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Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), mRNA.


RefSeq Accession Definition Sequence Price Select
NM_002121 Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), mRNA. Full Lenth $435.29
ORF Sequence $225.33


RefSeq Version NM_002121.4, 24797075
Length 1501 bp
Structure linear
Update Date 16-APR-2011
Organism Homo sapiens (human)
Definition Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), mRNA.
Product HLA class II histocompatibility antigen, DP beta 1 chain precursor
Comment

Summary: HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq].

RefSeq NP_002112.3
CDS 60..836
Exon (1)1..159
Exon (2)1..159
Exon (3)160..423
Exon (4)424..705
Exon (5)706..816
Exon (6)817..840
Exon (7)841..1501
Translation MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYLFQGRQECYAFNGTQRFLERYIYN REEFARFDSDVGEFRAVTELGRPAAEYWNSQKDILEEKRAVPDRMCRHNYELGGPMTLQR RVQPRVNVSPSKKGPLQHHNLLVCHVTDFYPGSIQVRWFLNGQEETAGVVSTNLIRNGDW TFQILVMLEMTPQQGDVYTCQVEHTSLDSPVTVEWKAQSDSARSKTLTGAGGFVLGLIIC GVGIFMHRRSKKVQRGSA
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Position Chain Variation Link
83+a, gdbSNP:117588675
83+a, gdbSNP:41540314
106+c, tdbSNP:41558014
106+c, tdbSNP:117791363
130+c, tdbSNP:11551416
167+a, cdbSNP:41544522
168+c, gdbSNP:1126504
168+c, gdbSNP:114172275
168+c, gdbSNP:77274677
170+g, tdbSNP:75052275
170+g, tdbSNP:115118356
170+g, tdbSNP:1126506
171+c, g, tdbSNP:12722013
172+a, tdbSNP:1126509
172+a, tdbSNP:115929243
172+a, tdbSNP:112949044
172+a, tdbSNP:75846523
174+c, tdbSNP:79389600
177+g, tdbSNP:1126511
178+g, tdbSNP:1126513
178+g, tdbSNP:78726154
181+g, tdbSNP:41540313
195+a, c, gdbSNP:41555313
228+g, tdbSNP:41553416
240+a, cdbSNP:41545716
241+c, gdbSNP:41561114
243+c, gdbSNP:12722018
243+c, gdbSNP:113059115
243+c, gdbSNP:111932842
243+c, gdbSNP:114297892
245+a, gdbSNP:41555423
249+c, tdbSNP:9277348
249+c, tdbSNP:114696398
249+c, tdbSNP:79694883
249+c, tdbSNP:111612620
250+a, tdbSNP:111368559
250+a, tdbSNP:112248439
250+a, tdbSNP:114994560
250+a, tdbSNP:1042117
251+c, tdbSNP:41555415
253+c, tdbSNP:1042121
253+c, tdbSNP:114756435
253+c, tdbSNP:113172996
253+c, tdbSNP:77225213
261+g, tdbSNP:77062860
273+g, tdbSNP:41552915
275+a, gdbSNP:12722022
275+a, gdbSNP:77578879
275+a, gdbSNP:112930210
275+a, gdbSNP:111359292
310+a, cdbSNP:79440159
310+a, cdbSNP:112152369
310+a, cdbSNP:114024430
310+a, cdbSNP:75493717
310+a, c, tdbSNP:707958
311+c, g, tdbSNP:9277351
311+g, tdbSNP:116722486
313+a, cdbSNP:116727227
313+a, cdbSNP:111654248
313+a, cdbSNP:1042131
314+a, gdbSNP:80330773
316+a, tdbSNP:41545212
317+c, gdbSNP:1042133
317+c, gdbSNP:116768010
318+c, tdbSNP:114493737
324+a, cdbSNP:41550319
336+c, gdbSNP:41560812
339+a, c, tdbSNP:1042136
339+a, cdbSNP:115274041
complement(339)-t, gdbSNP:111297925
339+a, c, tdbSNP:111936448
340+a, tdbSNP:41547212
342+c, tdbSNP:41547418
345+g, tdbSNP:41553216
351+a, gdbSNP:1042140
complement(351)-t, cdbSNP:111857387
351+a, gdbSNP:115343133
351+a, c, tdbSNP:113989999
351+a, gdbSNP:76170062
352+a, gdbSNP:114400256
352+a, gdbSNP:112670079
352+a, gdbSNP:12722027
354+c, tdbSNP:41554314
356+g, tdbSNP:41560217
360+g, tdbSNP:41546618
362+g, tdbSNP:41556420
364+c, tdbSNP:41551920
368+c, tdbSNP:61759928
371+a, gdbSNP:41545021
372+a, gdbSNP:1042151
372+a, gdbSNP:113526127
