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Homo sapiens interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B), mRNA.

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002187 Homo sapiens interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

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RefSeq Version NM_002187.2, 24497437
Length 2347 bp
Structure linear
Update Date 29-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B), mRNA.
Product interleukin-12 subunit beta precursor

Summary: This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008].

Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

RefSeq NP_002178.2
CDS 43..1029
Misc Feature(1)166..312
Misc Feature(2)415..693
Exon (1)43..130
Gene Synonym:CLMF; CLMF2; IL-12B; NKSF; NKSF2
Exon (2)131..406
Gene Synonym:CLMF; CLMF2; IL-12B; NKSF; NKSF2
Exon (3)407..524
Gene Synonym:CLMF; CLMF2; IL-12B; NKSF; NKSF2
Exon (4)525..739
Gene Synonym:CLMF; CLMF2; IL-12B; NKSF; NKSF2
Exon (5)740..897
Gene Synonym:CLMF; CLMF2; IL-12B; NKSF; NKSF2
Exon (6)898..1029
Gene Synonym:CLMF; CLMF2; IL-12B; NKSF; NKSF2
Exon (7)1030..2347
Gene Synonym:CLMF; CLMF2; IL-12B; NKSF; NKSF2
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Position Chain Variation Link
complement(78)-g, cdbSNP:139890370
complement(139)-g, adbSNP:3213096
complement(169)-t, cdbSNP:144020395
complement(188)-g, adbSNP:56347721
complement(197)-t, gdbSNP:140131034
complement(199)-g, adbSNP:183111978
complement(233)-t, cdbSNP:150659914
complement(250)-t, cdbSNP:201684769
complement(324)-g, adbSNP:142017503
complement(325)-t, cdbSNP:56287471
complement(341)-g, adbSNP:144694601
complement(342)-t, cdbSNP:142998256
complement(343)-g, adbSNP:200722574
complement(392)-, adbSNP:11317523
complement(413)-t, cdbSNP:199703726
complement(425)-c, adbSNP:183576218
complement(436)-t, cdbSNP:139186048
complement(477)-t, cdbSNP:56051849
complement(483)-t, gdbSNP:140642018
complement(526)-g, adbSNP:56369079
complement(553)-t, cdbSNP:189313574
complement(586)-t, cdbSNP:10045130
complement(597)-t, cdbSNP:142400793
complement(665)-g, adbSNP:138127918
complement(684)-g, adbSNP:149273360
complement(685)-t, cdbSNP:79446920
complement(711)-g, adbSNP:149027358
complement(719)-t, cdbSNP:55661460
complement(753)-t, cdbSNP:199527043
complement(780)-t, cdbSNP:192540461
complement(791)-t, cdbSNP:74644143
complement(797)-c, adbSNP:201757381
complement(865)-t, cdbSNP:189324104
complement(893)-t, cdbSNP:111492985
complement(902)-t, cdbSNP:146408881
complement(906)-t, cdbSNP:144054146
complement(912)-g, adbSNP:139163137
complement(915)-t, cdbSNP:144356274
complement(916)-c, adbSNP:150030340
complement(933)-t, cdbSNP:186003445
complement(934)-t, gdbSNP:3213119
complement(939)-g, adbSNP:150902695
complement(1003)-t, cdbSNP:201512006
complement(1015)-t, cdbSNP:56064925
complement(1023)-t, gdbSNP:138991749
complement(1024)-t, gdbSNP:143277765
complement(1030)-g, adbSNP:3213120
complement(1149..1150)-, tdbSNP:3213112
complement(1150)-, adbSNP:78509294
complement(1188)-c, adbSNP:3212227
complement(1217)-c, adbSNP:1805132
complement(1254)-c, adbSNP:3213113
complement(1258)-g, cdbSNP:55949756
complement(1259)-g, adbSNP:56396672
complement(1321)-g, adbSNP:186528423
complement(1369)-t, gdbSNP:41412344
complement(1437)-g, adbSNP:181215530
complement(1445)-g, adbSNP:188784749
complement(1549)-t, cdbSNP:3213114
complement(1559)-g, adbSNP:139879928
complement(1587)-t, gdbSNP:146117745
complement(1713)-, tdbSNP:56390703
complement(1717)-t, adbSNP:144366632
complement(1728)-t, cdbSNP:139698981
complement(1745)-c, adbSNP:41454346
complement(1775)-t, cdbSNP:41292468
complement(1912)-t, gdbSNP:56409614
complement(1930)-, tdbSNP:34324765
complement(1960)-g, adbSNP:55876812
