Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), mRNA.
| RefSeq Version | NM_006206.4, 172072625 |
| Length | 6574 bp |
| Structure | linear |
| Update Date | 24-APR-2011 |
| Organism | Homo sapiens (human) |
| Definition | Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), mRNA. |
| Product | alpha-type platelet-derived growth factor receptor precursor |
| Comment | Summary: This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. [provided by RefSeq]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. |
| RefSeq | NP_006197.1 |
| CDS | 332..3601 | Exon (1) | 1..319 | Exon (2) | 1..319 | Exon (3) | 320..380 | Exon (4) | 381..698 | Exon (5) | 699..959 | Exon (6) | 960..1090 | Exon (7) | 1091..1262 | Exon (8) | 1263..1452 | Exon (9) | 1453..1568 | Exon (10) | 1569..1695 | Exon (11) | 1696..1889 | Exon (12) | 1890..1984 | Exon (13) | 1985..2117 | Exon (14) | 2118..2222 | Exon (15) | 2223..2333 | Exon (16) | 2334..2487 | Exon (17) | 2488..2654 | Exon (18) | 2655..2770 | Exon (19) | 2771..2893 | Exon (20) | 2894..3005 | Exon (21) | 3006..3105 | Exon (22) | 3106..3211 | Exon (23) | 3212..3453 | Exon (24) | 3454..6574 |
| Translation | MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP
MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY
VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG
TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN
EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK
EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL
TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL
VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD
RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII
SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG
SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL
LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY
VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN
LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA
RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM
VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK
SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII
PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS
SDLVEDSFL
Order your protein of interest with our Guaranteed or It's Free Service now! For details, please click here. |
| Gene Symbol | PDGFRA |
| Gene Synonym | CD140A; MGC74795; PDGFR2; RHEPDGFRA |
| Chromosome | 4 |
| Locus Map | 4q12 |
| All Transcripts | NM_006206 |
| Title | Potential role of imatinib mesylate (Gleevec, STI-571) in the treatment of vestibular schwannoma . |
| Author | Altuna,X., Lopez,J.P., Yu,M.A., Arandazi,M.J., Harris,J.P., Wang-Rodriguez,J., An,Y., Dobrow,R., Doherty,J.K. and Ongkeko,W.M. |
| Journal | Otol. Neurotol. 32 (1), 163-170 (2011) |
| Title | Expression of platelet-derived growth factor-alpha receptor in human osteosarcoma is not a predictor of outcome . |
| Author | Sulzbacher,I., Birner,P., Dominkus,M., Pichlhofer,B. and Mazal,P.R. |
| Journal | Pathology 42 (7), 664-668 (2010) |
| Title | NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration . |
| Author | Kang,S.H., Fukaya,M., Yang,J.K., Rothstein,J.D. and Bergles,D.E. |
| Journal | Neuron 68 (4), 668-681 (2010) |
| Title | PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas . |
| Author | Ozawa,T., Brennan,C.W., Wang,L., Squatrito,M., Sasayama,T., Nakada,M., Huse,J.T., Pedraza,A., Utsuki,S., Yasui,Y., Tandon,A., Fomchenko,E.I., Oka,H., Levine,R.L., Fujii,K., Ladanyi,M. and Holland,E.C. |
| Journal | Genes Dev. 24 (19), 2205-2218 (2010) |
| Title | Fluorescence in situ hybridization analysis and immunophenotyping of c-Kit/PDGFRA and Bcl-2 expression in gastrointestinal stromal tumors . |
| Author | Orsenigo,M., Brich,S., Riva,C., Conca,E., Bertulli,R., Dileo,P., Gronchi,A., Casali,P.G., Pierotti,M.A., Tamborini,E. and Pilotti,S. |
| Journal | Anal. Quant. Cytol. Histol. 32 (4), 225-233 (2010) |
| Title | Ligand-induced interaction between alpha- and beta-type platelet-derived growth factor (PDGF) receptors: role of receptor heterodimers in kinase activation . |
| Author | Kanakaraj,P., Raj,S., Khan,S.A. and Bishayee,S. |
| Journal | Biochemistry 30 (7), 1761-1767 (1991) |
| Title | Chromosomal localization of the gene for AA-type platelet-derived growth factor receptor (PDGFRA) in humans and mice . |
| Author | Hsieh,C.L., Navankasattusas,S., Escobedo,J.A., Williams,L.T. and Francke,U. |
| Journal | Cytogenet. Cell Genet. 56 (3-4), 160-163 (1991) |
| Title | Platelet-derived growth factor receptor: current views of the two-subunit model . |
| Author | Hart,C.E. and Bowen-Pope,D.F. |
| Journal | J. Invest. Dermatol. 94 (6 SUPPL), 53S-57S (1990) |
| Title | An efficient directional cloning system to construct cDNA libraries containing full-length inserts at high frequency . |
| Author | Miki,T., Matsui,T., Heidaran,M.A. and Aaronson,S.A. |
| Journal | Gene 83 (1), 137-146 (1989) |
| Title | Isolation of a novel receptor cDNA establishes the existence of two . |
| Author | Matsui,T., Heidaran,M., Miki,T., Popescu,N., La Rochelle,W., Kraus,M., Pierce,J. and Aaronson,S. |
| Journal | Science 243 (4892), 800-804 (1989) |
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.
 |
Secured Online Quotation |
 |
Email: gene@genscript.com |
 |
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188 |
 |
Fax: 1-732-210-0262 1-732-885-5878 |