372+a, gdbSNP:114462698
372+a, gdbSNP:77545139
373+c, tdbSNP:111596796
374+a, gdbSNP:112050933
374+a, gdbSNP:116119081
374+a, gdbSNP:78377188
374+a, gdbSNP:1042153
396+a, gdbSNP:76968043
397+a, gdbSNP:76513735
397+a, gdbSNP:116369303
397+a, g, tdbSNP:111313297
397+a, g, tdbSNP:1042169
400+a, gdbSNP:9277354
400+a, gdbSNP:115755983
402+c, gdbSNP:116137909
402+c, gdbSNP:9277355
404+c, gdbSNP:1126532
405+a, gdbSNP:9277356
405+a, gdbSNP:115008006
complement(405)-t, cdbSNP:74644530
413+a, gdbSNP:77530367
413+a, gdbSNP:41542615
418+a, gdbSNP:41541915
419+c, tdbSNP:41563418
419+c, tdbSNP:77480353
433+a, gdbSNP:116838108
433+a, gdbSNP:112953328
433+a, gdbSNP:1126537
440+c, tdbSNP:1126541
440+c, tdbSNP:113130574
440+c, tdbSNP:116599140
460+a, gdbSNP:61736937
465+a, c, g, tdbSNP:113371840
465+c, tdbSNP:1042187
465+c, tdbSNP:114009083
490+a, gdbSNP:61736936
500+a, gdbSNP:1042212
500+a, gdbSNP:111531867
500+a, gdbSNP:113901925
500+a, gdbSNP:114642386
500+a, gdbSNP:77595155
514+a, gdbSNP:61736935
533+c, gdbSNP:61736934
567+a, gdbSNP:61997239
570+c, tdbSNP:61997236
616+a, tdbSNP:61736938
647+c, tdbSNP:1042331
647+c, tdbSNP:74630244
647+c, tdbSNP:115866623
655+c, tdbSNP:116283696
655+c, tdbSNP:79741964
655+c, tdbSNP:1042335
678+a, cdbSNP:14362
678+a, cdbSNP:116550526
678+a, cdbSNP:76893992
683+c, tdbSNP:76549543
683+c, tdbSNP:115288819
683+c, tdbSNP:1071597
695+c, tdbSNP:41559424
705+, largedeletiondbSNP:71733767
727+a, gdbSNP:114162773
727+a, gdbSNP:79430336
727+a, c, g, tdbSNP:9276
complement(759)-t, cdbSNP:11551421
759+a, gdbSNP:79566226
759+a, gdbSNP:114572290
790+c, tdbSNP:116452771
complement(790)-g, adbSNP:76912860
790+c, tdbSNP:3097675
835+, adbSNP:67523850
850+c, gdbSNP:114988017
850+c, gdbSNP:1126719
856+c, tdbSNP:1126723
856+c, tdbSNP:114535545
867+a, tdbSNP:116384347
867+a, tdbSNP:1042448
878+a, gdbSNP:9277522
878+a, gdbSNP:114665467
880+a, cdbSNP:114861001
880+a, cdbSNP:9277523
898+c, tdbSNP:1042467
898+c, tdbSNP:116477510
903+a, gdbSNP:114894448
903+a, gdbSNP:113779453
906+c, tdbSNP:115533601
906+c, tdbSNP:1042488
911+c, tdbSNP:1042497
911+c, tdbSNP:114639592
925+c, tdbSNP:115183241
925+c, tdbSNP:1042502
929+a, gdbSNP:1042507
929+a, gdbSNP:115683762
935+a, cdbSNP:114288125
935+a, cdbSNP:1042508
938+g, tdbSNP:1042511
938+g, tdbSNP:116393422
939+a, tdbSNP:115638518
939+a, tdbSNP:1042516
946+g, tdbSNP:113390552
958+c, gdbSNP:116166590
958+c, gdbSNP:3749985
982+a, gdbSNP:1042544
982+a, gdbSNP:114717252
982+a, gdbSNP:77962352
988+c, tdbSNP:114068468
complement(1007)-c, adbSNP:11551420
1044+c, tdbSNP:1042644
1075+a, gdbSNP:931
1075+a, gdbSNP:115174485
1077+c, gdbSNP:114009998
1077+c, gdbSNP:928
1084+c, tdbSNP:114645739
1084+c, tdbSNP:112596157
1104+c, tdbSNP:114882849
1104+c, tdbSNP:76092271
1104+c, tdbSNP:935
1111+a, gdbSNP:932
1111+a, gdbSNP:114543250
1120+c, tdbSNP:116158611
1120+c, tdbSNP:933
1125+, ttctcdbSNP:35277091
1129+c, tdbSNP:115797040
1144+a, gdbSNP:114385226
1144+a, gdbSNP:79200565
1144+a, gdbSNP:929
1181+a, cdbSNP:930
1181+a, cdbSNP:116632023
1181+a, cdbSNP:76388882
1184+a, gdbSNP:74634172
1184+a, gdbSNP:114921523
1184+a, gdbSNP:934
1200+c, gdbSNP:9277529
1200+c, gdbSNP:114425387
1208+a, gdbSNP:115180565
1208+a, gdbSNP:9277530
1212+a, gdbSNP:9277531
1212+a, gdbSNP:116229769
1212+a, gdbSNP:75594735
1236+g, tdbSNP:76275073
1236+g, tdbSNP:114899534
