• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2), transcript variant 1, mRNA.


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_004448 Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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RefSeq Version NM_004448.2, 54792095
Length 4624 bp
Structure linear
Update Date 29-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2), transcript variant 1, mRNA.
Product receptor tyrosine-protein kinase erbB-2 isoform a
Comment

Summary: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].


Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).

RefSeq NP_004439.2
CDS 239..4006
Misc Feature(1)392..757
Misc Feature(2)392..757
Misc Feature(3)803..1267
Misc Feature(4)941..1078
Misc Feature(5)1334..1696
Misc Feature(6)1766..>1870
Misc Feature(7)1922..2059
Misc Feature(8)2159..2290
Misc Feature(9)order(2165..2170,2174..2176,2183..2185,2192..2194,
Misc Feature(10)order(2168..2179,2183..2194,2201..2209,2213..2221,
Misc Feature(11)2195..2263
Misc Feature(12)2264..2305
Misc Feature(13)2264..2305
Misc Feature(14)2372..3208
Misc Feature(15)2396..3166
Misc Feature(16)order(2414..2419,2426..2431,2495..2497,2633..2635,
Misc Feature(17)order(2414..2419,2438..2440,2489..2491,2495..2497,
Misc Feature(18)2441..2443
Misc Feature(19)2822..2899
Misc Feature(20)2867..2869
Misc Feature(21)order(2888..2902,2915..2917,2927..2929)
Misc Feature(22)3005..3007
Misc Feature(23)3251..3253
Misc Feature(24)3305..3307
Misc Feature(25)3398..3400
Misc Feature(26)3557..3559
Misc Feature(27)3653..3655
Misc Feature(28)3821..3829
Misc Feature(29)3824..3826
Misc Feature(30)3899..3901
Misc Feature(31)3902..3904
Misc Feature(32)3980..3982
Misc Feature(33)3980..3982
Misc Feature(34)3980..3982
Misc Feature(35)3980..3982
Misc Feature(36)3980..3982
Exon (1)1..311
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (2)312..463
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (3)464..677
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (4)678..812
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (5)813..881
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (6)882..997
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (7)998..1139
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (8)1140..1259
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (9)1260..1386
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (10)1387..1460
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (11)1461..1551
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (12)1552..1751
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (13)1752..1884
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (14)1885..1975
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (15)1976..2136
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (16)2137..2184
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (17)2185..2323
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (18)2324..2446
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (19)2447..2545
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (20)2546..2731
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (21)2732..2887
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (22)2888..2963
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (23)2964..3110
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (24)3111..3208
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (25)3209..3397
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (26)3398..3650
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Exon (27)3651..4624
Gene:ERBB2
Gene Synonym:CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Translation MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL ELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLA LTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQC AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSAN IQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLP DLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQEC VEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARC PSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVG ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSP YVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVR LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFT HQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWM IDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA EEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEG AGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYV NQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQ GGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
