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Database:

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Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA.


Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu20074 Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA. pcDNA3.1+-DYK In-stock $99.00 5-7
OHu20074C Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA. Customized vector In-stock $149.00 5-7

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Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_002164.5, 323668304
Length 1212 bp
Structure linear
Update Date 04-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA.
Product indoleamine 2,3-dioxygenase 1
Comment

Summary: This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011].

RefSeq NP_002155.1
CDS 115..1326
Misc Feature(1)85..87
Misc Feature(2)136..1314
Misc Feature(3)136..1314
Exon (1)1..201
Gene:IDO1
Gene Synonym:IDO; IDO-1; INDO
Exon (2)202..297
Gene:IDO1
Gene Synonym:IDO; IDO-1; INDO
Exon (3)298..417
Gene:IDO1
Gene Synonym:IDO; IDO-1; INDO
Exon (4)418..536
Gene:IDO1
Gene Synonym:IDO; IDO-1; INDO
Exon (5)537..551
Gene:IDO1
Gene Synonym:IDO; IDO-1; INDO
Exon (6)552..651
Gene:IDO1
Gene Synonym:IDO; IDO-1; INDO
Exon (7)652..769
Gene:IDO1
Gene Synonym:IDO; IDO-1; INDO
Exon (8)770..821
Gene:IDO1
Gene Synonym:IDO; IDO-1; INDO
Exon (9)822..970
Gene:IDO1
Gene Synonym:IDO; IDO-1; INDO
Exon (10)971..1931
Gene:IDO1
Gene Synonym:IDO; IDO-1; INDO
Translation MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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Position Chain Variation Link
26+dbSNP:
26+c, tdbSNP:114621275
40..41+, ggggdbSNP:139463288
81+a, tdbSNP:377358744
83+a, gdbSNP:370408015
96+a, gdbSNP:146125455
107+a, cdbSNP:374566329
109+a, gdbSNP:377577519
124+c, tdbSNP:35059413
207+dbSNP:
207+c, tdbSNP:188033932
complement(241)-t, gdbSNP:75896742
322+dbSNP:
322+c, tdbSNP:374076241
343+c, tdbSNP:200980431
344+c, tdbSNP:35099072
383+a, gdbSNP:375715414
413+a, gdbSNP:200244502
428+dbSNP:
428+a, gdbSNP:12545877
434+g, tdbSNP:4463407
462+a, gdbSNP:12545878
539+dbSNP:
539+c, tdbSNP:61753677
569..570+dbSNP:
569..570+, gdbSNP:34155785
570+c, gdbSNP:115833371
577+c, tdbSNP:370075063
578+a, gdbSNP:200635255
582+a, tdbSNP:185712428
598+c, gdbSNP:201170433
614+c, gdbSNP:189439950
616+c, tdbSNP:377288389
663+dbSNP:
663+g, tdbSNP:372561405
669+c, gdbSNP:376724401
690+a, gdbSNP:201671570
691+c, tdbSNP:372512518
692+c, gdbSNP:371014998
705+a, tdbSNP:185947694
709+a, gdbSNP:375907817
710..711+cg, ttdbSNP:267606590
724+a, gdbSNP:369075008
739+a, tdbSNP:373871520
752+c, tdbSNP:376530940
759+c, tdbSNP:144836646
769+a, gdbSNP:373557196
771+dbSNP:
771+a, tdbSNP:148682026
869+dbSNP:
869+c, tdbSNP:376097320
895+g, tdbSNP:368545447
919+a, gdbSNP:200544059
921+c, tdbSNP:377110494
936+c, tdbSNP:374857714
937+a, gdbSNP:187334376
997+dbSNP:
997+a, tdbSNP:144063606
1019+c, gdbSNP:369888099
1068+a, gdbSNP:75174100
1073+a, tdbSNP:376170633
1113+c, tdbSNP:370900557
1161+c, tdbSNP:373317694
1162+a, gdbSNP:376621895
1186+a, gdbSNP:370251807
1206+c, gdbSNP:374895308
1304+a, cdbSNP:377702129
1356+a, gdbSNP:371336850
