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Homo sapiens hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (HCN4), mRNA.


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_005477 Homo sapiens hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (HCN4), mRNA. GenEZ ORF Cloning On-demand $TBD TBD

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RefSeq Version NM_005477.2, 210147528
Length 7245 bp
Structure linear
Update Date 17-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (HCN4), mRNA.
Product potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Comment

Summary: This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008].


Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

RefSeq NP_005468.1
CDS 995..4606
Misc Feature(1)866..868
Misc Feature(2)1619..1774
Misc Feature(3)1619..1774
Misc Feature(4)1643..1873
Misc Feature(5)1793..1855
Misc Feature(6)1874..1936
Misc Feature(7)1883..2527
Misc Feature(8)2015..2077
Misc Feature(9)2099..2161
Misc Feature(10)2255..2317
Misc Feature(11)2483..2545
Misc Feature(12)2759..>3166
Misc Feature(13)2777..3103
Misc Feature(14)order(2969..2974,2999..3007)
Misc Feature(15)order(3065..3073,3083..3091)
Exon (1)1..1779
Gene:HCN4
Gene Synonym:SSS2
Exon (2)1780..2203
Gene:HCN4
Gene Synonym:SSS2
Exon (3)2204..2365
Gene:HCN4
Gene Synonym:SSS2
Exon (4)2366..2584
Gene:HCN4
Gene Synonym:SSS2
Exon (5)2585..2731
Gene:HCN4
Gene Synonym:SSS2
Exon (6)2732..2972
Gene:HCN4
Gene Synonym:SSS2
Exon (7)2973..3137
Gene:HCN4
Gene Synonym:SSS2
Exon (8)3138..7228
Gene:HCN4
Gene Synonym:SSS2
Translation MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDAEEEGAGGRQDPSRRSIRLRPLPSPSPSA AAGGTESRSSALGAADSEGPARGAGKSSTNGDCRRFRGSLASLGSRGGGSGGTGSGSSHG HLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCE QPSVDTAIKVEGGAAAGDQILPEAEVRLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAV EREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNV VSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVE TRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVN LIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIG YGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSF HKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANAD PNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGE ICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSI LLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHRVQAAASATPTPTPVIWTPLIQA PLQAAAATTSVAIALTHHPRLPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSA SPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPSAGVA ATTIAGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLP PPPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFT PRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLT QDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGR PYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGPQREPGARPEPVRSKLP SNL
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Position Chain Variation Link
complement(63)-dbSNP:
complement(63)-g, cdbSNP:192441254
complement(410)-t, gdbSNP:140161530
complement(427)-t, gdbSNP:188896349
complement(497)-t, gdbSNP:146150604
complement(588)-g, adbSNP:183675842
complement(1030)-g, cdbSNP:201193660
complement(1101)-t, cdbSNP:143090627
complement(1528)-g, adbSNP:111892410
complement(1578)-g, adbSNP:201375192
complement(1581)-g, cdbSNP:200186692
complement(1615)-g, cdbSNP:138005226
complement(1737)-t, cdbSNP:191744064
complement(1876)-dbSNP:
complement(1876)-g, cdbSNP:190347872
complement(1984)-t, cdbSNP:146954200
complement(1988)-g, adbSNP:141185786
complement(2008)-g, cdbSNP:147771899
complement(2021)-t, cdbSNP:185719200
complement(2081)-t, cdbSNP:144168042
complement(2083)-g, adbSNP:140902511
complement(2084)-t, cdbSNP:151004999
complement(2185)-g, adbSNP:142643511
complement(2237)-dbSNP:
complement(2237)-t, cdbSNP:201978086
complement(2350)-g, adbSNP:148453034
complement(2379)-dbSNP:
complement(2379)-t, cdbSNP:146714274
complement(2431)-g, adbSNP:202001597
complement(2432)-g, cdbSNP:121908411
complement(2437)-g, adbSNP:200337785
complement(2449)-t, cdbSNP:148875639
complement(2453)-t, cdbSNP:202037304
complement(2464)-g, adbSNP:144298603
complement(2512)-g, adbSNP:139590882
