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Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNA.


RefSeq Accession Definition Services Price Order
NM_002755 Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNA. ORF Sequence $342.78
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RefSeq Version NM_002755.3, 169790828
Length 2603 bp
Structure linear
Update Date 21-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNA.
Product dual specificity mitogen-activated protein kinase kinase 1
Comment

Summary: The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008].

RefSeq NP_002746.1
CDS 476..1657
Misc Feature(1)350..352
Misc Feature(2)497..502
Misc Feature(3)497..502
Misc Feature(4)659..1651
Misc Feature(5)677..1558
Misc Feature(6)order(695..709,713..715,719..721,758..760,764..766,
Misc Feature(7)order(695..709,713..715,719..721,758..760,764..766,
Misc Feature(8)order(704..709,1043..1045,1049..1057,1106..1108,
Misc Feature(9)order(704..709,764..766,818..820,827..829,854..856,
Misc Feature(10)704..709
Misc Feature(11)order(716..718,776..781,884..886,1163..1165,1175..1186,
Misc Feature(12)905..913
Misc Feature(13)1094..1159
Misc Feature(14)1097..1111
Misc Feature(15)1127..1129
Misc Feature(16)1127..1129
Misc Feature(17)1127..1129
Misc Feature(18)1127..1129
Misc Feature(19)1127..1129
Misc Feature(20)1139..1141
Misc Feature(21)1139..1141
Misc Feature(22)1139..1141
Misc Feature(23)1139..1141
Misc Feature(24)1139..1141
Misc Feature(25)1283..1396
Misc Feature(26)1331..1333
Misc Feature(27)1331..1333
Misc Feature(28)1331..1333
Misc Feature(29)1349..1351
Misc Feature(30)1349..1351
Misc Feature(31)1367..1369
Misc Feature(32)1367..1369
Misc Feature(33)1385..1387
Misc Feature(34)1631..1633
Exon (1)1..555
Gene:MAP2K1
Gene Synonym:MAPKK1; MEK1; MKK1; PRKMK1
Exon (2)556..766
Gene:MAP2K1
Gene Synonym:MAPKK1; MEK1; MKK1; PRKMK1
Exon (3)767..913
Gene:MAP2K1
Gene Synonym:MAPKK1; MEK1; MKK1; PRKMK1
Exon (4)914..991
Gene:MAP2K1
Gene Synonym:MAPKK1; MEK1; MKK1; PRKMK1
Exon (5)992..1043
Gene:MAP2K1
Gene Synonym:MAPKK1; MEK1; MKK1; PRKMK1
Exon (6)1044..1168
Gene:MAP2K1
Gene Synonym:MAPKK1; MEK1; MKK1; PRKMK1
Exon (7)1169..1370
Gene:MAP2K1
Gene Synonym:MAPKK1; MEK1; MKK1; PRKMK1
Exon (8)1371..1435
Gene:MAP2K1
Gene Synonym:MAPKK1; MEK1; MKK1; PRKMK1
Exon (9)1436..1497
Gene:MAP2K1
Gene Synonym:MAPKK1; MEK1; MKK1; PRKMK1
Exon (10)1498..1543
Gene:MAP2K1
Gene Synonym:MAPKK1; MEK1; MKK1; PRKMK1
Exon (11)1544..2586
Gene:MAP2K1
Gene Synonym:MAPKK1; MEK1; MKK1; PRKMK1
Translation MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
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Position Chain Variation Link
28+dbSNP:
28+c, tdbSNP:73469977
49+c, tdbSNP:185210930
85+c, tdbSNP:140766704
254..255+, gcdbSNP:141005341
333+c, gdbSNP:111281925
391+c, gdbSNP:112542693
396+a, gdbSNP:41277718
436..437+, cdbSNP:142027715
440..441+, cdbSNP:67229745
474+a, gdbSNP:77796976
544+c, tdbSNP:140749690
546+c, gdbSNP:144700234
631+dbSNP:
631+c, tdbSNP:147489724
633+c, tdbSNP:121908594
673+c, tdbSNP:56200325
712+c, tdbSNP:148656020
739+a, gdbSNP:7494832
752+a, gdbSNP:151207265
754+c, tdbSNP:140387057
790+dbSNP:
790+c, tdbSNP:144166521
858+g, tdbSNP:121908596
864+a, gdbSNP:121908595
871+a, gdbSNP:139364105
886+c, tdbSNP:146415623
