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Homo sapiens G protein-coupled receptor 183 (GPR183), mRNA.


RefSeq Accession Definition Services Price Order
NM_004951 Homo sapiens G protein-coupled receptor 183 (GPR183), mRNA. ORF Sequence $314.94
Peptide Services
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RefSeq Version NM_004951.4, 194473709
Length 1801 bp
Structure linear
Update Date 29-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens G protein-coupled receptor 183 (GPR183), mRNA.
Product G-protein coupled receptor 183
Comment

Summary: This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008].


##Evidence-Data-START## Transcript exon combination :: AK313443.1, BC020752.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

RefSeq NP_004942.1
CDS 175..1260
Misc Feature(1)151..153
Misc Feature(2)268..345
Misc Feature(3)268..345
Misc Feature(4)301..>657
Misc Feature(5)334..1098
Misc Feature(6)406..459
Misc Feature(7)490..555
Misc Feature(8)550..576
Misc Feature(9)622..678
Misc Feature(10)751..819
Misc Feature(11)898..969
Misc Feature(12)1036..1110
Exon (1)1..156
Gene:GPR183
Gene Synonym:EBI2
Exon (2)157..1785
Gene:GPR183
Gene Synonym:EBI2
Translation MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNR KKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVN FMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERIT CMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNK KALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFN CCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNG K
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Position Chain Variation Link
complement(5..6)-dbSNP:
complement(5..6)-, gdbSNP:34324109
complement(33..34)-, tdbSNP:35060502
complement(104)-g, adbSNP:191373302
complement(140)-t, cdbSNP:188403352
complement(260)-g, adbSNP:200374704
complement(269)-g, adbSNP:192239624
complement(285)-g, adbSNP:141030009
complement(295)-g, cdbSNP:141594545
complement(325)-g, cdbSNP:145606686
complement(376)-g, adbSNP:200952492
complement(396)-t, gdbSNP:2230342
complement(420)-g, cdbSNP:1042263
complement(453)-t, cdbSNP:41280146
complement(469)-t, adbSNP:201620105
complement(477)-t, cdbSNP:2230343
complement(497)-g, adbSNP:142541591
complement(543)-g, adbSNP:41280144
complement(625)-t, cdbSNP:200057657
complement(746)-t, gdbSNP:200683203
complement(756..757)-, gdbSNP:34018220
complement(789)-g, adbSNP:146709613
complement(819)-g, adbSNP:143138028
complement(844)-g, adbSNP:182350912
complement(873)-g, adbSNP:144035947
complement(925)-t, cdbSNP:201755595
complement(941)-c, adbSNP:77635998
complement(974)-t, cdbSNP:200900247
complement(975)-t, adbSNP:144820165
complement(1016)-t, cdbSNP:149857139
complement(1024)-g, adbSNP:62637588
complement(1030)-t, adbSNP:150670001
complement(1044)-g, cdbSNP:144039046
complement(1138)-t, cdbSNP:200669857
complement(1288)-g, adbSNP:140312850
complement(1313)-g, adbSNP:2230341
complement(1318)-c, adbSNP:191644641
complement(1365)-g, adbSNP:58716363
complement(1384)-g, adbSNP:1042273
complement(1402)-g, adbSNP:146695518
complement(1720..1721)-g, adbSNP:1126594
complement(1721)-g, adbSNP:3181718
Gene SymbolGPR183
Gene SynonymEBI2
Chromosome13
Locus Map13q32.3
All Transcripts
RefSeq Accession Definition Sequence Price Select
NM_004951 Homo sapiens G protein-coupled receptor 183 (GPR183), mRNA. Full Length $522.29
ORF Sequence $314.94
Title Identification of structural motifs critical for epstein-barr virus-induced molecule 2 function and homology modeling of the ligand docking site .
Author Zhang,L., Shih,A.Y., Yang,X.V., Kuei,C., Wu,J., Deng,X., Mani,N.S., Mirzadegan,T., Sun,S., Lovenberg,T.W. and Liu,C.
Journal Mol. Pharmacol. 82 (6), 1094-1103 (2012)
Title EBI2 regulates CXCL13-mediated responses by heterodimerization with CXCR5 .
Author Barroso,R., Martinez Munoz,L., Barrondo,S., Vega,B., Holgado,B.L., Lucas,P., Baillo,A., Salles,J., Rodriguez-Frade,J.M. and Mellado,M.
Journal FASEB J. 26 (12), 4841-4854 (2012)
Title Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183) .
Author Benned-Jensen,T., Norn,C., Laurent,S., Madsen,C.M., Larsen,H.M., Arfelt,K.N., Wolf,R.M., Frimurer,T., Sailer,A.W. and Rosenkilde,M.M.
Journal J. Biol. Chem. 287 (42), 35470-35483 (2012)
Title EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors .
Author Norregaard,K., Benned-Jensen,T. and Rosenkilde,M.M.
Journal Curr Top Med Chem 11 (6), 618-628 (2011)
Title Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist .
Author Benned-Jensen,T. and Rosenkilde,M.M.
Journal Mol. Pharmacol. 74 (4), 1008-1021 (2008)
Title Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity .
Author Rosenkilde,M.M., Benned-Jensen,T., Andersen,H., Holst,P.J., Kledal,T.N., Luttichau,H.R., Larsen,J.K., Christensen,J.P. and Schwartz,T.W.
Journal J. Biol. Chem. 281 (19), 13199-13208 (2006)
Title Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors .
Author Birkenbach,M., Josefsen,K., Yalamanchili,R., Lenoir,G. and Kieff,E.
Journal J. Virol. 67 (4), 2209-2220 (1993)

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