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Database:

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Homo sapiens forkhead box G1 (FOXG1), mRNA.


Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu22100 Homo sapiens forkhead box G1 (FOXG1), mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu22100C Homo sapiens forkhead box G1 (FOXG1), mRNA. Customized vector On-demand $269.00 TBD

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Mutation services

Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Data sheet
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
Restriction Sites Hind III- EcoR I
RefSeq Version NM_005249.4, 375151583
Length 1470 bp
Structure linear
Update Date 10-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens forkhead box G1 (FOXG1), mRNA.
Product forkhead box protein G1
Comment

Summary: This locus encodes a member of the forked-head transcription factor family. The encoded protein, which functions as a repressor, may play a role in brain development. Mutations at this locus have been associated with Rett syndrome. [provided by RefSeq, Feb 2012].

RefSeq NP_005240.3
CDS 209..1678
Misc Feature(1)35..37
Misc Feature(2)35..37
Misc Feature(3)749..982
Misc Feature(4)749..982
Misc Feature(5)order(857..862,887..889,896..901,959..961)
Misc Feature(6)1355..1426
Exon (1)1..3206
Gene:FOXG1
Gene Synonym:BF1; BF2; FHKL3; FKH2; FKHL1; FKHL2; FKHL3; FKHL4; FOXG1A; FOXG1B; FOXG1C; HBF-1; HBF-2; HBF-3; HBF-G2; HBF2; HFK1; HFK2; HFK3; KHL2; QIN
Translation MLDMGDRKEVKMIPKSSFSINSLVPEAVQNDNHHASHGHHNSHHPQHHHHHHHHHHHPPP PAPQPPPPPQQQQPPPPPPPAPQPPQTRGAPAADDDKGPQQLLLPPPPPPPPAAALDGAK ADGLGGKGEPGGGPGELAPVGPDEKEKGAGAGGEEKKGAGEGGKDGEGGKEGEKKNGKYE KPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIRHNLSLNKCFV KVPRHYDDPGKGNYWMLDPSSDDVFIGGTTGKLRRRSTTSRAKLAFKRGARLTSTGLTFM DRAGSLYWPMSPFLSLHHPRASSTLSYNGTTSAYPSHPMPYSSVLTQNSLGNNHSFSTAN GLSVDRLVNGEIPYATHHLTAAALAASVPCGLSVPCSGTYSLNPCSVNLLAGQTSYFFPH VPHPSMTSQSSTSMSARAASSSTSPQAPSTLPCESLRPSLPSFTTGLSGGLSDYFTHQNQ GSSSNPLIH
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Position Chain Variation Link
265+c, tdbSNP:372915038
428..429+, agcdbSNP:398124201
464+a, cdbSNP:398124202
534+c, tdbSNP:398124203
655+c, gdbSNP:112803404
668..669+, gdbSNP:398124204
679+g, tdbSNP:398124205
697+c, tdbSNP:375378714
711+c, gdbSNP:148157138
802+c, gdbSNP:141088742
814+c, tdbSNP:201191801
832+c, gdbSNP:267606826
851+c, tdbSNP:267606828
894+a, gdbSNP:199502880
973+a, gdbSNP:121913678
1018+a, gdbSNP:374673901
complement(1093)-t, cdbSNP:142067350
1132+a, gdbSNP:267606827
1197+c, gdbSNP:150277632
1213+c, gdbSNP:368707795
1238+a, gdbSNP:372086115
1306+g, tdbSNP:139237860
1355+a, gdbSNP:202157686
1366+c, g, tdbSNP:143223844
1369+a, gdbSNP:147154860
1373+c, tdbSNP:369673538
1408+c, g, tdbSNP:138747073
1411+c, tdbSNP:201024952
1441+c, tdbSNP:34654108
1471+c, gdbSNP:373079213
1521+c, tdbSNP:376242569
1531+c, tdbSNP:144434028
1549+c, tdbSNP:200639648
1556+a, cdbSNP:1126890
1603+c, gdbSNP:369183477
1607+c, tdbSNP:371279404
1647+a, gdbSNP:148410675
1657+a, c, tdbSNP:142688661
1686+g, tdbSNP:373961431
1691+a, cdbSNP:151157846
1696+c, tdbSNP:377726805
1771+, cdbSNP:68024132
1778+, cdbSNP:397788971
