Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), mRNA.
| RefSeq Version | NM_002834.3, 33356176 |
| Length | 6300 bp |
| Structure | linear |
| Update Date | 01-MAY-2011 |
| Organism | Homo sapiens (human) |
| Definition | Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), mRNA. |
| Product | tyrosine-protein phosphatase non-receptor type 11 |
| Comment | Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq]. |
| RefSeq | NP_002825.3 |
| CDS | 381..2162 | Exon (1) | 1..394 | Exon (2) | 1..394 | Exon (3) | 395..517 | Exon (4) | 518..712 | Exon (5) | 713..905 | Exon (6) | 906..1022 | Exon (7) | 1023..1136 | Exon (8) | 1137..1233 | Exon (9) | 1234..1313 | Exon (10) | 1314..1472 | Exon (11) | 1473..1604 | Exon (12) | 1605..1759 | Exon (13) | 1760..1827 | Exon (14) | 1828..1979 | Exon (15) | 1980..2092 | Exon (16) | 2093..2194 | Exon (17) | 2195..6283 |
| Translation | MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
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| Gene Symbol | PTPN11 |
| Gene Synonym | BPTP3; CFC; MGC14433; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2 |
| Chromosome | 12 |
| Locus Map | 12q24 |
| All Transcripts | NM_002834 |
| Title | Recovery of anoikis in Src-transformed cells and human breast carcinoma cells by restoration of the SIRP alpha1/SHP-2 signaling system . |
| Author | Hara,K., Senga,T., Biswas,M.H., Hasegawa,H., Ito,S., Hyodo,T., Hirooka,Y., Niwa,Y., Goto,H. and Hamaguchi,M. |
| Journal | Cancer Res. 71 (4), 1229-1234 (2011) |
| Title | Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph . |
| Author | Casabonne,D., Reina,O., Benavente,Y., Becker,N., Maynadie,M., Foretova,L., Cocco,P., Gonzalez-Neira,A., Nieters,A., Boffetta,P., Middeldorp,J.M. and de Sanjose,S. |
| Journal | Haematologica 96 (2), 323-327 (2011) |
| Title | The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor contains an immunoreceptor tyrosine-based inhibitory motif that activates Shp2 . |
| Author | Philpott,N., Bakken,T., Pennell,C., Chen,L., Wu,J. and Cannon,M. |
| Journal | J. Virol. 85 (2), 1140-1144 (2011) |
| Title | OPLS-DA as a suitable method for selecting a set of gene transcripts discriminating RAS- and PTPN11-mutated cells in acute lymphoblastic leukaemia . |
| Author | Musumarra,G., Condorelli,D.F. and Fortuna,C.G. |
| Journal | Comb. Chem. High Throughput Screen. 14 (1), 36-46 (2011) |
| Title | Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo . |
| Author | Ikram,M.K., Sim,X., Jensen,R.A., Cotch,M.F., Hewitt,A.W., Ikram,M.A., Wang,J.J., Klein,R., Klein,B.E., Breteler,M.M., Cheung,N., Liew,G., Mitchell,P., Uitterlinden,A.G., Rivadeneira,F., Hofman,A., de Jong,P.T., van Duijn,C.M., Kao,L., Cheng,C.Y., Smith,A.V., Glazer,N.L., Lumley,T., McKnight,B., Psaty,B.M., Jonasson,F., Eiriksdottir,G., Aspelund,T., Harris,T.B., Launer,L.J., Taylor,K.D., Li,X., Iyengar,S.K., Xi,Q., Sivakumaran,T.A., Mackey,D.A., Macgregor,S., Martin,N.G., Young,T.L., Bis,J.C., Wiggins,K.L., Heckbert,S.R., Hammond,C.J., Andrew,T., Fahy,S., Attia,J., Holliday,E.G., Scott,R.J., Islam,F.M., Rotter,J.I., McAuley,A.K., Boerwinkle,E., Tai,E.S., Gudnason,V., Siscovick,D.S., Vingerling,J.R. and Wong,T.Y. |
| Journal | PLoS Genet. 6 (10), E1001184 (2010) |
| Title | Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction . |
| Author | Kharitonenkov,A., Schnekenburger,J., Chen,Z., Knyazev,P., Ali,S., Zwick,E., White,M. and Ullrich,A. |
| Journal | J. Biol. Chem. 270 (49), 29189-29193 (1995) |
| Title | Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase . |
| Author | Welham,M.J., Dechert,U., Leslie,K.B., Jirik,F. and Schrader,J.W. |
| Journal | J. Biol. Chem. 269 (38), 23764-23768 (1994) |
| Title | Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3 with sequence similarity to the src-homology region 2 . |
| Author | Adachi,M., Sekiya,M., Miyachi,T., Matsuno,K., Hinoda,Y., Imai,K. and Yachi,A. |
| Journal | FEBS Lett. 314 (3), 335-339 (1992) |
| Title | Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew . |
| Author | Freeman,R.M. Jr., Plutzky,J. and Neel,B.G. |
| Journal | Proc. Natl. Acad. Sci. U.S.A. 89 (23), 11239-11243 (1992) |
| Title | Protein-tyrosine phosphatase expression in pre-B cell NALM-6 . |
| Author | Adachi,M., Sekiya,M., Arimura,Y., Takekawa,M., Itoh,F., Hinoda,Y., Imai,K. and Yachi,A. |
| Journal | Cancer Res. 52 (3), 737-740 (1992) |
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