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Sequence in raw or FASTA format:


Blast Method:


Homo sapiens keratin 81 (KRT81), mRNA.

Clone ID Definition Vector Stock Status Price *Turnaround time Select
OHu24118D Homo sapiens keratin 81 (KRT81), mRNA. pcDNA3.1-C-(k)DYK On-demand Starting from $99 7-9
OHu24118C Homo sapiens keratin 81 (KRT81), mRNA. Your vector of choice On-demand Starting from $99 7-9
OHu24118M Mutant Clone for Homo sapiens keratin 81 (KRT81), mRNA. pcDNA3.1-C-(k)DYK On-demand Starting from $149 Additional 5 days
OHu24118CM Mutant Clone for Homo sapiens keratin 81 (KRT81), mRNA. Your vector of choice On-demand Starting from $149 Additional 5 days

*Business Day

Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_002281.3, 169790852
Length 1518 bp
Structure linear
Update Date 11-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens keratin 81 (KRT81), mRNA.
Product keratin, type II cuticular Hb1

Summary: The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008].

Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the bull length of the gene. The extent of this transcript is supported by transcript alignments.

RefSeq NP_002272.2
CDS 51..1568
Misc Feature(1)51..368
Misc Feature(2)51..368
Misc Feature(3)363..1298
Misc Feature(4)369..1289
Misc Feature(5)369..473
Misc Feature(6)474..503
Misc Feature(7)504..806
Misc Feature(8)723..1070
Misc Feature(9)807..857
Misc Feature(10)858..1289
Misc Feature(11)1074..>1328
Misc Feature(12)1290..1565
Exon (1)1..419
Gene Synonym:ghHkb1; Hb-1; HB1; hHAKB2-1; KRTHB1; MLN137
Exon (2)420..628
Gene Synonym:ghHkb1; Hb-1; HB1; hHAKB2-1; KRTHB1; MLN137
Exon (3)629..689
Gene Synonym:ghHkb1; Hb-1; HB1; hHAKB2-1; KRTHB1; MLN137
Exon (4)690..785
Gene Synonym:ghHkb1; Hb-1; HB1; hHAKB2-1; KRTHB1; MLN137
Exon (5)786..950
Gene Synonym:ghHkb1; Hb-1; HB1; hHAKB2-1; KRTHB1; MLN137
Exon (6)951..1076
Gene Synonym:ghHkb1; Hb-1; HB1; hHAKB2-1; KRTHB1; MLN137
Exon (7)1077..1297
Gene Synonym:ghHkb1; Hb-1; HB1; hHAKB2-1; KRTHB1; MLN137
Exon (8)1298..1329
Gene Synonym:ghHkb1; Hb-1; HB1; hHAKB2-1; KRTHB1; MLN137
Exon (9)1330..1910
Gene Synonym:ghHkb1; Hb-1; HB1; hHAKB2-1; KRTHB1; MLN137
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Position Chain Variation Link
complement(4)-g, cdbSNP:200940564
complement(10)-g, adbSNP:189745410
complement(38)-t, cdbSNP:148003777
complement(42)-t, gdbSNP:368423298
complement(51)-t, gdbSNP:202023317
complement(72)-t, g, cdbSNP:183915325
complement(87)-t, gdbSNP:79897879
complement(98)-g, cdbSNP:149101320
complement(110)-g, cdbSNP:75660643
complement(112)-t, cdbSNP:202205489
complement(137)-g, adbSNP:202176338
complement(160)-t, cdbSNP:202217596
complement(187)-g, cdbSNP:201215176
complement(204)-g, cdbSNP:2071588
complement(466)-t, gdbSNP:201846944
complement(690)-t, cdbSNP:145083574
complement(691)-t, adbSNP:149969945
complement(701)-g, adbSNP:140435760
complement(711)-g, cdbSNP:111866984
complement(712)-t, cdbSNP:147886632
complement(716)-t, cdbSNP:141008448
complement(726)-g, cdbSNP:140836779
complement(735)-t, cdbSNP:375883206
complement(755)-t, cdbSNP:147285901
complement(771)-g, adbSNP:145562431
complement(772)-t, cdbSNP:148570041
complement(785)-t, cdbSNP:375635026
complement(793)-c, adbSNP:6580873
complement(795)-t, cdbSNP:201895192
complement(803)-t, cdbSNP:149438181
complement(810)-t, cdbSNP:137888857
complement(823)-t, gdbSNP:373083957
complement(862)-c, adbSNP:144356330
complement(869)-g, adbSNP:146187254
complement(877)-t, gdbSNP:141587304
complement(896)-t, adbSNP:138597671
complement(901)-t, cdbSNP:369316032
complement(912)-g, adbSNP:144716678
complement(918)-g, adbSNP:374156610
complement(923)-g, cdbSNP:200239075
complement(924)-t, cdbSNP:200578000
complement(930)-t, cdbSNP:140829050
complement(943)-t, cdbSNP:375846478
complement(952)-t, cdbSNP:113592710
complement(967)-g, adbSNP:371943135
complement(971)-t, cdbSNP:138689166
complement(973)-g, adbSNP:202148780
complement(974)-c, adbSNP:148041985
complement(983)-g, adbSNP:143596068
complement(996)-g, adbSNP:4761786
complement(997)-t, cdbSNP:367880650
complement(1000)-t, cdbSNP:201504587
1019+c, tdbSNP:3187034
