Sequence in raw or FASTA format:
Homo sapiens noggin (NOG), mRNA.
|RefSeq Version||NM_005450.4, 189339247|
|Organism||Homo sapiens (human)|
|Definition||Homo sapiens noggin (NOG), mRNA.|
Summary: The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008].
Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
Gene Synonym:SYM1; SYNS1
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|Gene Synonym||SYM1; SYNS1|
|Title||An introduction of genetics in otosclerosis: a systematic review .|
|Author||Bittermann AJ, Wegner I, Noordman BJ, Vincent R, van der Heijden GJ and Grolman W.|
|Journal||Otolaryngol Head Neck Surg 150 (1), 34-39 (2014)|
|Title||Multiple synostoses syndrome in three members of a family displaying a novel mutation in NOGGIN gene .|
|Author||Aydin,H.U., Altunoglu,U., Uyguner,Z.O., Ozkan,T. and Kayserili,H.|
|Journal||J Plast Reconstr Aesthet Surg 66 (10), E287-E289 (2013)|
|Title||A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease .|
|Author||Ostensson M, Monten C, Bacelis J, Gudjonsdottir AH, Adamovic S, Ek J, Ascher H, Pollak E, Arnell H, Browaldh L, Agardh D, Wahlstrom J, Nilsson S and Torinsson-Naluai A.|
|Journal||PLoS ONE 8 (8), E70174 (2013)|
|Title||The expression patterns of gremlin 1 and noggin in normal adult and tumor tissues .|
|Author||Laurila R, Parkkila S, Isola J, Kallioniemi A and Alarmo EL.|
|Journal||Int J Clin Exp Pathol 6 (7), 1400-1408 (2013)|
|Title||Noggin attenuates the osteogenic activation of human valve interstitial cells in aortic valve sclerosis .|
|Author||Poggio P, Sainger R, Branchetti E, Grau JB, Lai EK, Gorman RC, Sacks MS, Parolari A, Bavaria JE and Ferrari G.|
|Journal||Cardiovasc. Res. 98 (3), 402-410 (2013)|
|Title||Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite .|
|Author||McMahon JA, Takada S, Zimmerman LB, Fan CM, Harland RM and McMahon AP.|
|Journal||Genes Dev. 12 (10), 1438-1452 (1998)|
|Title||The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4 .|
|Author||Zimmerman LB, De Jesus-Escobar JM and Harland RM.|
|Journal||Cell 86 (4), 599-606 (1996)|
|Title||Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern .|
|Author||Lamb TM and Harland RM.|
|Journal||Development 121 (11), 3627-3636 (1995)|
|Title||Identification of mammalian noggin and its expression in the adult nervous system .|
|Author||Valenzuela DM, Economides AN, Rojas E, Lamb TM, Nunez L, Jones P, Lp NY, Espinosa R 3rd, Brannan CI and Gilbert DJ.|
|Journal||J. Neurosci. 15 (9), 6077-6084 (1995)|
|Title||Localization of the gene (SYM1) for proximal symphalangism to human chromosome 17q21-q22 .|
|Author||Polymeropoulos MH, Poush J, Rubenstein JR and Francomano CA.|
|Journal||Genomics 27 (2), 225-229 (1995)|
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