Homo sapiens major histocompatibility complex, class I, C (HLA-C), mRNA.
| RefSeq Version | NM_002117.4, 52630341 |
| Length | 1543 bp |
| Structure | linear |
| Update Date | 01-MAY-2011 |
| Organism | Homo sapiens (human) |
| Definition | Homo sapiens major histocompatibility complex, class I, C (HLA-C), mRNA. |
| Product | HLA class I histocompatibility antigen, Cw-1 alpha chain precursor |
| Comment | Summary: HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq]. |
| RefSeq | NP_002108.4 |
| CDS | 8..1108 | Exon (1) | 1..80 | Exon (2) | 1..80 | Exon (3) | 81..350 | Exon (4) | 351..626 | Exon (5) | 627..902 | Exon (6) | 903..1022 | Exon (7) | 1023..1055 | Exon (8) | 1056..1103 | Exon (9) | 1104..1525 |
| Translation | MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRF
DSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQ
RMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQL
RAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLT
WQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEP
SSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGSDES
LITCKA
Order your protein of interest with our Guaranteed or It's Free Service now! For details, please click here. |
| Position | Chain | Variation | Link |
| complement(1) | - | g, c | dbSNP:115148805 |
| complement(1) | - | g, c | dbSNP:80232934 |
| complement(1) | - | g, c | dbSNP:79318845 |
| complement(1) | - | g, c | dbSNP:7767581 |
| 26 | + | c, t | dbSNP:41548414 |
| 26 | + | c, t | dbSNP:78078063 |
| complement(27) | - | t, c | dbSNP:116045151 |
| 27 | + | a, g | dbSNP:41548123 |
| 29 | + | a, g | dbSNP:2308525 |
| complement(29) | - | t, c | dbSNP:79267658 |
| complement(29) | - | t, c | dbSNP:112723279 |
| complement(29) | - | t, c | dbSNP:115346060 |
| 31 | + | c, t | dbSNP:41543119 |
| complement(35) | - | t, g | dbSNP:74572194 |
| 35 | + | a, c | dbSNP:2308527 |
| complement(35) | - | t, g | dbSNP:114620415 |
| complement(35) | - | t, g | dbSNP:113302428 |
| 36 | + | c, t | dbSNP:41562218 |
| 54 | + | c, g, t | dbSNP:1050451 |
| complement(54) | - | g, c | dbSNP:75527385 |
| complement(54) | - | g, c | dbSNP:116108880 |
| complement(66) | - | g, a | dbSNP:116543241 |
| 66 | + | c, t | dbSNP:41549413 |
| 67 | + | c, t | dbSNP:72558133 |
| 77 | + | a, g | dbSNP:41553415 |
| 80 | + | a, g, t | dbSNP:2074493 |
| complement(80) | - | c, a | dbSNP:76699324 |
| complement(80) | - | c, a | dbSNP:114506142 |
| 83 | + | a, t | dbSNP:41546415 |
| 86 | + | c, t | dbSNP:79057049 |
| 88 | + | c, t | dbSNP:41543915 |
| 90 | + | a, c | dbSNP:11547360 |
| 93 | + | a, t | dbSNP:61759936 |
| 96 | + | a, g | dbSNP:1131151 |
| 97 | + | c, g | dbSNP:41548017 |
| 99 | + | , a, g | dbSNP:41547413 |
| complement(104) | - | c, a | dbSNP:9264668 |
| complement(104) | - | c, a | dbSNP:78872756 |
| complement(104) | - | c, a | dbSNP:114656544 |
| complement(104) | - | c, a | dbSNP:112572251 |
| 105 | + | a, c, g, t | dbSNP:1071650 |
| 109 | + | a, c | dbSNP:1050446 |
| 110 | + | g, t | dbSNP:1050445 |
| 111 | + | c, g | dbSNP:72558124 |
| 112 | + | c, g, t | dbSNP:1050444 |
| complement(112) | - | g, a | dbSNP:114020617 |
| 113 | + | c, g, t | dbSNP:2308538 |
| 114 | + | c, g | dbSNP:41557119 |
| 115 | + | c, g | dbSNP:61759937 |
| 119 | + | c, t | dbSNP:3177892 |
| 119 | + | c, t | dbSNP:1050442 |
| 120 | + | a, g | dbSNP:72558134 |
| 122 | + | a, c | dbSNP:41558512 |
| 124 | + | c, t | dbSNP:41557015 |
| 124 | + | c, t | dbSNP:1050441 |
| 125 | + | a, g | dbSNP:1050440 |
| 125 | + | a, g | dbSNP:41551915 |
| complement(125) | - | t, c | dbSNP:115937021 |
| 128 | + | c, g | dbSNP:41555420 |
| 129 | + | a, c, g | dbSNP:41560916 |
| complement(130) | - | g, a | dbSNP:116458727 |
| 132 | + | a, g, t | dbSNP:45574634 |
| 133 | + | a, g | dbSNP:41542719 |
| complement(133) | - | t, c | dbSNP:74574595 |
| 133 | + | a, g | dbSNP:3177890 |
| complement(133) | - | t, c | dbSNP:116528219 |
| 134 | + | a, g | dbSNP:1050438 |
| 140 | + | c, t | dbSNP:72558135 |