complement(2530)-g, adbSNP:146306966
complement(2552)-g, adbSNP:12909882
complement(2554)-t, cdbSNP:200033529
complement(2557)-g, adbSNP:201999732
complement(2565)-t, cdbSNP:199852438
complement(2629)-dbSNP:
complement(2629)-g, adbSNP:140015730
complement(2642)-g, adbSNP:150691273
complement(2647)-t, gdbSNP:141966309
complement(2650)-g, adbSNP:148142070
complement(2651)-g, adbSNP:104894485
complement(2659)-g, adbSNP:147075615
complement(2668)-t, gdbSNP:201337528
complement(2677)-t, gdbSNP:62641690
complement(2687)-t, cdbSNP:201811340
complement(2697)-g, cdbSNP:138714806
complement(2833)-dbSNP:
complement(2833)-g, adbSNP:117731813
complement(2834)-t, cdbSNP:201319883
complement(2890)-t, cdbSNP:200737571
complement(2990)-dbSNP:
complement(2990)-t, gdbSNP:199943122
complement(3010)-c, adbSNP:104894488
complement(3019)-g, adbSNP:149033101
complement(3020)-t, cdbSNP:145134839
complement(3100)-g, adbSNP:200773333
complement(3103)-g, adbSNP:150378994
complement(3109)-g, adbSNP:201652877
complement(3175)-dbSNP:
complement(3175)-g, adbSNP:140354126
complement(3176)-t, cdbSNP:200468312
complement(3181)-g, cdbSNP:201156570
complement(3188)-t, cdbSNP:199530458
complement(3204)-t, cdbSNP:146732972
complement(3260)-t, cdbSNP:143339036
complement(3269)-t, cdbSNP:62641689
complement(3304)-t, cdbSNP:146809501
complement(3307)-g, adbSNP:142298104
complement(3320)-t, gdbSNP:148714049
complement(3392)-g, adbSNP:181894662
complement(3414)-t, cdbSNP:200395062
complement(3456)-t, cdbSNP:144206811
complement(3459)-g, adbSNP:201143364
complement(3471)-g, adbSNP:201997521
complement(3487)-t, gdbSNP:149640972
complement(3488)-g, adbSNP:200058167
complement(3490)-c, adbSNP:139394937
complement(3516)-g, adbSNP:200546024
complement(3520)-g, adbSNP:201499694
complement(3539)-c, adbSNP:202138767
complement(3550)-t, cdbSNP:117819825
complement(3586)-tc, aadbSNP:71442382
complement(3595)-t, gdbSNP:143188160
complement(3598)-g, c, adbSNP:138773305
complement(3642)-g, cdbSNP:148398509
complement(3651)-g, adbSNP:200575377
complement(3662)-g, adbSNP:184801511
complement(3667)-t, cdbSNP:191092709
complement(3695)-t, cdbSNP:201742383
complement(3724)-t, gdbSNP:200814534
complement(3794)-g, adbSNP:199638465
complement(3806)-, cdbSNP:35620549
complement(3825)-g, adbSNP:144450232
complement(3911)-t, cdbSNP:200495478
complement(3972)-g, adbSNP:199798661
complement(3973)-t, cdbSNP:75307879
complement(3996)-t, gdbSNP:12591469
complement(4004)-g, adbSNP:201418838
complement(4027)-c, adbSNP:186728422
complement(4072)-g, adbSNP:202188345
complement(4189)-g, cdbSNP:4493011
complement(4214)-g, adbSNP:200399862
complement(4282)-g, adbSNP:116042117
complement(4331)-t, cdbSNP:142735148
complement(4344)-g, adbSNP:140402087
complement(4358)-, cdbSNP:35241186
complement(4454)-g, adbSNP:200896834
complement(4455)-t, cdbSNP:145862018
complement(4524)-t, cdbSNP:141662311
complement(4571)-g, cdbSNP:200507617
complement(4575)-g, adbSNP:147982868
complement(4577)-c, adbSNP:143431889
complement(4581)-t, cdbSNP:147181577
complement(4590)-t, adbSNP:146751122
complement(4594)-t, cdbSNP:529004
complement(4657)-g, cdbSNP:184571419
complement(4716..4717)-, ggdbSNP:201771049
complement(4717..4718)-, tgdbSNP:201885222
complement(4718..4719)-, tgdbSNP:74569915
complement(4724..4725)-, gtdbSNP:35177144
complement(4724)-t, gdbSNP:200249977
complement(4724)-, tgdbSNP:61340538
complement(4725)-t, gdbSNP:201794707
complement(4726)-g, cdbSNP:201117747
complement(4733)-t, cdbSNP:41277726
complement(4836)-c, adbSNP:192410107
complement(4962)-g, cdbSNP:187942398
complement(4981)-g, cdbSNP:183633232
complement(5020)-t, gdbSNP:3743496
complement(5073)-g, adbSNP:191621714
complement(5109)-g, adbSNP:111607232
complement(5211)-t, cdbSNP:143616433
complement(5240)-g, adbSNP:138059941
complement(5271)-t, cdbSNP:73440095
complement(5308)-t, gdbSNP:199895735
complement(5308)-, adbSNP:3833037
complement(5314)-g, adbSNP:2623999
complement(5342)-g, adbSNP:189723970
complement(5448)-t, cdbSNP:78154416
complement(5450)-t, cdbSNP:185261766
complement(5501)-g, adbSNP:150371082
complement(5542)-t, cdbSNP:116280951
complement(5694)-t, gdbSNP:182384614
complement(5746)-t, cdbSNP:74786613
complement(5803)-g, adbSNP:117071871
