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Homo sapiens succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB), mRNA.


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_003000 Homo sapiens succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB), mRNA. GenEZ ORF Cloning On-demand $449.00 14

*Business Day

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RefSeq Version NM_003000.2, 115387093
Length 1161 bp
Structure linear
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB), mRNA.
Product succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor
Comment

Summary: Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008].

RefSeq NP_002991.2
CDS 152..994
Misc Feature(1)122..124
Misc Feature(2)164..964
Misc Feature(3)317..>478
Misc Feature(4)order(416..421,428..430,437..439,443..454)
Misc Feature(5)order(428..430,443..445,452..454)
Misc Feature(6)704..925
Exon (1)1..223
Gene:SDHB
Gene Synonym:CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP
Exon (2)224..351
Gene:SDHB
Gene Synonym:CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP
Exon (3)352..437
Gene:SDHB
Gene Synonym:CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP
Exon (4)438..574
Gene:SDHB
Gene Synonym:CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP
Exon (5)575..691
Gene:SDHB
Gene Synonym:CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP
Exon (6)692..793
Gene:SDHB
Gene Synonym:CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP
Exon (7)794..916
Gene:SDHB
Gene Synonym:CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP
Exon (8)917..1153
Gene:SDHB
Gene Synonym:CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP
Translation MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQT YEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTN LNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKL DGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSL YRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV
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Position Chain Variation Link
complement(13)-dbSNP:
complement(13)-c, adbSNP:114522228
complement(20)-t, cdbSNP:201399804
complement(35..36)-, cdbSNP:34633163
complement(42)-t, gdbSNP:200295549
complement(56)-g, adbSNP:377524880
complement(73)-g, adbSNP:201830436
complement(78)-t, cdbSNP:201016499
complement(84)-t, adbSNP:200229285
complement(107)-t, cdbSNP:202039513
complement(114)-g, adbSNP:201233054
complement(115)-g, adbSNP:143031690
complement(118)-c, adbSNP:371505816
complement(137)-t, cdbSNP:201837175
complement(144)-g, cdbSNP:376889033
146+a, gdbSNP:2295056
complement(147)-g, adbSNP:200890535
complement(156)-g, adbSNP:199948437
159+c, gdbSNP:11203289
169+a, cdbSNP:2746462
complement(172)-g, adbSNP:147815442
complement(174)-g, adbSNP:199848267
complement(175)-g, adbSNP:148738139
complement(182)-g, adbSNP:200868378
complement(183)-t, cdbSNP:111430410
complement(184)-g, adbSNP:146399542
complement(190)-t, cdbSNP:201745731
complement(201)-g, adbSNP:138979875
complement(216)-g, cdbSNP:141230910
complement(226)-dbSNP:
complement(226)-g, adbSNP:200329668
230+c, g, tdbSNP:74315369
complement(231)-t, cdbSNP:373976827
263..264+, ccdbSNP:398123690
complement(263)-g, adbSNP:202119350
complement(264)-t, cdbSNP:143058777
complement(274)-t, cdbSNP:137877851
complement(281)-t, cdbSNP:200418115
287+c, gdbSNP:74315370
complement(294)-t, adbSNP:202101384
complement(300)-t, cdbSNP:201219456
complement(309)-t, cdbSNP:34916635
complement(321)-t, cdbSNP:35962811
complement(329)-t, cdbSNP:34599281
complement(342)-t, gdbSNP:200131173
complement(359)-dbSNP:
complement(359)-t, gdbSNP:200890320
complement(373)-t, adbSNP:199678117
complement(376)-g, adbSNP:201762207
complement(415)-g, cdbSNP:41310416
419+c, tdbSNP:74315366
450+dbSNP:
450+c, tdbSNP:121917755
451+c, tdbSNP:11541235
453+a, gdbSNP:74315371
complement(458)-t, cdbSNP:140178341
complement(495)-c, adbSNP:200973284
complement(503)-t, cdbSNP:200021702
507+c, tdbSNP:11541234
complement(527)-t, cdbSNP:202095022
complement(530)-t, gdbSNP:201372280
546+a, c, gdbSNP:74315372
complement(550)-c, adbSNP:201403014
complement(552)-t, cdbSNP:200893429
complement(554)-t, cdbSNP:201585157
566+c, tdbSNP:397516834
569+g, tdbSNP:267607032
complement(574)-t, g, adbSNP:150542357
complement(598)-dbSNP:
complement(598)-c, adbSNP:200353146
