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Homo sapiens surfactant protein C (SFTPC), transcript variant 1, mRNA.

Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu22601 Homo sapiens surfactant protein C (SFTPC), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand $159.00 7-9
OHu22601C Homo sapiens surfactant protein C (SFTPC), transcript variant 1, mRNA. Customized vector On-demand $209.00 7-9

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Mutation services

Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_003018.3, 149999607
Length 594 bp
Update Date 10-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens surfactant protein C (SFTPC), transcript variant 1, mRNA.
Product pulmonary surfactant-associated protein C isoform 1 proprotein

Summary: This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010].

Transcript Variant: This variant (1) encodes the longer isoform (1).

RefSeq NP_003009.2
CDS 159..752
Misc Feature(1)102..104
Misc Feature(2)159..749
Misc Feature(3)159..749
Misc Feature(4)159..437
Misc Feature(5)438..749
Exon (1)1..200
Gene Synonym:BRICD6; PSP-C; SFTP2; SMDP2; SP-C
Exon (2)201..359
Gene Synonym:BRICD6; PSP-C; SFTP2; SMDP2; SP-C
Exon (3)360..482
Gene Synonym:BRICD6; PSP-C; SFTP2; SMDP2; SP-C
Exon (4)483..593
Gene Synonym:BRICD6; PSP-C; SFTP2; SMDP2; SP-C
Exon (5)594..770
Gene Synonym:BRICD6; PSP-C; SFTP2; SMDP2; SP-C
Exon (6)771..984
Gene Synonym:BRICD6; PSP-C; SFTP2; SMDP2; SP-C
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Position Chain Variation Link
25+c, gdbSNP:28438700
59+a, gdbSNP:74639360
67+c, gdbSNP:79647630
68+c, tdbSNP:77253713
92+c, tdbSNP:377267823
93+a, gdbSNP:367559125
103..104+, aadbSNP:369712955
107+c, tdbSNP:373338880
128+a, gdbSNP:200665803
141+c, tdbSNP:78201008
149+c, gdbSNP:371755328
168+a, gdbSNP:201896861
182+c, gdbSNP:144603526
184+c, tdbSNP:11552815
194+c, tdbSNP:369413166
200+a, gdbSNP:199905878
201+a, gdbSNP:376399274
212+a, gdbSNP:11552816
220+a, gdbSNP:371321234
225+c, tdbSNP:375581850
226+a, gdbSNP:75902455
234+a, gdbSNP:368656172
252+c, tdbSNP:192391655
261+c, tdbSNP:199854076
272+c, tdbSNP:375940265
273+a, g, tdbSNP:183533911
315+a, gdbSNP:200039720
317+c, tdbSNP:376182452
327+a, gdbSNP:369239281
334+a, gdbSNP:201567623
353+a, gdbSNP:188074517
354+a, gdbSNP:121917836
376+c, tdbSNP:121917834
383+a, gdbSNP:369210212
385+c, tdbSNP:201454136
386+c, gdbSNP:75413490
399+c, tdbSNP:377222742
422+a, gdbSNP:370641482
446+c, tdbSNP:79866047
458+c, tdbSNP:377655715
461+c, tdbSNP:370825102
476+a, cdbSNP:201933678
492+a, gdbSNP:372529179
505+a, cdbSNP:121918559
509+a, cdbSNP:35457216
522+a, tdbSNP:75609798
523+a, cdbSNP:77034580
525+a, gdbSNP:78029713
571+a, cdbSNP:4715
571+g, tdbSNP:386594846
597+a, gdbSNP:374909143
621+c, gdbSNP:202145169
632+c, gdbSNP:373783536
648+a, gdbSNP:371013652
692+a, gdbSNP:149606090
699+c, gdbSNP:201685063
715+a, gdbSNP:1124
721+a, tdbSNP:121917835
723+c, tdbSNP:76821562
729+a, gdbSNP:200839715
739+c, tdbSNP:121918560
749+c, tdbSNP:3203602
752+c, gdbSNP:370068089
764+a, tdbSNP:200469074
768+a, c, gdbSNP:12229
780+a, gdbSNP:1804453
788+a, gdbSNP:75518353
complement(866)-g, adbSNP:11552817
875+a, gdbSNP:7592
925+c, tdbSNP:1126931
926+a, g, tdbSNP:1139547
934+c, gdbSNP:8192331
complement(968)-t, cdbSNP:8192342
Gene SymbolSFTPC
Gene SynonymBRICD6; PSP-C; SFTP2; SMDP2; SP-C
Locus Map8p21
Title The BRICHOS domain, amyloid fibril formation, and their relationship .
Author Knight SD, Presto J, Linse S and Johansson J.
Journal Biochemistry 52 (43), 7523-7531 (2013)
Title Lung fibrosis-associated surfactant protein A1 and C variants induce latent transforming growth factor beta1 secretion in lung epithelial cells .
Author Maitra M, Dey M, Yuan WC, Nathanielsz PW and Garcia CK.
Journal J. Biol. Chem. 288 (38), 27159-27171 (2013)
Title Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci .
Author Weissglas-Volkov D, Aguilar-Salinas CA, Nikkola E, Deere KA, Cruz-Bautista I, Arellano-Campos O, Munoz-Hernandez LL, Gomez-Munguia L, Ordonez-Sanchez ML, Reddy PM, Lusis AJ, Matikainen N, Taskinen MR, Riba L, Cantor RM, Sinsheimer JS, Tusie-Luna T and Pajukanta P.
Journal J. Med. Genet. 50 (5), 298-308 (2013)
Title Detection of surfactant proteins A, B, C, and D in human nasal mucosa and their regulation in chronic rhinosinusitis with polyps .
Author Schicht M, Knipping S, Hirt R, Beileke S, Sel S, Paulsen F and Brauer L.
Journal Am J Rhinol Allergy 27 (1), 24-29 (2013)
Title The surfactant protein C mutation A116D alters cellular processing, stress tolerance, surfactant lipid composition, and immune cell activation .
Author Zarbock R, Woischnik M, Sparr C, Thurm T, Kern S, Kaltenborn E, Hector A, Hartl D, Liebisch G, Schmitz G and Griese M.
Journal BMC Pulm Med 12, 15 (2012)
Title Pulmonary Fibrosis, Familial .
Author Talbert,J.L. and Schwartz,D.A.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Title The pulmonary surfactant protein C (SP-C) precursor is a type II transmembrane protein .
Author Keller A, Eistetter HR, Voss T and Schafer KP.
Journal Biochem. J. 277 (PT 2), 493-499 (1991)
Title Interaction between perdeuterated dimyristoylphosphatidylcholine and low molecular weight pulmonary surfactant protein SP-C .
Author Simatos GA, Forward KB, Morrow MR and Keough KM.
Journal Biochemistry 29 (24), 5807-5814 (1990)
Title Hydrophobic surfactant-associated polypeptides: SP-C is a lipopeptide with two palmitoylated cysteine residues, whereas SP-B lacks covalently linked fatty acyl groups .
Author Curstedt T, Johansson J, Persson P, Eklund A, Robertson B, Lowenadler B and Jornvall H.
Journal Proc. Natl. Acad. Sci. U.S.A. 87 (8), 2985-2989 (1990)
Title Two SP-C genes encoding human pulmonary surfactant proteolipid .
Author Glasser SW, Korfhagen TR, Perme CM, Pilot-Matias TJ, Kister SE and Whitsett JA.
Journal J. Biol. Chem. 263 (21), 10326-10331 (1988)

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