| complement(141) | - | t, c | dbSNP:34483041 |
| 141 | + | a, g | dbSNP:1050437 |
| complement(141) | - | t, c | dbSNP:114190902 |
| 142 | + | a, g | dbSNP:72558125 |
| 145 | + | a, g | dbSNP:41554619 |
| 148 | + | c, t | dbSNP:41564220 |
| 149 | + | a, c, g, t | dbSNP:707911 |
| complement(149) | - | c, a | dbSNP:112836190 |
| complement(149) | - | c, a | dbSNP:78519882 |
| complement(149) | - | c, a | dbSNP:77331751 |
| complement(149) | - | c, a | dbSNP:117656410 |
| 150 | + | c, t | dbSNP:11539954 |
| 151 | + | a, c | dbSNP:16895957 |
| 161 | + | c, g | dbSNP:41561612 |
| 164 | + | a, g | dbSNP:75512631 |
| 167 | + | a, c | dbSNP:72558126 |
| 170 | + | a, c | dbSNP:41541118 |
| 172 | + | a, c, g | dbSNP:16895963 |
| 174 | + | a, g | dbSNP:41545521 |
| 178 | + | c, t | dbSNP:41555812 |
| 180 | + | c, t | dbSNP:77670405 |
| complement(183) | - | t, c | dbSNP:75322417 |
| complement(183) | - | t, c | dbSNP:113354829 |
| 183 | + | a, c, g | dbSNP:1050428 |
| 186 | + | a, g | dbSNP:41550118 |
| 189 | + | , c | dbSNP:72558127 |
| 190 | + | , c | dbSNP:72558128 |
| 191 | + | , c | dbSNP:72558129 |
| 192 | + | , a | dbSNP:41564312 |
| 193 | + | , g | dbSNP:41554915 |
| 194 | + | , t | dbSNP:41543115 |
| 195 | + | , c | dbSNP:41546812 |
| 196 | + | , g | dbSNP:41550113 |
| 197 | + | , t | dbSNP:41554618 |
| 198 | + | , c | dbSNP:41542120 |
| 200 | + | a, g | dbSNP:77850534 |
| 204 | + | a, g | dbSNP:79777994 |
| 206 | + | c, g, t | dbSNP:12721931 |
| 208 | + | a, g | dbSNP:1050420 |
| complement(208) | - | t, c | dbSNP:79708090 |
| complement(208) | - | t, c | dbSNP:113714360 |
| complement(208) | - | t, c | dbSNP:116597504 |
| 210 | + | a, g | dbSNP:72558130 |
| 211 | + | c, g | dbSNP:72558131 |
| 213 | + | a, g | dbSNP:41548913 |
| 214 | + | a, c, g | dbSNP:1065380 |
| 220 | + | c, g | dbSNP:1050414 |
| complement(220) | - | g, c | dbSNP:117036811 |
| complement(220) | - | g, c | dbSNP:113217200 |
| complement(220) | - | g, c | dbSNP:78496932 |
| 223 | + | g, t | dbSNP:11547353 |
| 224 | + | c, g | dbSNP:72558132 |
| 225 | + | a, c | dbSNP:1050409 |
| complement(225) | - | t, g | dbSNP:76349721 |
| complement(225) | - | t, g | dbSNP:113369774 |
| complement(225) | - | t, g | dbSNP:114612783 |
| 227 | + | c, g, t | dbSNP:41551015 |
| 228 | + | c, g | dbSNP:41546817 |
| 233 | + | a, g | dbSNP:1065382 |
| 235 | + | a, g | dbSNP:1065384 |
| 239 | + | , a, c | dbSNP:41564317 |
| 240 | + | , a | dbSNP:61759938 |
| 241 | + | , g | dbSNP:61759939 |
| 242 | + | c, g | dbSNP:77429690 |
| 246 | + | c, g | dbSNP:41540214 |
| 249 | + | c, t | dbSNP:72558136 |
| 250 | + | a, g | dbSNP:72558137 |
| 251 | + | c, g | dbSNP:41559013 |
| 263 | + | c, g, t | dbSNP:45438695 |
| complement(263) | - | g, c | dbSNP:77682952 |
| 265 | + | a, g | dbSNP:61759940 |
| 266 | + | a, g | dbSNP:1065385 |
| 271 | + | a, g | dbSNP:41555917 |
| complement(277) | - | g, c | dbSNP:28626310 |
| complement(277) | - | g, c | dbSNP:75671147 |
| complement(277) | - | g, c | dbSNP:114232695 |
| complement(277) | - | g, c | dbSNP:111835789 |
| 284 | + | c, t | dbSNP:74972087 |
| 285 | + | a, g | dbSNP:45609431 |
| 287 | + | c, t | dbSNP:76638752 |
| 294 | + | a, c | dbSNP:45500292 |
| 296 | + | a, g | dbSNP:41543814 |
| complement(296) | - | t, c | dbSNP:75725588 |
| complement(296) | - | t, c | dbSNP:111368183 |
| complement(296) | - | t, c | dbSNP:116378030 |
| 302 | + | c, g | dbSNP:41549514 |
| 303 | + | a, g | dbSNP:11547351 |
| 306 | + | a, t | dbSNP:41550619 |
| 308 | + | a, g, t | dbSNP:41559713 |
| 309 | + | a, g | dbSNP:2308557 |
| complement(309) | - | t, g, c, a | dbSNP:112152601 |
| complement(309) | - | t, c | dbSNP:114723182 |
| complement(309) | - | t, c | dbSNP:79214882 |
| complement(319) | - | t, g | dbSNP:76140723 |
| complement(319) | - | t, g | dbSNP:112523496 |
| complement(319) | - | t, g | dbSNP:115986584 |
| 319 | + | a, c | dbSNP:17408553 |
| 322 | + | a, g | dbSNP:41549919 |
| 329 | + | c, t | dbSNP:77376497 |
| 330 | + | a, g | dbSNP:45501796 |
