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Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 3 (GNB3), mRNA.

RefSeq Accession Definition Services Price Order
NM_002075 Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 3 (GNB3), mRNA. ORF Sequence $296.67
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RefSeq Version NM_002075.2, 21071080
Length 1923 bp
Structure linear
Update Date 18-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 3 (GNB3), mRNA.
Product guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

Summary: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described. [provided by RefSeq, Jul 2008].

RefSeq NP_002066.1
CDS 406..1428
Misc Feature(1)385..387
Misc Feature(2)385..387
Misc Feature(3)<535..1425
Misc Feature(4)<535..1425
Misc Feature(5)547..1425
Misc Feature(6)562..654
Misc Feature(7)order(565..567,619..621,631..633,649..654,688..693,
Misc Feature(8)688..780
Misc Feature(9)790..792
Misc Feature(10)826..915
Misc Feature(11)949..1041
Misc Feature(12)1075..1167
Misc Feature(13)1207..1299
Misc Feature(14)1333..1425
Exon (1)1..210
Gene Synonym:GNB3
Exon (2)211..375
Gene Synonym:GNB3
Exon (3)376..462
Gene Synonym:GNB3
Exon (4)463..501
Gene Synonym:GNB3
Exon (5)502..608
Gene Synonym:GNB3
Exon (6)609..672
Gene Synonym:GNB3
Exon (7)673..835
Gene Synonym:GNB3
Exon (8)836..902
Gene Synonym:GNB3
Exon (9)903..1104
Gene Synonym:GNB3
Exon (10)1105..1321
Gene Synonym:GNB3
Exon (11)1322..1923
Gene Synonym:GNB3
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Position Chain Variation Link
41+c, gdbSNP:77419422
213+c, tdbSNP:184474195
226+c, tdbSNP:189621570
230+a, gdbSNP:2071057
305+a, gdbSNP:181930580
356+a, gdbSNP:184754650
428+a, gdbSNP:199531660
461+c, tdbSNP:201491226
486+c, tdbSNP:145085793
523+a, gdbSNP:45569331
545+c, tdbSNP:116400596
546+a, gdbSNP:149095347
550+c, tdbSNP:144742962
582+c, tdbSNP:146702158
605+c, tdbSNP:140263599
631+a, g, tdbSNP:2234756
645+a, cdbSNP:190325696
646+a, gdbSNP:45616032
654+c, tdbSNP:145253610
660+a, gdbSNP:28395774
668+a, cdbSNP:201467320
711+c, tdbSNP:200048512
721+g, tdbSNP:147992054
748+a, g, tdbSNP:201963490
791+a, gdbSNP:201797921
806+a, gdbSNP:61747607
810+c, gdbSNP:201117275
839+a, cdbSNP:150490302
843+c, tdbSNP:200309858
864+c, tdbSNP:200864177
888+a, gdbSNP:75977062
909+a, gdbSNP:138319468
917+c, tdbSNP:144008405
946+a, g, tdbSNP:147291332
963+c, tdbSNP:139141966
1025+c, gdbSNP:200634640
1062+a, tdbSNP:45476395
1115+a, gdbSNP:113437937
1133+c, tdbSNP:200144483
1134+a, gdbSNP:147480203
1140+a, gdbSNP:112732503
1146+a, gdbSNP:13306410
1159+c, tdbSNP:28395780
1167+c, tdbSNP:2234757
1204+a, gdbSNP:150593798
1219+a, gdbSNP:5442
1226+c, tdbSNP:143381578
1230+c, tdbSNP:5443
1231+a, gdbSNP:201226859
1243+c, tdbSNP:28395776
1252+c, tdbSNP:202103093
1285+a, tdbSNP:200733665
1299+c, tdbSNP:140337095
1316+a, gdbSNP:144342814
1350+a, gdbSNP:144936565
1376+a, gdbSNP:28395775
1421+g, tdbSNP:5444
1485+a, gdbSNP:140282923
1546+c, tdbSNP:5445
1828+c, tdbSNP:5446
1883+a, tdbSNP:7975574
Gene SymbolGNB3
Gene SynonymGNB3
Locus Map12p13
All Transcripts
RefSeq Accession Definition Sequence Price Select
NM_002075 Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 3 (GNB3), mRNA. Full Length $557.67
ORF Sequence $296.67
Title G-protein beta3 subunit gene 825C/T polymorphism and its association with the presence, severity, and duration of vasculogenic erectile dysfunction .
Author Safarinejad,M.R., Safarinejad,S., Shafiei,N. and Safarinejad,S.
Journal Fertil. Steril. 99 (1), 69-75 (2013)
Title G protein beta3 subunit gene C825T and angiotensin converting enzyme gene insertion/deletion polymorphisms in hypertensive Tunisian population .
Author Kabadou,I.A., Soualmia,H., Jemaa,R., Feki,M., Kallel,A., Souheil,O., Taieb,S.H., Sanhaji,H. and Kaabachi,N.
Journal Clin. Lab. 59 (1-2), 85-92 (2013)
Title The Gbeta3 splice variant associated with the C825T gene polymorphism is an unstable and functionally inactive protein .
Author Sun,Z., Runne,C., Tang,X., Lin,F. and Chen,S.
Journal Cell. Signal. 24 (12), 2349-2359 (2012)
Title Association between the G-protein beta3 subunit C825T polymorphism with essential hypertension: a meta-analysis in Han Chinese population .
Author Lu,J., Guo,Q., Zhang,L. and Wang,W.
Journal Mol. Biol. Rep. 39 (9), 8937-8944 (2012)
Title G Protein beta3 subunit gene C825T polymorphism and its association with the presence and clinicopathological characteristics of prostate cancer .
Author Safarinejad,M.R., Safarinejad,S., Shafiei,N. and Safarinejad,S.
Journal J. Urol. 188 (1), 287-293 (2012)
Title Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families .
Author Yan,K., Kalyanaraman,V. and Gautam,N.
Journal J. Biol. Chem. 271 (12), 7141-7146 (1996)
Title Intersubunit surfaces in G protein alpha beta gamma heterotrimers. Analysis by cross-linking and mutagenesis of beta gamma .
Author Garcia-Higuera,I., Thomas,T.C., Yi,F. and Neer,E.J.
Journal J. Biol. Chem. 271 (1), 528-535 (1996)
Title Lipid modifications of trimeric G proteins .
Author Wedegaertner,P.B., Wilson,P.T. and Bourne,H.R.
Journal J. Biol. Chem. 270 (2), 503-506 (1995)
Title Chromosomal localization of the genes encoding two forms of the G protein beta polypeptide, beta 1 and beta 3, in man .
Author Levine,M.A., Modi,W.S. and O'Brien,S.J.
Journal Genomics 8 (2), 380-386 (1990)
Title Molecular cloning of beta 3 subunit, a third form of the G protein beta-subunit polypeptide .
Author Levine,M.A., Smallwood,P.M., Moen,P.T. Jr., Helman,L.J. and Ahn,T.G.
Journal Proc. Natl. Acad. Sci. U.S.A. 87 (6), 2329-2333 (1990)

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