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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1, mRNA.


RefSeq Accession Definition Services Price Order
NM_002834 Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1, mRNA. ORF Sequence $516.78
Peptide Services
Antibody Services
Protein Services


RefSeq Version NM_002834.3, 33356176
Length 6300 bp
Structure linear
Update Date 21-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1, mRNA.
Product tyrosine-protein phosphatase non-receptor type 11 isoform 1
Comment

Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].


Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

RefSeq NP_002825.3
CDS 381..2162
Misc Feature(1)336..338
Misc Feature(2)393..689
Misc Feature(3)393..689
Misc Feature(4)order(417..419,474..476,537..539,543..545)
Misc Feature(5)order(534..542,582..584,642..653,657..659)
Misc Feature(6)564..566
Misc Feature(7)564..566
Misc Feature(8)567..569
Misc Feature(9)567..569
Misc Feature(10)711..1034
Misc Feature(11)order(795..797,801..803,816..821)
Misc Feature(12)order(888..890,969..971)
Misc Feature(13)1116..1940
Misc Feature(14)1206..1937
Misc Feature(15)1218..1220
Misc Feature(16)order(1653..1655,1752..1757,1764..1766,1773..1778)
Misc Feature(17)1755..1775
Misc Feature(18)2004..2006
Misc Feature(19)2004..2006
Misc Feature(20)2052..2054
Misc Feature(21)2106..2108
Misc Feature(22)2106..2108
Misc Feature(23)2106..2108
Misc Feature(24)2118..2120
Misc Feature(25)2118..2120
Misc Feature(26)2151..2153
Exon (1)1..394
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (2)395..517
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (3)518..712
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (4)713..905
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (5)906..1022
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (6)1023..1136
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (7)1137..1233
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (8)1234..1313
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (9)1314..1472
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (10)1473..1604
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (11)1605..1759
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (12)1760..1827
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (13)1828..1979
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (14)1980..2092
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (15)2093..2194
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Exon (16)2195..6283
Gene:PTPN11
Gene Synonym:BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Translation MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
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Position Chain Variation Link
58+dbSNP:
58+g, tdbSNP:61941345
108+a, gdbSNP:58805176
201+a, gdbSNP:149766959
385+c, tdbSNP:267606990
398+dbSNP:
398+g, tdbSNP:79203122
409+a, gdbSNP:200613531
536+dbSNP:
536+c, tdbSNP:147388185
558..560+, ggtdbSNP:121918471
559..561+, gtgdbSNP:80338836
562+a, gdbSNP:121918461
564+g, tdbSNP:121918460
568+a, gdbSNP:121918459
594+g, tdbSNP:121918453
595+c, gdbSNP:121918454
598+c, tdbSNP:121918462
606+a, gdbSNP:121918464
607+a, c, g, tdbSNP:121918465
616+a, gdbSNP:121918466
635+c, tdbSNP:61736914
756+dbSNP:
756+c, tdbSNP:146497890
792+c, tdbSNP:267606989
806+c, tdbSNP:199498784
832+c, tdbSNP:202026962
847+a, gdbSNP:200712424
917+dbSNP:
917+c, tdbSNP:141015445
936+c, tdbSNP:143433437
938+g, tdbSNP:200920312
945+g, tdbSNP:79068130
971+a, cdbSNP:76982592
996+c, tdbSNP:78376169
1097+dbSNP:
1097+c, gdbSNP:138215269
1216+dbSNP:
1216+a, gdbSNP:121918456
1234+dbSNP:
1234+c, tdbSNP:121918463
1259+c, gdbSNP:117730996
1301+a, gdbSNP:202019810
1302+a, gdbSNP:28933386
1303+a, gdbSNP:121918455
1305+a, gdbSNP:201787206
1312+c, tdbSNP:201226824
1428+dbSNP:
1428+g, tdbSNP:146571700
1433+a, gdbSNP:190776554
1504+dbSNP:
1504+a, gdbSNP:41299183
1606+dbSNP:
1606+c, gdbSNP:201247699
1612+c, tdbSNP:121918467
1676+g, tdbSNP:150524715
1761+dbSNP:
1761+a, gdbSNP:121918468
1771+c, gdbSNP:121918469
1783+c, tdbSNP:121918457
1811+c, tdbSNP:139196273
1829+dbSNP:
1829+g, tdbSNP:143238917
1884+a, tdbSNP:121918458
1909+a, c, gdbSNP:121918470
1955+a, gdbSNP:143801479
1959+c, tdbSNP:191525506
2001+dbSNP:
2001+a, gdbSNP:186919241
2038+c, tdbSNP:148176616
2062+c, tdbSNP:141140214
2077+c, tdbSNP:150730493