| 334 | + | c, t | dbSNP:41558820 |
| 348 | + | a, c | dbSNP:1131123 |
| complement(348) | - | t, g | dbSNP:80061082 |
| complement(348) | - | t, g | dbSNP:115591076 |
| 350 | + | a, g | dbSNP:1131122 |
| 352 | + | g, t | dbSNP:41543218 |
| 353 | + | g, t | dbSNP:41563413 |
| 354 | + | a, c, g | dbSNP:41548520 |
| 357 | + | a, t | dbSNP:41560716 |
| 360 | + | a, c, t | dbSNP:1131119 |
| complement(360) | - | g, a | dbSNP:114211043 |
| complement(362) | - | t, g | dbSNP:115507127 |
| complement(362) | - | t, g | dbSNP:77138865 |
| 362 | + | a, c, t | dbSNP:1071649 |
| 363 | + | c, t | dbSNP:41546913 |
| 368 | + | a, t | dbSNP:1131118 |
| complement(368) | - | t, a | dbSNP:79218478 |
| complement(368) | - | t, a | dbSNP:112994647 |
| complement(368) | - | t, a | dbSNP:116270457 |
| 369 | + | a, c, g | dbSNP:2308567 |
| 370 | + | c, g, t | dbSNP:41556316 |
| 375 | + | a, c, g, t | dbSNP:1131115 |
| complement(375) | - | t, g, a | dbSNP:111435219 |
| complement(375) | - | t, g | dbSNP:115377398 |
| complement(375) | - | t, g | dbSNP:78394048 |
| 376 | + | a, c, g, t | dbSNP:1131114 |
| complement(376) | - | g, a | dbSNP:79008019 |
| 379 | + | c, t | dbSNP:41563216 |
| 381 | + | a, g | dbSNP:41564314 |
| 383 | + | g, t | dbSNP:45619135 |
| complement(386) | - | g, c | dbSNP:34592426 |
| complement(386) | - | g, c | dbSNP:116486037 |
| 391 | + | a, g | dbSNP:41540712 |
| 392 | + | c, t | dbSNP:41546215 |
| 394 | + | c, g | dbSNP:1050384 |
| complement(394) | - | g, c | dbSNP:78019324 |
| complement(394) | - | g, c | dbSNP:114527789 |
| 395 | + | a, c, g, t | dbSNP:41544015 |
| 397 | + | a, c | dbSNP:45558335 |
| 398 | + | a, c, g | dbSNP:77244469 |
| 403 | + | c, t | dbSNP:41563421 |
| 406 | + | c, t | dbSNP:41554814 |
| 413 | + | a, c, g | dbSNP:41562320 |
| 415 | + | a, g | dbSNP:45626438 |
| 416 | + | c, t | dbSNP:2308574 |
| complement(416) | - | g, a | dbSNP:77488553 |
| complement(416) | - | g, a | dbSNP:114934942 |
| 417 | + | a, g, t | dbSNP:41555122 |
| 418 | + | c, g, t | dbSNP:41562313 |
| 419 | + | a, c, g | dbSNP:2308575 |
| complement(419) | - | t, c | dbSNP:114279122 |
| complement(419) | - | t, c | dbSNP:79804822 |
| 420 | + | a, t | dbSNP:41542424 |
| 425 | + | g, t | dbSNP:41553719 |
| 426 | + | a, c, t | dbSNP:713032 |
| complement(426) | - | g, a | dbSNP:75412829 |
| complement(426) | - | g, a | dbSNP:115028194 |
| complement(426) | - | g, a | dbSNP:111523373 |
| 427 | + | a, c | dbSNP:1065406 |
| 428 | + | c, g | dbSNP:61759941 |
| 434 | + | c, g, t | dbSNP:72558147 |
| 437 | + | c, g | dbSNP:45580333 |
| 438 | + | g, t | dbSNP:41551916 |
| 453 | + | c, t | dbSNP:41550023 |
| 456 | + | a, t | dbSNP:41541817 |
| 460 | + | c, t | dbSNP:1050373 |
| complement(465) | - | g, a | dbSNP:17850337 |
| 466 | + | c, t | dbSNP:17839985 |
| 466 | + | c, t | dbSNP:1050371 |
| complement(466) | - | g, a | dbSNP:80317251 |
| complement(466) | - | g, a | dbSNP:113525542 |
| 469 | + | a, g | dbSNP:41557216 |
| complement(470) | - | t, g | dbSNP:112712832 |
| complement(470) | - | t, g | dbSNP:76907552 |
| 470 | + | a, c | dbSNP:79954918 |
| 474 | + | c, t | dbSNP:41542612 |
| 479 | + | a, g | dbSNP:78897778 |
| 480 | + | c, t | dbSNP:41543518 |
| 481 | + | c, t | dbSNP:41553316 |
| 482 | + | a, g | dbSNP:41562518 |
| 484 | + | c, g, t | dbSNP:41550715 |
| complement(484) | - | g, c | dbSNP:78552514 |
| complement(484) | - | g, c | dbSNP:75045195 |
| complement(484) | - | g, c | dbSNP:111254458 |
| 486 | + | c, t | dbSNP:72558148 |
| 491 | + | a, t | dbSNP:45505091 |
| 492 | + | a, c, g | dbSNP:2308584 |
| 493 | + | a, c, g | dbSNP:2308585 |
| complement(493) | - | g, c | dbSNP:113164917 |
| 497 | + | a, g | dbSNP:45578735 |
| 499 | + | c, t | dbSNP:41541313 |
| 503 | + | a, g | dbSNP:45622747 |
| complement(504) | - | g, a | dbSNP:112903647 |
| 504 | + | g, t | dbSNP:45465598 |
| 505 | + | c, g | dbSNP:45597335 |
| 506 | + | a, t | dbSNP:1050367 |
| 508 | + | c, t | dbSNP:11547350 |
| 511 | + | c, g | dbSNP:41557114 |
