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Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA.


RefSeq Accession Definition Services Price Order
NM_002164 Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA. ORF Sequence $351.48
Peptide Services
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Protein Services


RefSeq Version NM_002164.5, 323668304
Length 1944 bp
Structure linear
Update Date 29-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA.
Product indoleamine 2,3-dioxygenase 1
Comment

Summary: This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011].

RefSeq NP_002155.1
CDS 115..1326
Misc Feature(1)85..87
Misc Feature(2)136..1314
Misc Feature(3)136..1314
Exon (1)1..201
Gene:IDO1
Gene Synonym:IDO; IDO-1; INDO
Exon (2)202..297
Gene:IDO1
Gene Synonym:IDO; IDO-1; INDO
Exon (3)298..417
Gene:IDO1
Gene Synonym:IDO; IDO-1; INDO
Exon (4)418..536
Gene:IDO1
Gene Synonym:IDO; IDO-1; INDO
Exon (5)537..551
Gene:IDO1
Gene Synonym:IDO; IDO-1; INDO
Exon (6)552..651
Gene:IDO1
Gene Synonym:IDO; IDO-1; INDO
Exon (7)652..769
Gene:IDO1
Gene Synonym:IDO; IDO-1; INDO
Exon (8)770..821
Gene:IDO1
Gene Synonym:IDO; IDO-1; INDO
Exon (9)822..970
Gene:IDO1
Gene Synonym:IDO; IDO-1; INDO
Exon (10)971..1931
Gene:IDO1
Gene Synonym:IDO; IDO-1; INDO
Translation MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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Position Chain Variation Link
26+dbSNP:
26+c, tdbSNP:114621275
40..41+, ggggdbSNP:139463288
96+a, gdbSNP:146125455
124+c, tdbSNP:35059413
207+dbSNP:
207+c, tdbSNP:188033932
241+g, tdbSNP:75896742
343+dbSNP:
343+c, tdbSNP:200980431
344+c, tdbSNP:35099072
413+a, gdbSNP:200244502
428+dbSNP:
428+a, gdbSNP:12545877
434+g, tdbSNP:4463407
462+a, gdbSNP:12545878
539+dbSNP:
539+c, tdbSNP:61753677
569..570+dbSNP:
569..570+, gdbSNP:34155785
570+c, gdbSNP:115833371
578+a, gdbSNP:200635255
582+a, tdbSNP:185712428
598+c, gdbSNP:201170433
614+c, gdbSNP:189439950
690+dbSNP:
690+a, gdbSNP:201671570
705+a, tdbSNP:185947694
710..711+cg, ttdbSNP:267606590
759+c, tdbSNP:144836646
771+dbSNP:
771+a, tdbSNP:148682026
919+dbSNP:
919+a, gdbSNP:200544059
937+a, gdbSNP:187334376
997+dbSNP:
997+a, tdbSNP:144063606
1068+a, gdbSNP:75174100
1441+a, gdbSNP:112777448
1477+c, tdbSNP:146382455
1646+a, gdbSNP:181854364
1684+c, tdbSNP:139027344
1701+c, tdbSNP:201339184
1737+a, gdbSNP:187024006
1766+c, tdbSNP:191858087
1874..1875+, adbSNP:34719328
Gene SymbolIDO1
Gene SynonymIDO; IDO-1; INDO
Chromosome8
Locus Map8p12-p11
All Transcripts
RefSeq Accession Definition Sequence Price Select
NM_002164 Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA. Full Length $563.76
ORF Sequence $351.48
Title Human indoleamine 2,3-dioxygenase is a catalyst of physiological heme peroxidase reactions: implications for the inhibition of dioxygenase activity by hydrogen peroxide .
Author Freewan,M., Rees,M.D., Plaza,T.S., Glaros,E., Lim,Y.J., Wang,X.S., Yeung,A.W., Witting,P.K., Terentis,A.C. and Thomas,S.R.
Journal J. Biol. Chem. 288 (3), 1548-1567 (2013)
Title Tumoral indoleamine 2,3-dioxygenase expression predicts poor outcome in laryngeal squamous cell carcinoma .
Author Ye,J., Liu,H., Hu,Y., Li,P., Zhang,G. and Li,Y.
Journal Virchows Arch. 462 (1), 73-81 (2013)
Title Decreased expression of indoleamine 2,3-dioxygenase 1 in dendritic cells contributes to impaired regulatory T cell development in immune thrombocytopenia .
Author Catani,L., Sollazzo,D., Trabanelli,S., Curti,A., Evangelisti,C., Polverelli,N., Palandri,F., Baccarani,M., Vianelli,N. and Lemoli,R.M.
Journal Ann. Hematol. 92 (1), 67-78 (2013)
Title Systemic delivery of Salmonella typhimurium transformed with IDO shRNA enhances intratumoral vector colonization and suppresses tumor growth .
Author Blache,C.A., Manuel,E.R., Kaltcheva,T.I., Wong,A.N., Ellenhorn,J.D., Blazar,B.R. and Diamond,D.J.
Journal Cancer Res. 72 (24), 6447-6456 (2012)
Title IDO expression in brain tumors increases the recruitment of regulatory T cells and negatively impacts survival .
Author Wainwright,D.A., Balyasnikova,I.V., Chang,A.L., Ahmed,A.U., Moon,K.S., Auffinger,B., Tobias,A.L., Han,Y. and Lesniak,M.S.
Journal Clin. Cancer Res. 18 (22), 6110-6121 (2012)
Title Gene structure of human indoleamine 2,3-dioxygenase .
Author Kadoya,A., Tone,S., Maeda,H., Minatogawa,Y. and Kido,R.
Journal Biochem. Biophys. Res. Commun. 189 (1), 530-536 (1992)
Title Localization and developmental change of indoleamine 2,3-dioxygenase activity in the human placenta .
Author Kamimura,S., Eguchi,K., Yonezawa,M. and Sekiba,K.
Journal Acta Med. Okayama 45 (3), 135-139 (1991)
Title Molecular cloning, sequencing and expression of human interferon-gamma-inducible indoleamine 2,3-dioxygenase cDNA .
Author Dai,W. and Gupta,S.L.
Journal Biochem. Biophys. Res. Commun. 168 (1), 1-8 (1990)
Title Primary structure of human indoleamine 2,3-dioxygenase deduced from the nucleotide sequence of its cDNA .
Author Tone,S., Takikawa,O., Habara-Ohkubo,A., Kadoya,A., Yoshida,R. and Kido,R.
Journal Nucleic Acids Res. 18 (2), 367 (1990)
Title Tumour necrosis factor-alpha and lipopolysaccharide enhance interferon-induced tryptophan degradation and pteridine synthesis in human cells .
Author Werner-Felmayer,G., Werner,E.R., Fuchs,D., Hausen,A., Reibnegger,G. and Wachter,H.
Journal Biol. Chem. Hoppe-Seyler 370 (9), 1063-1069 (1989)

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