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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.


RefSeq Accession Definition Services Price Order
NM_004333 Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA. ORF Sequence $667.29
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Protein Services


RefSeq Version NM_004333.4, 187608632
Length 2949 bp
Structure linear
Update Date 29-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.
Product serine/threonine-protein kinase B-raf
Comment

Summary: This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008].

RefSeq NP_004324.2
CDS 62..2362
Misc Feature(1)65..67
Misc Feature(2)65..67
Misc Feature(3)416..418
Misc Feature(4)500..502
Misc Feature(5)512..514
Misc Feature(6)527..742
Misc Feature(7)order(533..535,548..550,554..565,569..571,608..610,
Misc Feature(8)764..901
Misc Feature(9)order(764..766,803..805,812..814,842..844,851..853,
Misc Feature(10)order(785..787,794..799,824..829,830..832)
Misc Feature(11)order(794..796,800..802)
Misc Feature(12)1154..1156
Misc Feature(13)1154..1156
Misc Feature(14)1154..1156
Misc Feature(15)1178..1180
Misc Feature(16)1178..1180
Misc Feature(17)1199..1204
Misc Feature(18)1247..1249
Misc Feature(19)1256..1258
Misc Feature(20)1262..1264
Misc Feature(21)1262..1264
Misc Feature(22)1316..1318
Misc Feature(23)1346..1348
Misc Feature(24)1349..1351
Misc Feature(25)1373..1378
Misc Feature(26)1379..1381
Misc Feature(27)1397..1399
Misc Feature(28)1397..1399
Misc Feature(29)1397..1399
Misc Feature(30)1400..1402
Misc Feature(31)1430..2200
Misc Feature(32)1448..2206
Misc Feature(33)order(1448..1462,1472..1474,1502..1504,1508..1510,
Misc Feature(34)order(1448..1462,1472..1474,1502..1504,1508..1510,
Misc Feature(35)order(1460..1462,1667..1669,1673..1675,1787..1789,
Misc Feature(36)order(1838..1852,1865..1870,1910..1915)
Misc Feature(37)1856..1858
Misc Feature(38)1865..1867
Misc Feature(39)2072..2074
Misc Feature(40)2246..2248
Misc Feature(41)2246..2248
Misc Feature(42)2309..2311
Misc Feature(43)2318..2320
Exon (1)1..199
Gene:BRAF
Gene Synonym:B-RAF1; BRAF1; NS7; RAFB1
Exon (2)200..301
Gene:BRAF
Gene Synonym:B-RAF1; BRAF1; NS7; RAFB1
Exon (3)302..565
Gene:BRAF
Gene Synonym:B-RAF1; BRAF1; NS7; RAFB1
Exon (4)566..669
Gene:BRAF
Gene Synonym:B-RAF1; BRAF1; NS7; RAFB1
Exon (5)670..772
Gene:BRAF
Gene Synonym:B-RAF1; BRAF1; NS7; RAFB1
Exon (6)773..921
Gene:BRAF
Gene Synonym:B-RAF1; BRAF1; NS7; RAFB1
Exon (7)922..1041
Gene:BRAF
Gene Synonym:B-RAF1; BRAF1; NS7; RAFB1
Exon (8)1042..1201
Gene:BRAF
Gene Synonym:B-RAF1; BRAF1; NS7; RAFB1
Exon (9)1202..1238
Gene:BRAF
Gene Synonym:B-RAF1; BRAF1; NS7; RAFB1
Exon (10)1239..1375
Gene:BRAF
Gene Synonym:B-RAF1; BRAF1; NS7; RAFB1
Exon (11)1376..1493
Gene:BRAF
Gene Synonym:B-RAF1; BRAF1; NS7; RAFB1
Exon (12)1494..1578
Gene:BRAF
Gene Synonym:B-RAF1; BRAF1; NS7; RAFB1
Exon (13)1579..1755
Gene:BRAF
Gene Synonym:B-RAF1; BRAF1; NS7; RAFB1
Exon (14)1756..1802
Gene:BRAF
Gene Synonym:B-RAF1; BRAF1; NS7; RAFB1
Exon (15)1803..1921
Gene:BRAF
Gene Synonym:B-RAF1; BRAF1; NS7; RAFB1
Exon (16)1922..2053
Gene:BRAF
Gene Synonym:B-RAF1; BRAF1; NS7; RAFB1
Exon (17)2054..2188
Gene:BRAF
Gene Synonym:B-RAF1; BRAF1; NS7; RAFB1
Exon (18)2189..2947
Gene:BRAF
Gene Synonym:B-RAF1; BRAF1; NS7; RAFB1
Translation MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
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Position Chain Variation Link
