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Blast Method:


Homo sapiens protein kinase C, beta (PRKCB), transcript variant 2, mRNA.

Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu18081 Homo sapiens protein kinase C, beta (PRKCB), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock $99.00 5-7
OHu18081C Homo sapiens protein kinase C, beta (PRKCB), transcript variant 2, mRNA. Customized vector In-stock $149.00 5-7

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Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_002738.6, 197100031
Length 2022 bp
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens protein kinase C, beta (PRKCB), transcript variant 2, mRNA.
Product protein kinase C beta type isoform 2

Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).

Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.

RefSeq NP_002729.2
CDS 198..2219
Misc Feature(1)30..32
Misc Feature(2)243..245
Misc Feature(3)243..245
Misc Feature(4)246..248
Misc Feature(5)306..455
Misc Feature(6)order(306..308,345..347,354..356,396..398,405..407,
Misc Feature(7)order(327..329,336..341,366..386)
Misc Feature(8)order(336..338,342..344)
Misc Feature(9)501..650
Misc Feature(10)order(501..503,540..542,549..551,591..593,600..602,
Misc Feature(11)order(522..524,531..536,561..581)
Misc Feature(12)order(531..533,537..539)
Misc Feature(13)672..1064
Misc Feature(14)order(756..758,774..776,933..935,939..941,957..959)
Misc Feature(15)1218..2186
Misc Feature(16)1221..1997
Misc Feature(17)order(1239..1253,1263..1265,1302..1304,1308..1310,
Misc Feature(18)order(1239..1244,1254..1256,1263..1265,1302..1304,
Misc Feature(19)order(1251..1253,1476..1478,1482..1484,1593..1595,
Misc Feature(20)1644..1715
Misc Feature(21)1695..1697
Misc Feature(22)2118..2120
Misc Feature(23)2118..2120
Misc Feature(24)2163..2180
Exon (1)1..370
Gene Synonym:PKC-beta; PKCB; PRKCB1; PRKCB2
Exon (2)371..402
Gene Synonym:PKC-beta; PKCB; PRKCB1; PRKCB2
Exon (3)403..485
Gene Synonym:PKC-beta; PKCB; PRKCB1; PRKCB2
Exon (4)486..597
Gene Synonym:PKC-beta; PKCB; PRKCB1; PRKCB2
Exon (5)598..726
Gene Synonym:PKC-beta; PKCB; PRKCB1; PRKCB2
Exon (6)727..883
Gene Synonym:PKC-beta; PKCB; PRKCB1; PRKCB2
Exon (7)884..1018
Gene Synonym:PKC-beta; PKCB; PRKCB1; PRKCB2
Exon (8)1019..1115
Gene Synonym:PKC-beta; PKCB; PRKCB1; PRKCB2
Exon (9)1116..1262
Gene Synonym:PKC-beta; PKCB; PRKCB1; PRKCB2
Exon (10)1263..1436
Gene Synonym:PKC-beta; PKCB; PRKCB1; PRKCB2
Exon (11)1437..1528
Gene Synonym:PKC-beta; PKCB; PRKCB1; PRKCB2
Exon (12)1529..1591
Gene Synonym:PKC-beta; PKCB; PRKCB1; PRKCB2
Exon (13)1592..1730
Gene Synonym:PKC-beta; PKCB; PRKCB1; PRKCB2
Exon (14)1731..1811
Gene Synonym:PKC-beta; PKCB; PRKCB1; PRKCB2
Exon (15)1812..1919
Gene Synonym:PKC-beta; PKCB; PRKCB1; PRKCB2
