Homo sapiens major histocompatibility complex, class II, DR beta 1 (HLA-DRB1), mRNA.
| RefSeq Version | NM_002124.2, 155030210 |
| Length | 1229 bp |
| Structure | linear |
| Update Date | 05-MAY-2011 |
| Organism | Homo sapiens (human) |
| Definition | Homo sapiens major histocompatibility complex, class II, DR beta 1 (HLA-DRB1), mRNA. |
| Product | major histocompatibility complex, class II, DR beta 1 precursor |
| Comment | Summary: HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq]. |
| RefSeq | NP_002115.2 |
| CDS | 44..844 | Exon (1) | 1..143 | Exon (2) | 1..143 | Exon (3) | 144..413 | Exon (4) | 414..695 | Exon (5) | 696..806 | Exon (6) | 807..830 | Exon (7) | 831..1166 |
| Translation | MVCLKLPGGSCMTALTVTLMVLSSPLALSGDTRPRFLWQPKRECHFFNGTERVRFLDRYF
YNQEESVRFDSDVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVVESFTV
QRRVQPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLNGQEEKAGMVSTGLIQNG
DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLL
FLGAGLFIYFRNQKGHSGLQPTGFLS
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| Position | Chain | Variation | Link |
| complement(3) | - | g, a | dbSNP:28366221 |
| 3 | + | c, t | dbSNP:1059544 |
| 4 | + | a, g | dbSNP:1059545 |
| complement(4) | - | t, c | dbSNP:28366220 |
| 11 | + | c, t | dbSNP:1059546 |
| complement(12) | - | g, a | dbSNP:71549221 |
| complement(14) | - | g, c | dbSNP:17204744 |
| complement(17) | - | t, c | dbSNP:17204737 |
| complement(20) | - | t, g | dbSNP:17211078 |
| complement(27) | - | g, a | dbSNP:17211071 |
| complement(34) | - | g, c | dbSNP:17211064 |
| 34 | + | c, g | dbSNP:1059547 |
| 57 | + | a, g | dbSNP:707953 |
| complement(57) | - | t, c | dbSNP:9270305 |
| complement(57) | - | t, c | dbSNP:80165193 |
| 59 | + | c, t | dbSNP:17879020 |
| complement(66) | - | t, c | dbSNP:111934004 |
| 70 | + | c, t | dbSNP:1059549 |
| 75 | + | a, g | dbSNP:1059551 |
| complement(76) | - | g, a | dbSNP:34396110 |
| complement(77) | - | t, a | dbSNP:116331390 |
| complement(80) | - | t, c | dbSNP:9270303 |
| 80 | + | a, g | dbSNP:78246137 |
| 83 | + | a, g | dbSNP:17878475 |
| complement(84) | - | c, a | dbSNP:9270302 |
| complement(85) | - | c, a | dbSNP:9270301 |
| complement(98) | - | g, a | dbSNP:34187469 |
| complement(102) | - | g, a | dbSNP:35053532 |
| complement(128) | - | c, a | dbSNP:9270299 |
| complement(140) | - | t, g | dbSNP:9256943 |
| 141 | + | a, g | dbSNP:17879746 |
| 146 | + | c, g | dbSNP:41308497 |
| complement(152) | - | g, a | dbSNP:9269960 |
| complement(155) | - | t, c, a | dbSNP:9269959 |
| complement(156) | - | t, c | dbSNP:9269958 |
| complement(158) | - | g, c, a | dbSNP:9269957 |
| 159 | + | a, t | dbSNP:17882663 |
| complement(160) | - | g, c | dbSNP:9269956 |
| complement(161) | - | t, g, c, a | dbSNP:9269955 |
| 162 | + | a, c, g, t | dbSNP:17878703 |
| 165 | + | a, c | dbSNP:3179213 |
| 166 | + | a, g | dbSNP:17887028 |
| 167 | + | g, t | dbSNP:1136758 |
| 168 | + | c, g | dbSNP:1136759 |