| complement(513) | - | c, a | dbSNP:75272234 |
| complement(519) | - | c, a | dbSNP:74867505 |
| complement(519) | - | c, a | dbSNP:76840369 |
| complement(519) | - | c, a | dbSNP:112937443 |
| complement(519) | - | c, a | dbSNP:114326955 |
| 519 | + | g, t | dbSNP:1050366 |
| 521 | + | a, g | dbSNP:41550816 |
| 525 | + | c, t | dbSNP:41540014 |
| 528 | + | c, t | dbSNP:61759942 |
| 530 | + | c, t | dbSNP:41551019 |
| 531 | + | a, c, g | dbSNP:41543523 |
| 533 | + | a, g | dbSNP:41552817 |
| 534 | + | a, t | dbSNP:17840047 |
| complement(534) | - | t, a | dbSNP:71543419 |
| 534 | + | a, c, g, t | dbSNP:2308590 |
| complement(534) | - | t, g | dbSNP:112170844 |
| complement(534) | - | t, a | dbSNP:77121231 |
| complement(534) | - | t, g | dbSNP:116669411 |
| complement(534) | - | g, a | dbSNP:75786125 |
| 536 | + | a, g | dbSNP:41551016 |
| 538 | + | a, g | dbSNP:41560918 |
| 542 | + | c, g | dbSNP:3206836 |
| complement(545..547) | - | ccg, gtc | dbSNP:71552047 |
| complement(545..546) | - | ag, ca | dbSNP:71533837 |
| 545 | + | c, g, t | dbSNP:697743 |
| complement(545) | - | g, a | dbSNP:74657757 |
| complement(546) | - | t, c, a | dbSNP:116683968 |
| 546 | + | a, g, t | dbSNP:2308592 |
| complement(546) | - | c, a | dbSNP:77236177 |
| complement(546) | - | c, a | dbSNP:113951262 |
| 547 | + | c, g | dbSNP:41547419 |
| complement(550) | - | t, c | dbSNP:113350320 |
| 557 | + | a, c | dbSNP:41561720 |
| 561 | + | a, t | dbSNP:75032224 |
| 565 | + | a, c, t | dbSNP:41553425 |
| 566 | + | a, c, g | dbSNP:1050685 |
| complement(566) | - | t, g | dbSNP:76841741 |
| complement(566) | - | t, c | dbSNP:79399665 |
| complement(566) | - | t, g | dbSNP:79487092 |
| complement(566) | - | t, g | dbSNP:116172881 |
| complement(567) | - | t, g | dbSNP:75929952 |
| 567 | + | a, c, t | dbSNP:1050686 |
| complement(567) | - | g, a | dbSNP:117778652 |
| complement(567) | - | g, a | dbSNP:74971492 |
| complement(567) | - | g, a | dbSNP:75542142 |
| 568 | + | c, g, t | dbSNP:41555814 |
| 569 | + | g, t | dbSNP:41562916 |
| 570 | + | c, g | dbSNP:41543517 |
| 571 | + | , a, c, g, t | dbSNP:41556120 |
| 571 | + | , t | dbSNP:75456335 |
| 572 | + | a, g | dbSNP:79878930 |
| 583 | + | c, g | dbSNP:41563115 |
| 585 | + | a, g | dbSNP:61759943 |
| 587 | + | a, g | dbSNP:2308598 |
| complement(590) | - | g, a | dbSNP:77935220 |
| 592 | + | a, c | dbSNP:41550613 |
| 596 | + | a, g | dbSNP:1050357 |
| complement(600) | - | g, a | dbSNP:17850339 |
| 601 | + | c, t | dbSNP:1131104 |
| complement(601) | - | g, a | dbSNP:80124956 |
| 602 | + | a, g | dbSNP:41552417 |
| 605 | + | a, g | dbSNP:41561213 |
| 606 | + | a, g | dbSNP:75912596 |
| complement(608) | - | t, c | dbSNP:79611583 |
| 608 | + | a, g | dbSNP:1131103 |
| 610 | + | c, g | dbSNP:17413678 |
| complement(610) | - | g, c | dbSNP:71543418 |
| complement(612) | - | t, g | dbSNP:71543417 |
| 612 | + | a, c | dbSNP:17413685 |
| 612 | + | a, c | dbSNP:41554416 |
| 615 | + | c, t | dbSNP:55730145 |
| 617 | + | c, g | dbSNP:41555616 |
| complement(617) | - | g, c | dbSNP:75935985 |
| 620 | + | c, t | dbSNP:41552115 |
| complement(623) | - | t, c | dbSNP:17849598 |
| 625..628 | + | g, t | dbSNP:17417024 |
| 625 | + | a, g, t | dbSNP:2308604 |
| complement(625) | - | t, c | dbSNP:78473126 |
| complement(625) | - | t, c | dbSNP:112040855 |
| 626 | + | a, g | dbSNP:41541114 |
| 628 | + | a, c | dbSNP:41547620 |
| 630 | + | a, c, g | dbSNP:1131096 |
| complement(630) | - | t, g | dbSNP:115500469 |
| complement(630) | - | t, g | dbSNP:77916677 |
| complement(630) | - | t, g | dbSNP:76138427 |
| 643 | + | c, t | dbSNP:1131292 |
| 655 | + | c, t | dbSNP:1050344 |
| complement(655) | - | g, a | dbSNP:79946831 |
| complement(655) | - | g, a | dbSNP:79262902 |
| complement(655) | - | g, a | dbSNP:115445355 |
| 657 | + | c, g, t | dbSNP:1050343 |
| 659 | + | a, c, g | dbSNP:1050716 |
| 659 | + | a, g | dbSNP:17413706 |
| complement(659) | - | g, c | dbSNP:78422529 |
| complement(659) | - | g, c | dbSNP:116229259 |
