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Homo sapiens ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (UCHL1), mRNA.


Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu19475 Homo sapiens ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (UCHL1), mRNA. pcDNA3.1+-DYK In-stock $99.00 5-7
OHu19475C Homo sapiens ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (UCHL1), mRNA. Customized vector In-stock $149.00 5-7

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Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_004181.4, 239835751
Length 672 bp
Structure linear
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (UCHL1), mRNA.
Product ubiquitin carboxyl-terminal hydrolase isozyme L1
Comment

Summary: The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009].

RefSeq NP_004172.2
CDS 97..768
Misc Feature(1)67..69
Misc Feature(2)97..99
Misc Feature(3)97..99
Misc Feature(4)109..753
Misc Feature(5)order(109..126,184..195,250..252,364..366,574..576,
Misc Feature(6)order(109..111,346..348,358..360,364..366,574..579)
Misc Feature(7)109..126
Misc Feature(8)112..114
Misc Feature(9)130..132
Misc Feature(10)order(346..348,364..366,577..579,622..624)
Misc Feature(11)466..468
Misc Feature(12)622..624
Misc Feature(13)631..633
Misc Feature(14)727..744
Misc Feature(15)754..756
Exon (1)1..129
Gene:UCHL1
Gene Synonym:HEL-117; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; Uch-L1
Exon (2)130..141
Gene:UCHL1
Gene Synonym:HEL-117; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; Uch-L1
Exon (3)142..270
Gene:UCHL1
Gene Synonym:HEL-117; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; Uch-L1
Exon (4)271..421
Gene:UCHL1
Gene Synonym:HEL-117; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; Uch-L1
Exon (5)422..507
Gene:UCHL1
Gene Synonym:HEL-117; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; Uch-L1
Exon (6)508..555
Gene:UCHL1
Gene Synonym:HEL-117; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; Uch-L1
Exon (7)556..622
Gene:UCHL1
Gene Synonym:HEL-117; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; Uch-L1
Exon (8)623..681
Gene:UCHL1
Gene Synonym:HEL-117; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; Uch-L1
Exon (9)682..1124
Gene:UCHL1
Gene Synonym:HEL-117; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; Uch-L1
Translation MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHE NFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSE TEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMP FPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
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Position Chain Variation Link
26+dbSNP:
26+c, gdbSNP:201100258
46+c, gdbSNP:371943957
47+c, tdbSNP:375794773
69+a, gdbSNP:201952662
complement(73)-t, cdbSNP:11556271
73+a, gdbSNP:386477779
80+c, tdbSNP:367935445
81+c, tdbSNP:9321
86+g, tdbSNP:200302762
111..112+a, gdbSNP:11556276
112+a, tdbSNP:201864413
116+a, cdbSNP:397515634
149+dbSNP:
149+a, cdbSNP:5030732
153+c, gdbSNP:370928430
216+c, gdbSNP:375032754
255+c, tdbSNP:11556278
311+dbSNP:
311+a, gdbSNP:189371541
319+a, gdbSNP:148096293
332+c, tdbSNP:11556275
360+c, tdbSNP:111649115
362+c, tdbSNP:11556279
375+c, g, tdbSNP:121917767
387+c, tdbSNP:192697162
443+dbSNP:
443+a, tdbSNP:372479324
complement(449)-t, cdbSNP:11556274
452+c, tdbSNP:141828940
466+a, cdbSNP:150601238
479+a, gdbSNP:376624356
499+a, cdbSNP:200775509
503+a, gdbSNP:139618482
531+dbSNP:
531+c, tdbSNP:142811772
540+a, gdbSNP:147393026
553+c, tdbSNP:139583787
576+dbSNP:
576+c, tdbSNP:146069195
609+c, tdbSNP:145093131
615+c, tdbSNP:374340108
654+dbSNP:
654+c, tdbSNP:116680633
705+dbSNP:
705+a, gdbSNP:147661219
711+c, tdbSNP:375527220
760+a, gdbSNP:112666846
781+a, gdbSNP:370431599
785+c, gdbSNP:369814359
788+c, tdbSNP:77194345
899+c, tdbSNP:183586019
945..946+gc, tgdbSNP:386673866
1002+g, tdbSNP:115323706
complement(1008)-c, adbSNP:11556270
complement(1013)-t, cdbSNP:140683078
1044+a, tdbSNP:116336893
1062+a, gdbSNP:116700032
1077+c, tdbSNP:78683791
1122+a, gdbSNP:369393584
Gene SymbolUCHL1
Gene SynonymHEL-117; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; Uch-L1
Chromosome4
Locus Map4p14
Title KSHV LANA and EBV LMP1 induce the expression of UCH-L1 following viral transformation .
Author Bentz GL, Bheda-Malge A, Wang L, Shackelford J, Damania B and Pagano JS.
Journal Virology 448, 293-302 (2014)
Title Heterogeneous expression and functional relevance of the ubiquitin carboxyl-terminal hydrolase L1 in melanoma .
Author Wulfanger J, Biehl K, Tetzner A, Wild P, Ikenberg K, Meyer S and Seliger B.
Journal Int. J. Cancer 133 (11), 2522-2532 (2013)
Title Prognostic relevance of ubiquitin C-terminal hydrolase L1 (UCH-L1) mRNA and protein expression in breast cancer patients .
Author Schroder C, Milde-Langosch K, Gebauer F, Schmid K, Mueller V, Wirtz RM, Meyer-Schwesinger C, Schluter H, Sauter G and Schumacher U.
Journal J. Cancer Res. Clin. Oncol. 139 (10), 1745-1755 (2013)
Title Expression of neuronal markers in the endometrium of women with and those without endometriosis .
Author Newman TA, Bailey JL, Stocker LJ, Woo YL, Macklon NS and Cheong YC.
Journal Hum. Reprod. 28 (9), 2502-2510 (2013)
Title The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis .
Author Sosna J, Voigt S, Mathieu S, Kabelitz D, Trad A, Janssen O, Meyer-Schwesinger C, Schutze S and Adam D.
Journal Cell Commun. Signal 11, 76 (2013)
Title Parkinson Disease Overview .
Author Farlow,J., Pankratz,N.D., Wojcieszek,J. and Foroud,T.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Title Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes .
Author Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE and Vandekerckhove J.
Journal Electrophoresis 13 (12), 960-969 (1992)
Title The gene for human neurone specific ubiquitin C-terminal hydrolase (UCHL1, PGP9.5) maps to chromosome 4p14 .
Author Edwards YH, Fox MF, Povey S, Hinks LJ, Thompson RJ and Day IN.
Journal Ann. Hum. Genet. 55 (PT 4), 273-278 (1991)
Title Neuronal protein gene product 9.5 (IEF SSP 6104) is expressed in cultured human MRC-5 fibroblasts of normal origin and is strongly down-regulated in their SV40 transformed counterparts .
Author Honore B, Rasmussen HH, Vandekerckhove J and Celis JE.
Journal FEBS Lett. 280 (2), 235-240 (1991)
Title The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase .
Author Day IN, Hinks LJ and Thompson RJ.
Journal Biochem. J. 268 (2), 521-524 (1990)

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