• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant 1, mRNA.


Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu27656 Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand $1699.00 25
OHu27656C Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant 1, mRNA. Customized vector On-demand $1699.00 25

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Mutation services

Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_004448.3, 584277099
Length 3768 bp
Structure linear
Update Date 26-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), transcript variant 1, mRNA.
Product receptor tyrosine-protein kinase erbB-2 isoform a precursor
Comment

Summary: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].


Transcript Variant: This variant (1) encodes the longest isoform (a).

RefSeq NP_004439.2
CDS 262..4029
Misc Feature(1)236..256
Misc Feature(2)415..780
Misc Feature(3)826..1290
Misc Feature(4)964..1101
Misc Feature(5)1357..1719
Misc Feature(6)1789..>1893
Misc Feature(7)1792..2190
Misc Feature(8)1945..2082
Misc Feature(9)2182..2313
Misc Feature(10)order(2188..2193,2197..2199,2206..2208,2215..2217,
Misc Feature(11)order(2191..2202,2206..2217,2224..2232,2236..2244,
Misc Feature(12)2218..2286
Misc Feature(13)2287..2328
Misc Feature(14)2287..2328
Misc Feature(15)2395..3231
Misc Feature(16)2419..3189
Misc Feature(17)order(2437..2442,2449..2454,2518..2520,2656..2658,
Misc Feature(18)order(2437..2442,2461..2463,2512..2514,2518..2520,
Misc Feature(19)2464..2466
Misc Feature(20)2845..2922
Misc Feature(21)2890..2892
Misc Feature(22)order(2911..2925,2938..2940,2950..2952)
Misc Feature(23)3028..3030
Misc Feature(24)3274..3276
Misc Feature(25)3328..3330
Misc Feature(26)3421..3423
Misc Feature(27)3580..3582
Misc Feature(28)3676..3678
Misc Feature(29)3844..3852
Misc Feature(30)3847..3849
Misc Feature(31)3922..3924
Misc Feature(32)3925..3927
Misc Feature(33)4003..4005
Misc Feature(34)4003..4005
Misc Feature(35)4003..4005
Misc Feature(36)4003..4005
Misc Feature(37)4003..4005
Exon (1)1..334
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (2)335..486
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (3)487..700
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (4)701..835
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (5)836..904
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (6)905..1020
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (7)1021..1162
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (8)1163..1282
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (9)1283..1409
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (10)1410..1483
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (11)1484..1574
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (12)1575..1774
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (13)1775..1907
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (14)1908..1998
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (15)1999..2159
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (16)2160..2207
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (17)2208..2346
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (18)2347..2469
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (19)2470..2568
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (20)2569..2754
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (21)2755..2910
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (22)2911..2986
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (23)2987..3133
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (24)3134..3231
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (25)3232..3420
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (26)3421..3673
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (27)3674..4647
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Translation MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL ELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLA LTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQC AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSAN IQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLP DLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQEC VEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARC PSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVG ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSP YVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVR LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFT HQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWM IDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA EEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEG AGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYV NQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQ GGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