| 675 | + | c, t | dbSNP:41545014 |
| 685 | + | a, g | dbSNP:41559418 |
| 695 | + | a, c | dbSNP:74500356 |
| 698 | + | a, g | dbSNP:1059578 |
| 704 | + | c, t | dbSNP:61759944 |
| 710 | + | a, g | dbSNP:41562012 |
| 710 | + | a, g | dbSNP:1050335 |
| 734 | + | c, t | dbSNP:1050328 |
| complement(734) | - | g, a | dbSNP:76367545 |
| 742 | + | c, g | dbSNP:1050326 |
| 751 | + | a, g | dbSNP:1050320 |
| complement(751) | - | t, c | dbSNP:77440575 |
| complement(751) | - | t, c | dbSNP:78609839 |
| complement(751) | - | t, c | dbSNP:115937139 |
| complement(754) | - | g, a | dbSNP:76717943 |
| complement(754) | - | g, a | dbSNP:114964434 |
| 754 | + | c, t | dbSNP:1050317 |
| 763 | + | c, t | dbSNP:2308618 |
| complement(763) | - | g, a | dbSNP:114309926 |
| complement(763) | - | g, a | dbSNP:79295030 |
| 764 | + | c, g | dbSNP:41547622 |
| 779 | + | a, c | dbSNP:41542217 |
| 813 | + | a, c | dbSNP:79767529 |
| complement(821) | - | t, c | dbSNP:78971410 |
| 821 | + | a, g | dbSNP:1050276 |
| 825 | + | c, t | dbSNP:78176797 |
| 836 | + | a, c, g | dbSNP:707908 |
| complement(836) | - | g, c | dbSNP:116256169 |
| complement(836) | - | g, c | dbSNP:74431961 |
| 841 | + | a, g | dbSNP:41542914 |
| complement(851) | - | t, g | dbSNP:28636630 |
| 853 | + | a, g | dbSNP:72558149 |
| 860 | + | a, g | dbSNP:2308622 |
| complement(860) | - | t, c | dbSNP:116796675 |
| complement(860) | - | t, c | dbSNP:79838042 |
| 862 | + | c, g | dbSNP:41540117 |
| complement(862) | - | c, a | dbSNP:115240290 |
| 868 | + | c, t | dbSNP:61759945 |
| 875 | + | c, t | dbSNP:41541219 |
| 879 | + | a, c | dbSNP:2308624 |
| 879 | + | a, c | dbSNP:1131015 |
| complement(879) | - | t, g | dbSNP:114522555 |
| complement(880) | - | t, c | dbSNP:115874418 |
| 880 | + | a, g | dbSNP:1131014 |
| 880 | + | a, g | dbSNP:41551714 |
| 887 | + | c, t | dbSNP:41558713 |
| 888 | + | g, t | dbSNP:41546713 |
| 892 | + | c, t | dbSNP:45481597 |
| 898 | + | a, c | dbSNP:2308628 |
| complement(898) | - | t, g | dbSNP:115363174 |
| complement(902) | - | t, c | dbSNP:114409993 |
| 902 | + | a, g | dbSNP:41556321 |
| complement(903) | - | t, c | dbSNP:9264621 |
| complement(903) | - | t, c | dbSNP:116342335 |
| complement(907) | - | t, c | dbSNP:114075875 |
| complement(907) | - | t, c | dbSNP:75148245 |
| complement(907) | - | t, c | dbSNP:34794906 |
| complement(917) | - | g, a | dbSNP:45485294 |
| complement(919) | - | g, a | dbSNP:11757919 |
| complement(919) | - | g, a | dbSNP:76964651 |
| complement(919) | - | g, a | dbSNP:116660158 |
| 930 | + | a, t | dbSNP:1065600 |
| 930 | + | a, t | dbSNP:41560120 |
| 932 | + | a, g, t | dbSNP:1050180 |
| complement(932) | - | t, c | dbSNP:76089826 |
| complement(932) | - | t, c | dbSNP:114917491 |
| complement(940) | - | g, a | dbSNP:45486697 |
| complement(941) | - | c, a | dbSNP:12209550 |
| 944 | + | g, t | dbSNP:41545712 |
| complement(951) | - | g, a | dbSNP:116047064 |
| complement(952) | - | t, c | dbSNP:115347548 |
| complement(963) | - | g, a | dbSNP:115272444 |
| 963 | + | c, t | dbSNP:17413387 |
| 963 | + | c, t | dbSNP:1050147 |
| complement(977) | - | t, g | dbSNP:45443998 |
| 979 | + | a, t | dbSNP:41556617 |
| complement(979) | - | t, a | dbSNP:116111058 |
| 986 | + | , a, c, g, t | dbSNP:41547312 |
| 989 | + | a, g | dbSNP:1050118 |
| 991 | + | c, g | dbSNP:41540512 |
| 992 | + | a, g | dbSNP:1130947 |
| 994 | + | c, t | dbSNP:1050106 |
| 996 | + | c, t | dbSNP:1050105 |
| 998 | + | a, g | dbSNP:1130935 |
| complement(998) | - | t, c | dbSNP:115504869 |
| 999 | + | a, t | dbSNP:41542414 |
| 1000 | + | g, t | dbSNP:2308650 |
| 1003 | + | a, g | dbSNP:41540416 |
| 1004 | + | c, t | dbSNP:41560617 |
| 1005 | + | a, g | dbSNP:1143551 |
| 1041 | + | a, g | dbSNP:76294545 |
| complement(1041) | - | t, c | dbSNP:116968219 |
| complement(1050) | - | g, a | dbSNP:75102585 |
| complement(1050) | - | g, a | dbSNP:115583167 |
| 1050 | + | c, t | dbSNP:41559915 |
| complement(1056) | - | g, c | dbSNP:35708511 |
| 1056 | + | c, g | dbSNP:1130863 |