2120+dbSNP:
2120+c, tdbSNP:139188627
2175+a, gdbSNP:201957261
2237+dbSNP:
2237+a, gdbSNP:150401860
2289+a, gdbSNP:56328752
2337+g, tdbSNP:11831567
2461+c, tdbSNP:190067634
2466+c, tdbSNP:181914703
2467+a, gdbSNP:187361583
2487+a, gdbSNP:192080780
2543+a, tdbSNP:7138192
2653+c, gdbSNP:3241
2661+g, tdbSNP:3240
2819+c, tdbSNP:73209639
2826+c, tdbSNP:59642166
2832+a, gdbSNP:112287134
2937+a, gdbSNP:181946923
2963+c, tdbSNP:138246203
3000+a, gdbSNP:142648640
3053..3054+, gdbSNP:35137864
3168+, gdbSNP:146940557
3226+a, gdbSNP:184934232
3247+a, gdbSNP:189739744
3297+g, tdbSNP:146895091
3317..3325+, tgatgatgadbSNP:199618935
3317..3319+, tgadbSNP:148422684
3319..3321+, atgdbSNP:80269561
3536+c, gdbSNP:139266170
3940+c, tdbSNP:182366345
3967+c, tdbSNP:188162577
4041+g, tdbSNP:191798571
4096+g, tdbSNP:183574699
4240+a, gdbSNP:144513512
4291+a, gdbSNP:188963648
4327+c, tdbSNP:192434262
4387+c, tdbSNP:183450083
4607+c, tdbSNP:11556500
4610..4611+, gdbSNP:35369108
4614+a, gdbSNP:186635899
4616+a, tdbSNP:78622120
4664+a, gdbSNP:17849095
4771+a, gdbSNP:148005691
4791+a, gdbSNP:141655134
4884+c, tdbSNP:145941353
5013+c, gdbSNP:76233443
5050+, adbSNP:35572550
5075+g, tdbSNP:191451558
5089+a, tdbSNP:190612693
5157+c, tdbSNP:55853479
5168+a, gdbSNP:141870860
5205+c, tdbSNP:41307084
5484+, tdbSNP:57848522
5496+c, gdbSNP:139164037
5554..5555+, tdbSNP:34105680
5664+a, gdbSNP:149928405
5702+c, tdbSNP:184174716
5848+c, tdbSNP:189762784
5992+c, tdbSNP:1985752
6063+a, cdbSNP:182289916
Gene SymbolPTPN11
Gene SynonymBPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Chromosome12
Locus Map12q24
All Transcripts
RefSeq Accession Definition Sequence Price Select
NM_002834 Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1, mRNA. Full Length $2835.00
ORF Sequence $516.78
NM_080601 Homo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 2, mRNA. Full Length $600.01
ORF Sequence $401.07
Title Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2 .
Author Yu,J., Deng,R., Zhu,H.H., Zhang,S.S., Zhu,C., Montminy,M., Davis,R. and Feng,G.S.
Journal J. Biol. Chem. 288 (6), 3823-3830 (2013)
Title The vitamin K-dependent anticoagulant factor, protein S, inhibits multiple VEGF-A-induced angiogenesis events in a Mer- and SHP2-dependent manner .
Author Fraineau,S., Monvoisin,A., Clarhaut,J., Talbot,J., Simonneau,C., Kanthou,C., Kanse,S.M., Philippe,M. and Benzakour,O.
Journal Blood 120 (25), 5073-5083 (2012)
Title Src homology 2 domain-containing phosphatase 2 (Shp2) is a component of the A-kinase-anchoring protein (AKAP)-Lbc complex and is inhibited by protein kinase A (PKA) under pathological hypertrophic conditions in the heart .
Author Burmeister,B.T., Taglieri,D.M., Wang,L. and Carnegie,G.K.
Journal J. Biol. Chem. 287 (48), 40535-40546 (2012)
Title The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of beta-catenin phosphorylation .
Author Timmerman,I., Hoogenboezem,M., Bennett,A.M., Geerts,D., Hordijk,P.L. and van Buul,J.D.
Journal Mol. Biol. Cell 23 (21), 4212-4225 (2012)
Title Src homology-2 domain-containing protein tyrosine phosphatase (SHP) 2 and p38 regulate the expression of chemokine CXCL8 in human astrocytes .
Author Mamik,M.K. and Ghorpade,A.
Journal PLoS ONE 7 (9), E45596 (2012)
Title Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction .
Author Kharitonenkov,A., Schnekenburger,J., Chen,Z., Knyazev,P., Ali,S., Zwick,E., White,M. and Ullrich,A.
Journal J. Biol. Chem. 270 (49), 29189-29193 (1995)
Title Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3 with sequence similarity to the src-homology region 2 .
Author Adachi,M., Sekiya,M., Miyachi,T., Matsuno,K., Hinoda,Y., Imai,K. and Yachi,A.
Journal FEBS Lett. 314 (3), 335-339 (1992)
Title Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew .
Author Freeman,R.M. Jr., Plutzky,J. and Neel,B.G.
Journal Proc. Natl. Acad. Sci. U.S.A. 89 (23), 11239-11243 (1992)
Title Protein-tyrosine phosphatase expression in pre-B cell NALM-6 .
Author Adachi,M., Sekiya,M., Arimura,Y., Takekawa,M., Itoh,F., Hinoda,Y., Imai,K. and Yachi,A.
Journal Cancer Res. 52 (3), 737-740 (1992)
Title cDNA cloning of new protein tyrosine phosphatases in the human colon .
Author Arimura,Y., Hinoda,Y., Itoh,F., Takekawa,M., Tsujisaki,M., Adachi,M., Imai,K. and Yachi,A.
Journal Tumour Biol. 13 (3), 180-186 (1992)

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