complement(1030)-t, cdbSNP:147870020
complement(1037)-g, adbSNP:371197615
complement(1040)-t, cdbSNP:7300801
complement(1048)-g, adbSNP:34187924
complement(1048)-g, adbSNP:75304109
complement(1095)-t, cdbSNP:201454353
complement(1097)-t, cdbSNP:147690541
complement(1103)-g, adbSNP:4761784
complement(1127)-t, cdbSNP:4761856
complement(1136)-g, adbSNP:372908259
complement(1143)-g, adbSNP:377419026
complement(1157)-g, adbSNP:150886963
complement(1168)-g, cdbSNP:142439125
complement(1219)-t, cdbSNP:372998713
complement(1259)-g, adbSNP:141521550
complement(1273)-t, cdbSNP:201447608
complement(1277)-g, cdbSNP:111382015
1287+a, gdbSNP:57419521
complement(1362)-t, cdbSNP:374136296
complement(1373)-g, adbSNP:371671670
complement(1374)-t, cdbSNP:371683842
complement(1380)-t, cdbSNP:367868606
complement(1387)-t, cdbSNP:139838048
complement(1413)-c, adbSNP:145963392
complement(1414)-g, adbSNP:201991772
complement(1417)-g, adbSNP:114447073
complement(1430..1431)-, gdbSNP:144562891
complement(1435)-g, adbSNP:74095618
complement(1445)-g, adbSNP:138017582
complement(1463)-g, adbSNP:373705395
complement(1485)-t, cdbSNP:150356449
complement(1499)-g, adbSNP:370312171
complement(1503)-t, cdbSNP:115355093
complement(1529)-c, adbSNP:377741143
complement(1544)-g, adbSNP:200814913
complement(1557)-g, adbSNP:376061576
complement(1558)-t, cdbSNP:138935547
complement(1575)-, gdbSNP:201146279
1599+a, c, g, tdbSNP:3657
complement(1602)-g, adbSNP:377645057
1670+c, gdbSNP:3660
complement(1704)-t, gdbSNP:192117741
complement(1808)-t, gdbSNP:371934116
Gene SymbolKRT81
Gene SynonymghHkb1; Hb-1; HB1; hHAKB2-1; KRTHB1; MLN137
Locus Map12q13
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_002281 Homo sapiens keratin 81 (KRT81), mRNA. On-demand Starting from $99 7-9
Title A miR-SNP of the KRT81 gene is associated with the prognosis of non-Hodgkin's lymphoma .
Author Xie Y, Diao L, Zhang L, Liu C, Xu Z and Liu S.
Journal Gene 539 (2), 198-202 (2014)
Title Impact of MiRSNPs on survival and progression in patients with multiple myeloma undergoing autologous stem cell transplantation .
Author de Larrea CF, Navarro A, Tejero R, Tovar N, Diaz T, Cibeira MT, Rosinol L, Ferrer G, Rovira M, Rozman M, Monzo M and Blade J.
Journal Clin. Cancer Res. 18 (13), 3697-3704 (2012)
Title A dual role for KRT81: a miR-SNP associated with recurrence in non-small-cell lung cancer and a novel marker of squamous cell lung carcinoma .
Author Campayo M, Navarro A, Vinolas N, Tejero R, Munoz C, Diaz T, Marrades R, Cabanas ML, Gimferrer JM, Gascon P, Ramirez J and Monzo M.
Journal PLoS ONE 6 (7), E22509 (2011)
Title Transcriptional activation of a subset of hair keratin genes by the NF-kappaB effector p65/RelA .
Author Gilon M, Sher N, Cohen S and Gat U.
Journal Differentiation 76 (5), 518-530 (2008)
Title New consensus nomenclature for mammalian keratins .
Author Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA and Wright MW.
Journal J. Cell Biol. 174 (2), 169-174 (2006)
Title A variable monilethrix phenotype associated with a novel mutation, Glu402Lys, in the helix termination motif of the type II hair keratin hHb1 .
Author Winter H, Labreze C, Chapalain V, Surleve-Bazeille JE, Mercier M, Rogers MA, Taieb A and Schweizer J.
Journal J. Invest. Dermatol. 111 (1), 169-172 (1998)
Title Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle .
Author Bowden PE, Hainey SD, Parker G, Jones DO, Zimonjic D, Popescu N and Hodgins MB.
Journal J. Invest. Dermatol. 110 (2), 158-164 (1998)
Title A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix .
Author Winter H, Rogers MA, Gebhardt M, Wollina U, Boxall L, Chitayat D, Babul-Hirji R, Stevens HP, Zlotogorski A and Schweizer J.
Journal Hum. Genet. 101 (2), 165-169 (1997)
Title Sequence data and chromosomal localization of human type I and type .
Author Rogers MA, Nischt R, Korge B, Krieg T, Fink TM, Lichter P, Winter H and Schweizer J.
Journal Exp. Cell Res. 220 (2), 357-362 (1995)
Title Sequence and expression of human hair keratin genes .
Author Bowden PE, Hainey S, Parker G and Hodgins MB.
Journal J. Dermatol. Sci. 7 (SUPPL), S152-S163 (1994)

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