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Position Chain Variation Link
102+dbSNP:
102+c, tdbSNP:375591649
304+c, tdbSNP:193171026
342+dbSNP:
342+c, tdbSNP:377542789
360+a, gdbSNP:4252610
361+c, tdbSNP:149937802
363+a, gdbSNP:369293607
401+a, gdbSNP:144019910
431+a, gdbSNP:140441229
497+dbSNP:
497+a, cdbSNP:61737968
510+c, tdbSNP:191376350
511+a, gdbSNP:376524324
519+c, tdbSNP:147785188
534+a, gdbSNP:369499945
601+c, tdbSNP:372811772
606+c, tdbSNP:200102353
612+a, gdbSNP:370676964
625+c, gdbSNP:141135746
626+c, tdbSNP:370959592
642+c, gdbSNP:4252613
644+c, gdbSNP:373824622
671+c, tdbSNP:200208742
689+a, gdbSNP:185670819
713+dbSNP:
713+g, tdbSNP:200963868
716+c, gdbSNP:151122410
759+a, gdbSNP:370810322
783+c, tdbSNP:141086703
789+c, tdbSNP:56114611
798+a, gdbSNP:146844678
851+dbSNP:
851+c, tdbSNP:113619125
936+dbSNP:
936+c, gdbSNP:140636713
995+c, tdbSNP:376183465
1053+dbSNP:
1053+c, tdbSNP:368210132
1069+g, tdbSNP:200382130
1117+a, gdbSNP:149210045
1188+dbSNP:
1188+a, tdbSNP:145697136
1200+c, tdbSNP:138280629
1326+dbSNP:
1326+a, gdbSNP:190567339
1340+a, tdbSNP:373474372
1374+c, tdbSNP:149567593
1395+a, gdbSNP:143225142
1399+a, gdbSNP:148068883
1413+dbSNP:
1413+c, tdbSNP:199514902
1418+a, cdbSNP:141116145
1440+a, gdbSNP:147204600
1468+a, cdbSNP:377649991
1503+dbSNP:
1503+a, gdbSNP:373728539
1509+a, gdbSNP:140507994
1528+a, gdbSNP:199668084
1530+c, tdbSNP:35757908
1531+a, gdbSNP:142783371
1555+c, tdbSNP:367606199
1562+a, gdbSNP:147382623
1587+dbSNP:
1587+g, tdbSNP:4252632
1617+g, tdbSNP:4252633
1627+c, tdbSNP:200497646
1632+a, gdbSNP:2230698
1633+c, tdbSNP:368989970
1646+a, gdbSNP:373192991
1670+a, gdbSNP:201097345
1677+c, tdbSNP:61737967
1697+c, tdbSNP:201021373
1703+c, tdbSNP:370565888
1704+c, tdbSNP:55984118
1720+c, tdbSNP:375382055
1721+a, gdbSNP:371450390
1727+c, tdbSNP:142456637
1728+a, gdbSNP:147076339
1732+c, g, tdbSNP:140670446
1750+a, gdbSNP:145762641
1756+c, tdbSNP:199530208
1757+a, gdbSNP:182572604
1806+dbSNP:
1806+c, tdbSNP:368632077
1807+a, gdbSNP:371623072
1815+a, gdbSNP:199657476
1828+c, tdbSNP:202202058
1830+a, gdbSNP:55928971
1852+c, tdbSNP:140711914
1868+a, gdbSNP:140980495
1881+c, tdbSNP:371585581
1895+a, gdbSNP:150203173
1942+dbSNP:
1942+c, tdbSNP:369690252
1946+c, tdbSNP:201470725
1947+a, gdbSNP:4252635
1974+c, tdbSNP:149337787
2007+dbSNP:
2007+c, tdbSNP:138893464
2054+a, c, gdbSNP:145409713
2056+c, tdbSNP:369903296
2092+a, gdbSNP:377370642
2118+a, gdbSNP:142816898
2159+c, tdbSNP:199726056
2189+dbSNP:
2189+c, gdbSNP:367599823
2190+c, tdbSNP:56110910
2193+c, tdbSNP:141678288
2194+a, gdbSNP:370514427
2201+c, gdbSNP:201784472
2220+dbSNP:
2220+c, tdbSNP:374222106
2221+a, gdbSNP:1801201
2224+a, g, tdbSNP:1136201
2263+c, gdbSNP:372616729
2265+c, gdbSNP:199841166
2369+dbSNP:
2369+g, tdbSNP:34602395
2409+a, gdbSNP:146883671
2419+c, tdbSNP:374098949
2457+c, tdbSNP:377617979
2524..2525+dbSNP:
2524..2525+cc, ttdbSNP:121913469
2525+c, tdbSNP:121913470
2553+c, tdbSNP:139745101
2564+c, tdbSNP:56366519
2566+c, gdbSNP:121913468
2581+dbSNP:
2581+, adbSNP:397516978
2583..2584+, gcatacgtgatgdbSNP:397516975
2585..2586+, atacgtgatggcdbSNP:397516976
2586..2587+, tacgtgatggctdbSNP:397516977
2587..2588+, tct, tgt, tttdbSNP:397516979
2587+a, gdbSNP:28933369
2587+g, ttatdbSNP:397516980
2588+c, gdbSNP:144434331
2590+g, tdbSNP:121913471
2600..2601+, gggctccccdbSNP:397516981
2601..2602+, ggctccccadbSNP:397516982
2640+a, gdbSNP:186232310
2652+a, gdbSNP:368499773
2685+a, cdbSNP:146603731
2704+a, gdbSNP:368094521
2767+dbSNP:
2767+c, tdbSNP:104886008
2769+a, gdbSNP:149176913
2779+c, tdbSNP:369828131
2781+a, gdbSNP:104886011
2784+c, tdbSNP:373165016
2796+c, tdbSNP:137852788
2797+c, tdbSNP:370816244
2802+c, tdbSNP:140231769
2812+a, gdbSNP:375043510
2829+c, tdbSNP:104886009
2835+c, tdbSNP:377653295
2853+c, tdbSNP:151263346
2866+c, tdbSNP:104886010
2875+a, gdbSNP:371081280
2881+a, gdbSNP:375637720
2931+dbSNP:
2931+a, gdbSNP:140453509