| complement(169) | - | c, a | dbSNP:9269951 |
| 170 | + | a, g | dbSNP:17882014 |
| 172 | + | a, g | dbSNP:17885011 |
| 176 | + | c, t | dbSNP:17879702 |
| 178 | + | a, t | dbSNP:17879981 |
| complement(182) | - | g, a | dbSNP:114435757 |
| 184 | + | c, t | dbSNP:45600431 |
| 187 | + | c, t | dbSNP:17886488 |
| 187 | + | c, t | dbSNP:1136763 |
| 188 | + | c, g | dbSNP:61759931 |
| 189 | + | c, g | dbSNP:17879469 |
| 191 | + | a, t | dbSNP:61759932 |
| 192 | + | a, c | dbSNP:61759933 |
| 193 | + | c, g | dbSNP:17881146 |
| 197 | + | a, c, g | dbSNP:74812266 |
| 198 | + | c, g | dbSNP:17882378 |
| complement(199..204) | - | , cgcacc | dbSNP:66939620 |
| 204 | + | a, g, t | dbSNP:17885382 |
| 204 | + | a, g | dbSNP:1136625 |
| 205 | + | g, t | dbSNP:74481206 |
| 207 | + | a, t | dbSNP:16822516 |
| 208 | + | a, c, g, t | dbSNP:17884840 |
| 208 | + | c, g | dbSNP:1059572 |
| complement(210..211) | - | , ca | dbSNP:67244437 |
| 210 | + | a, c, g, t | dbSNP:17878671 |
| 212 | + | c, g | dbSNP:17878947 |
| 214 | + | a, c, g | dbSNP:1059575 |
| 217 | + | a, t | dbSNP:17878437 |
| complement(218) | - | g, a | dbSNP:113465897 |
| 218 | + | , c, g, t | dbSNP:11554462 |
| 219 | + | a, g, t | dbSNP:3175105 |
| 219 | + | , a, g, t | dbSNP:17882777 |
| 220 | + | c, t | dbSNP:17884729 |
| 221 | + | a, g, t | dbSNP:17882300 |
| 221 | + | a, t | dbSNP:1059346 |
| 224 | + | c, g, t | dbSNP:1064664 |
| 227 | + | a, c | dbSNP:17879995 |
| 229 | + | a, c, t | dbSNP:17879242 |
| 231 | + | a, g | dbSNP:17879476 |
| 232 | + | a, g | dbSNP:17882603 |
| 232 | + | a, g | dbSNP:1059348 |
| 234 | + | a, g | dbSNP:55655909 |
| 235 | + | a, g | dbSNP:17885071 |
| 238 | + | a, g | dbSNP:17882641 |
| 239 | + | a, c, g, t | dbSNP:16822820 |
| 240 | + | a, c, t | dbSNP:17883134 |
| 241 | + | c, t | dbSNP:72558164 |
| 242 | + | c, g, t | dbSNP:17878614 |
| 243 | + | c, t | dbSNP:17878951 |
| 246 | + | a, g | dbSNP:17886928 |
| 247 | + | c, g | dbSNP:17885772 |
| 249 | + | a, t | dbSNP:17882455 |
| 251 | + | a, g | dbSNP:56158521 |
| complement(255) | - | c, a | dbSNP:11550037 |
| 259 | + | c, t | dbSNP:75044270 |
| 262 | + | a, g | dbSNP:72558165 |
| 263 | + | a, c, g | dbSNP:17885437 |
| 268 | + | c, g | dbSNP:17882006 |
| 269 | + | c, t | dbSNP:29029548 |
| 270 | + | a, t | dbSNP:17884945 |
| 271 | + | c, t | dbSNP:17879688 |
| 272 | + | a, c, t | dbSNP:17879937 |
| 273 | + | a, g, t | dbSNP:17886436 |
| 274 | + | a, g | dbSNP:55917654 |
| 276 | + | a, c, t | dbSNP:17879432 |
| 277 | + | a, g | dbSNP:35499948 |
| 278 | + | g, t | dbSNP:17885257 |
| 279 | + | c, t | dbSNP:17885908 |
| 282 | + | c, g, t | dbSNP:17884787 |
| 282 | + | c, g | dbSNP:1059582 |
| 283 | + | g, t | dbSNP:17880973 |
| 284 | + | a, g, t | dbSNP:17883065 |
| 287 | + | a, c | dbSNP:72558166 |
| 289 | + | a, g | dbSNP:17878622 |
| 289 | + | a, g | dbSNP:1059349 |
| 293 | + | c, t | dbSNP:17878902 |
| 294 | + | g, t | dbSNP:41308498 |
| 296 | + | c, g | dbSNP:17887012 |
| 298 | + | c, t | dbSNP:72558167 |