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Position Chain Variation Link
281+c, tdbSNP:193171026
337+dbSNP:
337+a, gdbSNP:4252610
338+c, tdbSNP:149937802
378+a, gdbSNP:144019910
408+a, gdbSNP:140441229
474+dbSNP:
474+a, cdbSNP:61737968
487+c, tdbSNP:191376350
496+c, tdbSNP:147785188
583+c, tdbSNP:200102353
602+c, gdbSNP:141135746
619+c, gdbSNP:4252613
648+c, tdbSNP:200208742
666+a, gdbSNP:185670819
690+dbSNP:
690+g, tdbSNP:200963868
693+c, gdbSNP:151122410
760+c, tdbSNP:141086703
766+c, tdbSNP:56114611
775+a, gdbSNP:146844678
828+dbSNP:
828+c, tdbSNP:113619125
913+dbSNP:
913+c, gdbSNP:140636713
1046+dbSNP:
1046+g, tdbSNP:200382130
1094+a, gdbSNP:149210045
1165+dbSNP:
1165+a, tdbSNP:145697136
1177+c, tdbSNP:138280629
1303+dbSNP:
1303+a, gdbSNP:190567339
1351+c, tdbSNP:149567593
1372+a, gdbSNP:143225142
1376+a, gdbSNP:148068883
1390+dbSNP:
1390+c, tdbSNP:199514902
1395+a, cdbSNP:141116145
1417+a, gdbSNP:147204600
1486+dbSNP:
1486+a, gdbSNP:140507994
1505+a, gdbSNP:199668084
1507+c, tdbSNP:35757908
1508+a, gdbSNP:142783371
1539+a, gdbSNP:147382623
1564+dbSNP:
1564+g, tdbSNP:4252632
1594+g, tdbSNP:4252633
1604+c, tdbSNP:200497646
1609+a, gdbSNP:2230698
1647+a, gdbSNP:201097345
1654+c, tdbSNP:61737967
1674+c, tdbSNP:201021373
1681+c, tdbSNP:55984118
1704+c, tdbSNP:142456637
1705+a, gdbSNP:147076339
1709+c, g, tdbSNP:140670446
1727+a, gdbSNP:145762641
1733+c, tdbSNP:199530208
1734+a, gdbSNP:182572604
1790+dbSNP:
1790+, gdbSNP:67116789
1792+a, gdbSNP:199657476
1804..1805+, tdbSNP:67881774
1805+c, tdbSNP:202202058
1807+a, gdbSNP:55928971
1829+c, tdbSNP:140711914
1845+a, gdbSNP:140980495
1872+a, gdbSNP:150203173
1923+dbSNP:
1923+c, tdbSNP:201470725
1924+a, gdbSNP:4252635
1951+c, tdbSNP:149337787
1974+c, tdbSNP:146179272
1984+dbSNP:
1984+c, tdbSNP:138893464
2011..2012+, gdbSNP:72478177
2031+c, gdbSNP:145409713
2045..2046+, gdbSNP:72125310
2095+a, gdbSNP:142816898
2136+c, tdbSNP:199726056
2167+dbSNP:
2167+c, tdbSNP:56110910
2170+c, tdbSNP:141678288
2178+c, gdbSNP:201784472
2198+dbSNP:
2198+a, gdbSNP:1801201
2201+a, g, tdbSNP:1136201
2206+g, tdbSNP:143124752
2239..2240+, gdbSNP:67526367
2242+c, gdbSNP:199841166
2346+dbSNP:
2346+g, tdbSNP:34602395
2386+a, gdbSNP:146883671
2501..2502+dbSNP:
2501..2502+cc, ttdbSNP:121913469
2502+c, tdbSNP:121913470
2530+c, tdbSNP:139745101
2541+c, tdbSNP:56366519
2543+c, gdbSNP:121913468
2564+dbSNP:
2564+a, gdbSNP:28933369
2565+c, gdbSNP:144434331
2567+g, tdbSNP:121913471
2617+a, gdbSNP:186232310
2662+a, cdbSNP:146603731
2744+dbSNP:
2744+c, tdbSNP:104886008
2746+a, gdbSNP:149176913
2758+a, gdbSNP:104886011
2773+c, tdbSNP:137852788
2779+c, tdbSNP:140231769
2806+c, tdbSNP:104886009
2808+a, gdbSNP:28933370
2830+c, tdbSNP:151263346
2843+c, tdbSNP:104886010
2851..2852+, tdbSNP:66920285
2908+dbSNP:
2908+a, gdbSNP:140453509
2932+a, gdbSNP:199638358
2943+a, cdbSNP:188440186
2944+c, gdbSNP:193920750
2978+dbSNP:
2978+a, gdbSNP:28933368
3007+c, tdbSNP:147028804
3018+c, gdbSNP:2172826
3024+a, gdbSNP:201399875
3028+g, tdbSNP:138957632
3064+c, tdbSNP:141423785
3152+dbSNP:
3152+c, tdbSNP:201193677
3203+a, cdbSNP:202110098
3220+dbSNP:
3220+, gdbSNP:67430188
3282+a, gdbSNP:140272156
3308+c, tdbSNP:4252654
3315+a, cdbSNP:192441765
3316+c, tdbSNP:4252655
3322+, gdbSNP:66515843
3348+c, tdbSNP:201905649
3384+a, gdbSNP:104886025
3387+c, tdbSNP:199905364
3390+a, cdbSNP:139630504
3401..3402+dbSNP:
3401..3402+, ggggggdbSNP:145292805
3411+a, cdbSNP:201374810
3420+c, tdbSNP:141142822
3456+c, gdbSNP:202149348
3488+g, tdbSNP:200796676
3543+c, tdbSNP:200455249
3551+a, gdbSNP:111611886
3569+c, tdbSNP:143958183
