdbSNP:201886381
4380..4381+, adbSNP:59376864
4381..4406+, ttatatatatatatatatatatatatdbSNP:58803473
4381..4382+, adbSNP:58787654
complement(4381)-t, adbSNP:2710277
4382..4407+, tatatatatatatatatatatatatadbSNP:368971244
4382..4395+, tatatatatatatadbSNP:145144440
4426+c, tdbSNP:59711518
4428..4429+, tadbSNP:57308697
4429..4434+, acacacdbSNP:144712994
4430+c, tdbSNP:59065647
4434..4443+, cacacacacadbSNP:61009195
complement(4436)-g, adbSNP:2710276
4438+c, tdbSNP:59866364
complement(4444)-t, g, c, adbSNP:112762440
complement(4466)-t, cdbSNP:2710275
4558+c, tdbSNP:185362936
4610+c, tdbSNP:76396773
4716..4720+, ccaaadbSNP:373034175
complement(4732)-t, cdbSNP:140236469
4782+a, gdbSNP:117329147
4864+a, gdbSNP:75672295
4915+c, tdbSNP:371216086
4930+a, gdbSNP:2156932
4948+c, tdbSNP:145309593
5003..5004+, tdbSNP:3832798
5004..5005+, tdbSNP:397840776
5035+c, gdbSNP:144970932
5069+a, gdbSNP:1051779
complement(5078)-t, adbSNP:11556573
5082+c, tdbSNP:1573612
5127+c, tdbSNP:61921366
5132+a, cdbSNP:79946282
5155+a, tdbSNP:190263521
5271+c, tdbSNP:1573613
5332+a, cdbSNP:72550766
5412+g, tdbSNP:72550767
5426+c, gdbSNP:1051782
complement(5462)-g, adbSNP:149191366
5515+c, gdbSNP:72550768
5532+c, tdbSNP:72550769
5592+g, tdbSNP:181509838
5594+c, gdbSNP:368340189
5646+a, gdbSNP:376727723
5747+c, gdbSNP:143357697
5769+c, tdbSNP:148372258
complement(5790)-t, cdbSNP:143279699
5791+a, gdbSNP:371528579
5833..5834+, tdbSNP:147213844
5876+a, gdbSNP:201259889
5877..5878+, aadbSNP:71057779
5886..5887+, aadbSNP:398018424
5891+a, cdbSNP:371340766
5905+c, tdbSNP:184235314
5933+c, tdbSNP:369549800
5942+a, tdbSNP:188566560
5976..5977+, adbSNP:368762633
5983..5984+, adbSNP:11458861
5988..5989+, aadbSNP:75609739
Gene SymbolETV6
Gene SynonymTEL; TEL/ABL
Locus Map12p13
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_001987 Homo sapiens ets variant 6 (ETV6), mRNA. In-stock Starting from $99 5-7
Title ETV6-NTRK3 is a common chromosomal rearrangement in radiation-associated thyroid cancer .
Author Leeman-Neill RJ, Kelly LM, Liu P, Brenner AV, Little MP, Bogdanova TI, Evdokimova VN, Hatch M, Zurnadzy LY, Nikiforova MN, Yue NJ, Zhang M, Mabuchi K, Tronko MD and Nikiforov YE.
Journal Cancer 120 (6), 799-807 (2014)
Title Blocking ETV6/RUNX1-induced MDM2 overexpression by Nutlin-3 reactivates p53 signaling in childhood leukemia .
Author Kaindl U, Morak M, Portsmouth C, Mecklenbrauker A, Kauer M, Zeginigg M, Attarbaschi A, Haas OA and Panzer-Grumayer R.
Journal Leukemia 28 (3), 600-608 (2014)
Title Mammary analogue secretory carcinoma of salivary glands with high-grade transformation: report of 3 cases with the ETV6-NTRK3 gene fusion and analysis of TP53, beta-catenin, EGFR, and CCND1 genes .
Author Skalova A, Vanecek T, Majewska H, Laco J, Grossmann P, Simpson RH, Hauer L, Andrle P, Hosticka L, Branzovsky J and Michal M.
Journal Am. J. Surg. Pathol. 38 (1), 23-33 (2014)
Title Gene network analysis in a pediatric cohort identifies novel lung function genes .
Author Ong BA, Li J, McDonough JM, Wei Z, Kim C, Chiavacci R, Mentch F, Caboot JB, Spergel J, Allen JL, Sleiman PM and Hakonarson H.
Journal PLoS ONE 8 (9), E72899 (2013)
Title Genetic variants associated with angiotensin-converting enzyme inhibitor-associated angioedema .
Author Pare G, Kubo M, Byrd JB, McCarty CA, Woodard-Grice A, Teo KK, Anand SS, Zuvich RL, Bradford Y, Ross S, Nakamura Y, Ritchie M and Brown NJ.
Journal Pharmacogenet. Genomics 23 (9), 470-478 (2013)
Title The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion .
Author Romana SP, Mauchauffe M, Le Coniat M, Chumakov I, Le Paslier D, Berger R and Bernard OA.
Journal Blood 85 (12), 3662-3670 (1995)
Title Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia .
Author Golub TR, Barker GF, Bohlander SK, Hiebert SW, Ward DC, Bray-Ward P, Morgan E, Raimondi SC, Rowley JD and Gilliland DG.
Journal Proc. Natl. Acad. Sci. U.S.A. 92 (11), 4917-4921 (1995)
Title Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11 .
Author Buijs A, Sherr S, van Baal S, van Bezouw S, van der Plas D, Geurts van Kessel A, Riegman P, Lekanne Deprez R, Zwarthoff E and Hagemeijer A.
Journal Oncogene 10 (8), 1511-1519 (1995)
Title The novel activation of ABL by fusion to an ets-related gene, TEL .
Author Papadopoulos P, Ridge SA, Boucher CA, Stocking C and Wiedemann LM.
Journal Cancer Res. 55 (1), 34-38 (1995)
Title Nucleotide sequence analysis of human abl and bcr-abl cDNAs .
Author Fainstein E, Einat M, Gokkel E, Marcelle C, Croce CM, Gale RP and Canaani E.
Journal Oncogene 4 (12), 1477-1481 (1989)

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