| 299 | + | a, g | dbSNP:17880292 |
| 300 | + | a, c, g, t | dbSNP:17885129 |
| complement(301) | - | g, a | dbSNP:17853228 |
| 302 | + | a, c, g | dbSNP:1059583 |
| 303 | + | a, c, g, t | dbSNP:1059584 |
| complement(304) | - | g, a | dbSNP:17853229 |
| 305 | + | c, g | dbSNP:17879954 |
| 306 | + | a, g | dbSNP:17879230 |
| 307 | + | a, c, g | dbSNP:17886514 |
| 308 | + | a, c, t | dbSNP:17882583 |
| 309 | + | a, c | dbSNP:1059586 |
| 318 | + | a, g | dbSNP:41508449 |
| 321 | + | a, g | dbSNP:17882098 |
| 322 | + | , g | dbSNP:17885020 |
| 323 | + | , a | dbSNP:17883087 |
| 324 | + | , a | dbSNP:17878577 |
| 326 | + | a, g | dbSNP:17878874 |
| 329 | + | a, c, t | dbSNP:17886918 |
| 332 | + | c, t | dbSNP:17881176 |
| 333 | + | g, t | dbSNP:41308499 |
| complement(334..335) | - | , t | dbSNP:71827189 |
| complement(336..337) | - | , t | dbSNP:71689970 |
| 336 | + | a, g | dbSNP:17882450 |
| complement(337..338) | - | , tc | dbSNP:28986201 |
| 337 | + | a, g | dbSNP:17885388 |
| 338 | + | c, g | dbSNP:17881965 |
| complement(339..340) | - | , tt | dbSNP:66585153 |
| 339 | + | a, g | dbSNP:17884070 |
| 340 | + | c, g | dbSNP:17879599 |
| 340 | + | c, g | dbSNP:1064591 |
| 341 | + | a, g, t | dbSNP:1064592 |
| complement(342) | - | t, g, c | dbSNP:9269942 |
| 342 | + | a, c, g | dbSNP:16822853 |
| complement(342) | - | , gc | dbSNP:71783033 |
| complement(343..344) | - | , g | dbSNP:28993507 |
| 343 | + | a, g | dbSNP:17880366 |
| complement(344..345) | - | , c | dbSNP:9281873 |
| 344 | + | c, g, t | dbSNP:17885222 |
| complement(344) | - | , g | dbSNP:67798196 |
| complement(345..346) | - | , cc | dbSNP:67187877 |
| 345 | + | a, c, g, t | dbSNP:17885869 |
| 346 | + | c, g, t | dbSNP:17884749 |
| 347 | + | , g, t | dbSNP:17883297 |
| 348 | + | c, g | dbSNP:17878857 |
| 348 | + | c, g | dbSNP:1059596 |
| 349 | + | a, c, g, t | dbSNP:3208330 |
| 350 | + | , a, c, g | dbSNP:16822805 |
| 351 | + | a, c, g, t | dbSNP:17886882 |
| complement(351) | - | , g | dbSNP:67476479 |
| 352 | + | c, g | dbSNP:17880261 |
| 356 | + | a, g | dbSNP:61759934 |
| 359 | + | a, g | dbSNP:17885079 |
| complement(360) | - | t, g | dbSNP:9269941 |
| 361 | + | c, t | dbSNP:16822512 |
| 362 | + | c, g, t | dbSNP:17884043 |
| 363 | + | a, t | dbSNP:17879620 |
| 364 | + | c, g, t | dbSNP:11554463 |
| 371 | + | c, t | dbSNP:29029549 |
| 379 | + | c, t | dbSNP:45542832 |
| 380 | + | a, c, g | dbSNP:17879213 |
| 382 | + | a, g | dbSNP:17885752 |
| 384 | + | c, t | dbSNP:17424145 |
| 386 | + | a, g | dbSNP:61759935 |
| 387 | + | a, g, t | dbSNP:17885482 |
| 388 | + | g, t | dbSNP:17882028 |
| 394 | + | a, c | dbSNP:17883271 |
| 400 | + | a, g | dbSNP:17878803 |
| 400 | + | a, g | dbSNP:1136782 |
| 403 | + | c, g | dbSNP:45594032 |
| 407 | + | a, c | dbSNP:17879125 |
| 409 | + | a, g | dbSNP:17878311 |
| 413 | + | a, g | dbSNP:17885959 |
| 418 | + | a, g, t | dbSNP:1071752 |
| complement(418) | - | t, a | dbSNP:113609047 |
| 420 | + | g, t | dbSNP:79706935 |
