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Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA.


RefSeq Accession Definition Sequence Price Select
NM_002164 Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA. Full Lenth $563.76
ORF Sequence $351.48


RefSeq Version NM_002164.5, 323668304
Length 1944 bp
Structure linear
Update Date 13-MAR-2011
Organism Homo sapiens (human)
Definition Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA.
Product indoleamine 2,3-dioxygenase 1
Comment

Summary: This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.

RefSeq NP_002155.1
CDS 115..1326
Exon (1)1..201
Exon (2)1..201
Exon (3)202..297
Exon (4)298..417
Exon (5)418..536
Exon (6)537..551
Exon (7)552..651
Exon (8)652..769
Exon (9)770..821
Exon (10)822..970
Exon (11)971..1931
Translation MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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Position Chain Variation Link
Gene SymbolIDO1
Gene SynonymIDO; IDO-1; INDO
Chromosome8
Locus Map8p12-p11
All Transcripts NM_002164
Title Coding region polymorphisms in the indoleamine 2,3-dioxygenase (INDO) gene and recurrent spontaneous abortion .
Author Amani,D., Ravangard,F., Niikawa,N., Yoshiura,K., Karimzadeh,M., Dehaghani,A.S. and Ghaderi,A.
Journal J. Reprod. Immunol. 88 (1), 42-47 (2011)
Title A specific interaction of L-tryptophan with CO of CO-bound indoleamine 2,3-dioxygenase identified by resonance Raman spectroscopy .
Author Yanagisawa,S., Sugimoto,H., Shiro,Y. and Ogura,T.
Journal Biochemistry 49 (47), 10081-10088 (2010)
Title High levels of IDO-expressing CD16+ peripheral cells, and Tregs in graft biopsies from kidney transplant recipients under belatacept treatment .
Author Furuzawa-Carballeda,J., Lima,G., Uribe-Uribe,N., Avila-Casado,C., Mancilla,E., Morales-Buenrostro,L.E., Perez-Garrido,J., Perez,M., Cardenas,G., Llorente,L. and Alberu,J.
Journal Transplant. Proc. 42 (9), 3489-3496 (2010)
Title Psychological stress-induced, IDO1-dependent tryptophan catabolism: implications on immunosuppression in mice and humans .
Author Kiank,C., Zeden,J.P., Drude,S., Domanska,G., Fusch,G., Otten,W. and Schuett,C.
Journal PLoS ONE 5 (7), E11825 (2010)
Title Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease .
Author Bonda,D.J., Mailankot,M., Stone,J.G., Garrett,M.R., Staniszewska,M., Castellani,R.J., Siedlak,S.L., Zhu,X., Lee,H.G., Perry,G., Nagaraj,R.H. and Smith,M.A.
Journal Redox Rep. 15 (4), 161-168 (2010)
Title Gene structure of human indoleamine 2,3-dioxygenase .
Author Kadoya,A., Tone,S., Maeda,H., Minatogawa,Y. and Kido,R.
Journal Biochem. Biophys. Res. Commun. 189 (1), 530-536 (1992)
Title Localization and developmental change of indoleamine 2,3-dioxygenase activity in the human placenta .
Author Kamimura,S., Eguchi,K., Yonezawa,M. and Sekiba,K.
Journal Acta Med. Okayama 45 (3), 135-139 (1991)
Title Molecular cloning, sequencing and expression of human interferon-gamma-inducible indoleamine 2,3-dioxygenase cDNA .
Author Dai,W. and Gupta,S.L.
Journal Biochem. Biophys. Res. Commun. 168 (1), 1-8 (1990)
Title Primary structure of human indoleamine 2,3-dioxygenase deduced from the nucleotide sequence of its cDNA .
Author Tone,S., Takikawa,O., Habara-Ohkubo,A., Kadoya,A., Yoshida,R. and Kido,R.
Journal Nucleic Acids Res. 18 (2), 367 (1990)
Title Tumour necrosis factor-alpha and lipopolysaccharide enhance interferon-induced tryptophan degradation and pteridine synthesis in human cells .
Author Werner-Felmayer,G., Werner,E.R., Fuchs,D., Hausen,A., Reibnegger,G. and Wachter,H.
Journal Biol. Chem. Hoppe-Seyler 370 (9), 1063-1069 (1989)

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