Exon (16)1920..2060
Gene Synonym:PKC-beta; PKCB; PRKCB1; PRKCB2
Exon (17)2061..8014
Gene Synonym:PKC-beta; PKCB; PRKCB1; PRKCB2
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Position Chain Variation Link
28+a, gdbSNP:371723231
173+c, tdbSNP:188342168
189+a, gdbSNP:374642745
211+a, cdbSNP:201366670
223+a, cdbSNP:368093414
232+a, tdbSNP:370984906
262+a, gdbSNP:200442462
276+a, cdbSNP:75964872
284+a, gdbSNP:146177740
359+c, tdbSNP:115667450
406+g, tdbSNP:370311602
461+c, tdbSNP:115750906
462+a, gdbSNP:371650623
482+c, tdbSNP:371087215
496+g, tdbSNP:3729895
521+a, gdbSNP:116749372
536+a, gdbSNP:377143661
656+c, gdbSNP:372836893
690+c, gdbSNP:199648786
710+c, tdbSNP:115645964
711+a, gdbSNP:200811816
719+c, tdbSNP:116345778
803+c, tdbSNP:3729896
885+c, gdbSNP:200005518
899+a, gdbSNP:114093019
899+c, tdbSNP:386441537
911+a, gdbSNP:17847891
1046+c, tdbSNP:17847884
1078+a, gdbSNP:199901715
1090+a, gdbSNP:147975795
1103+a, gdbSNP:115598469
1117+c, gdbSNP:141851225
1127+c, tdbSNP:201781724
1142+a, gdbSNP:146104501
1147+c, tdbSNP:202044032
1159+c, tdbSNP:139055681
1172+c, gdbSNP:374744056
1178+a, gdbSNP:114856527
1192+c, gdbSNP:149128755
1217+c, tdbSNP:116346810
1226+c, tdbSNP:56041613
1288+c, gdbSNP:148312044
1301+c, tdbSNP:202161442
1302+a, gdbSNP:141758720
1347+a, gdbSNP:200238437
1365+a, gdbSNP:267604474
1388+c, tdbSNP:432998
1397+g, tdbSNP:141827066
1434+a, tdbSNP:369508594
1435+g, tdbSNP:201855972
1463+c, tdbSNP:55942437
1502+c, tdbSNP:369762663
1568+a, gdbSNP:376961976
1579+a, gdbSNP:370646498
1589+c, tdbSNP:200457901
1696+a, cdbSNP:111341519
1721+c, tdbSNP:17847876
1727+c, tdbSNP:367690547
1745+a, gdbSNP:376039132
1869+a, gdbSNP:368238909
1884+c, tdbSNP:17847879
1920+a, cdbSNP:201555288
1960+a, c, gdbSNP:35631544
1967+c, tdbSNP:3729904
1989+a, gdbSNP:114846751
2047+a, tdbSNP:371799088
2068+a, gdbSNP:374654582
2084+c, tdbSNP:369345275
2108+a, tdbSNP:149446950
2165+c, tdbSNP:143953612
2228+a, gdbSNP:199871261
2238+a, gdbSNP:369724465
2266+c, tdbSNP:373045947
2347+a, tdbSNP:3380
2366+c, gdbSNP:146020925
2397+a, gdbSNP:41280844
2433+a, gdbSNP:4787872
complement(2474)-t, cdbSNP:149339486
2476+c, tdbSNP:189252078
2603+c, tdbSNP:144672987
2605+c, tdbSNP:148546127
2610+a, gdbSNP:114644570
2688+a, gdbSNP:78674142
2697+a, cdbSNP:370678030
2795+a, gdbSNP:142859099
complement(2822)-t, cdbSNP:3785380
3000+c, tdbSNP:182199378
complement(3016)-t, cdbSNP:3785379
3027+a, gdbSNP:147723634
3043..3052+, tcttttttttdbSNP:3837785
3052+a, gdbSNP:79376982
3062..3071+, aaaaaaaaagdbSNP:72271620
complement(3107)-t, cdbSNP:3785378
3113+a, gdbSNP:374468788
3139+c, tdbSNP:56687328
3167+a, gdbSNP:185582992
3230+g, tdbSNP:116093872
3237+c, gdbSNP:371790470
3379+c, tdbSNP:140893375
3385+a, cdbSNP:71379853