| 421 | + | c, t | dbSNP:62799161 |
| 422 | + | c, g, t | dbSNP:17405219 |
| complement(424) | - | t, g | dbSNP:17424180 |
| 426 | + | c, g | dbSNP:80190494 |
| 427 | + | c, t | dbSNP:74944677 |
| 428 | + | a, c, g | dbSNP:1136791 |
| 429 | + | a, g | dbSNP:76895951 |
| 430 | + | a, g | dbSNP:62889561 |
| complement(433) | - | t, c | dbSNP:111823233 |
| 439 | + | a, g | dbSNP:17405226 |
| 440 | + | g, t | dbSNP:1136795 |
| complement(441..442) | - | , t | dbSNP:35616319 |
| complement(441) | - | g, a | dbSNP:117994013 |
| complement(442) | - | t, g | dbSNP:115205732 |
| complement(443..444) | - | , t | dbSNP:66896735 |
| complement(446..447) | - | , g | dbSNP:34749207 |
| 446 | + | g, t | dbSNP:17433947 |
| 448 | + | c, g | dbSNP:17401330 |
| complement(449) | - | , g | dbSNP:67245200 |
| 454 | + | c, t | dbSNP:1064596 |
| complement(466) | - | g, c | dbSNP:77689370 |
| 470 | + | c, t | dbSNP:41557115 |
| 472 | + | c, t | dbSNP:1059615 |
| 478 | + | c, g | dbSNP:17885192 |
| complement(481) | - | g, a | dbSNP:112201403 |
| 487 | + | c, t | dbSNP:2308764 |
| complement(489) | - | t, c | dbSNP:74626234 |
| complement(489) | - | t, c | dbSNP:116633902 |
| 495 | + | a, g | dbSNP:2308765 |
| complement(498) | - | t, c | dbSNP:112796209 |
| complement(504) | - | g, c | dbSNP:111965977 |
| complement(528) | - | c, a | dbSNP:78466762 |
| complement(528) | - | c, a | dbSNP:111534875 |
| 534 | + | a, g, t | dbSNP:707954 |
| 538 | + | c, t | dbSNP:2308767 |
| complement(548) | - | t, c | dbSNP:112408735 |
| complement(554) | - | t, c | dbSNP:75482121 |
| 554 | + | a, g | dbSNP:2308768 |
| 556 | + | g, t | dbSNP:63548860 |
| 560 | + | a, g | dbSNP:2308769 |
| complement(565) | - | t, c | dbSNP:113051160 |
| complement(565) | - | t, c | dbSNP:78767604 |
| 571 | + | a, g | dbSNP:2308770 |
| complement(574) | - | g, a | dbSNP:17850461 |
| 577 | + | c, g | dbSNP:77637983 |
| complement(577) | - | g, c | dbSNP:113627837 |
| 582 | + | a, g | dbSNP:1059353 |
| 583 | + | c, g | dbSNP:2308771 |
| 586 | + | c, t | dbSNP:1059647 |
| 592 | + | c, t | dbSNP:62930562 |
| 600 | + | c, t | dbSNP:1059662 |
| complement(601) | - | t, g | dbSNP:113663708 |
| 601 | + | c, t | dbSNP:1059665 |
| complement(605) | - | t, c | dbSNP:112116022 |
| complement(613) | - | t, c | dbSNP:79182498 |
| 613 | + | a, g | dbSNP:1059671 |
| 613 | + | a, g | dbSNP:16822692 |
| complement(625..626) | - | , t | dbSNP:67077836 |
| 627 | + | a, g | dbSNP:3205588 |
| 628 | + | a, g | dbSNP:16822974 |
| complement(628) | - | t, c | dbSNP:75673486 |
| complement(628) | - | t, c | dbSNP:112268155 |
| complement(630) | - | t, c | dbSNP:35300013 |
| complement(630) | - | , c | dbSNP:67687262 |
| 633 | + | a, c, g | dbSNP:2308775 |
| 634 | + | a, g | dbSNP:701831 |
| 637 | + | a, g | dbSNP:1064611 |
| 637 | + | a, g | dbSNP:16822972 |
| 643 | + | a, g | dbSNP:2308777 |
| complement(646) | - | g, a | dbSNP:17849399 |
| 646 | + | c, t | dbSNP:17405325 |
| complement(646) | - | g, a | dbSNP:111866063 |
