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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


Homo sapiens neurotrophin 4 (NTF4), mRNA.


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_006179 Homo sapiens neurotrophin 4 (NTF4), mRNA. GenEZ ORF Cloning On-demand $399.00 14

*Business Day

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RefSeq Version NM_006179.4, 169658373
Length 999 bp
Structure linear
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens neurotrophin 4 (NTF4), mRNA.
Product neurotrophin-4 preproprotein
Comment

Summary: This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008].


Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

RefSeq NP_006170.1
CDS 142..774
Misc Feature(1)124..126
Misc Feature(2)397..768
Exon (1)1..129
Gene:NTF4
Gene Synonym:GLC10; GLC1O; NT-4; NT-4/5; NT-5; NT4; NT5; NTF5
Exon (2)130..999
Gene:NTF4
Gene Synonym:GLC10; GLC1O; NT-4; NT-4/5; NT-5; NT4; NT5; NTF5
Translation MLPLPSCSLPILLLFLLPSVPIESQPPPSTLPPFLAPEWDLLSPRVVLSRGAPAGPPLLF LLEAGAFRESAGAPANRSRRGVSETAPASRRGELAVCDAVSGWVTDRRTAVDLRGREVEV LGEVPAAGGSPLRQYFFETRCKADNAEEGGPGAGGGGCRGVDRRHWVSECKAKQSYVRAL TADAQGRVGWRWIRIDTACVCTLLSRTGRA
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Position Chain Variation Link
complement(37)-dbSNP:
complement(37)-t, cdbSNP:372197508
complement(169)-t, gdbSNP:201071858
complement(344)-t, cdbSNP:200786116
complement(364)-t, cdbSNP:186082918
complement(384)-t, cdbSNP:145884553
complement(401)-t, gdbSNP:367858798
404+c, tdbSNP:61732310
complement(407)-t, cdbSNP:374367338
complement(418)-t, cdbSNP:371019044
complement(435)-g, adbSNP:199958178
complement(452)-c, adbSNP:202216349
complement(461)-g, cdbSNP:377741315
complement(468)-g, adbSNP:374113081
complement(472)-g, cdbSNP:371058489
complement(481)-g, cdbSNP:377553005
complement(507)-g, adbSNP:373941167
complement(520)-c, adbSNP:369484075
complement(521)-g, adbSNP:145846156
complement(538)-g, adbSNP:144842220
complement(558)-t, gdbSNP:62127897
complement(559..560)-, tdbSNP:34922845
complement(559)-g, adbSNP:201069064
complement(577)-c, adbSNP:140946623
complement(594)-t, cdbSNP:374345134
complement(622)-t, cdbSNP:369066724
complement(634)-t, gdbSNP:371734511
complement(640)-g, cdbSNP:200878406
complement(658)-t, adbSNP:367957078
complement(668)-t, cdbSNP:374415552
complement(673)-g, adbSNP:370717457
complement(693)-g, cdbSNP:147294437
complement(700)-g, adbSNP:144346396
complement(702)-g, adbSNP:142027939
complement(706)-g, cdbSNP:375526828
complement(721)-g, adbSNP:369788069
complement(739)-t, cdbSNP:200081067
complement(744)-g, adbSNP:377015369
complement(746)-g, adbSNP:373152998
758+a, gdbSNP:121918428
complement(761)-g, adbSNP:371861346
complement(766)-g, cdbSNP:200675509
complement(800)-t, cdbSNP:116348522
complement(833)-g, adbSNP:151306084
complement(884)-t, cdbSNP:115969617
complement(966)-g, cdbSNP:112004444
Gene SymbolNTF4
Gene SynonymGLC10; GLC1O; NT-4; NT-4/5; NT-5; NT4; NT5; NTF5
Chromosome19
Locus Map19q13.3
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_006179 Homo sapiens neurotrophin 4 (NTF4), mRNA. On-demand $399.00 14
XM_005258962 PREDICTED: Homo sapiens neurotrophin 4 (NTF4), transcript variant X1, mRNA. On-demand $399.00 14
XM_006723232 PREDICTED: Homo sapiens neurotrophin 4 (NTF4), transcript variant X2, mRNA. On-demand $399.00 14
Title Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis .
Author Peng WM, Maintz L, Allam JP, Raap U, Gutgemann I, Kirfel J, Wardelmann E, Perner S, Zhao W, Fimmers R, Walgenbach K, Oldenburg J, Schwartz LB and Novak N.
Journal Blood 122 (10), 1779-1788 (2013)
Title The inorganic perspectives of neurotrophins and Alzheimer's disease .
Author Travaglia A, Pietropaolo A, La Mendola D, Nicoletti VG and Rizzarelli E.
Journal J. Inorg. Biochem. 111, 130-137 (2012)
Title Evaluation of NTF4 as a causative gene for primary open-angle glaucoma .
Author Chen LJ, Ng TK, Fan AH, Leung DY, Zhang M, Wang N, Zheng Y, Liang XY, Chiang SW, Tam PO and Pang CP.
Journal Mol. Vis. 18, 1763-1772 (2012)
Title Immune cell NT-3 expression is associated with brain atrophy in multiple sclerosis patients .
Author Kalinowska-Lyszczarz A, Pawlak MA, Michalak S, Paprzycki W and Losy J.
Journal J. Neuroimmunol. 240-241, 109-113 (2011)
Title Brain-derived neurotrophic factor and neurotrophin-4/5 are expressed in breast cancer and can be targeted to inhibit tumor cell survival .
Author Vanhecke E, Adriaenssens E, Verbeke S, Meignan S, Germain E, Berteaux N, Nurcombe V, Le Bourhis X and Hondermarck H.
Journal Clin. Cancer Res. 17 (7), 1741-1752 (2011)
Title Differential role of the low affinity neurotrophin receptor (p75) in retrograde axonal transport of the neurotrophins .
Author Curtis R, Adryan KM, Stark JL, Park JS, Compton DL, Weskamp G, Huber LJ, Chao MV, Jaenisch R and Lee KF.
Journal Neuron 14 (6), 1201-1211 (1995)
Title Human chromosome 19 contains the neurotrophin-5 gene locus and three related genes that may encode novel acidic neurotrophins .
Author Berkemeier LR, Ozcelik T, Francke U and Rosenthal A.
Journal Somat. Cell Mol. Genet. 18 (3), 233-245 (1992)
Title Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity .
Author Ip NY, Ibanez CF, Nye SH, McClain J, Jones PF, Gies DR, Belluscio L, Le Beau MM, Espinosa R 3rd and Squinto SP.
Journal Proc. Natl. Acad. Sci. U.S.A. 89 (7), 3060-3064 (1992)
Title Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB .
Author Berkemeier LR, Winslow JW, Kaplan DR, Nikolics K, Goeddel DV and Rosenthal A.
Journal Neuron 7 (5), 857-866 (1991)
Title Dissociation equilibrium constant of beta nerve growth factor .
Author Bothwell,M.A. and Shooter,E.M.
Journal J. Biol. Chem. 252 (23), 8532-8536 (1977)

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