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Homo sapiens EPH receptor A3 (EPHA3), transcript variant 1, mRNA.


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_005233 Homo sapiens EPH receptor A3 (EPHA3), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $899.00 20

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RefSeq Version NM_005233.5, 156547090
Length 5837 bp
Structure linear
Update Date 17-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens EPH receptor A3 (EPHA3), transcript variant 1, mRNA.
Product ephrin type-A receptor 3 isoform a precursor
Comment

Summary: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008].


Transcript Variant: This variant (1) encodes the longer isoform (a).

RefSeq NP_005224.2
CDS 226..3177
Misc Feature(1)136..138
Misc Feature(2)310..828
Misc Feature(3)order(382..384,388..402,421..426,430..432,436..438,
Misc Feature(4)1012..1128
Misc Feature(5)1201..1488
Misc Feature(6)order(1201..1203,1426..1428,1465..1467)
Misc Feature(7)order(1468..1473,1477..1482)
Misc Feature(8)1534..1809
Misc Feature(9)order(1534..1536,1726..1728,1771..1773)
Misc Feature(10)order(1774..1779,1783..1788)
Misc Feature(11)1849..1920
Misc Feature(12)2011..2013
Misc Feature(13)2011..2013
Misc Feature(14)2029..2031
Misc Feature(15)2029..2031
Misc Feature(16)2071..2871
Misc Feature(17)2086..2859
Misc Feature(18)order(2104..2106,2110..2118,2128..2130,2176..2178,
Misc Feature(19)order(2104..2106,2113..2118,2176..2178,2182..2184,
Misc Feature(20)2326..2328
Misc Feature(21)order(2461..2463,2473..2475,2572..2586,2611..2613,
Misc Feature(22)2512..2592
Misc Feature(23)2560..2562
Misc Feature(24)2560..2562
Misc Feature(25)2947..3144
Misc Feature(26)2959..3147
Misc Feature(27)3166..3174
Exon (1)1..313
Gene:EPHA3
Gene Synonym:EK4; ETK; ETK1; HEK; HEK4; TYRO4
Exon (2)314..378
Gene:EPHA3
Gene Synonym:EK4; ETK; ETK1; HEK; HEK4; TYRO4
Exon (3)379..1039
Gene:EPHA3
Gene Synonym:EK4; ETK; ETK1; HEK; HEK4; TYRO4
Exon (4)1040..1195
Gene:EPHA3
Gene Synonym:EK4; ETK; ETK1; HEK; HEK4; TYRO4
Exon (5)1196..1531
Gene:EPHA3
Gene Synonym:EK4; ETK; ETK1; HEK; HEK4; TYRO4
Exon (6)1532..1656
Gene:EPHA3
Gene Synonym:EK4; ETK; ETK1; HEK; HEK4; TYRO4
Exon (7)1657..1819
Gene:EPHA3
Gene Synonym:EK4; ETK; ETK1; HEK; HEK4; TYRO4
Exon (8)1820..1922
Gene:EPHA3
Gene Synonym:EK4; ETK; ETK1; HEK; HEK4; TYRO4
Exon (9)1923..1987
Gene:EPHA3
Gene Synonym:EK4; ETK; ETK1; HEK; HEK4; TYRO4
Exon (10)1988..2113
Gene:EPHA3
Gene Synonym:EK4; ETK; ETK1; HEK; HEK4; TYRO4
Exon (11)2114..2299
Gene:EPHA3
Gene Synonym:EK4; ETK; ETK1; HEK; HEK4; TYRO4
Exon (12)2300..2361
Gene:EPHA3
Gene Synonym:EK4; ETK; ETK1; HEK; HEK4; TYRO4
Exon (13)2362..2571