| complement(649) | - | g, a | dbSNP:34938122 |
| complement(653) | - | g, c | dbSNP:36044702 |
| complement(661) | - | g, a | dbSNP:17849968 |
| complement(661) | - | g, a | dbSNP:34295373 |
| 667 | + | c, t | dbSNP:3200488 |
| 668 | + | c, g | dbSNP:1059699 |
| complement(668) | - | g, c | dbSNP:111739605 |
| 670 | + | a, g | dbSNP:1059705 |
| complement(670) | - | t, c | dbSNP:17849401 |
| 672 | + | c, t | dbSNP:17423930 |
| complement(672) | - | g, a | dbSNP:115376174 |
| complement(673) | - | t, c | dbSNP:28732329 |
| 673 | + | a, g | dbSNP:34555743 |
| complement(674) | - | t, g, c | dbSNP:33926824 |
| 677 | + | c, g | dbSNP:1136846 |
| 678 | + | a, c, g, t | dbSNP:17885501 |
| 679 | + | a, g | dbSNP:1071837 |
| complement(682..683) | - | , ca | dbSNP:68086438 |
| complement(683..684) | - | , ca | dbSNP:35837054 |
| complement(685) | - | t, c | dbSNP:111403823 |
| complement(689) | - | g, c | dbSNP:33936261 |
| complement(695) | - | , largedeletion | dbSNP:71683868 |
| 697 | + | a, t | dbSNP:78817721 |
| complement(697) | - | t, a | dbSNP:112748470 |
| complement(697) | - | , largedeletion | dbSNP:71757220 |
| complement(701) | - | g, a | dbSNP:34624872 |
| complement(702) | - | t, c | dbSNP:17856290 |
| complement(748) | - | g, a | dbSNP:113175445 |
| 773 | + | a, g | dbSNP:3830125 |
| 775 | + | a, c | dbSNP:3830126 |
| 779 | + | c, t | dbSNP:1059362 |
| 781 | + | a, g | dbSNP:1059808 |
| complement(784) | - | g, a | dbSNP:115775635 |
| complement(785) | - | t, g | dbSNP:115368176 |
| complement(795) | - | t, c | dbSNP:114456878 |
| complement(795) | - | t, c | dbSNP:79558343 |
| complement(795) | - | t, c | dbSNP:71547382 |
| 808 | + | a, g | dbSNP:1071760 |
| 820 | + | c, t | dbSNP:35067512 |
| 822 | + | a, c | dbSNP:17887154 |
| complement(828) | - | g, c | dbSNP:9269744 |
| complement(833) | - | g, a | dbSNP:35445101 |
| complement(836) | - | g, a | dbSNP:34475960 |
| complement(846) | - | t, g, c | dbSNP:9269693 |
| complement(849) | - | t, g | dbSNP:34955866 |
| complement(855..856) | - | , g | dbSNP:9279724 |
| complement(856) | - | , g | dbSNP:68069105 |
| complement(857) | - | , g | dbSNP:71730912 |
| complement(858..859) | - | , g | dbSNP:41285181 |
| complement(859) | - | , g | dbSNP:71822874 |
| 863 | + | c, t | dbSNP:1059920 |
| 866 | + | a, g | dbSNP:1064691 |
| complement(866) | - | t, c | dbSNP:74196494 |
| 873 | + | c, t | dbSNP:1064692 |
| 874 | + | c, t | dbSNP:1064694 |
| 874 | + | c, t | dbSNP:3200773 |
| 876 | + | a, t | dbSNP:3200775 |
| 879 | + | g, t | dbSNP:1064695 |
| complement(880) | - | g, a | dbSNP:115103320 |
| 884 | + | a, g | dbSNP:1064697 |
| 884 | + | a, g | dbSNP:3208370 |
| complement(893) | - | t, c | dbSNP:35324556 |
| 894 | + | a, g | dbSNP:36217730 |
| complement(901) | - | t, g | dbSNP:35236441 |
| complement(902) | - | t, c | dbSNP:35521457 |
| complement(905..906) | - | , a | dbSNP:71810699 |
| 906 | + | c, t | dbSNP:3200855 |
| 906 | + | c, t | dbSNP:1064699 |