complement(6088)-t, cdbSNP:191013007
complement(6096)-t, gdbSNP:187377882
complement(6109)-t, gdbSNP:181626404
complement(6265)-t, cdbSNP:79656991
complement(6478)-c, adbSNP:56193811
complement(6595)-t, cdbSNP:549377
complement(6656)-t, cdbSNP:148078581
complement(6857)-g, adbSNP:143667826
complement(6960)-t, cdbSNP:11631286
complement(6999)-g, cdbSNP:74933243
complement(7027)-g, cdbSNP:7167434
complement(7051)-g, adbSNP:524457
complement(7142..7143)-, tdbSNP:199965428
complement(7178)-g, adbSNP:3743493
complement(7205)-t, adbSNP:60307833
complement(7206)-t, adbSNP:57100128
complement(7220)-t, adbSNP:75776477
complement(7226)-t, cdbSNP:186403235
Gene SymbolHCN4
Gene SynonymSSS2
Chromosome15
Locus Map15q24.1
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_005477 Homo sapiens hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (HCN4), mRNA. On-demand TBD TBD
Title Hyperpolarisation-activated cyclic nucleotide channel 4 (HCN4) involvement in Tourette's syndrome autoimmunity .
Author Yeh,C.B., Shui,H.A., Chu,T.H., Chen,Y.A., Tsung,H.C. and Shyu,J.F.
Journal J. Neuroimmunol. 250 (1-2), 18-26 (2012)
Title Adrenergic regulation of HCN4 channel requires protein association with beta2-adrenergic receptor .
Author Greene,D., Kang,S., Kosenko,A. and Hoshi,N.
Journal J. Biol. Chem. 287 (28), 23690-23697 (2012)
Title Meta-analysis identifies six new susceptibility loci for atrial fibrillation .
Author Ellinor,P.T., Lunetta,K.L., Albert,C.M., Glazer,N.L., Ritchie,M.D., Smith,A.V., Arking,D.E., Muller-Nurasyid,M., Krijthe,B.P., Lubitz,S.A., Bis,J.C., Chung,M.K., Dorr,M., Ozaki,K., Roberts,J.D., Smith,J.G., Pfeufer,A., Sinner,M.F., Lohman,K., Ding,J., Smith,N.L., Smith,J.D., Rienstra,M., Rice,K.M., Van Wagoner,D.R., Magnani,J.W., Wakili,R., Clauss,S., Rotter,J.I., Steinbeck,G., Launer,L.J., Davies,R.W., Borkovich,M., Harris,T.B., Lin,H., Volker,U., Volzke,H., Milan,D.J., Hofman,A., Boerwinkle,E., Chen,L.Y., Soliman,E.Z., Voight,B.F., Li,G., Chakravarti,A., Kubo,M., Tedrow,U.B., Rose,L.M., Ridker,P.M., Conen,D., Tsunoda,T., Furukawa,T., Sotoodehnia,N., Xu,S., Kamatani,N., Levy,D., Nakamura,Y., Parvez,B., Mahida,S., Furie,K.L., Rosand,J., Muhammad,R., Psaty,B.M., Meitinger,T., Perz,S., Wichmann,H.E., Witteman,J.C., Kao,W.H., Kathiresan,S., Roden,D.M., Uitterlinden,A.G., Rivadeneira,F., McKnight,B., Sjogren,M., Newman,A.B., Liu,Y., Gollob,M.H., Melander,O., Tanaka,T., Stricker,B.H., Felix,S.B., Alonso,A., Darbar,D., Barnard,J., Chasman,D.I., Heckbert,S.R., Benjamin,E.J., Gudnason,V. and Kaab,S.
Journal Nat. Genet. 44 (6), 670-675 (2012)
Title Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases .
Author Tu,E., Waterhouse,L., Duflou,J., Bagnall,R.D. and Semsarian,C.
Journal Brain Pathol. 21 (6), 692-698 (2011)
Title Association of polymorphisms in HCN4 with mood disorders and obsessive compulsive disorder .
Author Kelmendi,B., Holsbach-Beltrame,M., McIntosh,A.M., Hilt,L., George,E.D., Kitchen,R.R., Carlyle,B.C., Pittenger,C., Coric,V., Nolen-Hoeksema,S., Sanacora,G. and Simen,A.A.
Journal Neurosci. Lett. 496 (3), 195-199 (2011)
Title Pacemaker channel dysfunction in a patient with sinus node disease .
Author Schulze-Bahr,E., Neu,A., Friederich,P., Kaupp,U.B., Breithardt,G., Pongs,O. and Isbrandt,D.
Journal J. Clin. Invest. 111 (10), 1537-1545 (2003)
Title Functional comparison of HCN isoforms expressed in ventricular and .
Author Qu,J., Altomare,C., Bucchi,A., DiFrancesco,D. and Robinson,R.B.
Journal Pflugers Arch. 444 (5), 597-601 (2002)
Title Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli .
Author Stevens,D.R., Seifert,R., Bufe,B., Muller,F., Kremmer,E., Gauss,R., Meyerhof,W., Kaupp,U.B. and Lindemann,B.
Journal Nature 413 (6856), 631-635 (2001)
Title Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis .
Author Seifert,R., Scholten,A., Gauss,R., Mincheva,A., Lichter,P. and Kaupp,U.B.
Journal Proc. Natl. Acad. Sci. U.S.A. 96 (16), 9391-9396 (1999)
Title Two pacemaker channels from human heart with profoundly different activation kinetics .
Author Ludwig,A., Zong,X., Stieber,J., Hullin,R., Hofmann,F. and Biel,M.
Journal EMBO J. 18 (9), 2323-2329 (1999)


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