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Database:

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Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNA.


Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu48447 Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNA. pcDNA3.1+-DYK In-stock $99.00 5-7
OHu48447C Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNA. Customized vector In-stock $149.00 5-7

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Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Data sheet
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
Restriction Sites Hind III- EcoR I
RefSeq Version NM_002755.3, 169790828
Length 1182 bp
Structure linear
Update Date 25-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNA.
Product dual specificity mitogen-activated protein kinase kinase 1
Comment

Summary: The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008].

RefSeq NP_002746.1
CDS 476..1657
Misc Feature(1)350..352
Misc Feature(2)497..502
Misc Feature(3)497..502
Misc Feature(4)659..1651
Misc Feature(5)677..1558
Misc Feature(6)order(695..709,713..715,719..721,758..760,764..766,
Misc Feature(7)order(695..709,713..715,719..721,758..760,764..766,
Misc Feature(8)order(704..709,1043..1045,1049..1057,1106..1108,
Misc Feature(9)order(704..709,764..766,818..820,827..829,854..856,
Misc Feature(10)704..709
Misc Feature(11)order(716..718,776..781,884..886,1163..1165,1175..1186,
Misc Feature(12)905..913
Misc Feature(13)1094..1159
Misc Feature(14)1097..1111
Misc Feature(15)1127..1129
Misc Feature(16)1127..1129
Misc Feature(17)1127..1129
Misc Feature(18)1127..1129
Misc Feature(19)1127..1129
Misc Feature(20)1139..1141
Misc Feature(21)1139..1141
Misc Feature(22)1139..1141
Misc Feature(23)1139..1141
Misc Feature(24)1139..1141
Misc Feature(25)1283..1396
Misc Feature(26)1331..1333
Misc Feature(27)1331..1333
Misc Feature(28)1331..1333
Misc Feature(29)1349..1351
Misc Feature(30)1349..1351
Misc Feature(31)1367..1369
Misc Feature(32)1367..1369
Misc Feature(33)1385..1387
Misc Feature(34)1631..1633
Exon (1)1..555
Gene:MAP2K1
Gene Synonym:CFC3; MAPKK1; MEK1; MKK1; PRKMK1
Exon (2)556..766
Gene:MAP2K1
Gene Synonym:CFC3; MAPKK1; MEK1; MKK1; PRKMK1
Exon (3)767..913
Gene:MAP2K1
Gene Synonym:CFC3; MAPKK1; MEK1; MKK1; PRKMK1
Exon (4)914..991
Gene:MAP2K1
Gene Synonym:CFC3; MAPKK1; MEK1; MKK1; PRKMK1
Exon (5)992..1043
Gene:MAP2K1
Gene Synonym:CFC3; MAPKK1; MEK1; MKK1; PRKMK1
Exon (6)1044..1168
Gene:MAP2K1
Gene Synonym:CFC3; MAPKK1; MEK1; MKK1; PRKMK1
Exon (7)1169..1370
Gene:MAP2K1
Gene Synonym:CFC3; MAPKK1; MEK1; MKK1; PRKMK1
Exon (8)1371..1435
Gene:MAP2K1
Gene Synonym:CFC3; MAPKK1; MEK1; MKK1; PRKMK1
Exon (9)1436..1497
Gene:MAP2K1
Gene Synonym:CFC3; MAPKK1; MEK1; MKK1; PRKMK1
Exon (10)1498..1543
Gene:MAP2K1
Gene Synonym:CFC3; MAPKK1; MEK1; MKK1; PRKMK1
Exon (11)1544..2586
Gene:MAP2K1
Gene Synonym:CFC3; MAPKK1; MEK1; MKK1; PRKMK1
Translation MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
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Position Chain Variation Link
28+dbSNP:
28+c, tdbSNP:73469977
49+c, tdbSNP:185210930
85+c, tdbSNP:140766704
254..255+, gcdbSNP:141005341
318+a, gdbSNP:369406498
333+c, gdbSNP:111281925
391+c, gdbSNP:112542693
396+a, gdbSNP:41277718
439..440+, cdbSNP:142027715
474+a, gdbSNP:77796976
481+c, g, tdbSNP:377720622
544+c, tdbSNP:140749690
599+dbSNP:
599+c, tdbSNP:397516789
631+c, tdbSNP:147489724
633+c, tdbSNP:121908594
644+a, cdbSNP:397516790
673+c, tdbSNP:56200325
712+c, tdbSNP:148656020
739+a, gdbSNP:7494832
750+g, tdbSNP:397516791
751+c, gdbSNP:377323150
752+a, gdbSNP:151207265
754+c, tdbSNP:140387057
755+a, gdbSNP:368143400
790+dbSNP:
790+c, tdbSNP:144166521
846+c, tdbSNP:397516792
853+c, tdbSNP:369401783
858+g, tdbSNP:121908596
863+c, tdbSNP:397516793
864+a, gdbSNP:121908595
871+a, g, tdbSNP:139364105