941+dbSNP:
941+a, gdbSNP:199504372
944+a, gdbSNP:201208360
946+a, gdbSNP:200487483
967+a, gdbSNP:140822439
1099+dbSNP:
1099+c, tdbSNP:191996882
1102+c, tdbSNP:144639340
1111+c, tdbSNP:138466751
1123+c, tdbSNP:148968935
1186+dbSNP:
1186+a, gdbSNP:17586159
1309+a, gdbSNP:148151221
1323+c, tdbSNP:144080051
1375+dbSNP:
1375+c, tdbSNP:147333830
1402+a, tdbSNP:146869577
1432+c, tdbSNP:143019052
1494+dbSNP:
1494+a, cdbSNP:184970289
1573+dbSNP:
1573+c, tdbSNP:200293968
1612+c, tdbSNP:150841154
1614+a, gdbSNP:28730804
1652+a, gdbSNP:200442489
1916+a, cdbSNP:181822467
1944+a, gdbSNP:184860087
1965+g, tdbSNP:14303
2061+c, tdbSNP:190094372
2082+g, tdbSNP:56366941
2113+c, tdbSNP:181853123
2249+a, gdbSNP:147974693
2314+c, tdbSNP:8684
2407+a, gdbSNP:186510658
2434+g, tdbSNP:11540657
2450+a, gdbSNP:191261480
2453+g, tdbSNP:14538
2473+a, cdbSNP:74022018
2545+c, tdbSNP:180838974
2547+a, gdbSNP:138560168
2574+c, tdbSNP:199531879
2576+a, gdbSNP:77444537
Gene SymbolMAP2K1
Gene SynonymMAPKK1; MEK1; MKK1; PRKMK1
Chromosome15
Locus Map15q22.1-q22.33
All Transcripts
RefSeq Accession Definition Sequence Price Select
NM_002755 Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNA. Full Length $754.87
ORF Sequence $342.78
Title MEK1 inactivates Myt1 to regulate Golgi membrane fragmentation and mitotic entry in mammalian cells .
Author Villeneuve,J., Scarpa,M., Ortega-Bellido,M. and Malhotra,V.
Journal EMBO J. 32 (1), 72-85 (2013)
Title Nuclear translocation of MEK1 triggers a complex T cell response through the corepressor silencing mediator of retinoid and thyroid hormone receptor .
Author Guo,L., Chen,C., Liang,Q., Karim,M.Z., Gorska,M.M. and Alam,R.
Journal J. Immunol. 190 (1), 159-167 (2013)
Title IL1beta down-regulation of sex hormone-binding globulin production by decreasing HNF-4alpha via MEK-1/2 and JNK MAPK pathways .
Author Simo,R., Barbosa-Desongles,A., Hernandez,C. and Selva,D.M.
Journal Mol. Endocrinol. 26 (11), 1917-1927 (2012)
Title Regulation of hepatitis C virus replication and gene expression by the MAPK-ERK pathway .
Author Pei,R., Zhang,X., Xu,S., Meng,Z., Roggendorf,M., Lu,M. and Chen,X.
Journal Virol Sin 27 (5), 278-285 (2012)
Title Mitogen-activated protein kinase pathway in osteosarcoma .
Author Na,K.Y., Kim,Y.W. and Park,Y.K.
Journal Pathology 44 (6), 540-546 (2012)
Title MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase .
Author Xu,S., Robbins,D., Frost,J., Dang,A., Lange-Carter,C. and Cobb,M.H.
Journal Proc. Natl. Acad. Sci. U.S.A. 92 (15), 6808-6812 (1995)
Title The MAPK signaling cascade .
Author Seger,R. and Krebs,E.G.
Journal FASEB J. 9 (9), 726-735 (1995)
Title B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222 .
Author Papin,C., Eychene,A., Brunet,A., Pages,G., Pouyssegur,J., Calothy,G. and Barnier,J.V.
Journal Oncogene 10 (8), 1647-1651 (1995)
Title MAP kinase binds to the NH2-terminal activation domain of c-Myc .
Author Gupta,S. and Davis,R.J.
Journal FEBS Lett. 353 (3), 281-285 (1994)
Title Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases .
Author Seger,R., Seger,D., Lozeman,F.J., Ahn,N.G., Graves,L.M., Campbell,J.S., Ericsson,L., Harrylock,M., Jensen,A.M. and Krebs,E.G.
Journal J. Biol. Chem. 267 (36), 25628-25631 (1992)

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