Sequence in raw or FASTA format:
Homo sapiens cyclin A1 (CCNA1), transcript variant 1, mRNA.
|RefSeq Version||NM_003914.3, 161377466|
|Organism||Homo sapiens (human)|
|Definition||Homo sapiens cyclin A1 (CCNA1), transcript variant 1, mRNA.|
|Product||cyclin-A1 isoform a|
Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
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|Title||Altered expression of cyclin A 1 in muscle of patients with facioscapulohumeral muscle dystrophy (FSHD-1) .|
|Author||Pakula A, Schneider J, Janke J, Zacharias U, Schulz H, Hubner N, Mahler A, Spuler A, Spuler S, Carlier P and Boschmann M.|
|Journal||PLoS ONE 8 (9), E73573 (2013)|
|Title||Cyclin A1 modulates the expression of vascular endothelial growth factor and promotes hormone-dependent growth and angiogenesis of breast cancer .|
|Author||Syed Khaja AS, Dizeyi N, Kopparapu PK, Anagnostaki L, Harkonen P and Persson JL.|
|Journal||PLoS ONE 8 (8), E72210 (2013)|
|Title||Foxo3a drives proliferation in anaplastic thyroid carcinoma through transcriptional regulation of cyclin A1: a paradigm shift that impacts current therapeutic strategies .|
|Author||Marlow LA, von Roemeling CA, Cooper SJ, Zhang Y, Rohl SD, Arora S, Gonzales IM, Azorsa DO, Reddi HV, Tun HW, Doppler HR, Storz P, Smallridge RC and Copland JA.|
|Journal||J. Cell. Sci. 125 (PT 18), 4253-4263 (2012)|
|Title||Inverse relationship between TCTP/RhoA and p53 /cyclin A/actin expression in ovarian cancer cells .|
|Author||Kloc M, Tejpal N, Sidhu J, Ganachari M, Flores-Villanueva P, Jennings NB, Sood AK, Kubiak JZ and Ghobrial RM.|
|Journal||Folia Histochem. Cytobiol. 50 (3), 358-367 (2012)|
|Title||Expression of cyclins A and E in melanocytic skin lesions and its correlation with some clinicopathologic features .|
|Author||Alekseenko A, Wojas-Pelc A, Lis GJ, Wisniowski Z, Czerwinska M, Niewiara L and Litwin JA.|
|Journal||Folia Histochem. Cytobiol. 50 (2), 263-269 (2012)|
|Title||Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines .|
|Author||Yang R, Morosetti R and Koeffler HP.|
|Journal||Cancer Res. 57 (5), 913-920 (1997)|
|Title||Cyclin-binding motifs are essential for the function of p21CIP1 .|
|Author||Chen J, Saha P, Kornbluth S, Dynlacht BD and Dutta A.|
|Journal||Mol. Cell. Biol. 16 (9), 4673-4682 (1996)|
|Title||A distinct cyclin A is expressed in germ cells in the mouse .|
|Author||Sweeney C, Murphy M, Kubelka M, Ravnik SE, Hawkins CF, Wolgemuth DJ and Carrington M.|
|Journal||Development 122 (1), 53-64 (1996)|
|Title||Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins .|
|Author||Hall M, Bates S and Peters G.|
|Journal||Oncogene 11 (8), 1581-1588 (1995)|
|Title||Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation .|
|Author||Xu M, Sheppard KA, Peng CY, Yee AS and Piwnica-Worms H.|
|Journal||Mol. Cell. Biol. 14 (12), 8420-8431 (1994)|
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