1441+a, gdbSNP:112777448
1477+c, tdbSNP:146382455
1646+a, gdbSNP:181854364
1675+c, tdbSNP:372492160
1684+c, tdbSNP:139027344
1701+c, tdbSNP:201339184
1727+a, tdbSNP:376997707
1737+a, gdbSNP:187024006
1743+a, gdbSNP:370645816
1766+c, tdbSNP:191858087
1843+c, tdbSNP:372424675
1857+c, gdbSNP:375417495
1890..1891+, adbSNP:34719328
Gene SymbolIDO1
Gene SynonymIDO; IDO-1; INDO
Chromosome8
Locus Map8p12-p11
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_002164 Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA. In-stock $99.00 5-7
Title Checks and balances between human cytomegalovirus replication and indoleamine-2,3-dioxygenase .
Author Zimmermann A, Hauka S, Maywald M, Le VT, Schmidt SK, Daubener W and Hengel H.
Journal J. Gen. Virol. 95 (PT 3), 659-670 (2014)
Title The SOCS3-independent expression of IDO2 supports the homeostatic generation of T regulatory cells by human dendritic cells .
Author Trabanelli S, Ocadlikova D, Ciciarello M, Salvestrini V, Lecciso M, Jandus C, Metz R, Evangelisti C, Laury-Kleintop L, Romero P, Prendergast GC, Curti A and Lemoli RM.
Journal J. Immunol. 192 (3), 1231-1240 (2014)
Title Pro-inflammatory cytokines downregulate Hsp27 and cause apoptosis of human retinal capillary endothelial cells .
Author Nahomi RB, Palmer A, Green KM, Fort PE and Nagaraj RH.
Journal Biochim. Biophys. Acta 1842 (2), 164-174 (2014)
Title Cyclooxygenase-2 (COX-2) inhibition constrains indoleamine 2,3-dioxygenase 1 (IDO1) activity in acute myeloid leukaemia cells .
Author Iachininoto MG, Nuzzolo ER, Bonanno G, Mariotti A, Procoli A, Locatelli F, De Cristofaro R and Rutella S.
Journal Molecules 18 (9), 10132-10145 (2013)
Title IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis .
Author De Luca A, Carvalho A, Cunha C, Iannitti RG, Pitzurra L, Giovannini G, Mencacci A, Bartolommei L, Moretti S, Massi-Benedetti C, Fuchs D, De Bernardis F, Puccetti P and Romani L.
Journal PLoS Pathog. 9 (7), E1003486 (2013)
Title Gene structure of human indoleamine 2,3-dioxygenase .
Author Kadoya A, Tone S, Maeda H, Minatogawa Y and Kido R.
Journal Biochem. Biophys. Res. Commun. 189 (1), 530-536 (1992)
Title Localization and developmental change of indoleamine 2,3-dioxygenase activity in the human placenta .
Author Kamimura S, Eguchi K, Yonezawa M and Sekiba K.
Journal Acta Med. Okayama 45 (3), 135-139 (1991)
Title Molecular cloning, sequencing and expression of human interferon-gamma-inducible indoleamine 2,3-dioxygenase cDNA .
Author Dai W and Gupta SL.
Journal Biochem. Biophys. Res. Commun. 168 (1), 1-8 (1990)
Title Primary structure of human indoleamine 2,3-dioxygenase deduced from the nucleotide sequence of its cDNA .
Author Tone S, Takikawa O, Habara-Ohkubo A, Kadoya A, Yoshida R and Kido R.
Journal Nucleic Acids Res. 18 (2), 367 (1990)
Title Tumour necrosis factor-alpha and lipopolysaccharide enhance interferon-induced tryptophan degradation and pteridine synthesis in human cells .
Author Werner-Felmayer G, Werner ER, Fuchs D, Hausen A, Reibnegger G and Wachter H.
Journal Biol. Chem. Hoppe-Seyler 370 (9), 1063-1069 (1989)

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