complement(2009)-t, gdbSNP:185933681
complement(2020)-, adbSNP:56081148
complement(2124)-t, gdbSNP:1368439
complement(2215)-c, adbSNP:181807125
complement(2251)-g, adbSNP:144817848
Gene SymbolIL12B
Gene SynonymCLMF; CLMF2; IL-12B; NKSF; NKSF2
Locus Map5q31.1-q33.1
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_002187 Homo sapiens interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B), mRNA. In-stock $418.00 $369.00 10
Title Inherited IL-12p40 deficiency: genetic, immunologic, and clinical features of 49 patients from 30 kindreds .
Author Prando,C., Samarina,A., Bustamante,J., Boisson-Dupuis,S., Cobat,A., Picard,C., AlSum,Z., Al-Jumaah,S., Al-Hajjar,S., Frayha,H., Al-Mousa,H., Ben-Mustapha,I., Adimi,P., Feinberg,J., de Suremain,M., Janniere,L., Filipe-Santos,O., Mansouri,N., Stephan,J.L., Nallusamy,R., Kumararatne,D.S., Bloorsaz,M.R., Ben-Ali,M., Elloumi-Zghal,H., Chemli,J., Bouguila,J., Bejaoui,M., Alaki,E., AlFawaz,T.S., Al Idrissi,E., ElGhazali,G., Pollard,A.J., Murugasu,B., Wah Lee,B., Halwani,R., Al-Zahrani,M., Al Shehri,M.A., Al-Zahrani,M., Bin-Hussain,I., Mahdaviani,S.A., Parvaneh,N., Abel,L., Mansouri,D., Barbouche,R., Al-Muhsen,S. and Casanova,J.L.
Journal Medicine (Baltimore) 92 (2), 109-122 (2013)
Title Exploring ankylosing spondylitis-associated ERAP1, IL23R and IL12B gene polymorphisms in subphenotypes of psoriatic arthritis .
Author Jadon,D., Tillett,W., Wallis,D., Cavill,C., Bowes,J., Waldron,N., Dixon,A., Sengupta,R., Barton,A., Korendowych,E. and McHugh,N.J.
Journal Rheumatology (Oxford) 52 (2), 261-266 (2013)
Title Polymorphisms in the IL-18 and IL-12B genes and their association with the clinical outcome in Croatian patients with Type 1 diabetes .
Author Hadzija,M.P., Korolija,M., Jemin,N., Pavkovic,I., Pavkovic,P., Medvidovic,E.P. and Hadzija,M.
Journal Gene 512 (2), 477-481 (2013)
Title Role of IL-12p40 in cervical carcinoma .
Author Zijlmans,H.J., Punt,S., Fleuren,G.J., Trimbos,J.B., Kenter,G.G. and Gorter,A.
Journal Br. J. Cancer 107 (12), 1956-1962 (2012)
Title Identification of IL18RAP/IL18R1 and IL12B as leprosy risk genes demonstrates shared pathogenesis between inflammation and infectious diseases .
Author Liu,H., Irwanto,A., Tian,H., Fu,X., Yu,Y., Yu,G., Low,H., Chu,T., Li,Y., Shi,B., Chen,M., Sun,Y., Yuan,C., Lu,N., You,J., Bao,F., Li,J., Liu,J., Liu,H., Liu,D., Yu,X., Zhang,L., Yang,Q., Wang,N., Niu,G., Ma,S., Zhou,Y., Wang,C., Chen,S., Zhang,X., Liu,J. and Zhang,F.
Journal Am. J. Hum. Genet. 91 (5), 935-941 (2012)
Title Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5 .
Author Sieburth,D., Jabs,E.W., Warrington,J.A., Li,X., Lasota,J., LaForgia,S., Kelleher,K., Huebner,K., Wasmuth,J.J. and Wolf,S.F.
Journal Genomics 14 (1), 59-62 (1992)
Title Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor .
Author Gearing,D.P. and Cosman,D.
Journal Cell 66 (1), 9-10 (1991)
Title Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor .
Author Gubler,U., Chua,A.O., Schoenhaut,D.S., Dwyer,C.M., McComas,W., Motyka,R., Nabavi,N., Wolitzky,A.G., Quinn,P.M., Familletti,P.C. et al.
Journal Proc. Natl. Acad. Sci. U.S.A. 88 (10), 4143-4147 (1991)
Title Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells .
Author Wolf,S.F., Temple,P.A., Kobayashi,M., Young,D., Dicig,M., Lowe,L., Dzialo,R., Fitz,L., Ferenz,C., Hewick,R.M. et al.
Journal J. Immunol. 146 (9), 3074-3081 (1991)
Title Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells .
Author Stern,A.S., Podlaski,F.J., Hulmes,J.D., Pan,Y.C., Quinn,P.M., Wolitzky,A.G., Familletti,P.C., Stremlo,D.L., Truitt,T., Chizzonite,R. et al.
Journal Proc. Natl. Acad. Sci. U.S.A. 87 (17), 6808-6812 (1990)

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