complement(606)-g, adbSNP:200414835
complement(619)-g, adbSNP:199718947
complement(667)-t, cdbSNP:138937650
complement(672)-g, adbSNP:200301019
complement(674)-g, cdbSNP:202203339
complement(678)-t, cdbSNP:201082445
complement(680)-g, adbSNP:149091125
complement(681)-t, cdbSNP:150437793
complement(692)-dbSNP:
complement(692)-t, cdbSNP:201385062
complement(694)-g, adbSNP:199809975
complement(695)-t, cdbSNP:201928318
complement(703)-g, adbSNP:202098600
complement(719)-t, cdbSNP:199789177
complement(720)-g, adbSNP:201900648
726+c, gdbSNP:397516835
complement(732)-g, cdbSNP:200535030
741+c, gdbSNP:74315367
751+a, gdbSNP:397516836
complement(757)-g, adbSNP:199653121
complement(758)-t, cdbSNP:201517260
785+c, tdbSNP:17354040
complement(789)-g, adbSNP:202014362
complement(800)-dbSNP:
complement(800)-g, adbSNP:200245469
complement(839)-g, adbSNP:138996609
complement(851)-g, adbSNP:201728852
complement(853)-t, cdbSNP:370397369
complement(860)-g, adbSNP:186768244
complement(867)-g, c, adbSNP:201098090
876+a, gdbSNP:74315368
complement(887)-t, cdbSNP:146800605
complement(890)-t, cdbSNP:200896502
complement(904)-t, cdbSNP:201094649
complement(912)-, gdbSNP:34309090
complement(922)-dbSNP:
complement(922)-g, cdbSNP:199714034
complement(1012)-t, cdbSNP:201588339
complement(1023)-g, adbSNP:200504954
complement(1024)-g, adbSNP:199701267
complement(1096)-t, cdbSNP:201155896
complement(1100)-t, cdbSNP:200366300
complement(1104)-g, adbSNP:201950006
complement(1113..1114)-, adbSNP:35417465
complement(1123)-t, cdbSNP:191249882
complement(1127)-g, adbSNP:111686611
complement(1137)-g, adbSNP:201524374
complement(1144)-t, cdbSNP:200374366
complement(1146)-t, gdbSNP:202218720
complement(1153)-t, cdbSNP:75557632
Gene SymbolSDHB
Gene SynonymCWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP
Chromosome1
Locus Map1p36.1-p35
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_003000 Homo sapiens succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB), mRNA. On-demand $449.00 14
Title Identification of succinate dehydrogenase-deficient bladder paragangliomas .
Author Mason EF, Sadow PM, Wagner AJ, Remillard SP, Flood TA, Belanger EC, Hornick JL and Barletta JA.
Journal Am. J. Surg. Pathol. 37 (10), 1612-1618 (2013)
Title Reduced succinate dehydrogenase B expression is associated with growth and de-differentiation of colorectal cancer cells .
Author Zhang D, Wang W, Xiang B, Li N, Huang S, Zhou W, Sun Y, Wang X, Ma J, Li G, Li X and Shen S.
Journal Tumour Biol. 34 (4), 2337-2347 (2013)
Title [Familial paraganglioma syndrome: phenotype and relevance of a new .
Author Diaz-Soto G, Serrano Morte A, Rodriguez Martin C, Garcia-Talavera P, Abril CM and Puig-Domingo M.
Journal Med Clin (Barc) 140 (10), 453-457 (2013)
Title Paraganglioma of the carotid body: treatment strategy and SDH-gene mutations .
Author Fruhmann J, Geigl JB, Konstantiniuk P and Cohnert TU.
Journal Eur J Vasc Endovasc Surg 45 (5), 431-436 (2013)
Title Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma .
Author Astuti D, Latif F, Dallol A, Dahia PL, Douglas F, George E, Skoldberg F, Husebye ES, Eng C and Maher ER.
Journal Am. J. Hum. Genet. 69 (1), 49-54 (2001)
Title Structural organization of the gene encoding the human iron-sulfur subunit of succinate dehydrogenase .
Author Au HC, Ream-Robinson D, Bellew LA, Broomfield PL, Saghbini M and Scheffler IE.
Journal Gene 159 (2), 249-253 (1995)
Title Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins .
Author Fridell RA, Harding LS, Bogerd HP and Cullen BR.
Journal Virology 209 (2), 347-357 (1995)
Title Hereditary Paraganglioma-Pheochromocytoma Syndromes .
Author Kirmani,S. and Young,W.F.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Title Human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of iron sulfur (Ip) subunit of liver mitochondria .
Author Kita K, Oya H, Gennis RB, Ackrell BA and Kasahara M.
Journal Biochem. Biophys. Res. Commun. 166 (1), 101-108 (1990)
Title Use of the DNA polymerase chain reaction for homology probing: isolation of partial cDNA or genomic clones encoding the iron-sulfur protein of succinate dehydrogenase from several species .
Author Gould SJ, Subramani S and Scheffler IE.
Journal Proc. Natl. Acad. Sci. U.S.A. 86 (6), 1934-1938 (1989)

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