Gene:EPHA3
Gene Synonym:EK4; ETK; ETK1; HEK; HEK4; TYRO4
Exon (14)2572..2721
Gene:EPHA3
Gene Synonym:EK4; ETK; ETK1; HEK; HEK4; TYRO4
Exon (15)2722..2915
Gene:EPHA3
Gene Synonym:EK4; ETK; ETK1; HEK; HEK4; TYRO4
Exon (16)2916..3071
Gene:EPHA3
Gene Synonym:EK4; ETK; ETK1; HEK; HEK4; TYRO4
Exon (17)3072..5809
Gene:EPHA3
Gene Synonym:EK4; ETK; ETK1; HEK; HEK4; TYRO4
Translation MDCQLSILLLLSCSVLDSFGELIPQPSNEVNLLDSKTIQGELGWISYPSHGWEEISGVDE HYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETF NLYYMESDDDHGVKFREHQFTKIDTIAADESFTQMDLGDRILKLNTEIREVGPVNKKGFY LAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPDTVPMDSQSLVEVRGSCVNNSKEEDPP RMYCSTEGEWLVPIGKCSCNAGYEERGFMCQACRPGFYKALDGNMKCAKCPPHSSTQEDG SMNCRCENNYFRADKDPPSMACTRPPSSPRNVISNINETSVILDWSWPLDTGGRKDVTFN IICKKCGWNIKQCEPCSPNVRFLPRQFGLTNTTVTVTDLLAHTNYTFEIDAVNGVSELSS PPRQFAAVSITTNQAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEKQEQ ETSYTILRARGTNVTISSLKPDTIYVFQIRARTAAGYGTNSRKFEFETSPDSFSISGESS QVVMIAISAAVAIILLTVVIYVLIGRFCGYKSKHGADEKRLHFGNGHLKLPGLRTYVDPH TYEDPTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYT EKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTV IQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYT TRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEG YRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSN LLLDQSNVDITTFRTTGDWLNGVWTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVG PQKKIISSIKALETQSKNGPVPV
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Position Chain Variation Link
19+dbSNP:
19+a, gdbSNP:13074375
22+a, cdbSNP:184354535
25+a, gdbSNP:147840036
157+c, tdbSNP:111643515
186+a, tdbSNP:188399674
211+c, gdbSNP:72919864
274+c, gdbSNP:201110271
286+a, gdbSNP:141456190
297+g, tdbSNP:200437524
360+dbSNP:
360+c, gdbSNP:139262347
393+dbSNP:
393+c, tdbSNP:149992625
491+a, gdbSNP:142484873
510+a, tdbSNP:200290249
568+a, gdbSNP:200995645
570+g, tdbSNP:141613520
582+a, tdbSNP:184977302
596+a, gdbSNP:202143347
610+a, gdbSNP:201357801
615+c, tdbSNP:113122729
670..671+, cdbSNP:34813653
743+c, tdbSNP:141287594
846+g, tdbSNP:200567888
909+g, tdbSNP:143609637
934+a, gdbSNP:139652107
969+c, tdbSNP:150099876
1019+a, gdbSNP:138376716
1025+a, gdbSNP:138974536
1048+dbSNP:
1048+c, tdbSNP:201468736
1066+c, tdbSNP:182691254
1075+a, cdbSNP:200484511
1117+c, gdbSNP:142109561
1144+a, gdbSNP:148593404
1206+dbSNP:
1206+c, tdbSNP:140674679
1236+c, tdbSNP:201113556
1286+a, gdbSNP:144727411
1294+a, gdbSNP:149937883
1310+c, tdbSNP:202046045
1355+a, gdbSNP:200415022
1487+a, cdbSNP:144998277
1506+a, gdbSNP:56112995
1550+dbSNP:
1550+c, tdbSNP:112239794
1719+dbSNP:
1719+a, cdbSNP:144696297
1729+a, gdbSNP:75391524
1799+a, tdbSNP:150469112