886+c, tdbSNP:146415623
941+dbSNP:
941+a, gdbSNP:199504372
944+a, gdbSNP:201208360
946+a, gdbSNP:200487483
967+a, gdbSNP:140822439
1099+dbSNP:
1099+c, tdbSNP:191996882
1102+c, tdbSNP:144639340
1111+c, tdbSNP:138466751
1123+c, tdbSNP:148968935
1186+dbSNP:
1186+a, gdbSNP:17586159
1201+g, tdbSNP:373745627
1279+c, gdbSNP:371652992
1309+a, gdbSNP:148151221
1323+c, tdbSNP:144080051
1350+c, gdbSNP:397516794
1354+c, tdbSNP:370521459
1375+dbSNP:
1375+c, tdbSNP:147333830
1402+a, tdbSNP:146869577
1432+c, tdbSNP:143019052
1494+dbSNP:
1494+a, cdbSNP:184970289
1526+dbSNP:
1526+g, tdbSNP:373210982
1573+dbSNP:
1573+c, tdbSNP:200293968
1605+c, tdbSNP:371140798
1610+a, gdbSNP:373794940
1612+c, tdbSNP:150841154
1614+a, gdbSNP:28730804
1652+a, gdbSNP:200442489
1680+c, tdbSNP:376181437
1709+c, tdbSNP:372452427
1729+a, gdbSNP:369901206
1813+c, tdbSNP:373707256
1916+a, cdbSNP:181822467
1944+a, gdbSNP:184860087
complement(1965)-t, gdbSNP:14303
1996+g, tdbSNP:371021779
2000+c, tdbSNP:372877813
2061+c, tdbSNP:190094372
2082+g, tdbSNP:56366941
2113+c, tdbSNP:181853123
complement(2249)-g, adbSNP:147974693
2301+a, gdbSNP:375853830
2314+c, tdbSNP:8684
2407+a, gdbSNP:186510658
complement(2434)-t, gdbSNP:11540657
2450+a, gdbSNP:191261480
complement(2453)-t, gdbSNP:14538
2473+a, cdbSNP:74022018
2545+c, tdbSNP:180838974
2547+a, gdbSNP:138560168
2574+c, tdbSNP:199531879
2576+a, gdbSNP:77444537
Gene SymbolMAP2K1
Gene SynonymCFC3; MAPKK1; MEK1; MKK1; PRKMK1
Chromosome15
Locus Map15q22.1-q22.33
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_002755 Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNA. In-stock $99.00 5-7
XM_006720608 PREDICTED: Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), transcript variant X3, mRNA. On-demand $219.00 7-9
XM_005254541 PREDICTED: Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), transcript variant X2, mRNA. On-demand $159.00 7-9
Title MEK1/2 overactivation can promote growth arrest by mediating ERK1/2-dependent phosphorylation of p70S6K .
Author Guegan JP, Ezan F, Gailhouste L, Langouet S and Baffet G.
Journal J. Cell. Physiol. 229 (7), 903-915 (2014)
Title High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias .
Author Waterfall JJ, Arons E, Walker RL, Pineda M, Roth L, Killian JK, Abaan OD, Davis SR, Kreitman RJ and Meltzer PS.
Journal Nat. Genet. 46 (1), 8-10 (2014)
Title MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer .
Author Li L, Wang J, Zhang Y, Zhang Y, Ma L, Weng W, Qiao Y, Xiao W, Wang H, Yu W, Pan Q, He Y and Sun F.
Journal FEBS Lett. 587 (24), 3921-3927 (2013)
Title EGFR/MEK/ERK/CDK5-dependent integrin-independent FAK phosphorylated on serine 732 contributes to microtubule depolymerization and mitosis in tumor cells .
Author Rea K, Sensi M, Anichini A, Canevari S and Tomassetti A.
Journal Cell Death Dis 4, E815 (2013)
Title MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase .
Author Xu S, Robbins D, Frost J, Dang A, Lange-Carter C and Cobb MH.
Journal Proc. Natl. Acad. Sci. U.S.A. 92 (15), 6808-6812 (1995)
Title The MAPK signaling cascade .
Author Seger R and Krebs EG.
Journal FASEB J. 9 (9), 726-735 (1995)
Title B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222 .
Author Papin C, Eychene A, Brunet A, Pages G, Pouyssegur J, Calothy G and Barnier JV.
Journal Oncogene 10 (8), 1647-1651 (1995)
Title Cardiofaciocutaneous Syndrome .
Author Rauen,K.A.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Title Noonan Syndrome .
Author Allanson,J.E. and Roberts,A.E.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Title Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases .
Author Seger R, Seger D, Lozeman FJ, Ahn NG, Graves LM, Campbell JS, Ericsson L, Harrylock M, Jensen AM and Krebs EG.
Journal J. Biol. Chem. 267 (36), 25628-25631 (1992)

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