• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1, mRNA.


Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu25096 Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand $219.00 7-9
OHu25096C Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1, mRNA. Customized vector On-demand $269.00 7-9

*Business Day

Mutation services

Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Data sheet
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
Restriction Sites Hind III- EcoR I
RefSeq Version NM_002834.3, 33356176
Length 1782 bp
Structure linear
Update Date 17-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1, mRNA.
Product tyrosine-protein phosphatase non-receptor type 11 isoform 1
Comment

Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].


Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

RefSeq NP_002825.3
CDS 381..2162
Misc Feature(1)336..338
Misc Feature(2)384..386
Misc Feature(3)384..386
Misc Feature(4)393..689
Misc Feature(5)order(417..419,474..476,537..539,543..545)
Misc Feature(6)order(534..542,582..584,642..653,657..659)
Misc Feature(7)564..566
Misc Feature(8)564..566
Misc Feature(9)567..569
Misc Feature(10)567..569
Misc Feature(11)711..1034
Misc Feature(12)order(795..797,801..803,816..821)
Misc Feature(13)order(888..890,969..971)
Misc Feature(14)1116..1940
Misc Feature(15)1206..1937
Misc Feature(16)order(1653..1655,1752..1757,1764..1766,1773..1778)
Misc Feature(17)1755..1775
Misc Feature(18)2004..2006
Misc Feature(19)2004..2006
Misc Feature(20)2052..2054
Misc Feature(21)2106..2108
Misc Feature(22)2106..2108
Misc Feature(23)2106..2108
Misc Feature(24)2118..2120
Misc Feature(25)2118..2120
Misc Feature(26)2151..2153
Exon (1)1..394
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (2)395..517
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (3)518..712
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (4)713..905
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (5)906..1022
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (6)1023..1136
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (7)1137..1233
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (8)1234..1313
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (9)1314..1472
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (10)1473..1604
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (11)1605..1759
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (12)1760..1827
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (13)1828..1979
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (14)1980..2092
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (15)2093..2194
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (16)2195..6283
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Translation MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
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Position Chain Variation Link
58+dbSNP:
58+g, tdbSNP:61941345
64+c, tdbSNP:373537430
85+c, tdbSNP:375766559
94+c, gdbSNP:377496292
108+a, gdbSNP:58805176
201+a, gdbSNP:149766959
354+a, gdbSNP:375495669
385+c, tdbSNP:267606990
398+dbSNP:
398+g, tdbSNP:79203122
408+a, gdbSNP:368633510
409+a, gdbSNP:200613531
428+a, gdbSNP:372736227
436+g, tdbSNP:397507500
446+a, gdbSNP:397516808
499+a, gdbSNP:397516795
504+a, gdbSNP:397507501
512+a, cdbSNP:397507502
535+dbSNP:
535+c, tdbSNP:397507503
536+c, tdbSNP:147388185
546+a, gdbSNP:397507504
552+a, c, gdbSNP:397507505
554+a, c, gdbSNP:397507506
558..560+, ggtdbSNP:121918471
558+a, g, tdbSNP:397507507
559..562+gtga, tdbSNP:397507508
559..561+, gtgdbSNP:80338836
559+c, g, tdbSNP:397507509
561+a, c, gdbSNP:397507510
562+a, g, tdbSNP:121918461
564+a, g, tdbSNP:121918460
568+a, gdbSNP:121918459
585+c, gdbSNP:397507511
589+a, gdbSNP:397516801