| 907 | + | c, t | dbSNP:12363 |
| 909 | + | c, t | dbSNP:3180268 |
| 909 | + | c, t | dbSNP:3201237 |
| 910 | + | c, g, t | dbSNP:3205664 |
| 910 | + | g, t | dbSNP:3180799 |
| 910 | + | g, t | dbSNP:16822969 |
| 912 | + | c, t | dbSNP:3205665 |
| complement(912) | - | g, a | dbSNP:9269688 |
| complement(913) | - | , a | dbSNP:71864678 |
| 917 | + | a, t | dbSNP:1064701 |
| 918 | + | c, g | dbSNP:1141869 |
| 918 | + | c, g | dbSNP:16822686 |
| 920 | + | c, t | dbSNP:16822967 |
| 920 | + | c, t | dbSNP:3200898 |
| 929 | + | a, g | dbSNP:3200923 |
| complement(930) | - | g, a | dbSNP:116358897 |
| 931 | + | a, g | dbSNP:1060081 |
| complement(937..938) | - | , cctc | dbSNP:34896825 |
| complement(938) | - | t, c | dbSNP:34844328 |
| complement(939) | - | g, c | dbSNP:36084494 |
| complement(944) | - | g, c | dbSNP:34007709 |
| complement(947) | - | t, g | dbSNP:34022924 |
| 947 | + | a, c | dbSNP:3200956 |
| complement(951) | - | g, a | dbSNP:113734598 |
| complement(953) | - | t, a | dbSNP:35463048 |
| 954 | + | a, g | dbSNP:1060129 |
| complement(959) | - | g, a | dbSNP:34009233 |
| 963 | + | c, t | dbSNP:1060150 |
| 963 | + | c, t | dbSNP:1060362 |
| 969 | + | a, g | dbSNP:1060153 |
| 969 | + | a, g, t | dbSNP:1064707 |
| complement(972..973) | - | , gc | dbSNP:34160410 |
| complement(973..974) | - | , ag | dbSNP:35165835 |
| 973 | + | a, g | dbSNP:3200044 |
| complement(985) | - | t, c | dbSNP:112871130 |
| 993 | + | c, t | dbSNP:1064684 |
| 1001 | + | g, t | dbSNP:1060173 |
| complement(1001) | - | c, a | dbSNP:1732 |
| complement(1005) | - | g, a | dbSNP:35716402 |
| 1008 | + | c, t | dbSNP:1060176 |
| complement(1008) | - | g, a | dbSNP:78862599 |
| complement(1009) | - | g, a | dbSNP:113804375 |
| 1011 | + | a, c, g | dbSNP:3173177 |
| complement(1011) | - | g, c | dbSNP:35000099 |
| 1013 | + | a, g | dbSNP:3200047 |
| 1014 | + | c, t | dbSNP:1064709 |
| 1015 | + | c, t | dbSNP:1064710 |
| 1016 | + | c, t | dbSNP:3208409 |
| complement(1027..1028) | - | , gg | dbSNP:35306263 |
| 1028 | + | c, t | dbSNP:1060185 |
| complement(1029..1030) | - | , t | dbSNP:66798450 |
| complement(1030..1031) | - | , tg | dbSNP:9281863 |
| complement(1030) | - | t, g | dbSNP:35195677 |
| complement(1031..1032) | - | , tg | dbSNP:71685135 |
| complement(1031) | - | g, a | dbSNP:115000072 |
| complement(1032..1033) | - | , tg | dbSNP:113493811 |
| complement(1032) | - | t, c | dbSNP:117447036 |
| 1035 | + | a, t | dbSNP:1060190 |
| complement(1038) | - | t, c | dbSNP:1730 |
| 1039 | + | a, g | dbSNP:1064712 |
| complement(1039) | - | t, c | dbSNP:115149483 |
| 1042 | + | a, g | dbSNP:1064708 |
| complement(1042) | - | t, c | dbSNP:72847688 |
| 1046 | + | c, t | dbSNP:1064713 |
| 1047 | + | a, c, g | dbSNP:3201069 |
| complement(1056..1057) | - | , g | dbSNP:34205910 |
| complement(1058) | - | t, g | dbSNP:80136018 |
| complement(1060) | - | g, c | dbSNP:34542752 |
| complement(1070) | - | g, a | dbSNP:35263976 |
| complement(1072) | - | g, a | dbSNP:118029006 |
