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Homo sapiens bone marrow stromal cell antigen 2 (BST2), mRNA.


RefSeq Accession Definition Sequence Price Select
NM_004335 Homo sapiens bone marrow stromal cell antigen 2 (BST2), mRNA. Full Lenth $285.07
ORF Sequence $159.00


RefSeq Version NM_004335.2, 7262372
Length 983 bp
Structure linear
Update Date 17-APR-2011
Organism Homo sapiens (human)
Definition Homo sapiens bone marrow stromal cell antigen 2 (BST2), mRNA.
Product bone marrow stromal antigen 2 precursor
Comment

Summary: Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq].

RefSeq NP_004326.1
CDS 10..552
Exon (1)10..294
Exon (2)295..361
Exon (3)362..422
Exon (4)423..567
Exon (5)568..948
Translation MASTSYDYCRVPMEDGDKRCKLLLGIGILVLLIIVILGVPLIIFTIKANSEACRDGLRAV MECRNVTHLLQQELTEAQKGFQDVEAQAATCNHTVMALMASLDAEKAQGQKKVEELEGEI TTLNHKLQDASAEVERLRRENQVLSVRIADKKYYPSSQDSSSAAAPQLLIVLLGLSALLQ
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Position Chain Variation Link
213+c, tdbSNP:11542666
complement(252)-g, adbSNP:34737311
436+g, tdbSNP:1804402
444+c, tdbSNP:11542665
complement(567)-, largedeletiondbSNP:71694748
632+c, tdbSNP:3209223
639+a, gdbSNP:1804403
complement(651..652)-, tdbSNP:112207449
660+a, gdbSNP:1054231
685+a, gdbSNP:1054245
722+a, cdbSNP:9576
777+c, gdbSNP:13485
complement(870..871)-, aadbSNP:71734218
900+c, tdbSNP:1054324
complement(916..917)-, tdbSNP:71774804
929+a, cdbSNP:1133258
Gene SymbolBST2
Gene SynonymCD317; TETHERIN
Chromosome19
Locus Map19p13.1
All Transcripts NM_004335
Title BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-action .
Author Skasko,M., Tokarev,A., Chen,C.C., Fischer,W.B., Pillai,S.K. and Guatelli,J.
Journal Virology 411 (1), 65-77 (2011)
Title Budding capability of the influenza virus neuraminidase can be modulated by tetherin .
Author Yondola,M.A., Fernandes,F., Belicha-Villanueva,A., Uccelini,M., Gao,Q., Carter,C. and Palese,P.
Journal J. Virol. 85 (6), 2480-2491 (2011)
Title Differential effects of human immunodeficiency virus type 1 Vpu on the stability of BST-2/tetherin .
Author Andrew,A.J., Miyagi,E. and Strebel,K.
Journal J. Virol. 85 (6), 2611-2619 (2011)
Title IFN-gamma-induced BST2 mediates monocyte adhesion to human endothelial cells .
Author Yoo,H., Park,S.H., Ye,S.K. and Kim,M.
Journal Cell. Immunol. 267 (1), 23-29 (2011)
Title Tetherin restricts direct cell-to-cell infection of HIV-1 .
Author Kuhl,B.D., Sloan,R.D., Donahue,D.A., Bar-Magen,T., Liang,C. and Wainberg,M.A.
Journal Retrovirology 7, 115 (2010)
Title Characterization of antibodies submitted to the B cell section of the 8th Human Leukocyte Differentiation Antigens Workshop by flow cytometry and immunohistochemistry .
Author Vidal-Laliena,M., Romero,X., March,S., Requena,V., Petriz,J. and Engel,P.
Journal Cell. Immunol. 236 (1-2), 6-16 (2005)
Title Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways .
Author Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O., Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H. and Sugano,S.
Journal Oncogene 22 (21), 3307-3318 (2003)
Title Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells .
Author Ohtomo,T., Sugamata,Y., Ozaki,Y., Ono,K., Yoshimura,Y., Kawai,S., Koishihara,Y., Ozaki,S., Kosaka,M., Hirano,T. and Tsuchiya,M.
Journal Biochem. Biophys. Res. Commun. 258 (3), 583-591 (1999)
Title Cloning of a cDNA encoding rat bone marrow stromal cell antigen 1 (BST-1) from the islets of Langerhans .
Author Furuya,Y., Takasawa,S., Yonekura,H., Tanaka,T., Takahara,J. and Okamoto,H.
Journal Gene 165 (2), 329-330 (1995)
Title Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth .
Author Ishikawa,J., Kaisho,T., Tomizawa,H., Lee,B.O., Kobune,Y., Inazawa,J., Oritani,K., Itoh,M., Ochi,T., Ishihara,K. et al.
Journal Genomics 26 (3), 527-534 (1995)

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