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Homo sapiens matrix metallopeptidase 20 (MMP20), mRNA.

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_004771 Homo sapiens matrix metallopeptidase 20 (MMP20), mRNA. GenEZ ORF Cloning On-demand $699.00 18

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RefSeq Version NM_004771.3, 45359864
Length 1956 bp
Structure linear
Update Date 17-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens matrix metallopeptidase 20 (MMP20), mRNA.
Product matrix metalloproteinase-20 preproprotein

Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011].

RefSeq NP_004762.2
CDS 14..1465
Misc Feature(1)116..298
Misc Feature(2)305..328
Misc Feature(3)359..826
Misc Feature(4)order(515..517,551..553,572..592,617..619,689..694,
Misc Feature(5)order(689..694,701..703,719..721)
Misc Feature(6)890..1462
Misc Feature(7)order(920..922,926..928,1055..1057,1061..1063,1196..1198,
Exon (1)140..387
Gene Synonym:AI2A2; MMP-20
Exon (2)388..536
Gene Synonym:AI2A2; MMP-20
Exon (3)537..662
Gene Synonym:AI2A2; MMP-20
Exon (4)663..824
Gene Synonym:AI2A2; MMP-20
Exon (5)825..966
Gene Synonym:AI2A2; MMP-20
Exon (6)967..1103
Gene Synonym:AI2A2; MMP-20
Exon (7)1104..1260
Gene Synonym:AI2A2; MMP-20
Exon (8)1261..1364
Gene Synonym:AI2A2; MMP-20
Exon (9)1365..1956
Gene Synonym:AI2A2; MMP-20
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Position Chain Variation Link
complement(47)-g, adbSNP:201172301
complement(66)-c, adbSNP:2245803
complement(79)-t, cdbSNP:144554695
complement(88)-g, adbSNP:149295645
complement(105)-g, adbSNP:61730847
complement(112)-g, adbSNP:199516216
complement(116)-t, g, cdbSNP:61751462
complement(128)-g, adbSNP:143867898
complement(177)-t, cdbSNP:202146356
complement(215)-t, cdbSNP:138308694
complement(223)-t, cdbSNP:140041158
complement(244)-t, cdbSNP:185057360
complement(252)-t, cdbSNP:143113210
complement(266)-t, cdbSNP:199926748
complement(267)-t, cdbSNP:200482846
complement(287)-t, cdbSNP:61730848
complement(339)-t, cdbSNP:146053692
complement(385)-g, adbSNP:143362660
complement(396)-t, gdbSNP:61753771
complement(402)-g, adbSNP:61730849
complement(422)-t, cdbSNP:145904752
complement(428)-g, adbSNP:17099014
complement(443)-t, cdbSNP:146424395
complement(456)-g, adbSNP:190817531
complement(466)-g, adbSNP:143965716
complement(477)-g, adbSNP:139116285
complement(488)-t, cdbSNP:199623165
complement(518)-c, adbSNP:17099008
complement(533)-c, adbSNP:142180012
complement(559)-g, adbSNP:148659857
complement(610)-c, adbSNP:147183005
complement(638)-g, cdbSNP:199788797
complement(646)-t, cdbSNP:201805835
complement(658)-t, cdbSNP:143750033
complement(680)-t, cdbSNP:145109609
complement(698)-t, cdbSNP:199531622
complement(736)-t, cdbSNP:139717539
complement(737)-t, cdbSNP:147459787
complement(742)-t, cdbSNP:149347703
complement(745)-t, cdbSNP:61730850
complement(763)-g, adbSNP:141334366
complement(770)-g, adbSNP:138853084
complement(823)-g, adbSNP:11225343
complement(831)-t, cdbSNP:141875245
complement(837)-t, cdbSNP:1784423
complement(838)-t, cdbSNP:201174058
complement(855)-c, adbSNP:1784424
complement(866)-t, cdbSNP:182862570
complement(883)-t, adbSNP:17098831
complement(895)-g, adbSNP:141603134
complement(896)-g, cdbSNP:146876571
complement(922)-g, adbSNP:145296288
complement(923)-t, cdbSNP:148818720
complement(940)-g, cdbSNP:145529899
complement(965)-g, adbSNP:149696445
complement(980)-t, g, adbSNP:200265019
complement(981)-t, cdbSNP:147615125
complement(985)-t, cdbSNP:145192230
complement(995)-g, adbSNP:139809661