591+c, tdbSNP:397507512
594+c, g, tdbSNP:121918453
595+c, gdbSNP:121918454
597..598+ac, ctdbSNP:397516802
597+a, cdbSNP:397507513
598+c, tdbSNP:121918462
606+a, gdbSNP:121918464
607+a, c, g, tdbSNP:121918465
608+c, g, tdbSNP:397507514
615+a, cdbSNP:397516803
616+a, gdbSNP:121918466
624+a, gdbSNP:397507515
635+c, tdbSNP:61736914
669+c, gdbSNP:397507516
675+a, tdbSNP:387907158
695+a, tdbSNP:397516804
697+a, cdbSNP:397507517
708+a, gdbSNP:397507518
709+a, cdbSNP:397507519
733..734+dbSNP:
733..734+, ctdbSNP:398122859
756+c, tdbSNP:146497890
772+a, gdbSNP:397516805
789..793+, gtacgdbSNP:398122857
792+c, tdbSNP:267606989
797+c, g, tdbSNP:397507520
806+c, tdbSNP:199498784
832+c, tdbSNP:202026962
835+a, gdbSNP:397507521
838..843+aagaacacaggggagagca, ctggtgdbSNP:398122858
841+c, gdbSNP:376027245
847+a, gdbSNP:200712424
866+c, tdbSNP:397507522
898+a, gdbSNP:369155025
917+dbSNP:
917+c, tdbSNP:141015445
936+c, tdbSNP:143433437
938+g, tdbSNP:200920312
945+g, tdbSNP:79068130
952+a, cdbSNP:370763866
complement(971)-c, adbSNP:76982592
complement(996)-t, cdbSNP:78376169
1041+dbSNP:
1041+, adbSNP:397516807
1041+a, tdbSNP:397516806
1097+c, gdbSNP:138215269
1147+dbSNP:
1147+a, gdbSNP:397507523
1150..1151+, acadbSNP:397507524
1154+g, tdbSNP:397516809
1161+c, tdbSNP:397507525
1165+g, tdbSNP:397507526
1174+a, gdbSNP:376607329
1182+a, g, tdbSNP:397507527
1204+a, cdbSNP:397507528
1216+a, c, gdbSNP:121918456
1224+a, gdbSNP:397507529
1226+c, gdbSNP:397507530
1233+c, g, tdbSNP:397507531
1234+dbSNP:
1234+c, g, tdbSNP:121918463
1235+g, tdbSNP:397516810
1238+a, tdbSNP:397516811
1259+c, g, tdbSNP:117730996
1260+a, gdbSNP:376007642
1301+a, gdbSNP:202019810
1302+a, gdbSNP:28933386
1303+a, c, gdbSNP:121918455
1305+a, gdbSNP:201787206
1312+c, tdbSNP:201226824
1363+dbSNP:
1363+c, tdbSNP:369430257
1370+a, cdbSNP:369739920
1376+c, tdbSNP:397507533
1391+a, gdbSNP:371951288
1428+g, tdbSNP:146571700
1432+a, gdbSNP:397507534
1433+a, gdbSNP:190776554
1500+dbSNP:
1500+c, gdbSNP:397507535
1504+a, gdbSNP:41299183
1511+a, cdbSNP:370059077
1606+dbSNP:
1606+c, gdbSNP:201247699
1612+c, tdbSNP:121918467
1662+a, gdbSNP:397507536
1676+g, tdbSNP:150524715
1695+, cdbSNP:398122860
1746+a, gdbSNP:397516796
1761+dbSNP:
1761+a, g, tdbSNP:121918468
1762+c, gdbSNP:397509344
1771+c, gdbSNP:121918469
1782+a, cdbSNP:397507537
1783+c, tdbSNP:121918457
1811+c, tdbSNP:139196273
1829+dbSNP:
1829+g, tdbSNP:143238917
1833+g, tdbSNP:397507538
1851+a, c, tdbSNP:397507539
1852+a, c, tdbSNP:397507540
1872+c, tdbSNP:397507541
1873+g, tdbSNP:397507542
1882+a, gdbSNP:397507543
1884+a, g, tdbSNP:121918458
1885+c, tdbSNP:397507544
1887+a, c, gdbSNP:397507545
1888+a, g, tdbSNP:397507546
1890+a, gdbSNP:397507547
1896+c, tdbSNP:387907157
1897..1898+ag, ccdbSNP:397509345
1897+a, cdbSNP:397507548
1901+a, gdbSNP:374285143
1908+a, c, gdbSNP:397507549
1909+a, c, gdbSNP:121918470
1910+c, gdbSNP:397507550
1955+a, gdbSNP:143801479
1959+c, tdbSNP:191525506
1975+a, gdbSNP:397507551
2001+dbSNP:
2001+a, gdbSNP:186919241
2030+a, gdbSNP:374896287
2038+c, tdbSNP:148176616
2058+c, tdbSNP:397516797
2062+c, tdbSNP:141140214
2063+a, gdbSNP:397516798
2077+c, tdbSNP:150730493
2104+dbSNP:
2104+a, gdbSNP:397516799
2120+c, tdbSNP:139188627
2126+c, tdbSNP:397516800
2175+a, gdbSNP:201957261
2237+dbSNP:
2237+a, gdbSNP:150401860
2289+a, gdbSNP:56328752
2337+g, tdbSNP:11831567
2461+c, tdbSNP:190067634
2466+c, tdbSNP:181914703
2467+a, gdbSNP:187361583
2487+a, gdbSNP:192080780
2543+a, tdbSNP:7138192
2610+c, tdbSNP:372026055
2653+c, gdbSNP:3241
2661+g, tdbSNP:3240
2819+c, tdbSNP:73209639
2826+c, tdbSNP:59642166
2832+a, gdbSNP:112287134
2937+a, gdbSNP:181946923
complement(2963)-t, cdbSNP:138246203
complement(3000)-g, adbSNP:142648640
3053..3054+, gdbSNP:35137864
3168+, gdbSNP:146940557
