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Homo sapiens matrix metallopeptidase 10 (stromelysin 2) (MMP10), mRNA.


Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu23759 Homo sapiens matrix metallopeptidase 10 (stromelysin 2) (MMP10), mRNA. pcDNA3.1+-DYK On-demand $219.00 7-9
OHu23759C Homo sapiens matrix metallopeptidase 10 (stromelysin 2) (MMP10), mRNA. Customized vector On-demand $269.00 7-9

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Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Data sheet
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
Restriction Sites Hind III- EcoR I
RefSeq Version NM_002425.2, 296080749
Length 1431 bp
Structure linear
Update Date 11-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens matrix metallopeptidase 10 (stromelysin 2) (MMP10), mRNA.
Product stromelysin-2 preproprotein
Comment

Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008].

RefSeq NP_002416.1
CDS 38..1468
Misc Feature(1)11..13
Misc Feature(2)11..13
Misc Feature(3)134..295
Misc Feature(4)302..325
Misc Feature(5)356..826
Misc Feature(6)356..826
Misc Feature(7)order(512..514,548..550,569..589,614..616,686..691,
Misc Feature(8)order(686..691,698..700,716..718)
Misc Feature(9)893..1465
Misc Feature(10)893..1042
Misc Feature(11)order(923..925,929..931,1055..1057,1061..1063,1199..1201,
Misc Feature(12)1043..1183
Misc Feature(13)1187..1333
Misc Feature(14)1334..1465
Exon (1)1..142
Gene:MMP10
Gene Synonym:SL-2; STMY2
Exon (2)143..384
Gene:MMP10
Gene Synonym:SL-2; STMY2
Exon (3)385..533
Gene:MMP10
Gene Synonym:SL-2; STMY2
Exon (4)534..659
Gene:MMP10
Gene Synonym:SL-2; STMY2
Exon (5)660..824
Gene:MMP10
Gene Synonym:SL-2; STMY2
Exon (6)825..969
Gene:MMP10
Gene Synonym:SL-2; STMY2
Exon (7)970..1103
Gene:MMP10
Gene Synonym:SL-2; STMY2
Exon (8)1104..1263
Gene:MMP10
Gene Synonym:SL-2; STMY2
Exon (9)1264..1367
Gene:MMP10
Gene Synonym:SL-2; STMY2
Exon (10)1368..1759
Gene:MMP10
Gene Synonym:SL-2; STMY2
Translation MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSL AHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYN SFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFW AIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQG FPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
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Position Chain Variation Link
47+c, gdbSNP:17435959
complement(60)-c, adbSNP:12807719
complement(79)-g, cdbSNP:201701748
complement(93)-g, cdbSNP:376598135
complement(115)-t, cdbSNP:371965135
complement(121)-t, gdbSNP:368118730
complement(126)-t, cdbSNP:375202970
complement(145)-dbSNP:
complement(145)-t, gdbSNP:375362001
complement(149)-g, adbSNP:200258046
complement(162)-t, cdbSNP:146174390
complement(190)-c, adbSNP:201260782
complement(195)-t, cdbSNP:486055
complement(217)-g, adbSNP:377224881
complement(230)-t, cdbSNP:17293607
complement(249)-t, cdbSNP:370170526
complement(253)-t, cdbSNP:142309975
complement(257)-t, cdbSNP:201191140
complement(283)-t, adbSNP:147825425
complement(310)-g, adbSNP:375572358
complement(320)-t, cdbSNP:144369862
complement(322)-g, adbSNP:140654514
complement(324)-g, adbSNP:369076335
complement(330)-t, adbSNP:200687439
complement(331)-g, cdbSNP:150588971
complement(351)-t, adbSNP:147639719
complement(354)-g, adbSNP:181247657
complement(355)-t, cdbSNP:190380615
373+c, tdbSNP:17860949
complement(417)-dbSNP:
complement(417)-t, cdbSNP:202049265
complement(421)-g, adbSNP:368271223
complement(422)-c, adbSNP:201319536
complement(435)-g, adbSNP:144660356
complement(437)-t, cdbSNP:142065601
complement(461)-c, adbSNP:374020139
