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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


Homo sapiens BCL2-associated athanogene 3 (BAG3), mRNA.


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_004281 Homo sapiens BCL2-associated athanogene 3 (BAG3), mRNA. GenEZ ORF Cloning On-demand $849.00 20

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RefSeq Version NM_004281.3, 62530382
Length 2608 bp
Structure linear
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens BCL2-associated athanogene 3 (BAG3), mRNA.
Product BAG family molecular chaperone regulator 3
Comment

Summary: BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008].

RefSeq NP_004272.2
CDS 307..2034
Misc Feature(1)310..312
Misc Feature(2)310..312
Misc Feature(3)373..465
Misc Feature(4)order(418..420,451..453)
Misc Feature(5)817..819
Misc Feature(6)898..900
Misc Feature(7)1024..1026
Misc Feature(8)1045..1047
Misc Feature(9)1096..1098
Misc Feature(10)1126..1128
Misc Feature(11)1126..1128
Misc Feature(12)1129..1131
Misc Feature(13)1129..1131
Misc Feature(14)1141..1143
Misc Feature(15)1141..1143
Misc Feature(16)1153..1155
Misc Feature(17)1159..1161
Misc Feature(18)1159..1161
Misc Feature(19)1171..1173
Misc Feature(20)1171..1173
Misc Feature(21)1177..1179
Misc Feature(22)1435..1437
Misc Feature(23)1435..1437
Misc Feature(24)1435..1437
Misc Feature(25)1447..1449
Misc Feature(26)1462..1464
Misc Feature(27)1462..1464
Misc Feature(28)1522..1524
Misc Feature(29)1576..1800
Exon (1)1..486
Gene:BAG3
Gene Synonym:BAG-3; BIS; CAIR-1; MFM6
Exon (2)487..813
Gene:BAG3
Gene Synonym:BAG-3; BIS; CAIR-1; MFM6
Exon (3)814..1215
Gene:BAG3
Gene Synonym:BAG-3; BIS; CAIR-1; MFM6
Exon (4)1216..2571
Gene:BAG3
Gene Synonym:BAG-3; BIS; CAIR-1; MFM6
Translation MSAATHSPMMQVASGNGDRDPLPPGWEIKIDPQTGWPFFVDHNSRTTTWNDPRVPSEGPK ETPSSANGPSREGSRLPPAREGHPVYPQLRPGYIPIPVLHEGAENRQVHPFHVYPQPGMQ RFRTEAAAAAPQRSQSPLRGMPETTQPDKQCGQVAAAAAAQPPASHGPERSQSPAASDCS SSSSSASLPSSGRSSLGSHQLPRGYISIPVIHEQNVTRPAAQPSFHQAQKTHYPAQQGEY QTHQPVYHKIQGDDWEPRPLRAASPFRSSVQGASSREGSPARSSTPLHSPSPIRVHTVVD RPQQPMTHRETAPVSQPENKPESKPGPVGPELPPGHIPIQVIRKEVDSKPVSQKPPPPSE KVEVKVPPAPVPCPPPSPGPSAVPSSPKSVATEERAAPSTAPAEATPPKPGEAEAPPKHP GVLKVEAILEKVQGLEQAVDNFEGKKTDKKYLMIEEYLTKELLALDSVDPEGRADVRQAR RDGVRKVQTILEKLEQKAIDVPGQVQVYELQPSNLEADQPLQAIMEMGAVAADKGKKNAG NAEDPHTETQQPEATAAATSNPSSMTDTPGNPAAP
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Position Chain Variation Link
23+dbSNP:
23+c, gdbSNP:192502283
36+c, tdbSNP:144814361
complement(39)-t, cdbSNP:2736419
complement(41)-t, cdbSNP:2736420
65+c, tdbSNP:372429257
212+a, gdbSNP:111750619
216+a, gdbSNP:185840368
287+a, cdbSNP:370244783
290+a, gdbSNP:200388926
331+a, gdbSNP:137965903
340+a, gdbSNP:367917821
380+g, tdbSNP:142391650
402+g, tdbSNP:372083121
408+c, gdbSNP:145934400
409+a, gdbSNP:200072558
417+c, tdbSNP:397516880
434+a, cdbSNP:201329879