| complement(1056) | - | g, c | dbSNP:76207830 |
| complement(1056) | - | g, c | dbSNP:116716035 |
| 1059 | + | c, g | dbSNP:61759946 |
| 1094 | + | a, g | dbSNP:1130838 |
| complement(1094) | - | t, c | dbSNP:75268046 |
| complement(1094) | - | t, c | dbSNP:115114271 |
| complement(1094) | - | t, c | dbSNP:111461137 |
| 1102 | + | , a | dbSNP:41544716 |
| 1154 | + | c, t | dbSNP:1049853 |
| complement(1154) | - | g, a | dbSNP:112426044 |
| complement(1154) | - | g, a | dbSNP:114477682 |
| 1154 | + | c, t | dbSNP:113867234 |
| complement(1154) | - | g, a | dbSNP:79042096 |
| complement(1192) | - | t, c | dbSNP:113829443 |
| 1192 | + | a, g | dbSNP:1049724 |
| 1200 | + | a, g | dbSNP:1049709 |
| complement(1200) | - | t, c | dbSNP:112902401 |
| 1200 | + | a, g | dbSNP:77326983 |
| complement(1201) | - | g, a | dbSNP:78069525 |
| complement(1201) | - | g, a | dbSNP:113988916 |
| 1201 | + | c, t | dbSNP:1065711 |
| complement(1207..1208) | - | , ca | dbSNP:71695980 |
| 1209 | + | c, t | dbSNP:3176007 |
| complement(1209) | - | g, a | dbSNP:115825919 |
| complement(1218) | - | g, a | dbSNP:113224529 |
| complement(1218) | - | g, a | dbSNP:114998626 |
| complement(1218) | - | g, a | dbSNP:41289069 |
| 1233 | + | a, g | dbSNP:1049668 |
| complement(1233) | - | t, c | dbSNP:114345535 |
| complement(1241) | - | c, a | dbSNP:116801519 |
| 1241 | + | g, t | dbSNP:1049663 |
| 1246 | + | c, g | dbSNP:1049650 |
| complement(1246) | - | g, c | dbSNP:115404146 |
| 1246 | + | c, g | dbSNP:112714725 |
| complement(1246) | - | g, c | dbSNP:112485283 |
| complement(1254) | - | g, a | dbSNP:116229144 |
| complement(1287) | - | g, a | dbSNP:115934919 |
| 1287 | + | c, t | dbSNP:1049579 |
| complement(1332) | - | t, c | dbSNP:1094 |
| complement(1332) | - | t, c | dbSNP:111620948 |
| complement(1332) | - | t, c | dbSNP:115142437 |
| complement(1334) | - | , c | dbSNP:9279068 |
| complement(1335) | - | , c | dbSNP:60232921 |
| complement(1338) | - | , c | dbSNP:71755550 |
| complement(1338) | - | , c | dbSNP:35877659 |
| complement(1338) | - | , c | dbSNP:111740154 |
| complement(1364) | - | t, g | dbSNP:77863514 |
| complement(1364) | - | t, g | dbSNP:116306107 |
| 1364 | + | a, c | dbSNP:1130592 |
| 1367 | + | c, t | dbSNP:3207555 |
| complement(1367) | - | g, a | dbSNP:116376444 |
| 1368..1369 | + | , c, t | dbSNP:3207561 |
| complement(1369) | - | g, a | dbSNP:116070186 |
| complement(1369) | - | , a | dbSNP:71744726 |
| complement(1370) | - | g, c | dbSNP:9264589 |
| complement(1371) | - | , c | dbSNP:67384697 |
| 1374 | + | c, t | dbSNP:1130586 |
| complement(1374) | - | g, a | dbSNP:116527348 |
| complement(1375) | - | t, c | dbSNP:115820394 |
| 1375 | + | a, g | dbSNP:1130580 |
| complement(1375) | - | t, c | dbSNP:74421021 |
| 1386 | + | a, g | dbSNP:1130576 |
| complement(1386) | - | t, c | dbSNP:114923631 |
| complement(1393) | - | , taag | dbSNP:60637457 |
| 1402 | + | a, c | dbSNP:1130559 |
| complement(1402) | - | t, g | dbSNP:114231718 |
| complement(1407) | - | t, c | dbSNP:116628280 |
| 1407 | + | a, g | dbSNP:1130558 |
| 1408 | + | a, t | dbSNP:1130554 |
| complement(1408) | - | t, a | dbSNP:115118952 |
| complement(1411) | - | t, c | dbSNP:116144556 |
| 1411 | + | a, g | dbSNP:1130552 |
| 1415 | + | c, g, t | dbSNP:1071643 |
| complement(1415) | - | g, c | dbSNP:117859176 |
| complement(1415) | - | g, c | dbSNP:79506496 |
| complement(1421) | - | , at | dbSNP:71687584 |
| 1432 | + | g, t | dbSNP:1130538 |
| complement(1432) | - | c, a | dbSNP:76420376 |
| complement(1432) | - | c, a | dbSNP:115766056 |
| complement(1432) | - | c, a | dbSNP:112415910 |
| complement(1451..1452) | - | , c | dbSNP:34238273 |
| complement(1452..1453) | - | , c | dbSNP:9281298 |
| complement(1453) | - | t, c | dbSNP:116302614 |
| 1454..1455 | + | , c, g | dbSNP:3189472 |
| complement(1454) | - | t, c | dbSNP:115906458 |
| 1455..1456 | + | c, g | dbSNP:1130525 |
| complement(1455) | - | g, c | dbSNP:114537826 |
| complement(1455) | - | g, c | dbSNP:74616764 |
