Sequence in raw or FASTA format:
Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 3 (GNB3), transcript variant 1, mRNA.
|RefSeq Version||NM_002075.3, 662033911|
|Organism||Homo sapiens (human)|
|Definition||Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 3 (GNB3), transcript variant 1, mRNA.|
|Product||guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1|
Summary: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014].
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
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|Title||G-protein beta3 subunit genetic variation moderates five-year depressive symptom trajectories of primary care attendees .|
|Author||Bousman CA, Potiriadis M, Everall IP and Gunn JM.|
|Journal||J Affect Disord 165, 64-68 (2014)|
|Title||GNB3, eNOS, and mitochondrial DNA polymorphisms correlate to natural longevity in a Xinjiang Uygur population .|
|Author||Nijiati M, Saidaming A, Qiao J, Cheng Z, Qiu C and Sun Y.|
|Journal||PLoS ONE 8 (12), E81806 (2013)|
|Title||Mouse model implicates GNB3 duplication in a childhood obesity syndrome .|
|Author||Goldlust IS, Hermetz KE, Catalano LM, Barfield RT, Cozad R, Wynn G, Ozdemir AC, Conneely KN, Mulle JG, Dharamrup S, Hegde MR, Kim KH, Angle B, Colley A, Webb AE, Thorland EC, Ellison JW, Rosenfeld JA, Ballif BC, Shaffer LG, Demmer LA and Rudd MK.|
|Journal||Proc. Natl. Acad. Sci. U.S.A. 110 (37), 14990-14994 (2013)|
|Title||The C825T polymorphism of the G-protein beta3 subunit gene and its association with hypertension and stroke: an updated meta-analysis .|
|Author||Guo L, Zhang LL, Zheng B, Liu Y, Cao XJ, Pi Y, Li BH and Li JC.|
|Journal||PLoS ONE 8 (6), E65863 (2013)|
|Title||Characterization of the splice variant Gbeta3v of the human G-protein Gbeta3 subunit .|
|Author||Rosskopf D, Kielbik M, Manthey I, Bilmen G, Eisenhardt A and Siffert W.|
|Journal||Biochim. Biophys. Acta 1626 (1-3), 33-42 (2003)|
|Title||Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families .|
|Author||Yan K, Kalyanaraman V and Gautam N.|
|Journal||J. Biol. Chem. 271 (12), 7141-7146 (1996)|
|Title||Intersubunit surfaces in G protein alpha beta gamma heterotrimers. Analysis by cross-linking and mutagenesis of beta gamma .|
|Author||Garcia-Higuera I, Thomas TC, Yi F and Neer EJ.|
|Journal||J. Biol. Chem. 271 (1), 528-535 (1996)|
|Title||Lipid modifications of trimeric G proteins .|
|Author||Wedegaertner PB, Wilson PT and Bourne HR.|
|Journal||J. Biol. Chem. 270 (2), 503-506 (1995)|
|Title||Chromosomal localization of the genes encoding two forms of the G protein beta polypeptide, beta 1 and beta 3, in man .|
|Author||Levine MA, Modi WS and O'Brien SJ.|
|Journal||Genomics 8 (2), 380-386 (1990)|
|Title||Molecular cloning of beta 3 subunit, a third form of the G protein beta-subunit polypeptide .|
|Author||Levine MA, Smallwood PM, Moen PT Jr, Helman LJ and Ahn TG.|
|Journal||Proc. Natl. Acad. Sci. U.S.A. 87 (6), 2329-2333 (1990)|
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