1835+c, tdbSNP:111723999
2098+, adbSNP:35458312
2152..2156+, cttttdbSNP:138317321
2156..2160+, tctttdbSNP:75768168
2222+a, gdbSNP:1042761
2225+c, tdbSNP:375413059
2233+g, tdbSNP:191019765
2278+a, gdbSNP:1042762
2303+a, gdbSNP:373061437
2487+c, tdbSNP:189418563
2571+g, tdbSNP:1042766
2789+, adbSNP:372395431
2847+a, gdbSNP:181934041
Gene SymbolFOXG1
Gene SynonymBF1; BF2; FHKL3; FKH2; FKHL1; FKHL2; FKHL3; FKHL4; FOXG1A; FOXG1B; FOXG1C; HBF-1; HBF-2; HBF-3; HBF-G2; HBF2; HFK1; HFK2; HFK3; KHL2; QIN
Chromosome14
Locus Map14q13
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_005249 Homo sapiens forkhead box G1 (FOXG1), mRNA. On-demand TBD TBD
Title Transcriptional repression of AIB1 by FoxG1 leads to apoptosis in breast cancer cells .
Author Li JV, Chien CD, Garee JP, Xu J, Wellstein A and Riegel AT.
Journal Mol. Endocrinol. 27 (7), 1113-1127 (2013)
Title 14q12 microdeletions excluding FOXG1 give rise to a congenital variant Rett syndrome-like phenotype .
Author Ellaway CJ, Ho G, Bettella E, Knapman A, Collins F, Hackett A, McKenzie F, Darmanian A, Peters GB, Fagan K and Christodoulou J.
Journal Eur. J. Hum. Genet. 21 (5), 522-527 (2013)
Title 14q12 and severe Rett-like phenotypes: new clinical insights and physical mapping of FOXG1-regulatory elements .
Author Allou L, Lambert L, Amsallem D, Bieth E, Edery P, Destree A, Rivier F, Amor D, Thompson E, Nicholl J, Harbord M, Nemos C, Saunier A, Moustaine A, Vigouroux A, Jonveaux P and Philippe C.
Journal Eur. J. Hum. Genet. 20 (12), 1216-1223 (2012)
Title Further delineation of the phenotype of chromosome 14q13 deletions: (positional) involvement of FOXG1 appears the main determinant of phenotype severity, with no evidence for a holoprosencephaly locus .
Author Santen GW, Sun Y, Gijsbers AC, Carre A, Holvoet M, Haeringen Av, Lesnik Oberstein SA, Tomoda A, Mabe H, Polak M, Devriendt K, Ruivenkamp CA and Bijlsma EK.
Journal J. Med. Genet. 49 (6), 366-372 (2012)
Title The oncogene qin codes for a transcriptional repressor .
Author Li J, Chang HW, Lai E, Parker EJ and Vogt PK.
Journal Cancer Res. 55 (23), 5540-5544 (1995)
Title The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q .
Author Wiese S, Murphy DB, Schlung A, Burfeind P, Schmundt D, Schnulle V, Mattei MG and Thies U.
Journal Biochim. Biophys. Acta 1262 (2-3), 105-112 (1995)
Title Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending .
Author Pierrou S, Hellqvist M, Samuelsson L, Enerback S and Carlsson P.
Journal EMBO J. 13 (20), 5002-5012 (1994)
Title Human brain factor 1, a new member of the fork head gene family .
Author Murphy DB, Wiese S, Burfeind P, Schmundt D, Mattei MG, Schulz-Schaeffer W and Thies U.
Journal Genomics 21 (3), 551-557 (1994)
Title The human homologue of the retroviral oncogene qin maps to chromosome 14q13 .
Author Kastury K, Li J, Druck T, Su H, Vogt PK, Croce CM and Huebner K.
Journal Proc. Natl. Acad. Sci. U.S.A. 91 (9), 3616-3618 (1994)
Title The retroviral oncogene qin belongs to the transcription factor family that includes the homeotic gene fork head .
Author Li J and Vogt PK.
Journal Proc. Natl. Acad. Sci. U.S.A. 90 (10), 4490-4494 (1993)

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