479+g, tdbSNP:138785335
480+c, tdbSNP:141858419
487+dbSNP:
487+a, gdbSNP:187116556
493+c, gdbSNP:144041999
517+c, tdbSNP:387906874
518+c, tdbSNP:35434411
536+c, tdbSNP:141355480
537+a, gdbSNP:143752613
555+a, cdbSNP:151331972
580+c, gdbSNP:371026669
586+a, tdbSNP:145393807
612+c, tdbSNP:202006167
634+c, gdbSNP:374304325
645+a, cdbSNP:367861849
673+c, tdbSNP:387906875
674+a, gdbSNP:199991063
687+a, tdbSNP:140594879
697+c, gdbSNP:140672627
706+a, tdbSNP:375257731
738+a, cdbSNP:144928892
757+c, tdbSNP:2234962
766+c, gdbSNP:376198104
769+a, gdbSNP:61756328
771..772+, gcgdbSNP:139438727
776..777+, ggcdbSNP:370215533
777+a, gdbSNP:148985314
779+c, tdbSNP:369981590
791+c, tdbSNP:373446989
800+c, tdbSNP:143756613
complement(801)-g, adbSNP:35261472
804+c, tdbSNP:111682654
814+dbSNP:
814+c, tdbSNP:200479768
815+a, gdbSNP:140904592
855+c, gdbSNP:112929734
880+a, gdbSNP:201487919
912+g, tdbSNP:74157690
920+a, tdbSNP:141497285
922+a, c, gdbSNP:199700646
932+c, tdbSNP:121918312
933+a, gdbSNP:188555685
942+c, tdbSNP:150379892
951+c, tdbSNP:138078305
952+a, g, tdbSNP:148282376
957+c, tdbSNP:371353268
958+c, tdbSNP:397514506
959+a, gdbSNP:201638005
985+c, gdbSNP:149517238
999+a, gdbSNP:144034433
1010+c, tdbSNP:371731106
1011+a, gdbSNP:141328836
1017+g, tdbSNP:369377620
1020+a, gdbSNP:377183466
1021+a, gdbSNP:148544471
1049+a, gdbSNP:369947845
1077+c, tdbSNP:200212999
1078+c, tdbSNP:117671123
1081+c, tdbSNP:375687199
1091+c, tdbSNP:397516883
1101+a, gdbSNP:180736121
1127+c, tdbSNP:143919208
1133+a, gdbSNP:372970842
1139+a, gdbSNP:200232102
1160+c, tdbSNP:375650805
1161+a, gdbSNP:147259596
1176+c, gdbSNP:140737221
1178+c, tdbSNP:368866313
1186+c, tdbSNP:144585878
1187+a, gdbSNP:151335530
1194+c, tdbSNP:139399890
1197+c, tdbSNP:372571986
1198+a, gdbSNP:150048651
1204+a, gdbSNP:78439745
1210+c, gdbSNP:199677021
1211+c, tdbSNP:201416791
1267+dbSNP:
1267+c, tdbSNP:376832654
1308+g, tdbSNP:3858339
1335+a, cdbSNP:117972572
1340+a, tdbSNP:189646603
1380+c, tdbSNP:201979259
1391+c, tdbSNP:200812717
1444+c, tdbSNP:144692954
1446+g, tdbSNP:201449869
1450+a, gdbSNP:370667806
1472+a, gdbSNP:140251789
1478+c, tdbSNP:200242752
1490+a, gdbSNP:111787446
1520+c, tdbSNP:11199064
1526+c, tdbSNP:3858340
1542+a, gdbSNP:113856701
1545+c, tdbSNP:201137108
1546+a, gdbSNP:117749531
1570+a, gdbSNP:371476147
1602+a, gdbSNP:196295
1605+a, gdbSNP:374858685
1627+a, gdbSNP:201181493
1668+c, tdbSNP:372417286
1669+a, gdbSNP:397516881
1691+c, tdbSNP:397514507
1723+c, gdbSNP:199682693
1724+a, gdbSNP:150156178
1729+a, gdbSNP:138832242
1731+c, tdbSNP:376404396
1736+a, gdbSNP:387906876
1742+a, gdbSNP:34656239
1809+a, cdbSNP:147277075
1860+a, tdbSNP:139125612
1892+c, gdbSNP:369690617
1893+c, tdbSNP:149358702
1894+a, gdbSNP:144678100
1911+c, tdbSNP:200427679
1941+c, gdbSNP:148597097
1942..1943+, cdbSNP:34165294
1963..1964+, gdbSNP:34008271
1963+a, gdbSNP:79949996
1979+c, tdbSNP:185537639