1848+dbSNP:
1848+a, tdbSNP:149643424
1851+a, gdbSNP:56330723
1860+c, tdbSNP:200724434
1871+c, tdbSNP:147450955
1879+a, gdbSNP:142865154
1907+a, gdbSNP:139544432
1915+a, gdbSNP:55712516
1927+dbSNP:
1927+a, tdbSNP:56077781
1947+c, tdbSNP:145276281
1994+dbSNP:
1994+c, tdbSNP:56081642
2010..2011+, tdbSNP:35329896
2014+a, gdbSNP:61733120
2047+a, gdbSNP:17855794
2139+dbSNP:
2139+c, tdbSNP:148141668
2153+c, gdbSNP:146728702
2160+a, gdbSNP:143310803
2166+g, tdbSNP:201062946
2169+c, tdbSNP:138119313
2178+c, tdbSNP:148670200
2211+a, gdbSNP:146238137
2260+c, tdbSNP:202059523
2279+c, tdbSNP:200071736
2291+c, tdbSNP:139451236
2356+dbSNP:
2356+c, tdbSNP:57909419
2358+a, cdbSNP:140661567
2363+dbSNP:
2363+a, cdbSNP:199630398
2383+a, gdbSNP:200791821
2462+a, cdbSNP:149696182
2469+c, tdbSNP:56175540
2500+a, gdbSNP:146856660
2555+c, gdbSNP:34437982
2625+dbSNP:
2625+c, tdbSNP:1398197
2627+a, tdbSNP:73139269
2683+c, tdbSNP:150609332
2761+dbSNP:
2761+c, gdbSNP:142030914
2772+c, tdbSNP:144153931
2817+c, tdbSNP:148616739
2859+c, gdbSNP:142081551
2874+a, gdbSNP:145084709
2909+c, tdbSNP:141716319
2910+c, tdbSNP:76565471
2946+dbSNP:
2946+c, tdbSNP:73846185
2957+a, cdbSNP:148297854
2966+a, gdbSNP:17801309
2995+c, tdbSNP:35124509
2996+a, gdbSNP:150555764
3027+c, tdbSNP:1054750
3065+a, cdbSNP:192800580
3066+c, tdbSNP:145149969
3111+dbSNP:
3111+a, gdbSNP:55836286
3169+c, tdbSNP:147992008
3171+c, tdbSNP:147581559
3183+a, gdbSNP:199509777
3226+a, gdbSNP:201042153
3332+a, gdbSNP:183966245
3346..3347+, cdbSNP:36097210
3473+c, tdbSNP:3762717
3578+a, gdbSNP:188207366
3702+a, gdbSNP:73139144
3985+, tadbSNP:77890779
4045+a, tdbSNP:202222982
4050+c, tdbSNP:76905803
4173+a, cdbSNP:182032149
4185+c, gdbSNP:186325629
4209+c, tdbSNP:191674555
4210+a, gdbSNP:141674458
4229+a, gdbSNP:181612461
4270+a, cdbSNP:199684787
4295+a, tdbSNP:74438214
4323+c, gdbSNP:201083429
4514+c, tdbSNP:186377358
4582+a, cdbSNP:7650184
4583+c, tdbSNP:73846200
4630+g, tdbSNP:191581645
4803+a, gdbSNP:182509403
4872+a, gdbSNP:73139147
4883+c, tdbSNP:7650466
5018..5019+, cdbSNP:34215402
5077+c, tdbSNP:186746038
5253+a, gdbSNP:150121394
5481+a, gdbSNP:73139148
5495..5496+, tdbSNP:34339302
5530+a, gdbSNP:138605369
5573+c, tdbSNP:189642147
5728+a, cdbSNP:142920086
Gene SymbolEPHA3
Gene SynonymEK4; ETK; ETK1; HEK; HEK4; TYRO4
Chromosome3
Locus Map3p11.2
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_005233 Homo sapiens EPH receptor A3 (EPHA3), transcript variant 1, mRNA. On-demand $899.00 20
NM_182644 Homo sapiens EPH receptor A3 (EPHA3), transcript variant 2, mRNA. On-demand $699.00 18
Title EphA3 maintains tumorigenicity and is a therapeutic target in glioblastoma multiforme .