3226+a, gdbSNP:184934232
3247+a, gdbSNP:189739744
3297+g, tdbSNP:146895091
3317..3325+, tgatgatgadbSNP:199618935
3317..3319+, tgadbSNP:148422684
3361..3363+, atgdbSNP:80269561
3536+c, gdbSNP:139266170
3565+a, gdbSNP:377746315
3698+g, tdbSNP:371375321
3940+c, tdbSNP:182366345
3967+c, tdbSNP:188162577
4041+g, tdbSNP:191798571
4096+g, tdbSNP:183574699
4240+a, gdbSNP:144513512
4291+a, gdbSNP:188963648
4327+c, tdbSNP:192434262
4387+c, tdbSNP:183450083
4406..4410+, cttgadbSNP:372329301
complement(4607)-t, cdbSNP:11556500
4610..4611+, gdbSNP:35369108
4614+a, gdbSNP:186635899
4616+a, tdbSNP:78622120
complement(4664)-g, adbSNP:17849095
4715+a, gdbSNP:373724024
4771+a, gdbSNP:148005691
complement(4791)-g, adbSNP:141655134
4798+a, gdbSNP:371690901
4884+c, tdbSNP:145941353
5013+c, gdbSNP:76233443
5050+, adbSNP:35572550
5075+g, tdbSNP:191451558
complement(5089)-t, adbSNP:190612693
5157+c, tdbSNP:55853479
complement(5168)-g, adbSNP:141870860
5205+c, tdbSNP:41307084
5486+, tdbSNP:57848522
5496+c, gdbSNP:139164037
5543+a, gdbSNP:374962107
5554..5555+, tdbSNP:34105680
5664+a, gdbSNP:149928405
5702+c, tdbSNP:184174716
5848+c, tdbSNP:189762784
complement(5992)-t, cdbSNP:1985752
6060+a, gdbSNP:372268360
complement(6063)-c, adbSNP:182289916
Gene SymbolPTPN11
Gene SynonymBPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Chromosome12
Locus Map12q24
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_002834 Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1, mRNA. On-demand $219.00 7-9
NM_002834 Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1, mRNA. On-demand $219.00 7-9
NM_002834 Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1, mRNA. On-demand $219.00 7-9
NM_002834 Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1, mRNA. On-demand $219.00 7-9
Title The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalon .
Author Ehrman LA, Nardini D, Ehrman S, Rizvi TA, Gulick J, Krenz M, Dasgupta B, Robbins J, Ratner N, Nakafuku M and Waclaw RR.
Journal J. Neurosci. 34 (10), 3767-3778 (2014)
Title Liver kinase B1 expression promotes phosphatase activity and abrogation of receptor tyrosine kinase phosphorylation in human cancer cells .
Author Okon IS, Coughlan KA and Zou MH.
Journal J. Biol. Chem. 289 (3), 1639-1648 (2014)
Title Shp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellum .
Author Li K, Leung AW, Guo Q, Yang W and Li JY.
Journal J. Neurosci. 34 (3), 922-931 (2014)
Title Scalp melanoma in a woman with LEOPARD syndrome: possible implication of PTPN11 signaling in melanoma pathogenesis .
Author Cheng YP, Chiu HY, Hsiao TL, Hsiao CH, Lin CC and Liao YH.
Journal J. Am. Acad. Dermatol. 69 (4), E186-E187 (2013)
Title LEOPARD Syndrome .
Author Gelb,B.D. and Tartaglia,M.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Title Noonan Syndrome .
Author Allanson,J.E. and Roberts,A.E.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Title Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3 with sequence similarity to the src-homology region 2 .
Author Adachi M, Sekiya M, Miyachi T, Matsuno K, Hinoda Y, Imai K and Yachi A.
Journal FEBS Lett. 314 (3), 335-339 (1992)
Title Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew .
Author Freeman RM Jr, Plutzky J and Neel BG.
Journal Proc. Natl. Acad. Sci. U.S.A. 89 (23), 11239-11243 (1992)
Title Protein-tyrosine phosphatase expression in pre-B cell NALM-6 .
Author Adachi M, Sekiya M, Arimura Y, Takekawa M, Itoh F, Hinoda Y, Imai K and Yachi A.
Journal Cancer Res. 52 (3), 737-740 (1992)
Title cDNA cloning of new protein tyrosine phosphatases in the human colon .
Author Arimura Y, Hinoda Y, Itoh F, Takekawa M, Tsujisaki M, Adachi M, Imai K and Yachi A.
Journal Tumour Biol. 13 (3), 180-186 (1992)

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