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Homo sapiens matrix metallopeptidase 10 (stromelysin 2) (MMP10), mRNA.


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002425 Homo sapiens matrix metallopeptidase 10 (stromelysin 2) (MMP10), mRNA. GenEZ ORF Cloning On-demand $699.00 18

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RefSeq Version NM_002425.2, 296080749
Length 1777 bp
Structure linear
Update Date 17-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens matrix metallopeptidase 10 (stromelysin 2) (MMP10), mRNA.
Product stromelysin-2 preproprotein
Comment

Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008].

RefSeq NP_002416.1
CDS 38..1468
Misc Feature(1)11..13
Misc Feature(2)11..13
Misc Feature(3)134..295
Misc Feature(4)302..325
Misc Feature(5)356..826
Misc Feature(6)order(512..514,548..550,569..589,614..616,686..691,
Misc Feature(7)order(686..691,698..700,716..718)
Misc Feature(8)893..1465
Misc Feature(9)order(923..925,929..931,1055..1057,1061..1063,1199..1201,
Exon (1)1..142
Gene:MMP10
Gene Synonym:SL-2; STMY2
Exon (2)143..384
Gene:MMP10
Gene Synonym:SL-2; STMY2
Exon (3)385..533
Gene:MMP10
Gene Synonym:SL-2; STMY2
Exon (4)534..659
Gene:MMP10
Gene Synonym:SL-2; STMY2
Exon (5)660..824
Gene:MMP10
Gene Synonym:SL-2; STMY2
Exon (6)825..969
Gene:MMP10
Gene Synonym:SL-2; STMY2
Exon (7)970..1103
Gene:MMP10
Gene Synonym:SL-2; STMY2
Exon (8)1104..1263
Gene:MMP10
Gene Synonym:SL-2; STMY2
Exon (9)1264..1367
Gene:MMP10
Gene Synonym:SL-2; STMY2
Exon (10)1368..1759
Gene:MMP10
Gene Synonym:SL-2; STMY2
Translation MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIV KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSL AHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYN SFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFW AIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQG FPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
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Position Chain Variation Link
complement(36)-c, adbSNP:149031570
complement(47)-g, cdbSNP:17435959
complement(60)-c, adbSNP:12807719
complement(79)-g, cdbSNP:201701748
complement(149)-dbSNP:
complement(149)-g, adbSNP:200258046
complement(162)-t, cdbSNP:146174390
complement(190)-c, adbSNP:201260782
complement(195)-t, cdbSNP:486055
complement(230)-t, cdbSNP:17293607
complement(253)-t, cdbSNP:142309975
complement(257)-t, cdbSNP:201191140
complement(283)-t, adbSNP:147825425
complement(320)-t, cdbSNP:144369862
complement(322)-g, adbSNP:140654514
complement(330)-t, adbSNP:200687439
complement(331)-g, cdbSNP:150588971
complement(351)-t, adbSNP:147639719
complement(354)-g, adbSNP:181247657
complement(355)-t, cdbSNP:190380615
complement(373)-t, cdbSNP:17860949
complement(417)-dbSNP:
complement(417)-t, cdbSNP:202049265
complement(422)-c, adbSNP:201319536
complement(435)-g, adbSNP:144660356
complement(437)-t, cdbSNP:142065601
complement(478)-t, adbSNP:138841233
complement(513)-g, adbSNP:199975457
complement(523)-t, cdbSNP:17860950
complement(537)-dbSNP:
complement(537)-t, cdbSNP:138352595
complement(599)-g, cdbSNP:200519348
complement(600)-g, cdbSNP:200232227
complement(635)-c, adbSNP:202054159
complement(645)-g, cdbSNP:150476362
complement(709)-dbSNP:
complement(709)-g, cdbSNP:201828295
complement(715)-t, gdbSNP:17860971
complement(725)-t, cdbSNP:199916865
complement(771)-g, adbSNP:147985027
complement(772)-g, adbSNP:143430465
complement(790)-t, cdbSNP:141241387
complement(810)-c, adbSNP:183383744
complement(822)-t, cdbSNP:147796026
complement(837)-dbSNP:
complement(837)-t, gdbSNP:144464068
complement(859)-t, cdbSNP:142147520
complement(880)-t, cdbSNP:145128689
complement(882)-g, adbSNP:17860973
complement(923)-t, cdbSNP:139185475
complement(925)-g, adbSNP:201257125
complement(980)-dbSNP:
complement(980)-g, adbSNP:150825082
complement(981)-t, cdbSNP:143542625
complement(984)-g, cdbSNP:61751515
complement(985)-t, cdbSNP:146089838
complement(996)-t, cdbSNP:142985644
complement(1063)-g, adbSNP:41319748
complement(1084)-g, adbSNP:148135915
complement(1087)-g, adbSNP:199784762
complement(1089)-g, adbSNP:201248623
complement(1123)-dbSNP:
complement(1123)-t, gdbSNP:17359286
complement(1167)-g, adbSNP:149436433
complement(1205)-c, adbSNP:139168339
complement(1237)-t, gdbSNP:147267769
complement(1243)-c, adbSNP:143648713
complement(1248)-g, adbSNP:138753435
complement(1329)-dbSNP:
complement(1329)-t, cdbSNP:140778053
complement(1357)-t, adbSNP:17860996
complement(1385)-dbSNP:
complement(1385)-t, cdbSNP:199912063
complement(1400)-c, adbSNP:113672399
complement(1456)-t, cdbSNP:150990119
complement(1461)-t, adbSNP:17861009
complement(1539)-t, cdbSNP:140680964
complement(1540)-g, cdbSNP:470171
complement(1573)-t, cdbSNP:17293348
complement(1603)-g, cdbSNP:181142824
complement(1610)-g, adbSNP:470168
complement(1619)-g, adbSNP:189050260
complement(1627)-t, cdbSNP:147279060
complement(1650)-g, adbSNP:113974479
Gene SymbolMMP10
Gene SynonymSL-2; STMY2
Chromosome11
Locus Map11q22.3
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_002425 Homo sapiens matrix metallopeptidase 10 (stromelysin 2) (MMP10), mRNA. On-demand $699.00 18
Title Matrix metalloproteinases and educational attainment in refractive error: evidence of gene-environment interactions in the Age-Related Eye Disease Study .
Author Wojciechowski,R., Yee,S.S., Simpson,C.L., Bailey-Wilson,J.E. and Stambolian,D.
Journal Ophthalmology 120 (2), 298-305 (2013)
Title C-terminal truncated hepatitis B virus x protein is associated with metastasis and enhances invasiveness by C-Jun/matrix metalloproteinase protein 10 activation in hepatocellular carcinoma .
Author Sze,K.M., Chu,G.K., Lee,J.M. and Ng,I.O.
Journal Hepatology 57 (1), 131-139 (2013)
Title Synergistic effect of thrombin and CD40 ligand on endothelial matrix metalloproteinase-10 expression and microparticle generation in vitro and in vivo .
Author Martinez de Lizarrondo,S., Roncal,C., Calvayrac,O., Rodriguez,C., Varo,N., Purroy,A., Lorente,L., Rodriguez,J.A., Doeuvre,L., Hervas-Stubbs,S., Angles-Cano,E., Paramo,J.A., Martinez-Gonzalez,J. and Orbe,J.
Journal Arterioscler. Thromb. Vasc. Biol. 32 (6), 1477-1487 (2012)
Title Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential .
Author Justilien,V., Regala,R.P., Tseng,I.C., Walsh,M.P., Batra,J., Radisky,E.S., Murray,N.R. and Fields,A.P.
Journal PLoS ONE 7 (4), E35040 (2012)
Title Application of MMP-7 and MMP-10 in assisting the diagnosis of malignant pleural effusion .
Author Cheng,D., Liang,B. and Li,Y.H.
Journal Asian Pac. J. Cancer Prev. 13 (2), 505-509 (2012)
Title Expression pattern of matrix metalloproteinases in human liver .
Author Lichtinghagen,R., Helmbrecht,T., Arndt,B. and Boker,K.H.
Journal Eur J Clin Chem Clin Biochem 33 (2), 65-71 (1995)
Title Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins .
Author Fosang,A.J., Neame,P.J., Hardingham,T.E., Murphy,G. and Hamilton,J.A.
Journal J. Biol. Chem. 266 (24), 15579-15582 (1991)
Title Localization of stromelysin 2 gene to the q22.3-23 region of chromosome 11 by in situ hybridization .
Author Jung,J.Y., Warter,S. and Rumpler,Y.
Journal Ann. Genet. 33 (1), 21-23 (1990)
Title Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts .
Author Sirum,K.L. and Brinckerhoff,C.E.
Journal Biochemistry 28 (22), 8691-8698 (1989)
Title The collagenase gene family in humans consists of at least four members .
Author Muller,D., Quantin,B., Gesnel,M.C., Millon-Collard,R., Abecassis,J. and Breathnach,R.
Journal Biochem. J. 253 (1), 187-192 (1988)


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