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Database:

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Homo sapiens galactokinase 2 (GALK2), transcript variant 1, mRNA.


Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu48218 Homo sapiens galactokinase 2 (GALK2), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand $219.00 7-9
OHu48218C Homo sapiens galactokinase 2 (GALK2), transcript variant 1, mRNA. Customized vector On-demand $269.00 7-9

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Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Data sheet
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
Restriction Sites Hind III- EcoR I
RefSeq Version NM_002044.3, 573459781
Length 1377 bp
Structure linear
Update Date 26-FEB-2014
Organism Homo sapiens (human)
Definition Homo sapiens galactokinase 2 (GALK2), transcript variant 1, mRNA.
Product N-acetylgalactosamine kinase isoform 1
Comment

Summary: This gene encodes a highly efficient N-acetylgalactosamine (GalNAc) kinase, which has galactokinase activity when galactose is present at high concentrations. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014].


Transcript Variant: This variant (1) encodes the longest isoform (1).


##Evidence-Data-START## Transcript exon combination :: BC005141.2, M84443.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025086 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

RefSeq NP_002035.1
CDS 308..1684
Misc Feature(1)299..301
Misc Feature(2)359..1672
Misc Feature(3)359..1672
Misc Feature(4)383..526
Misc Feature(5)434..436
Misc Feature(6)452..463
Misc Feature(7)866..877
Misc Feature(8)1355..1597
Exon (1)1..360
Gene:GALK2
Gene Synonym:GK2
Exon (2)361..449
Gene:GALK2
Gene Synonym:GK2
Exon (3)450..573
Gene:GALK2
Gene Synonym:GK2
Exon (4)574..664
Gene:GALK2
Gene Synonym:GK2
Exon (5)665..811
Gene:GALK2
Gene Synonym:GK2
Exon (6)812..910
Gene:GALK2
Gene Synonym:GK2
Exon (7)911..1063
Gene:GALK2
Gene Synonym:GK2
Exon (8)1064..1274
Gene:GALK2
Gene Synonym:GK2
Exon (9)1275..1476
Gene:GALK2
Gene Synonym:GK2
Exon (10)1477..3330
Gene:GALK2
Gene Synonym:GK2
Translation MATESPATRRVQVAEHPRLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLP MAVEQDVLIAVEPVKTYALQLANTNPLYPDFSTSANNIQIDKTKPLWHNYFLCGLKGIQE HFGLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSER YIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSHF NIRVMECRLAAKLLAKYKSLQWDKVLRLEEVQAKLGISLEEMLLVTEDALHPEPYNPEEI CRCLGISLEELRTQILSPNTQDVLIFKLYQRAKHVYSEAARVLQFKKICEEAPENMVQLL GELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSF LANVHKAYYQRSDGSLAPEKQSLFATKPGGGALVLLEA
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Position Chain Variation Link
36+dbSNP:
36+g, tdbSNP:184156669
251+c, tdbSNP:187183178
298+c, gdbSNP:376738182
315+a, cdbSNP:202114334
316+a, gdbSNP:150631282
380+dbSNP:
380+a, gdbSNP:139521545
458+dbSNP:
458+a, gdbSNP:35720727
477+c, tdbSNP:75689896
497+g, tdbSNP:147777330
534+c, tdbSNP:147019358
539+a, gdbSNP:370698577
555+a, gdbSNP:117291857
563+a, cdbSNP:371025596
573+c, tdbSNP:149095986
596+dbSNP:
596+a, gdbSNP:150063259
605+a, gdbSNP:370436045
622+a, tdbSNP:143136439
636+a, gdbSNP:374849566
674+dbSNP:
674+c, g, tdbSNP:148234101
685+c, tdbSNP:372905837
732+c, gdbSNP:201904223
773+a, tdbSNP:374871677
784+c, tdbSNP:141479055
845+dbSNP:
845+c, tdbSNP:201505722
846+a, gdbSNP:371610941
851+a, gdbSNP:35507772
852+c, tdbSNP:138250523
868+a, gdbSNP:374509174
885+c, tdbSNP:200800702
893+a, cdbSNP:142740588
944..945+dbSNP:
944..945+, cdbSNP:35345200
947+a, gdbSNP:369854223
949+c, tdbSNP:374001931
950+a, gdbSNP:373914978
967+a, gdbSNP:146167779
987+a, gdbSNP:139978578
1045+a, gdbSNP:376077359
1049+c, tdbSNP:370443921
1050+a, gdbSNP:201091452
1059+c, tdbSNP:199727284
1078+dbSNP:
1078+a, cdbSNP:372217244
1135+a, gdbSNP:183088402
1143+c, tdbSNP:375576432
1166+a, gdbSNP:367574130
1182+a, cdbSNP:77917939
1191+a, gdbSNP:371808630
1210+a, cdbSNP:75004292
1213+a, gdbSNP:78829055
1215+c, gdbSNP:74851274
1253+a, cdbSNP:144789254
1289+dbSNP:
1289+c, tdbSNP:374431370
1301+a, gdbSNP:368842223
1306+c, gdbSNP:113276417
1316+a, gdbSNP:374804284
1319+a, gdbSNP:148552843
1326+c, tdbSNP:146874010
1327+a, gdbSNP:199834761
1328+c, tdbSNP:144322038
1329+a, gdbSNP:376875144
1352+g, tdbSNP:147794087
1421+c, tdbSNP:375693032
1444+c, tdbSNP:367931698
1447+c, tdbSNP:370063191
1506+dbSNP:
1506+c, gdbSNP:139485976
1528+c, tdbSNP:1055254
1538+a, gdbSNP:377181822
1548+c, tdbSNP:373620147
1549+a, gdbSNP:371198789
1557+c, tdbSNP:376206527
1560+a, cdbSNP:150920378
1620+c, tdbSNP:370217644
1640+a, gdbSNP:200728035
1657+c, tdbSNP:147218231
1673+c, tdbSNP:199516811
1739+c, gdbSNP:182130124
1903+a, tdbSNP:186777348
1912+c, tdbSNP:148622656
2099+c, tdbSNP:375041430
2101+c, tdbSNP:367997810
2104+c, gdbSNP:77994602
2121+c, tdbSNP:141143208
2142+a, gdbSNP:184970229
2154..2156+, gacdbSNP:373769446
2194+c, tdbSNP:373923791
2196+c, gdbSNP:150753064
2225+a, gdbSNP:368311811
2299..2300+, atdbSNP:78262056
2300+, tdbSNP:5812480
2313..2314+, ttdbSNP:3075141
2362+a, gdbSNP:190065403
2429+c, tdbSNP:192926937
2450+c, tdbSNP:375999919
2487+c, tdbSNP:80110211
2534..2536+, ttcdbSNP:201186301
2536..2538+, cttdbSNP:375628334
2543..2544+, ctdbSNP:3075142
2545..2546+, ctdbSNP:397774483
2545+a, gdbSNP:202094466
2557..2558+, tdbSNP:34484949
2637+g, tdbSNP:370667288
2668+c, tdbSNP:185562132
2687+a, gdbSNP:189368783
2763+c, tdbSNP:182022714
2835+c, g, tdbSNP:185268010
2859+a, cdbSNP:116742387
2938+a, gdbSNP:2078024
3226+a, cdbSNP:368454790
3286+g, tdbSNP:188461311
Gene SymbolGALK2
Gene SynonymGK2
Chromosome15
Locus Map15q21.1-q21.2
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_001289031 Homo sapiens galactokinase 2 (GALK2), transcript variant 4, mRNA. On-demand $219.00 7-9
NM_001001556 Homo sapiens galactokinase 2 (GALK2), transcript variant 2, mRNA. On-demand $219.00 7-9
NM_002044 Homo sapiens galactokinase 2 (GALK2), transcript variant 1, mRNA. On-demand $219.00 7-9
NM_001289030 Homo sapiens galactokinase 2 (GALK2), transcript variant 3, mRNA. On-demand $219.00 7-9
XM_005254279 PREDICTED: Homo sapiens galactokinase 2 (GALK2), transcript variant X1, mRNA. On-demand $219.00 7-9
XM_006720461 PREDICTED: Homo sapiens galactokinase 2 (GALK2), transcript variant X7, mRNA. On-demand $219.00 7-9
XM_005254280 PREDICTED: Homo sapiens galactokinase 2 (GALK2), transcript variant X2, mRNA. On-demand $219.00 7-9
XM_006720462 PREDICTED: Homo sapiens galactokinase 2 (GALK2), transcript variant X8, mRNA. On-demand $219.00 7-9
XM_006720463 PREDICTED: Homo sapiens galactokinase 2 (GALK2), transcript variant X9, mRNA. On-demand $219.00 7-9
XM_005254284 PREDICTED: Homo sapiens galactokinase 2 (GALK2), transcript variant X6, mRNA. On-demand $219.00 7-9
XM_006720464 PREDICTED: Homo sapiens galactokinase 2 (GALK2), transcript variant X10, mRNA. On-demand $219.00 7-9
Title Mechanistic studies on human N-acetylgalactosamine kinase .
Author Agnew A and Timson D.
Journal J Enzyme Inhib Med Chem 25 (3), 370-376 (2010)
Title The molecular architecture of human N-acetylgalactosamine kinase .
Author Thoden JB and Holden HM.
Journal J. Biol. Chem. 280 (38), 32784-32791 (2005)
Title Identification of the GalNAc kinase amino acid sequence .
Author Pastuszak I, O'Donnell J and Elbein AD.
Journal J. Biol. Chem. 271 (39), 23653-23656 (1996)
Title Kidney N-acetylgalactosamine (GalNAc)-1-phosphate kinase, a new pathway of GalNAc activation .
Author Pastuszak I, Drake R and Elbein AD.
Journal J. Biol. Chem. 271 (34), 20776-20782 (1996)
Title Comparison of the enzymatic activities of human galactokinase GALK1 and a related human galactokinase protein GK2 .
Author Ai Y, Basu M, Bergsma DJ and Stambolian D.
Journal Biochem. Biophys. Res. Commun. 212 (2), 687-691 (1995)
Title Cloning of a human galactokinase gene (GK2) on chromosome 15 by complementation in yeast .
Author Lee RT, Peterson CL, Calman AF, Herskowitz I and O'Donnell JJ.
Journal Proc. Natl. Acad. Sci. U.S.A. 89 (22), 10887-10891 (1992)

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