complement(475)-g, adbSNP:375646898
complement(478)-t, adbSNP:138841233
complement(485)-t, adbSNP:369815189
complement(492)-t, cdbSNP:377610675
complement(513)-g, adbSNP:199975457
complement(518)-c, adbSNP:374140620
complement(523)-t, cdbSNP:17860950
complement(537)-dbSNP:
complement(537)-t, cdbSNP:138352595
complement(546)-g, adbSNP:372152001
complement(558)-t, cdbSNP:368619679
complement(577)-t, cdbSNP:374394583
complement(599)-g, cdbSNP:200519348
complement(600)-g, cdbSNP:200232227
complement(615)-t, cdbSNP:371872352
complement(634)-g, adbSNP:368114567
complement(635)-c, adbSNP:202054159
complement(645)-g, cdbSNP:150476362
complement(701)-dbSNP:
complement(701)-g, adbSNP:377625989
complement(709)-g, cdbSNP:201828295
complement(715)-t, gdbSNP:17860971
complement(725)-t, cdbSNP:199916865
complement(771)-g, adbSNP:147985027
complement(772)-g, adbSNP:143430465
complement(790)-t, cdbSNP:141241387
complement(799)-t, adbSNP:369185884
complement(810)-c, adbSNP:183383744
complement(822)-t, cdbSNP:147796026
complement(823)-g, adbSNP:374155678
complement(824)-t, cdbSNP:376370910
complement(837)-dbSNP:
complement(837)-t, gdbSNP:144464068
complement(843)-t, gdbSNP:371569952
complement(859)-t, cdbSNP:142147520
complement(880)-t, cdbSNP:145128689
complement(882)-g, adbSNP:17860973
complement(890)-t, adbSNP:368001846
complement(922)-g, adbSNP:370246000
complement(923)-t, cdbSNP:139185475
complement(925)-g, adbSNP:201257125
complement(929)-t, cdbSNP:377721971
complement(980)-dbSNP:
complement(980)-g, adbSNP:150825082
complement(981)-t, cdbSNP:143542625
complement(984)-g, cdbSNP:61751515
complement(985)-t, cdbSNP:146089838
complement(996)-t, cdbSNP:142985644
complement(1024)-g, adbSNP:369297931
1063+a, gdbSNP:41319748
complement(1084)-g, adbSNP:148135915
complement(1087)-g, adbSNP:199784762
complement(1089)-g, adbSNP:201248623
complement(1107)-dbSNP:
complement(1107)-t, cdbSNP:370615545
complement(1123)-t, gdbSNP:17359286
complement(1123)-t, gdbSNP:386543476
complement(1167)-g, adbSNP:149436433
complement(1179)-t, gdbSNP:377147064
complement(1184)-t, cdbSNP:372673583
complement(1205)-c, adbSNP:139168339
complement(1214)-g, cdbSNP:368858787
complement(1237)-t, gdbSNP:147267769
complement(1243)-c, adbSNP:143648713
complement(1247)-c, adbSNP:375465947
complement(1248)-g, adbSNP:138753435
complement(1288)-dbSNP:
complement(1288)-c, adbSNP:368166063
complement(1329)-t, cdbSNP:140778053
complement(1354)-t, cdbSNP:376050277
complement(1357)-t, adbSNP:17860996
complement(1385)-dbSNP:
complement(1385)-t, cdbSNP:199912063
complement(1400)-c, adbSNP:113672399
complement(1453)-g, adbSNP:374308064
complement(1456)-t, cdbSNP:150990119
complement(1461)-t, adbSNP:17861009
complement(1464)-t, cdbSNP:374367122
complement(1465)-g, adbSNP:371073877
complement(1494)-t, cdbSNP:376568655
complement(1539)-t, cdbSNP:140680964
complement(1540)-g, cdbSNP:470171
complement(1573)-t, cdbSNP:17293348
complement(1603)-g, cdbSNP:181142824
complement(1610)-g, adbSNP:470168
complement(1619)-g, adbSNP:189050260
complement(1627)-t, cdbSNP:147279060
complement(1650)-g, adbSNP:113974479
Gene SymbolMMP10
Gene SynonymSL-2; STMY2
Chromosome11
Locus Map11q22.3
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_002425 Homo sapiens matrix metallopeptidase 10 (stromelysin 2) (MMP10), mRNA. On-demand $219.00 7-9
Title [Association between matrix metalloproteinase-10 gene polymorphisms and instability of carotid plaque] .
Author Zhu F, Jin XP, Huang MW, Zhu M, Chen QL, Wang F, Hu XF, Wang WF, Li WL, Li C, Zhu ZY and Zheng Z.
Journal Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30 (6), 711-715 (2013)
