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Homo sapiens matrix metallopeptidase 10 (stromelysin 2) (MMP10), mRNA.


RefSeq Accession Definition Sequence Price Select
NM_002425 Homo sapiens matrix metallopeptidase 10 (stromelysin 2) (MMP10), mRNA. Full Lenth $515.33
ORF Sequence $414.99


RefSeq Version NM_002425.2, 296080749
Length 1777 bp
Structure linear
Update Date 09-APR-2011
Organism Homo sapiens (human)
Definition Homo sapiens matrix metallopeptidase 10 (stromelysin 2) (MMP10), mRNA.
Product stromelysin-2 preproprotein
Comment

Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq].

RefSeq NP_002416.1
CDS 38..1468
Exon (1)1..142
Exon (2)1..142
Exon (3)143..384
Exon (4)385..533
Exon (5)534..659
Exon (6)660..824
Exon (7)825..969
Exon (8)970..1103
Exon (9)1104..1263
Exon (10)1264..1367
Exon (11)1368..1759
Translation MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSL AHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYN SFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFW AIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQG FPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
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Position Chain Variation Link
47+c, gdbSNP:17435959
complement(60)-c, adbSNP:12807719
complement(195)-t, cdbSNP:486055
complement(230)-t, cdbSNP:17293607
373+c, tdbSNP:17860949
523+c, tdbSNP:17860950
715+g, tdbSNP:17860971
complement(829)-g, adbSNP:75807421
882+a, gdbSNP:17860973
complement(984)-g, cdbSNP:61751515
1063+a, gdbSNP:41319748
complement(1123)-t, gdbSNP:17359286
1357+a, tdbSNP:17860996
complement(1400)-c, adbSNP:113672399
1461+a, tdbSNP:17861009
complement(1540)-g, cdbSNP:470171
complement(1573)-t, cdbSNP:17293348
complement(1610)-g, adbSNP:470168
complement(1650)-g, adbSNP:113974479
Gene SymbolMMP10
Gene SynonymSL-2; STMY2
Chromosome11
Locus Map11q22.3
All Transcripts NM_002425
Title Immunohistochemical and transcriptional expression of matrix metalloproteinases in full-term human umbilical cord and human umbilical vein endothelial cells .
Author Mauro,A., Buscemi,M. and Gerbino,A.
Journal J. Mol. Histol. 41 (6), 367-377 (2010)
Title A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM) .
Author Romero,R., Friel,L.A., Velez Edwards,D.R., Kusanovic,J.P., Hassan,S.S., Mazaki-Tovi,S., Vaisbuch,E., Kim,C.J., Erez,O., Chaiworapongsa,T., Pearce,B.D., Bartlett,J., Salisbury,B.A., Anant,M.K., Vovis,G.F., Lee,M.S., Gomez,R., Behnke,E., Oyarzun,E., Tromp,G., Williams,S.M. and Menon,R.
Journal Am. J. Obstet. Gynecol. 203 (4), 361 (2010)
Title Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study .
Author Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V., Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
Journal Diabetes Care 33 (10), 2250-2253 (2010)
Title Nitric oxide-mediated invasion in Barrett's high-grade dysplasia and adenocarcinoma .
Author Clemons,N.J., Shannon,N.B., Abeyratne,L.R., Walker,C.E., Saadi,A., O'Donovan,M.L., Lao-Sirieix,P.P. and Fitzgerald,R.C.
Journal Carcinogenesis 31 (9), 1669-1675 (2010)
Title Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection .
Author Nalpas,B., Lavialle-Meziani,R., Plancoulaine,S., Jouanguy,E., Nalpas,A., Munteanu,M., Charlotte,F., Ranque,B., Patin,E., Heath,S., Fontaine,H., Vallet-Pichard,A., Pontoire,D., Bourliere,M., Casanova,J.L., Lathrop,M., Brechot,C., Poynard,T., Matsuda,F., Pol,S. and Abel,L.
Journal Gut 59 (8), 1120-1126 (2010)
Title Expression pattern of matrix metalloproteinases in human liver .
Author Lichtinghagen,R., Helmbrecht,T., Arndt,B. and Boker,K.H.
Journal Eur J Clin Chem Clin Biochem 33 (2), 65-71 (1995)
Title Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins .
Author Fosang,A.J., Neame,P.J., Hardingham,T.E., Murphy,G. and Hamilton,J.A.
Journal J. Biol. Chem. 266 (24), 15579-15582 (1991)
Title Localization of stromelysin 2 gene to the q22.3-23 region of chromosome 11 by in situ hybridization .
Author Jung,J.Y., Warter,S. and Rumpler,Y.
Journal Ann. Genet. 33 (1), 21-23 (1990)
Title Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts .
Author Sirum,K.L. and Brinckerhoff,C.E.
Journal Biochemistry 28 (22), 8691-8698 (1989)
Title The collagenase gene family in humans consists of at least four members .
Author Muller,D., Quantin,B., Gesnel,M.C., Millon-Collard,R., Abecassis,J. and Breathnach,R.
Journal Biochem. J. 253 (1), 187-192 (1988)

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