3389+a, tdbSNP:371807314
3390+, adbSNP:59543980
3391+a, tdbSNP:79997806
3401+a, gdbSNP:116357421
3403+a, gdbSNP:76359194
3444+g, tdbSNP:78750834
3515+a, gdbSNP:8059889
3518+a, gdbSNP:113196567
3558+a, gdbSNP:190191882
3621+a, gdbSNP:374319540
complement(3735)-t, cdbSNP:147946613
3757+a, gdbSNP:181718271
3780+, cdbSNP:35860232
3784+a, gdbSNP:185391750
3810+a, gdbSNP:41303765
3843+c, gdbSNP:368007255
3844+a, gdbSNP:75859222
3850+c, tdbSNP:112729951
3858+c, gdbSNP:140599804
3971+c, tdbSNP:113823327
3983+c, tdbSNP:190250028
4021+c, tdbSNP:114738789
4046+a, cdbSNP:181254533
4055+, cdbSNP:138855260
4056+c, tdbSNP:185977261
4150+a, tdbSNP:371761150
4178+a, tdbSNP:114136375
4290+c, gdbSNP:114638203
complement(4319)-g, adbSNP:150101137
4399+a, cdbSNP:73550432
4405+a, gdbSNP:145450586
4475+a, gdbSNP:41309270
4497+a, tdbSNP:41311262
4504+a, gdbSNP:3209801
4508+a, gdbSNP:1131276
4511+a, gdbSNP:1131277
4512+a, tdbSNP:190798839
4561+, adbSNP:145016072
4585+c, gdbSNP:2021847
complement(4661)-g, adbSNP:148858748
4691+a, tdbSNP:371842506
4705+a, gdbSNP:145309658
4752+g, tdbSNP:41313541
4809+a, gdbSNP:369926841
4858..4859+, cdbSNP:34197974
5055+a, cdbSNP:34097947
5185+c, tdbSNP:138047682
complement(5268)-t, cdbSNP:140957380
5275+g, tdbSNP:41311260
5283+a, cdbSNP:41311258
5377+a, gdbSNP:183896121
5424+c, tdbSNP:144891284
5493+a, tdbSNP:188939352
5715+c, gdbSNP:77825011
5734+a, gdbSNP:138780084
5740+a, gdbSNP:28552982
5781+c, tdbSNP:41303763
5797+a, gdbSNP:150831990
5891+a, gdbSNP:2239338
5924+a, cdbSNP:73550434
5946..5947+, gdbSNP:34630014
5967+c, gdbSNP:2239339
complement(6022)-t, gdbSNP:138123553
6052..6053+, gadbSNP:34045233
6053..6054+, gadbSNP:371140609
6082+c, gdbSNP:147259878
complement(6085)-g, cdbSNP:140931038
6099+c, tdbSNP:191748340
6139+c, gdbSNP:35434839
6190+a, gdbSNP:369641483
6226+c, tdbSNP:41311256
6257+c, gdbSNP:374358833
6264+c, tdbSNP:376874115
6285+a, tdbSNP:411103
6319+a, gdbSNP:11865035
6332+c, tdbSNP:8056058
complement(6347)-g, cdbSNP:3087957
6400+a, gdbSNP:148593800
6496+c, gdbSNP:113354788
6517+a, gdbSNP:183148409
6591..6592+, adbSNP:139806286
6648..6649+, ttttg, ttttgttttgttttg, ttttgttttgttttgttttgdbSNP:10639027
6648+c, gdbSNP:199618218
6649..6650+, ttttgdbSNP:35423969
6677..6678+, gttttgttttgttttdbSNP:10657133
6733..6734+, tagatdbSNP:138369749
6734..6735+, gattadbSNP:201843272
6734+a, tdbSNP:111528401
6737..6738+, tagatdbSNP:3216342
6737+c, tdbSNP:77746351
6762+a, gdbSNP:2239340
6773+g, tdbSNP:187559261
6896+a, gdbSNP:191675978
6915+a, gdbSNP:184182024
6970+a, gdbSNP:78946887
6985+c, tdbSNP:397299
7058+, adbSNP:200055220
7059..7075+, acacacacacacacacadbSNP:368430381
7059+, adbSNP:371994904
7059+a, c, gdbSNP:28605861
7063+, adbSNP:34377767
7077..7078+, gcacdbSNP:377077346
7114..7115+, ggdbSNP:201572518