Author Day,B.W., Stringer,B.W., Al-Ejeh,F., Ting,M.J., Wilson,J., Ensbey,K.S., Jamieson,P.R., Bruce,Z.C., Lim,Y.C., Offenhauser,C., Charmsaz,S., Cooper,L.T., Ellacott,J.K., Harding,A., Leveque,L., Inglis,P., Allan,S., Walker,D.G., Lackmann,M., Osborne,G., Khanna,K.K., Reynolds,B.A., Lickliter,J.D. and Boyd,A.W.
Journal Cancer Cell 23 (2), 238-248 (2013)
Title Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci .
Author Ludwig,K.U., Mangold,E., Herms,S., Nowak,S., Reutter,H., Paul,A., Becker,J., Herberz,R., AlChawa,T., Nasser,E., Bohmer,A.C., Mattheisen,M., Alblas,M.A., Barth,S., Kluck,N., Lauster,C., Braumann,B., Reich,R.H., Hemprich,A., Potzsch,S., Blaumeiser,B., Daratsianos,N., Kreusch,T., Murray,J.C., Marazita,M.L., Ruczinski,I., Scott,A.F., Beaty,T.H., Kramer,F.J., Wienker,T.F., Steegers-Theunissen,R.P., Rubini,M., Mossey,P.A., Hoffmann,P., Lange,C., Cichon,S., Propping,P., Knapp,M. and Nothen,M.M.
Journal Nat. Genet. 44 (9), 968-971 (2012)
Title Effects of cancer-associated EPHA3 mutations on lung cancer .
Author Zhuang,G., Song,W., Amato,K., Hwang,Y., Lee,K., Boothby,M., Ye,F., Guo,Y., Shyr,Y., Lin,L., Carbone,D.P., Brantley-Sieders,D.M. and Chen,J.
Journal J. Natl. Cancer Inst. 104 (15), 1182-1197 (2012)
Title Aberrant expression of EphA3 in gastric carcinoma: correlation with tumor angiogenesis and survival .
Author Xi,H.Q., Wu,X.S., Wei,B. and Chen,L.
Journal J. Gastroenterol. 47 (7), 785-794 (2012)
Title Cancer somatic mutations disrupt functions of the EphA3 receptor tyrosine kinase through multiple mechanisms .
Author Lisabeth,E.M., Fernandez,C. and Pasquale,E.B.
Journal Biochemistry 51 (7), 1464-1475 (2012)
Title Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases .
Author Cerretti,D.P., Vanden Bos,T., Nelson,N., Kozlosky,C.J., Reddy,P., Maraskovsky,E., Park,L.S., Lyman,S.D., Copeland,N.G., Gilbert,D.J. et al.
Journal Mol. Immunol. 32 (16), 1197-1205 (1995)
Title Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors .
Author Beckmann,M.P., Cerretti,D.P., Baum,P., Vanden Bos,T., James,L., Farrah,T., Kozlosky,C., Hollingsworth,T., Shilling,H., Maraskovsky,E. et al.
Journal EMBO J. 13 (16), 3757-3762 (1994)
Title Localization of a human receptor tyrosine kinase (ETK1) to chromosome region 3p11.2 .
Author Wicks,I.P., Lapsys,N.M., Baker,E., Campbell,L.J., Boyd,A.W. and Sutherland,G.R.
Journal Genomics 19 (1), 38-41 (1994)
Title Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines .
Author Wicks,I.P., Wilkinson,D., Salvaris,E. and Boyd,A.W.
Journal Proc. Natl. Acad. Sci. U.S.A. 89 (5), 1611-1615 (1992)
Title Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line .
Author Boyd,A.W., Ward,L.D., Wicks,I.P., Simpson,R.J., Salvaris,E., Wilks,A., Welch,K., Loudovaris,M., Rockman,S. and Busmanis,I.
Journal J. Biol. Chem. 267 (5), 3262-3267 (1992)


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