1980+a, gdbSNP:142981190
1986+a, gdbSNP:111920656
1996+a, gdbSNP:372524229
2004+a, gdbSNP:199837016
2059+c, tdbSNP:374883210
2060+a, gdbSNP:377178592
2064+c, tdbSNP:369267138
2065+c, tdbSNP:116329258
2126+g, tdbSNP:111435244
2195+a, gdbSNP:189488870
2219+a, gdbSNP:112913322
2243..2245+, ttgdbSNP:369572262
2252+c, gdbSNP:8946
2272..2274+, ttgdbSNP:71758126
2277..2279+, gttdbSNP:3981124
2277+c, gdbSNP:375488756
2279+g, tdbSNP:369648772
2336+a, tdbSNP:113733053
2337..2338+, ctdbSNP:201877964
2338..2339+, ttdbSNP:59447464
2341..2342+, tgdbSNP:200363755
2353+c, tdbSNP:148967962
2536+a, tdbSNP:181519469
2569+a, gdbSNP:11199065
Gene SymbolBAG3
Gene SynonymBAG-3; BIS; CAIR-1; MFM6
Chromosome10
Locus Map10q25.2-q26.2
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_004281 Homo sapiens BCL2-associated athanogene 3 (BAG3), mRNA. On-demand $849.00 20
XM_005270287 PREDICTED: Homo sapiens BCL2-associated athanogene 3 (BAG3), transcript variant X1, mRNA. On-demand $849.00 20
Title BAG3 regulates epithelial-mesenchymal transition and angiogenesis in human hepatocellular carcinoma .
Author Xiao H, Cheng S, Tong R, Lv Z, Ding C, Du C, Xie H, Zhou L, Wu J and Zheng S.
Journal Lab. Invest. 94 (3), 252-261 (2014)
Title Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro .
Author Rauch JN and Gestwicki JE.
Journal J. Biol. Chem. 289 (3), 1402-1414 (2014)
Title BAG3 is upregulated by c-Jun and stabilizes JunD .
Author Li C, Li S, Kong DH, Meng X, Zong ZH, Liu BQ, Guan Y, Du ZX and Wang HQ.
Journal Biochim. Biophys. Acta 1833 (12), 3346-3354 (2013)
Title BAG3 sensitizes cancer cells exposed to DNA damaging agents via direct interaction with GRP78 .
Author Kong DH, Zhang Q, Meng X, Zong ZH, Li C, Liu BQ, Guan Y and Wang HQ.
Journal Biochim. Biophys. Acta 1833 (12), 3245-3253 (2013)
Title The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines .
Author Liao Q, Ozawa F, Friess H, Zimmermann A, Takayama S, Reed JC, Kleeff J and Buchler MW.
Journal FEBS Lett. 503 (2-3), 151-157 (2001)
Title CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70 .
Author Doong H, Price J, Kim YS, Gasbarre C, Probst J, Liotta LA, Blanchette J, Rizzo K and Kohn E.
Journal Oncogene 19 (38), 4385-4395 (2000)
Title Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death .
Author Lee JH, Takahashi T, Yasuhara N, Inazawa J, Kamada S and Tsujimoto Y.
Journal Oncogene 18 (46), 6183-6190 (1999)
Title An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators .
Author Takayama S, Xie Z and Reed JC.
Journal J. Biol. Chem. 274 (2), 781-786 (1999)
Title Myofibrillar Myopathy .
Author Selcen,D. and Engel,A.G.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Title Dilated Cardiomyopathy Overview .
Author Hershberger,R.E. and Morales,A.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)

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