| complement(1455) | - | , g, c | dbSNP:28420948 |
| complement(1455) | - | , g | dbSNP:67157575 |
| complement(1464) | - | t, c | dbSNP:115510686 |
| complement(1483) | - | g, a | dbSNP:114027487 |
| complement(1484..1485) | - | g, a | dbSNP:11547334 |
| 1487 | + | a, g | dbSNP:1049281 |
| complement(1487) | - | t, c | dbSNP:115058257 |
| complement(1487) | - | t, c | dbSNP:74862196 |
| 1487 | + | a, g | dbSNP:75173003 |
| 1491 | + | g, t | dbSNP:1049268 |
| complement(1520) | - | g, a | dbSNP:35075694 |
| complement(1520) | - | g, a | dbSNP:75589800 |
| complement(1520) | - | g, a | dbSNP:114408988 |
| 1520 | + | c, t | dbSNP:112064486 |
| Gene Symbol | HLA-C |
| Gene Synonym | D6S204; FLJ27082; HLA-Cw; HLA-JY3; HLC-C; PSORS1 |
| Chromosome | 6 |
| Locus Map | 6p21.3 |
| All Transcripts | NM_002117 |
| Title | An additive effect of protective host genetic factors correlates with HIV nonprogression status . |
| Author | Salgado,M., Simon,A., Sanz-Minguela,B., Rallon,N.I., Lopez,M., Vicario,J.L., Benito,J.M. and Rodes,B. |
| Journal | J. Acquir. Immune Defic. Syndr. 56 (4), 300-305 (2011) |
| Title | MHC variation and risk of childhood B-cell precursor acute lymphoblastic leukemia . |
| Author | Hosking,F.J., Leslie,S., Dilthey,A., Moutsianas,L., Wang,Y., Dobbins,S.E., Papaemmanuil,E., Sheridan,E., Kinsey,S.E., Lightfoot,T., Roman,E., Irving,J.A., Allan,J.M., Taylor,M., Greaves,M., McVean,G. and Houlston,R.S. |
| Journal | Blood 117 (5), 1633-1640 (2011) |
| Title | The major genetic determinants of HIV-1 control affect HLA class I peptide presentation . |
| Author | Pereyra,F., Jia,X., McLaren,P.J., Telenti,A., de Bakker,P.I., Walker,B.D., Ripke,S., Brumme,C.J., Pulit,S.L., Carrington,M., Kadie,C.M., Carlson,J.M., Heckerman,D., Graham,R.R., Plenge,R.M., Deeks,S.G., Gianniny,L., Crawford,G., Sullivan,J., Gonzalez,E., Davies,L., Camargo,A., Moore,J.M., Beattie,N., Gupta,S., Crenshaw,A., Burtt,N.P., Guiducci,C., Gupta,N., Gao,X., Qi,Y., Yuki,Y., Piechocka-Trocha,A., Cutrell,E., Rosenberg,R., Moss,K.L., Lemay,P., O'Leary,J., Schaefer,T., Verma,P., Toth,I., Block,B., Baker,B., Rothchild,A., Lian,J., Proudfoot,J., Alvino,D.M., Vine,S., Addo,M.M., Allen,T.M., Altfeld,M., Henn,M.R., Le Gall,S., Streeck,H., Haas,D.W., Kuritzkes,D.R., Robbins,G.K., Shafer,R.W., Gulick,R.M., Shikuma,C.M., Haubrich,R., Riddler,S., Sax,P.E., Daar,E.S., Ribaudo,H.J., Agan,B., Agarwal,S., Ahern,R.L., Allen,B.L., Altidor,S., Altschuler,E.L., Ambardar,S., Anastos,K., Anderson,B., Anderson,V., Andrady,U., Antoniskis,D., Bangsberg,D., Barbaro,D., Barrie,W., Bartczak,J., Barton,S., Basden,P., Basgoz,N., Bazner,S., Bellos,N.C., Benson,A.M., Berger,J., Bernard,N.F., Bernard,A.M., Birch,C., Bodner,S.J., Bolan,R.K., Boudreaux,E.T., Bradley,M., Braun,J.F., Brndjar,J.E., Brown,S.J., Brown,K., Brown,S.T., Burack,J., Bush,L.M., Cafaro,V., Campbell,O., Campbell,J., Carlson,R.H., Carmichael,J.K., Casey,K.K., Cavacuiti,C., Celestin,G., Chambers,S.T., Chez,N., Chirch,L.M., Cimoch,P.J., Cohen,D., Cohn,L.E., Conway,B., Cooper,D.A., Cornelson,B., Cox,D.T., Cristofano,M.V., Cuchural,G. Jr., Czartoski,J.L., Dahman,J.M., Daly,J.S., Davis,B.T., Davis,K., Davod,S.M., DeJesus,E., Dietz,C.A., Dunham,E., Dunn,M.E., Ellerin,T.B., Eron,J.J., Fangman,J.J., Farel,C.E., Ferlazzo,H., Fidler,S., Fleenor-Ford,A., Frankel,R., Freedberg,K.A., French,N.K., Fuchs,J.D., Fuller,J.D., Gaberman,J., Gallant,J.E., Gandhi,R.T., Garcia,E., Garmon,D., Gathe,J.C. Jr., Gaultier,C.R., Gebre,W., Gilman,F.D., Gilson,I., Goepfert,P.A., Gottlieb,M.S., Goulston,C., Groger,R.K., Gurley,T.D., Haber,S., Hardwicke,R., Hardy,W.D., Harrigan,P.R., Hawkins,T.N., Heath,S., Hecht,F.M., Henry,W.K., Hladek,M., Hoffman,R.P., Horton,J.M., Hsu,R.K., Huhn,G.D., Hunt,P., Hupert,M.J., Illeman,M.L., Jaeger,H., Jellinger,R.M., John,M., Johnson,J.A., Johnson,K.L., Johnson,H., Johnson,K., Joly,J., Jordan,W.C., Kauffman,C.A., Khanlou,H., Killian,R.K., Kim,A.Y., Kim,D.D., Kinder,C.A., Kirchner,J.T., Kogelman,L