complement(996)-t, cdbSNP:147430004
complement(1005)-g, adbSNP:147526712
complement(1007)-g, adbSNP:148721639
complement(1138)-t, cdbSNP:144219408
complement(1149)-g, adbSNP:149589493
complement(1151)-g, adbSNP:184655088
complement(1232)-g, adbSNP:150191942
complement(1264)-g, adbSNP:138278626
complement(1267)-g, adbSNP:146377521
complement(1268)-t, cdbSNP:200903478
complement(1300)-t, cdbSNP:200893460
complement(1326)-g, cdbSNP:61753770
complement(1342)-g, adbSNP:139032178
complement(1343)-t, cdbSNP:201488609
complement(1365)-c, adbSNP:79248469
complement(1396)-t, gdbSNP:145152907
complement(1433)-t, cdbSNP:143537032
complement(1487)-t, cdbSNP:189995623
complement(1496)-t, cdbSNP:200195120
complement(1569)-g, adbSNP:111760689
complement(1620)-, adbSNP:35128445
complement(1683)-g, adbSNP:185868865
complement(1692)-t, gdbSNP:12278482
complement(1764)-g, cdbSNP:17098541
complement(1837)-, tdbSNP:66475234
complement(1841)-g, adbSNP:140087742
complement(1854)-t, adbSNP:146080568
complement(1883)-t, cdbSNP:183248988
complement(1892)-t, adbSNP:2292729
Gene SymbolMMP20
Gene SynonymAI2A2; MMP-20
Locus Map11q22.3
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_004771 Homo sapiens matrix metallopeptidase 20 (MMP20), mRNA. On-demand $699.00 18
Title Novel KLK4 and MMP20 mutations discovered by whole-exome sequencing .
Author Wang,S.K., Hu,Y., Simmer,J.P., Seymen,F., Estrella,N.M., Pal,S., Reid,B.M., Yildirim,M., Bayram,M., Bartlett,J.D. and Hu,J.C.
Journal J. Dent. Res. 92 (3), 266-271 (2013)
Title Genetic variation in MMP20 contributes to higher caries experience .
Author Tannure,P.N., Kuchler,E.C., Lips,A., Costa Mde,C., Luiz,R.R., Granjeiro,J.M. and Vieira,A.R.
Journal J Dent 40 (5), 381-386 (2012)
Title A multidisciplinary approach for the diagnosis of hypocalcified amelogenesis imperfecta in two Chilean families .
Author Urzua,B., Ortega-Pinto,A., Farias,D.A., Franco,E., Morales-Bozo,I., Moncada,G., Escobar-Pezoa,N., Scholz,U. and Cifuentes,V.
Journal Acta Odontol. Scand. 70 (1), 7-14 (2012)
Title Prognostic significance of matrix metalloproteinase-20 overexpression in laryngeal squamous cell carcinoma .
Author Liu,Y., Li,Y., Liu,Z., Zhang,L., Anniko,M. and Duan,M.
Journal Acta Otolaryngol. 131 (7), 769-773 (2011)
Title MMP1 and MMP20 contribute to tooth agenesis in humans .
Author Kuchler,E.C., Menezes,R., Callahan,N., Costa,M.C., Modesto,A., Meira,R., Patir,A., Seymen,F., Paiva,K.B., Nunes,F.D., Granjeiro,J.M. and Vieira,A.R.
Journal Arch. Oral Biol. 56 (5), 506-511 (2011)
Title Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP) .
Author Stracke,J.O., Fosang,A.J., Last,K., Mercuri,F.A., Pendas,A.M., Llano,E., Perris,R., Di Cesare,P.E., Murphy,G. and Knauper,V.
Journal FEBS Lett. 478 (1-2), 52-56 (2000)
Title Matrix metalloproteinases .
Author Nagase,H. and Woessner,J.F. Jr.
Journal J. Biol. Chem. 274 (31), 21491-21494 (1999)
Title Proteinases in developing dental enamel .
Author Bartlett,J.D. and Simmer,J.P.
Journal Crit. Rev. Oral Biol. Med. 10 (4), 425-441 (1999)
Title Identification and structural and functional characterization of human enamelysin (MMP-20) .
Author Llano,E., Pendas,A.M., Knauper,V., Sorsa,T., Salo,T., Salido,E., Murphy,G., Simmer,J.P., Bartlett,J.D. and Lopez-Otin,C.
Journal Biochemistry 36 (49), 15101-15108 (1997)
Title Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3 .
Author Pendas,A.M., Santamaria,I., Alvarez,M.V., Pritchard,M. and Lopez-Otin,C.
Journal Genomics 37 (2), 266-268 (1996)

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