Title Enhanced wound healing, kinase and stem cell marker expression in diabetic organ-cultured human corneas upon MMP-10 and cathepsin F gene silencing .
Author Saghizadeh M, Epifantseva I, Hemmati DM, Ghiam CA, Brunken WJ and Ljubimov AV.
Journal Invest. Ophthalmol. Vis. Sci. 54 (13), 8172-8180 (2013)
Title Marked induction of matrix metalloproteinase-10 by respiratory syncytial virus infection in human nasal epithelial cells .
Author Hirakawa S, Kojima T, Obata K, Okabayashi T, Yokota S, Nomura K, Obonai T, Fuchimoto J, Himi T, Tsutsumi H and Sawada N.
Journal J. Med. Virol. 85 (12), 2141-2150 (2013)
Title proMetalloproteinase-10 is associated with brain damage and clinical outcome in acute ischemic stroke .
Author Rodriguez JA, Sobrino T, Orbe J, Purroy A, Martinez-Vila E, Castillo J and Paramo JA.
Journal J. Thromb. Haemost. 11 (8), 1464-1473 (2013)
Title Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array .
Author Eeles RA, Olama AA, Benlloch S, Saunders EJ, Leongamornlert DA, Tymrakiewicz M, Ghoussaini M, Luccarini C, Dennis J, Jugurnauth-Little S, Dadaev T, Neal DE, Hamdy FC, Donovan JL, Muir K, Giles GG, Severi G, Wiklund F, Gronberg H, Haiman CA, Schumacher F, Henderson BE, Le Marchand L, Lindstrom S, Kraft P, Hunter DJ, Gapstur S, Chanock SJ, Berndt SI, Albanes D, Andriole G, Schleutker J, Weischer M, Canzian F, Riboli E, Key TJ, Travis RC, Campa D, Ingles SA, John EM, Hayes RB, Pharoah PD, Pashayan N, Khaw KT, Stanford JL, Ostrander EA, Signorello LB, Thibodeau SN, Schaid D, Maier C, Vogel W, Kibel AS, Cybulski C, Lubinski J, Cannon-Albright L, Brenner H, Park JY, Kaneva R, Batra J, Spurdle AB, Clements JA, Teixeira MR, Dicks E, Lee A, Dunning AM, Baynes C, Conroy D, Maranian MJ, Ahmed S, Govindasami K, Guy M, Wilkinson RA, Sawyer EJ, Morgan A, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As NJ, Woodhouse CJ, Thompson A, Dudderidge T, Ogden C, Cooper CS, Lophatananon A, Cox A, Southey MC, Hopper JL, English DR, Aly M, Adolfsson J, Xu J, Zheng SL, Yeager M, Kaaks R, Diver WR, Gaudet MM, Stern MC, Corral R, Joshi AD, Shahabi A, Wahlfors T, Tammela TL, Auvinen A, Virtamo J, Klarskov P, Nordestgaard BG, Roder MA, Nielsen SF, Bojesen SE, Siddiq A, Fitzgerald LM, Kolb S, Kwon EM, Karyadi DM, Blot WJ, Zheng W, Cai Q, McDonnell SK, Rinckleb AE, Drake B, Colditz G, Wokolorczyk D, Stephenson RA, Teerlink C, Muller H, Rothenbacher D, Sellers TA, Lin HY, Slavov C, Mitev V, Lose F, Srinivasan S, Maia S, Paulo P, Lange E, Cooney KA, Antoniou AC, Vincent D, Bacot F, Tessier DC, Kote-Jarai Z and Easton DF.
Journal Nat. Genet. 45 (4), 385-391 (2013)
Title Expression pattern of matrix metalloproteinases in human liver .
Author Lichtinghagen R, Helmbrecht T, Arndt B and Boker KH.
Journal Eur J Clin Chem Clin Biochem 33 (2), 65-71 (1995)
Title Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins .
Author Fosang AJ, Neame PJ, Hardingham TE, Murphy G and Hamilton JA.
Journal J. Biol. Chem. 266 (24), 15579-15582 (1991)
Title Localization of stromelysin 2 gene to the q22.3-23 region of chromosome 11 by in situ hybridization .
Author Jung JY, Warter S and Rumpler Y.
Journal Ann. Genet. 33 (1), 21-23 (1990)
Title Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts .
Author Sirum KL and Brinckerhoff CE.
Journal Biochemistry 28 (22), 8691-8698 (1989)
Title The collagenase gene family in humans consists of at least four members .
Author Muller D, Quantin B, Gesnel MC, Millon-Collard R, Abecassis J and Breathnach R.
Journal Biochem. J. 253 (1), 187-192 (1988)

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