., Kojic,E.M., Korthuis,P.T., Kurisu,W., Kwon,D.S., LaMar,M., Lampiris,H., Lanzafame,M., Lederman,M.M., Lee,D.M., Lee,J.M., Lee,M.J., Lee,E.T., Lemoine,J., Levy,J.A., Llibre,J.M., Liguori,M.A., Little,S.J., Liu,A.Y., Lopez,A.J., Loutfy,M.R., Loy,D., Mohammed,D.Y., Man,A., Mansour,M.K., Marconi,V.C., Markowitz,M., Marques,R., Martin,J.N., Martin,H.L. Jr., Mayer,K.H., McElrath,M.J., McGhee,T.A., McGovern,B.H., McGowan,K., McIntyre,D., Mcleod,G.X., Menezes,P., Mesa,G., Metroka,C.E., Meyer-Olson,D., Miller,A.O., Montgomery,K., Mounzer,K.C., Nagami,E.H., Nagin,I., Nahass,R.G., Nelson,M.O., Nielsen,C., Norene,D.L., O'Connor,D.H., Ojikutu,B.O., Okulicz,J., Oladehin,O.O., Oldfield,E.C. III, Olender,S.A., Ostrowski,M., Owen,W.F. Jr., Pae,E., Parsonnet,J., Pavlatos,A.M., Perlmutter,A.M., Pierce,M.N., Pincus,J.M., Pisani,L., Price,L.J., Proia,L., Prokesch,R.C., Pujet,H.C., Ramgopal,M., Rathod,A., Rausch,M., Ravishankar,J., Rhame,F.S., Richards,C.S., Richman,D.D., Rodes,B., Rodriguez,M., Rose,R.C. III, Rosenberg,E.S., Rosenthal,D., Ross,P.E., Rubin,D.S., Rumbaugh,E., Saenz,L., Salvaggio,M.R., Sanchez,W.C., Sanjana,V.M., Santiago,S., Schmidt,W., Schuitemaker,H., Sestak,P.M., Shalit,P., Shay,W., Shirvani,V.N., Silebi,V.I., Sizemore,J.M. Jr., Skolnik,P.R., Sokol-Anderson,M., Sosman,J.M., Stabile,P., Stapleton,J.T., Starrett,S., Stein,F., Stellbrink,H.J., Sterman,F.L., Stone,V.E., Stone,D.R., Tambussi,G., Taplitz,R.A., Tedaldi,E.M., Telenti,A., Theisen,W., Torres,R., Tosiello,L., Tremblay,C., Tribble,M.A., Trinh,P.D., Tsao,A., Ueda,P., Vaccaro,A., Valadas,E., Vanig,T.J., Vecino,I., Vega,V.M., Veikley,W., Wade,B.H., Walworth,C., Wanidworanun,C., Ward,D.J., Warner,D.A., Weber,R.D., Webster,D., Weis,S., Wheeler,D.A., White,D.J., Wilkins,E., Winston,A., Wlodaver,C.G., van't Wout,A., Wright,D.P., Yang,O.O., Yurdin,D.L., Zabukovic,B.W., Zachary,K.C., Zeeman,B. and Zhao,M. |
| Journal | Science 330 (6010), 1551-1557 (2010) |
| Title | Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human natural killer cells . |
| Author | Kohler,K., Xiong,S., Brzostek,J., Mehrabi,M., Eissmann,P., Harrison,A., Cordoba,S.P., Oddos,S., Miloserdov,V., Gould,K., Burroughs,N.J., van der Merwe,P.A. and Davis,D.M. |
| Journal | PLoS ONE 5 (11), E15374 (2010) |
| Title | A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis . |
| Author | Field,J., Browning,S.R., Johnson,L.J., Danoy,P., Varney,M.D., Tait,B.D., Gandhi,K.S., Charlesworth,J.C., Heard,R.N., Stewart,G.J., Kilpatrick,T.J., Foote,S.J., Bahlo,M., Butzkueven,H., Wiley,J., Booth,D.R., Taylor,B.V., Brown,M.A., Rubio,J.P. and Stankovich,J. |
| Journal | PLoS ONE 5 (10), E13454 (2010) |
| Title | Distinctive polymorphism at the HLA-C locus: implications for the expression of HLA-C . |
| Author | Zemmour,J. and Parham,P. |
| Journal | J. Exp. Med. 176 (4), 937-950 (1992) |
| Title | Unusual HLA-B alleles in two tribes of Brazilian Indians . |
| Author | Belich,M.P., Madrigal,J.A., Hildebrand,W.H., Zemmour,J., Williams,R.C., Luz,R., Petzl-Erler,M.L. and Parham,P. |
| Journal | Nature 357 (6376), 326-329 (1992) |
| Title | The molecular basis for reactivity of anti-Cw1 and anti-Cw3 alloantisera with HLA-B46 haplotypes . |
| Author | Zemmour,J., Gumperz,J.E., Hildebrand,W.H., Ward,F.E., Marsh,S.G., Williams,R.C. and Parham,P. |
| Journal | Tissue Antigens 39 (5), 249-257 (1992) |
| Title | Isolation and characterization of a genomic HLA-Cw6 clone . |
| Author | Steinle,A., Nossner,E. and Schendel,D.J. |
| Journal | Tissue Antigens 39 (3), 134-137 (1992) |
| Title | Evolutionary relationship between immunoglobulins and transplantation antigens . |
| Author | Peterson,P.A., Rask,L., Sege,K., Klareskog,L., Anundi,H. and Ostberg,L. |
| Journal | Proc. Natl. Acad. Sci. U.S.A. 72 (4), 1612-1616 (1975) |
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.
 |
Secured Online Quotation |
 |
Email: gene@genscript.com |
 |
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188 |
 |
Fax: 1-732-210-0262 1-732-885-5878 |