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Homo sapiens chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) (CCL18), mRNA.

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002988 Homo sapiens chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) (CCL18), mRNA. GenEZ ORF Cloning On-demand $299.00 14

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RefSeq Version NM_002988.2, 22547150
Length 793 bp
Structure linear
Update Date 17-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) (CCL18), mRNA.
Product C-C motif chemokine 18 precursor

Summary: This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Jul 2008].

RefSeq NP_002979.1
CDS 61..330
Misc Feature(1)34..36
Misc Feature(2)148..318
Misc Feature(3)order(148..162,166..189,217..222,286..318)
Misc Feature(4)order(154..156,160..162,199..201,205..207,220..222,
Misc Feature(5)order(154..156,160..162,211..213,217..222,238..240,
Misc Feature(6)order(154..156,238..240,265..267)
Misc Feature(7)order(154..162,166..189)
Misc Feature(8)order(160..162,199..201,205..207,235..237,241..243,
Misc Feature(9)order(166..174,181..189,253..255,259..261)
Misc Feature(10)order(205..207,226..228,280..282,286..288,295..300,
Misc Feature(11)217..222
Misc Feature(12)order(247..249,253..255)
Exon (1)1..127
Gene Synonym:AMAC-1; AMAC1; CKb7; DC-CK1; DCCK1; MIP-4; PARC; SCYA18
Exon (2)128..239
Gene Synonym:AMAC-1; AMAC1; CKb7; DC-CK1; DCCK1; MIP-4; PARC; SCYA18
Exon (3)240..770
Gene Synonym:AMAC-1; AMAC1; CKb7; DC-CK1; DCCK1; MIP-4; PARC; SCYA18
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Position Chain Variation Link
79+a, gdbSNP:73290772
157+a, gdbSNP:138061691
186+a, gdbSNP:201008180
280+a, gdbSNP:149506889
281+a, gdbSNP:150076657
288+a, gdbSNP:200043307
297+c, gdbSNP:148220878
376+a, tdbSNP:138678712
424+a, gdbSNP:14304
510+c, tdbSNP:113206976
520+c, tdbSNP:142865584
581+a, gdbSNP:766555
608+a, gdbSNP:766556
758+a, g, tdbSNP:111899690
Gene SymbolCCL18
Gene SynonymAMAC-1; AMAC1; CKb7; DC-CK1; DCCK1; MIP-4; PARC; SCYA18
Locus Map17q11.2
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_002988 Homo sapiens chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) (CCL18), mRNA. On-demand $299.00 14
Title Enhanced production of CCL18 by tolerogenic dendritic cells is associated with inhibition of allergic airway reactivity .
Author Bellinghausen,I., Reuter,S., Martin,H., Maxeiner,J., Luxemburger,U., Tureci,O., Grabbe,S., Taube,C. and Saloga,J.
Journal J. Allergy Clin. Immunol. 130 (6), 1384-1393 (2012)
Title Pulmonary CCL18 recruits human regulatory T cells .
Author Chenivesse,C., Chang,Y., Azzaoui,I., Ait Yahia,S., Morales,O., Ple,C., Foussat,A., Tonnel,A.B., Delhem,N., Yssel,H., Vorng,H., Wallaert,B. and Tsicopoulos,A.
Journal J. Immunol. 189 (1), 128-137 (2012)
Title Gene expression profiles in paired gingival biopsies from periodontitis-affected and healthy tissues revealed by massively parallel sequencing .
Author Davanian,H., Stranneheim,H., Bage,T., Lagervall,M., Jansson,L., Lundeberg,J. and Yucel-Lindberg,T.
Journal PLoS ONE 7 (9), E46440 (2012)
Title Chemokines CCL3/MIP1alpha, CCL5/RANTES and CCL18/PARC are independent risk predictors of short-term mortality in patients with acute coronary syndromes .
Author de Jager,S.C., Bongaerts,B.W., Weber,M., Kraaijeveld,A.O., Rousch,M., Dimmeler,S., van Dieijen-Visser,M.P., Cleutjens,K.B., Nelemans,P.J., van Berkel,T.J. and Biessen,E.A.
Journal PLoS ONE 7 (9), E45804 (2012)
Title Serum level of CC-chemokine ligand 18 is increased in patients with non-small-cell lung cancer and correlates with survival time in adenocarcinomas .
Author Plones,T., Krohn,A., Burger,M., Veelken,H., Passlick,B., Muller-Quernheim,J. and Zissel,G.
Journal PLoS ONE 7 (7), E41746 (2012)
Title Chemokine PARC gene (SCYA18) generated by fusion of two MIP-1alpha/LD78alpha-like genes .
Author Tasaki,Y., Fukuda,S., Iio,M., Miura,R., Imai,T., Sugano,S., Yoshie,O., Hughes,A.L. and Nomiyama,H.
Journal Genomics 55 (3), 353-357 (1999)
Title Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern .
Author Kodelja,V., Muller,C., Politz,O., Hakij,N., Orfanos,C.E. and Goerdt,S.
Journal J. Immunol. 160 (3), 1411-1418 (1998)
Title A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes .
Author Hieshima,K., Imai,T., Baba,M., Shoudai,K., Ishizuka,K., Nakagawa,T., Tsuruta,J., Takeya,M., Sakaki,Y., Takatsuki,K., Miura,R., Opdenakker,G., Van Damme,J., Yoshie,O. and Nomiyama,H.
Journal J. Immunol. 159 (3), 1140-1149 (1997)
Title A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells .
Author Adema,G.J., Hartgers,F., Verstraten,R., de Vries,E., Marland,G., Menon,S., Foster,J., Xu,Y., Nooyen,P., McClanahan,T., Bacon,K.B. and Figdor,C.G.
Journal Nature 387 (6634), 713-717 (1997)
Title The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases .
Author Wells,T.N. and Peitsch,M.C.
Journal J. Leukoc. Biol. 61 (5), 545-550 (1997)

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