complement(43)-dbSNP:
complement(43)-t, cdbSNP:71645935
complement(57)-g, adbSNP:71645936
complement(340)-dbSNP:
complement(340)-t, gdbSNP:150050723
complement(406)-t, cdbSNP:149547328
complement(427)-g, adbSNP:201123489
complement(436)-c, adbSNP:201507202
complement(467)-c, adbSNP:138086018
complement(544)-g, cdbSNP:61730029
complement(562..563)-, tdbSNP:35546910
complement(640)-dbSNP:
complement(640)-t, cdbSNP:142723570
complement(769)-dbSNP:
complement(769)-g, adbSNP:138333692
complement(797)-dbSNP:
complement(797)-g, cdbSNP:180177034
complement(831)-g, adbSNP:180177035
complement(889)-g, adbSNP:199790021
complement(939)-dbSNP:
complement(939)-, tdbSNP:68070244
complement(962)-g, adbSNP:34776339
complement(976)-t, cdbSNP:145675911
complement(1070)-dbSNP:
complement(1070)-g, adbSNP:200373902
complement(1084)-t, cdbSNP:56092510
complement(1085)-t, cdbSNP:201481342
complement(1090)-t, cdbSNP:140486841
complement(1093)-t, cdbSNP:56094800
complement(1109)-c, adbSNP:202209106
complement(1116)-t, cdbSNP:201882896
complement(1127)-g, cdbSNP:151308995
complement(1129)-t, cdbSNP:143335467
complement(1145)-t, gdbSNP:149230176
complement(1205)-dbSNP:
complement(1205)-t, adbSNP:147732750
complement(1266)-dbSNP:
complement(1266)-t, gdbSNP:199927105
complement(1267)-t, gdbSNP:201758035
complement(1288)-t, cdbSNP:145035762
complement(1391)-dbSNP:
complement(1391)-t, cdbSNP:121913371
complement(1393)-t, cdbSNP:56101602
complement(1444)-t, cdbSNP:56216404
complement(1446)-t, gdbSNP:180177032
complement(1449)-t, gdbSNP:180177033
complement(1451)-g, cdbSNP:121913349
1452+a, g, tdbSNP:121913348
complement(1457)-g, cdbSNP:121913353
1458+a, c, g, tdbSNP:121913351
complement(1466..1468)-agt, agc, ggadbSNP:121913358
complement(1466)-g, c, adbSNP:121913357
1467+a, c, g, tdbSNP:121913355
complement(1472)-t, gdbSNP:121913376
complement(1516)-dbSNP:
complement(1516)-g, cdbSNP:180177036
complement(1556)-g, adbSNP:180177037
complement(1562)-g, adbSNP:180177038
complement(1563)-g, adbSNP:180177039
complement(1661)-dbSNP:
complement(1661)-g, cdbSNP:180177041
complement(1693)-g, adbSNP:149702741
complement(1765)-dbSNP:
complement(1765)-g, adbSNP:199714538
complement(1775)-t, adbSNP:139510971
complement(1786)-t, cdbSNP:200228275
complement(1802)-g, adbSNP:180177040
complement(1803)-dbSNP:
complement(1803)-g, adbSNP:121913370
complement(1817)-g, adbSNP:121913340
complement(1821)-c, adbSNP:121913335
complement(1822)-c, adbSNP:121913336
complement(1835)-g, adbSNP:121913363
complement(1836)-t, adbSNP:55939351
complement(1837)-g, adbSNP:121913362
1842+a, g, tdbSNP:121913338
complement(1843)-t, adbSNP:121913337
complement(1845)-t, cdbSNP:121913225
complement(1846)-t, gdbSNP:121913341
complement(1847)-g, cdbSNP:121913361
complement(1850..1851)-ct, tcdbSNP:121913368
complement(1850)-g, cdbSNP:121913369
1851+a, g, tdbSNP:121913366
complement(1857)-t, cdbSNP:121913375
complement(1858)-tactacg, adbSNP:121913374
complement(1859..1860)-gt, ag, aadbSNP:121913227
complement(1859)-t, g, adbSNP:121913378
complement(1860..1861)-at, tgdbSNP:121913377
complement(1860)-t, c, adbSNP:113488022
complement(1862..1864)-, aaadbSNP:121913226
complement(1862)-g, adbSNP:121913364
complement(1864)-c, adbSNP:121913365
complement(1867)-t, cdbSNP:191566526
complement(1868)-t, cdbSNP:104886015
complement(1874..1875)-tt, agdbSNP:121913372
complement(1875)-g, adbSNP:121913373
complement(1975)-dbSNP:
complement(1975)-t, adbSNP:180177042
complement(1990)-t, cdbSNP:9648696
complement(2071)-dbSNP:
complement(2071)-t, adbSNP:201793951
complement(2136)-g, adbSNP:55715359
complement(2257)-dbSNP:
complement(2257)-g, cdbSNP:142592480
complement(2296)-t, cdbSNP:56046546
complement(2307)-t, gdbSNP:200490285
complement(2352)-g, adbSNP:139420557
complement(2367)-t, cdbSNP:200360246
complement(2388)-c, adbSNP:202148822
complement(2419)-t, adbSNP:143647707
complement(2455..2456)-, adbSNP:200393520
complement(2577)-t, adbSNP:140083479
complement(2578)-g, adbSNP:184804021
complement(2737)-t, cdbSNP:192498662
complement(2749)-t, cdbSNP:114105685
Gene SymbolBRAF
Gene SynonymB-RAF1; BRAF1; NS7; RAFB1
Chromosome7
Locus Map7q34
All Transcripts
RefSeq Accession Definition Sequence Price Select
NM_004333 Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA. Full Length $855.21
ORF Sequence $667.29
Title Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer .
Author Xing,M., Alzahrani,A.S., Carson,K.A., Viola,D., Elisei,R., Bendlova,B., Yip,L., Mian,C., Vianello,F., Tuttle,R.M., Robenshtok,E., Fagin,J.A., Puxeddu,E., Fugazzola,L., Czarniecka,A., Jarzab,B., O'Neill,C.J., Sywak,M.S., Lam,A.K., Riesco-Eizaguirre,G., Santisteban,P., Nakayama,H., Tufano,R.P., Pai,S.I., Zeiger,M.A., Westra,W.H., Clark,D.P., Clifton-Bligh,R., Sidransky,D., Ladenson,P.W. and Sykorova,V.
Journal JAMA 309 (14), 1493-1501 (2013)
Title Kidins220/ARMS associates with B-Raf and the TCR, promoting sustained Erk signaling in T cells .
Author Deswal,S., Meyer,A., Fiala,G.J., Eisenhardt,A.E., Schmitt,L.C., Salek,M., Brummer,T., Acuto,O. and Schamel,W.W.
Journal J. Immunol. 190 (5), 1927-1935 (2013)
Title BRAF inhibitor activity in V600R metastatic melanoma .
Author Klein,O., Clements,A., Menzies,A.M., O'Toole,S., Kefford,R.F. and Long,G.V.
Journal Eur. J. Cancer 49 (5), 1073-1079 (2013)
Title Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling .
Author Freeman,A.K., Ritt,D.A. and Morrison,D.K.
Journal Mol. Cell 49 (4), 751-758 (2013)
Title Prognostic prediction of BRAF(V600E) and its relationship with sodium iodide symporter in classic variant of papillary thyroid carcinomas .
Author Gao,W.L., Wie,L.L., Chao,Y.G., Wie,L. and Song,T.L.
Journal Clin. Lab. 58 (9-10), 919-926 (2012)
Title 95-kilodalton B-Raf serine/threonine kinase: identification of the protein and its major autophosphorylation site .
Author Stephens,R.M., Sithanandam,G., Copeland,T.D., Kaplan,D.R., Rapp,U.R. and Morrison,D.K.
Journal Mol. Cell. Biol. 12 (9), 3733-3742 (1992)
Title Chromosomal assignment of two human B-raf(Rmil) proto-oncogene loci: B-raf-1 encoding the p94Braf/Rmil and B-raf-2, a processed pseudogene .
Author Eychene,A., Barnier,J.V., Apiou,F., Dutrillaux,B. and Calothy,G.
Journal Oncogene 7 (8), 1657-1660 (1992)
Title B-raf and a B-raf pseudogene are located on 7q in man .
Author Sithanandam,G., Druck,T., Cannizzaro,L.A., Leuzzi,G., Huebner,K. and Rapp,U.R.
Journal Oncogene 7 (4), 795-799 (1992)
Title Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies .
Author Sithanandam,G., Kolch,W., Duh,F.M. and Rapp,U.R.
Journal Oncogene 5 (12), 1775-1780 (1990)
Title B-raf, a new member of the raf family, is activated by DNA rearrangement .
Author Ikawa,S., Fukui,M., Ueyama,Y., Tamaoki,N., Yamamoto,T. and Toyoshima,K.
Journal Mol. Cell. Biol. 8 (6), 2651-2654 (1988)

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