7317+a, gdbSNP:377532181
7330+c, tdbSNP:3729908
7334+a, c, gdbSNP:41278144
7344+a, gdbSNP:200017388
7360+c, gdbSNP:202022036
7426+c, tdbSNP:148637931
7494+c, tdbSNP:142427207
7531+c, tdbSNP:424741
7532+a, gdbSNP:367894275
7534+c, gdbSNP:140062455
7535+a, gdbSNP:374831115
7607+a, gdbSNP:187700395
7630+a, gdbSNP:113336763
7669+c, tdbSNP:192474372
7700+c, gdbSNP:185685652
7712+c, tdbSNP:368074978
7713+a, gdbSNP:190510502
7789+c, tdbSNP:181492069
complement(7904)-t, cdbSNP:144042856
7933..7934+, tdbSNP:34526646
7942+c, tdbSNP:1063471
7955+c, tdbSNP:146441057
Gene SymbolPRKCB
Gene SynonymPKC-beta; PKCB; PRKCB1; PRKCB2
Locus Map16p11.2
Title Protein kinase C isoforms in atherosclerosis: pro- or anti-inflammatory? .
Author Fan HC, Fernandez-Hernando C and Lai JH.
Journal Biochem. Pharmacol. 88 (2), 139-149 (2014)
Title PKC-beta exacerbates in vitro brain barrier damage in hyperglycemic settings via regulation of RhoA/Rho-kinase/MLC2 pathway .
Author Srivastava K, Shao B and Bayraktutan U.
Journal J. Cereb. Blood Flow Metab. 33 (12), 1928-1936 (2013)
Title Tyrosine phosphorylation on spleen tyrosine kinase (Syk) is differentially regulated in human and murine platelets by protein kinase C isoforms .
Author Buitrago L, Bhavanasi D, Dangelmaier C, Manne BK, Badolia R, Borgognone A, Tsygankov AY, McKenzie SE and Kunapuli SP.
Journal J. Biol. Chem. 288 (40), 29160-29169 (2013)
Title Modulation of Rack-1/PKCbetaII signalling by soluble AbetaPPalpha in SH-SY5Y cells .
Author Buoso E, Biundo F, Lanni C, Aiello S, Grossi S, Schettini G, Govoni
Journal Curr Alzheimer Res 10 (7), 697-705 (2013)
Title Role of HIF1alpha and PKCbeta in mediating the effect of oxygen and glucose in a novel wound assay .
Author Gadad PC, Matthews KH and Knott RM.
Journal Microvasc. Res. 88, 61-69 (2013)
Title Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters .
Author Obeid LM, Blobe GC, Karolak LA and Hannun YA.
Journal J. Biol. Chem. 267 (29), 20804-20810 (1992)
Title Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes .
Author Goode N, Hughes K, Woodgett JR and Parker PJ.
Journal J. Biol. Chem. 267 (24), 16878-16882 (1992)
Title Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor .
Author Moss SJ, Doherty CA and Huganir RL.
Journal J. Biol. Chem. 267 (20), 14470-14476 (1992)
Title Down-regulation of human protein kinase C alpha is associated with terminal neutrophil differentiation .
Author Devalia V, Thomas NS, Roberts PJ, Jones HM and Linch DC.
Journal Blood 80 (1), 68-76 (1992)
Title Positive and negative regulation of the transcription of the human protein kinase C beta gene .
Author Niino YS, Ohno S and Suzuki K.
Journal J. Biol. Chem. 267 (9), 6158-6163 (1992)

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