2949+c, tdbSNP:369203202
2950+c, tdbSNP:375135008
2955+a, gdbSNP:199638358
2961+c, gdbSNP:370134709
complement(2966)-c, adbSNP:188440186
2967+c, gdbSNP:193920750
3001+dbSNP:
3001+a, gdbSNP:28933368
3030+c, tdbSNP:147028804
3041+c, gdbSNP:2172826
3047+a, gdbSNP:201399875
3051+g, tdbSNP:138957632
3087+c, tdbSNP:141423785
3175+dbSNP:
3175+c, tdbSNP:201193677
3226+a, cdbSNP:202110098
3294+dbSNP:
3294+c, tdbSNP:373188896
3305+a, gdbSNP:140272156
3331+c, tdbSNP:4252654
3338+a, cdbSNP:192441765
3339+c, tdbSNP:4252655
3371+c, tdbSNP:201905649
3403+c, tdbSNP:377602610
3407+a, gdbSNP:104886025
3410+c, tdbSNP:199905364
3413+a, cdbSNP:139630504
3418+a, gdbSNP:370561486
3426..3427+dbSNP:
3426..3427+, ggggggdbSNP:145292805
3434+a, cdbSNP:201374810
3436+c, tdbSNP:369832936
3443+c, tdbSNP:141142822
3451+a, gdbSNP:376450229
3479+c, gdbSNP:202149348
3510+a, cdbSNP:376673270
3511+g, tdbSNP:200796676
3549+c, gdbSNP:373724781
3566+c, tdbSNP:200455249
3574+a, gdbSNP:111611886
3592+c, tdbSNP:143958183
3612+a, gdbSNP:368135224
3636+a, tdbSNP:148211805
3664+c, tdbSNP:150165942
3684+dbSNP:
3684+a, cdbSNP:146177313
3691+c, gdbSNP:138611862
3699+a, gdbSNP:370079170
3702+a, c, tdbSNP:112561362
3714+a, gdbSNP:144501267
3735+g, tdbSNP:373365159
3743+a, gdbSNP:150680317
3745+c, tdbSNP:201482456
3769+c, gdbSNP:1058808
complement(3792)-g, adbSNP:4252656
3831+c, tdbSNP:149815705
3835+g, tdbSNP:182815010
3872+c, gdbSNP:373605104
3874+c, tdbSNP:201353217
3881+c, tdbSNP:145772320
3891+c, tdbSNP:141627242
3908+a, cdbSNP:55943169
3912+c, tdbSNP:188050006
3950+a, gdbSNP:372043866
3966+c, tdbSNP:4252657
3983+c, gdbSNP:141494080
3991+a, gdbSNP:144533600
3998+c, tdbSNP:375408471
4002+a, gdbSNP:368770921
4015+a, gdbSNP:184203026
4018+a, gdbSNP:36085723
4034+g, tdbSNP:2230700
4035+a, cdbSNP:376055107
4046+c, tdbSNP:369214536
4079+a, gdbSNP:192237900
4095+c, tdbSNP:4252658
4104..4105+, adbSNP:4252659
4104..4105+, adbSNP:199996595
4104..4105+, adbSNP:386591968
4151..4152+, gdbSNP:36042695
4189..4190+, cdbSNP:35040721
4230+a, tdbSNP:189417058
4286+c, tdbSNP:139158322
4442+c, gdbSNP:4252660
4465+c, gdbSNP:377267613
4620+c, tdbSNP:4252661
Gene SymbolERBB2
Gene SynonymCD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Chromosome17
Locus Map17q12
Title Serum human epidermal growth factor receptor 2 levels as a real-time marker for tumor burden in breast cancer patients .
Author Kim,H.A., Lee,J.K., Kim,E.K., Seol,H. and Noh,W.C.
Journal J Surg Oncol 109 (5), 421-425 (2014)
Title p95-HER2 and trastuzumab resistance in metastatic breast cancer; is immunohistochemistry appropriate? .
Author Kocar M, Bozkurtlar E, Telli F, Yumuk F, Kaya H, Kocar H and Serdar Turhal N.
Journal J BUON 19 (1), 245-249 (2014)
Title Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism .
Author Corominas R, Yang X, Lin GN, Kang S, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Trigg SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T, Vidal M and Iakoucheva LM.
Journal Nat Commun 5, 3650 (2014)
Title Overexpression of her-2 associated with the progression of esophageal cancer patients .
Author Wang,G., Zhang,W., Jiang,W. and Luan,L.
Journal Hepatogastroenterology 60 (128), 1972-1978 (2013)
Title Translational control by an upstream open reading frame in the HER-2/neu transcript .
Author Child SJ, Miller MK and Geballe AP.
Journal J. Biol. Chem. 274 (34), 24335-24341 (1999)
Title Cell type-dependent and -independent control of HER-2/neu translation .
Author Child SJ, Miller MK and Geballe AP.
Journal Int. J. Biochem. Cell Biol. 31 (1), 201-213 (1999)
Title Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system .
Author Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M and Waterfield MD.
Journal Biochem. J. 288 (PT 2), 395-405 (1992)
Title Regulated coupling of the Neu receptor to phosphatidylinositol 3'-kinase and its release by oncogenic activation .
Author Peles E, Lamprecht R, Ben-Levy R, Tzahar E and Yarden Y.
Journal J. Biol. Chem. 267 (17), 12266-12274 (1992)
Title G to A polymorphism at amino acid codon 655 of the human erbB-2/HER2 gene .
Author Papewalis J, Nikitin AYu and Rajewsky MF.
Journal Nucleic Acids Res. 19 (19), 5452 (1991)
Title Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma .
Author Peles E, Levy RB, Or E, Ullrich A and Yarden Y.
Journal EMBO J. 10 (8), 2077-2086 (1991)

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