1236+g, tdbSNP:9277532
1246+c, tdbSNP:9277533
1246+c, tdbSNP:116653986
1246+c, tdbSNP:78362728
1332+a, gdbSNP:115967922
1332+a, gdbSNP:112903692
1332+a, gdbSNP:9277534
1386+a, gdbSNP:9277535
1386+a, gdbSNP:113151950
1386+a, gdbSNP:114459399
1400+c, gdbSNP:74531771
1410+a, tdbSNP:115991335
1415+c, tdbSNP:115107409
1415+c, tdbSNP:113369634
1415+c, tdbSNP:9277536
1449+g, tdbSNP:3097677
1449+g, tdbSNP:114143554
Gene SymbolHLA-DPB1
Gene SynonymDPB1; HLA-DP1B; HLA-DPB
Chromosome6
Locus Map6p21.3
All Transcripts NM_002121
Title Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population .
Author Guo,X., Zhang,Y., Li,J., Ma,J., Wei,Z., Tan,W. and O'Brien,S.J.
Journal Hepatology 53 (2), 422-428 (2011)
Title Genome-wide association study identifies susceptibility loci for IgA nephropathy .
Author Gharavi,A.G., Kiryluk,K., Choi,M., Li,Y., Hou,P., Xie,J., Sanna-Cherchi,S., Men,C.J., Julian,B.A., Wyatt,R.J., Novak,J., He,J.C., Wang,H., Lv,J., Zhu,L., Wang,W., Wang,Z., Yasuno,K., Gunel,M., Mane,S., Umlauf,S., Tikhonova,I., Beerman,I., Savoldi,S., Magistroni,R., Ghiggeri,G.M., Bodria,M., Lugani,F., Ravani,P., Ponticelli,C., Allegri,L., Boscutti,G., Frasca,G., Amore,A., Peruzzi,L., Coppo,R., Izzi,C., Viola,B.F., Prati,E., Salvadori,M., Mignani,R., Gesualdo,L., Bertinetto,F., Mesiano,P., Amoroso,A., Scolari,F., Chen,N., Zhang,H. and Lifton,R.P.
Journal Nat. Genet. 43 (4), 321-327 (2011)
Title HLA-DRB1*0407 and *1304 are risk factors for scleroderma renal crisis .
Author Nguyen,B., Mayes,M.D., Arnett,F.C., Del Junco,D., Reveille,J.D., Gonzalez,E.B., Draeger,H.T., Perry,M., Hendiani,A., Anand,K.K. and Assassi,S.
Journal Arthritis Rheum. (2010) In press
Title A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis .
Author Field,J., Browning,S.R., Johnson,L.J., Danoy,P., Varney,M.D., Tait,B.D., Gandhi,K.S., Charlesworth,J.C., Heard,R.N., Stewart,G.J., Kilpatrick,T.J., Foote,S.J., Bahlo,M., Butzkueven,H., Wiley,J., Booth,D.R., Taylor,B.V., Brown,M.A., Rubio,J.P. and Stankovich,J.
Journal PLoS ONE 5 (10), E13454 (2010)
Title Extended LTA, TNF, LST1 and HLA gene haplotypes and their association with rubella vaccine-induced immunity .
Author Ovsyannikova,I.G., Vierkant,R.A., Pankratz,V.S., Jacobson,R.M. and Poland,G.A.
Journal PLoS ONE 5 (7), E11806 (2010)
Title HLA class II nucleotide sequences, 1992 .
Author Marsh,S.G. and Bodmer,J.G.
Journal Tissue Antigens 40 (5), 229-243 (1992)
Title A novel HLA-DPB1 sequence, DPB1*2301 .
Author Eiermann,T.H., Uhl,S., Fakler,J. and Goldmann,S.F.
Journal Tissue Antigens 40 (2), 108-110 (1992)
Title Family study on HLA-DPB1 polymorphism: linkage analysis with HLA-DR/DQ and two 'new' alleles .
Author Mitsunaga,S., Kuwata,S., Tokunaga,K., Uchikawa,C., Takahashi,K., Akaza,T., Mitomi,Y. and Juji,T.
Journal Hum. Immunol. 34 (3), 203-211 (1992)
Title A new HLA-DPB1 allele from a patient with systemic lupus erythematosus .
Author Korioth,F., Hartung,K., Deicher,H. and Frey,J.
Journal Tissue Antigens 39 (4), 216-219 (1992)
Title Positive correlation between oligonucleotide typing and T-cell recognition of HLA-DP molecules .
Author de Koster,H.S., Kenter,M.J., D'Amaro,J., Luiten,R.M., Schroeijers,W.E., Giphart,M.J. and Termijtelen,A.
Journal Immunogenetics 34 (1), 12-22 (1991)

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