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Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 3 (GNB3), transcript variant 1, mRNA.

Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu28823 Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 3 (GNB3), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand $219.00 7-9
OHu28823C Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 3 (GNB3), transcript variant 1, mRNA. Customized vector On-demand $269.00 7-9

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Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_002075.3, 662033911
Length 1023 bp
Update Date 04-JUL-2014
Organism Homo sapiens (human)
Definition Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 3 (GNB3), transcript variant 1, mRNA.
Product guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1

Summary: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014].

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

RefSeq NP_002066.1
CDS 211..1233
Misc Feature(1)190..192
Misc Feature(2)190..192
Misc Feature(3)352..1230
Misc Feature(4)352..1230
Misc Feature(5)<355..1230
Misc Feature(6)367..459
Misc Feature(7)order(370..372,424..426,436..438,454..459,478..483,
Misc Feature(8)493..585
Misc Feature(9)595..597
Misc Feature(10)631..720
Misc Feature(11)754..846
Misc Feature(12)880..972
Misc Feature(13)1012..1104
Misc Feature(14)1138..1230
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Position Chain Variation Link
Gene SymbolGNB3
Gene SynonymGNB3
Locus Map12p13
Title G-protein beta3 subunit genetic variation moderates five-year depressive symptom trajectories of primary care attendees .
Author Bousman CA, Potiriadis M, Everall IP and Gunn JM.
Journal J Affect Disord 165, 64-68 (2014)
Title GNB3, eNOS, and mitochondrial DNA polymorphisms correlate to natural longevity in a Xinjiang Uygur population .
Author Nijiati M, Saidaming A, Qiao J, Cheng Z, Qiu C and Sun Y.
Journal PLoS ONE 8 (12), E81806 (2013)
Title Mouse model implicates GNB3 duplication in a childhood obesity syndrome .
Author Goldlust IS, Hermetz KE, Catalano LM, Barfield RT, Cozad R, Wynn G, Ozdemir AC, Conneely KN, Mulle JG, Dharamrup S, Hegde MR, Kim KH, Angle B, Colley A, Webb AE, Thorland EC, Ellison JW, Rosenfeld JA, Ballif BC, Shaffer LG, Demmer LA and Rudd MK.
Journal Proc. Natl. Acad. Sci. U.S.A. 110 (37), 14990-14994 (2013)
Title The C825T polymorphism of the G-protein beta3 subunit gene and its association with hypertension and stroke: an updated meta-analysis .
Author Guo L, Zhang LL, Zheng B, Liu Y, Cao XJ, Pi Y, Li BH and Li JC.
Journal PLoS ONE 8 (6), E65863 (2013)
Title Characterization of the splice variant Gbeta3v of the human G-protein Gbeta3 subunit .
Author Rosskopf D, Kielbik M, Manthey I, Bilmen G, Eisenhardt A and Siffert W.
Journal Biochim. Biophys. Acta 1626 (1-3), 33-42 (2003)
Title Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families .
Author Yan K, Kalyanaraman V and Gautam N.
Journal J. Biol. Chem. 271 (12), 7141-7146 (1996)
Title Intersubunit surfaces in G protein alpha beta gamma heterotrimers. Analysis by cross-linking and mutagenesis of beta gamma .
Author Garcia-Higuera I, Thomas TC, Yi F and Neer EJ.
Journal J. Biol. Chem. 271 (1), 528-535 (1996)
Title Lipid modifications of trimeric G proteins .
Author Wedegaertner PB, Wilson PT and Bourne HR.
Journal J. Biol. Chem. 270 (2), 503-506 (1995)
Title Chromosomal localization of the genes encoding two forms of the G protein beta polypeptide, beta 1 and beta 3, in man .
Author Levine MA, Modi WS and O'Brien SJ.
Journal Genomics 8 (2), 380-386 (1990)
Title Molecular cloning of beta 3 subunit, a third form of the G protein beta-subunit polypeptide .
Author Levine MA, Smallwood PM, Moen PT Jr, Helman LJ and Ahn TG.
Journal Proc. Natl. Acad. Sci. U.S.A. 87 (6), 2329-2333 (1990)

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