| complement(1075..1076) | - | , a | dbSNP:71660512 |
| complement(1077) | - | t, c | dbSNP:34306157 |
| 1077 | + | a, g | dbSNP:3201080 |
| complement(1081) | - | t, c | dbSNP:118126743 |
| complement(1083) | - | g, a | dbSNP:1729 |
| complement(1084) | - | g, c | dbSNP:34215479 |
| complement(1085) | - | g, a | dbSNP:34900518 |
| 1086 | + | c, g, t | dbSNP:1064715 |
| complement(1086) | - | g, c | dbSNP:74184083 |
| complement(1086) | - | g, c | dbSNP:75033906 |
| complement(1088) | - | t, g | dbSNP:34923246 |
| complement(1089) | - | g, a | dbSNP:35418460 |
| complement(1090) | - | c, a | dbSNP:6920823 |
| 1097 | + | c, t | dbSNP:1064717 |
| 1098 | + | a, g | dbSNP:3205684 |
| 1109 | + | c, t | dbSNP:1060270 |
| complement(1111..1112) | - | , t | dbSNP:35078527 |
| complement(1112) | - | t, g | dbSNP:35513414 |
| complement(1113) | - | g, a | dbSNP:35413567 |
| complement(1114) | - | g, c | dbSNP:36042073 |
| complement(1116..1117) | - | , c | dbSNP:35993567 |
| complement(1119) | - | t, c | dbSNP:35705303 |
| complement(1120..1121) | - | gg, ca | dbSNP:71535483 |
| 1120 | + | c, t | dbSNP:1141883 |
| complement(1120) | - | g, a | dbSNP:74202142 |
| complement(1120) | - | g, a | dbSNP:78551490 |
| complement(1121) | - | g, c | dbSNP:77071338 |
| 1121 | + | c, g | dbSNP:3208415 |
| complement(1122) | - | t, g | dbSNP:34266013 |
| complement(1124..1125) | - | , tt | dbSNP:35136435 |
| complement(1133) | - | t, c | dbSNP:35297326 |
| complement(1153) | - | t, g | dbSNP:114103896 |
| complement(1155) | - | g, c | dbSNP:34839759 |
| Gene Symbol | HLA-DRB1 |
| Gene Synonym | DRB1; DRw10; FLJ75017; FLJ76359; HLA-DR1B; HLA-DRB; HLA-DRB1*; SS1 |
| Chromosome | 6 |
| Locus Map | 6p21.3 |
| All Transcripts | NM_002124 |
| Title | Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility loci . |
| Author | Freudenberg,J., Lee,H.S., Han,B.G., Shin,H.D., Kang,Y.M., Sung,Y.K., Shim,S.C., Choi,C.B., Lee,A.T., Gregersen,P.K. and Bae,S.C. |
| Journal | Arthritis Rheum. 63 (4), 884-893 (2011) |
| Title | Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis . |
| Author | Hedstrom,A.K., Sundqvist,E., Baarnhielm,M., Nordin,N., Hillert,J., Kockum,I., Olsson,T. and Alfredsson,L. |
| Journal | Brain 134 (PT 3), 653-664 (2011) |
| Title | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 . |
| Author | Anderson,C.A., Boucher,G., Lees,C.W., Franke,A., D'Amato,M., Taylor,K.D., Lee,J.C., Goyette,P., Imielinski,M., Latiano,A., Lagace,C., Scott,R., Amininejad,L., Bumpstead,S., Baidoo,L., Baldassano,R.N., Barclay,M., Bayless,T.M., Brand,S., Buning,C., Colombel,J.F., Denson,L.A., De Vos,M., Dubinsky,M., Edwards,C., Ellinghaus,D., Fehrmann,R.S., Floyd,J.A., Florin,T., Franchimont,D., Franke,L., Georges,M., Glas,J., Glazer,N.L., Guthery,S.L., Haritunians,T., Hayward,N.K., Hugot,J.P., Jobin,G., Laukens,D., Lawrance,I., Lemann,M., Levine,A., Libioulle,C., Louis,E., McGovern,D.P., Milla,M., Montgomery,G.W., Morley,K.I., Mowat,C., Ng,A., Newman,W., Ophoff,R.A., Papi,L., Palmieri,O., Peyrin-Biroulet,L., Panes,J., Phillips,A., Prescott,N.J., Proctor,D.D., Roberts,R., Russell,R., Rutgeerts,P., Sanderson,J., Sans,M., Schumm,P., Seibold,F., Sharma,Y., Simms,L.A., Seielstad,M., Steinhart,A.H., Targan,S.R., van