3613+a, tdbSNP:148211805
3641+c, tdbSNP:150165942
3661+dbSNP:
3661+a, cdbSNP:146177313
3668+c, gdbSNP:138611862
3679+a, c, tdbSNP:112561362
3691+a, gdbSNP:144501267
3720+a, gdbSNP:150680317
3722+c, tdbSNP:201482456
3746+c, gdbSNP:1058808
3769+a, gdbSNP:4252656
3808+c, tdbSNP:149815705
3812+g, tdbSNP:182815010
3851+c, tdbSNP:201353217
3858+c, tdbSNP:145772320
3868+c, tdbSNP:141627242
3885+a, cdbSNP:55943169
3889+c, tdbSNP:188050006
3943+c, tdbSNP:4252657
3960+c, gdbSNP:141494080
3968+a, gdbSNP:144533600
3992+a, gdbSNP:184203026
3995+a, gdbSNP:36085723
4011+g, tdbSNP:2230700
4056+a, gdbSNP:192237900
4072+c, tdbSNP:4252658
4080+, adbSNP:4252659
4081..4082+, adbSNP:199996595
4094..4095+, cdbSNP:66498387
4128..4129+, gdbSNP:36042695
4166..4167+, cdbSNP:35040721
4196+, tdbSNP:67751411
4207+a, tdbSNP:189417058
4263+c, tdbSNP:139158322
4374+, adbSNP:71753268
4419+c, gdbSNP:4252660
4597+c, tdbSNP:4252661
Gene SymbolERBB2
Gene SynonymCD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Chromosome17
Locus Map17q12
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_001005862 Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2), transcript variant 2, mRNA. On-demand $1699.00 25
NM_004448 Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2), transcript variant 1, mRNA. On-demand $1699.00 25
Title HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab .
Author Ithimakin,S., Day,K.C., Malik,F., Zen,Q., Dawsey,S.J., Bersano-Begey,T.F., Quraishi,A.A., Ignatoski,K.W., Daignault,S., Davis,A., Hall,C.L., Palanisamy,N., Heath,A.N., Tawakkol,N., Luther,T.K., Clouthier,S.G., Chadwick,W.A., Day,M.L., Kleer,C.G., Thomas,D.G., Hayes,D.F., Korkaya,H. and Wicha,M.S.
Journal Cancer Res. 73 (5), 1635-1646 (2013)
Title Racially restricted contribution of immunoglobulin Fcgamma and Fcgamma receptor genotypes to humoral immunity to human epidermal growth factor receptor 2 in breast cancer .
Author Pandey,J.P., Namboodiri,A.M., Kistner-Griffin,E., Iwasaki,M., Kasuga,Y., Hamada,G.S. and Tsugane,S.
Journal Clin. Exp. Immunol. 171 (3), 273-277 (2013)
Title HER2 gene copy number status may influence clinical efficacy to anti-EGFR monoclonal antibodies in metastatic colorectal cancer patients .
Author Martin,V., Landi,L., Molinari,F., Fountzilas,G., Geva,R., Riva,A., Saletti,P., De Dosso,S., Spitale,A., Tejpar,S., Kalogeras,K.T., Mazzucchelli,L., Frattini,M. and Cappuzzo,F.
Journal Br. J. Cancer 108 (3), 668-675 (2013)
Title Comparison of fluorescence in situ hybridization (FISH) and dual-ISH (DISH) in the determination of HER2 status in breast cancer .
Author Mansfield,A.S., Sukov,W.R., Eckel-Passow,J.E., Sakai,Y., Walsh,F.J., Lonzo,M., Wiktor,A.E., Dogan,A. and Jenkins,R.B.
Journal Am. J. Clin. Pathol. 139 (2), 144-150 (2013)
Title Change in HER2 (ERBB2) gene status after taxane-based chemotherapy for breast cancer: polyploidization can lead to diagnostic pitfalls with potential impact for clinical management .
Author Valent,A., Penault-Llorca,F., Cayre,A. and Kroemer,G.
Journal Cancer Genet 206 (1-2), 37-41 (2013)
Title Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system .
Author Gout,I., Dhand,R., Panayotou,G., Fry,M.J., Hiles,I., Otsu,M. and Waterfield,M.D.
Journal Biochem. J. 288 (PT 2), 395-405 (1992)
Title Regulated coupling of the Neu receptor to phosphatidylinositol 3'-kinase and its release by oncogenic activation .
Author Peles,E., Lamprecht,R., Ben-Levy,R., Tzahar,E. and Yarden,Y.
Journal J. Biol. Chem. 267 (17), 12266-12274 (1992)
Title Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas .
Author Arteaga,C.L., Johnson,M.D., Todderud,G., Coffey,R.J., Carpenter,G. and Page,D.L.
Journal Proc. Natl. Acad. Sci. U.S.A. 88 (23), 10435-10439 (1991)
Title G to A polymorphism at amino acid codon 655 of the human erbB-2/HER2 gene .
Author Papewalis,J., Nikitin,A.Yu. and Rajewsky,M.F.
Journal Nucleic Acids Res. 19 (19), 5452 (1991)
Title Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma .
Author Peles,E., Levy,R.B., Or,E., Ullrich,A. and Yarden,Y.
Journal EMBO J. 10 (8), 2077-2086 (1991)


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