den Berg,L.H., Vatn,M., Verspaget,H., Walters,T., Wijmenga,C., Wilson,D.C., Westra,H.J., Xavier,R.J., Zhao,Z.Z., Ponsioen,C.Y., Andersen,V., Torkvist,L., Gazouli,M., Anagnou,N.P., Karlsen,T.H., Kupcinskas,L., Sventoraityte,J., Mansfield,J.C., Kugathasan,S., Silverberg,M.S., Halfvarson,J., Rotter,J.I., Mathew,C.G., Griffiths,A.M., Gearry,R., Ahmad,T., Brant,S.R., Chamaillard,M., Satsangi,J., Cho,J.H., Schreiber,S., Daly,M.J., Barrett,J.C., Parkes,M., Annese,V., Hakonarson,H., Radford-Smith,G., Duerr,R.H., Vermeire,S., Weersma,R.K. and Rioux,J.D. |
| Journal | Nat. Genet. 43 (3), 246-252 (2011) |
| Title | Genome-wide association study identifies susceptibility loci for IgA nephropathy . |
| Author | Gharavi,A.G., Kiryluk,K., Choi,M., Li,Y., Hou,P., Xie,J., Sanna-Cherchi,S., Men,C.J., Julian,B.A., Wyatt,R.J., Novak,J., He,J.C., Wang,H., Lv,J., Zhu,L., Wang,W., Wang,Z., Yasuno,K., Gunel,M., Mane,S., Umlauf,S., Tikhonova,I., Beerman,I., Savoldi,S., Magistroni,R., Ghiggeri,G.M., Bodria,M., Lugani,F., Ravani,P., Ponticelli,C., Allegri,L., Boscutti,G., Frasca,G., Amore,A., Peruzzi,L., Coppo,R., Izzi,C., Viola,B.F., Prati,E., Salvadori,M., Mignani,R., Gesualdo,L., Bertinetto,F., Mesiano,P., Amoroso,A., Scolari,F., Chen,N., Zhang,H. and Lifton,R.P. |
| Journal | Nat. Genet. 43 (4), 321-327 (2011) |
| Title | Bimodal distribution of RNA expression levels in human skeletal muscle tissue . |
| Author | Mason,C.C., Hanson,R.L., Ossowski,V., Bian,L., Baier,L.J., Krakoff,J. and Bogardus,C. |
| Journal | BMC Genomics 12, 98 (2011) |
| Title | HLA-DRB1 first domain sequence for a novel DR4 allele designated DRB1*0413 . |
| Author | Petersdorf,E.W., Smith,A.G., Martin,P.J. and Hansen,J.A. |
| Journal | Tissue Antigens 40 (5), 267-268 (1992) |
| Title | Molecular analysis of HLA-DRB1*08/12 alleles: identification of two additional alleles . |
| Author | Eberle,M. and Baxter-Lowe,L.A. |
| Journal | Hum. Immunol. 34 (1), 24-30 (1992) |
| Title | Molecular genetic analysis of HLA-DR and HLA-DQ genes among anti-U1-70-kd autoantibody positive connective tissue disease patients . |
| Author | Kaneoka,H., Hsu,K.C., Takeda,Y., Sharp,G.C. and Hoffman,R.W. |
| Journal | Arthritis Rheum. 35 (1), 83-94 (1992) |
| Title | The evolutionary origin of the HLA-DR3 haplotype . |
| Author | Vincek,V., Klein,D., Figueroa,F., Hauptfeld,V., Kasahara,M., O'hUigin,C., Mach,B. and Klein,J. |
| Journal | Immunogenetics 35 (4), 263-271 (1992) |
| Title | Mhc-DRB diversity of the chimpanzee (Pan troglodytes) . |
| Author | Kenter,M., Otting,N., Anholts,J., Jonker,M., Schipper,R. and Bontrop,R.E. |
| Journal | Immunogenetics 37 (1), 1-11 (1992) |
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