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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), mRNA.


Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu23897 Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), mRNA. pcDNA3.1+-DYK In-stock $1149.00 16
OHu23897C Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), mRNA. Customized vector In-stock $1149.00 16

*Business Day

Mutation services

Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_006206.4, 172072625
Length 3270 bp
Structure linear
Update Date 11-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), mRNA.
Product platelet-derived growth factor receptor alpha precursor
Comment

Summary: This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012].


Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data.

RefSeq NP_006197.1
CDS 332..3601
Misc Feature(1)134..136
Misc Feature(2)413..643
Misc Feature(3)1010..1210
Misc Feature(4)1013..1264
Misc Feature(5)1268..1570
Misc Feature(6)1574..1822
Misc Feature(7)1817..1822
Misc Feature(8)1916..1978
Misc Feature(9)1994..3199
Misc Feature(10)1994..1996
Misc Feature(11)2045..2047
Misc Feature(12)2051..2053
Misc Feature(13)2063..2068
Misc Feature(14)2075..2077
Misc Feature(15)2108..3190
Misc Feature(16)order(2126..2131,2135..2146,2150..2152,2204..2206,
Misc Feature(17)order(2126..2131,2135..2146,2150..2152,2204..2206,
Misc Feature(18)2489..2491
Misc Feature(19)2489..2491
Misc Feature(20)2522..2524
Misc Feature(21)2522..2524
Misc Feature(22)2555..2557
Misc Feature(23)2555..2557
Misc Feature(24)2591..2593
Misc Feature(25)2591..2593
Misc Feature(26)2615..2617
Misc Feature(27)2615..2617
Misc Feature(28)2630..2632
Misc Feature(29)2633..2635
Misc Feature(30)2633..2635
Misc Feature(31)order(2783..2785,2795..2797,2891..2905,2930..2932,
Misc Feature(32)2834..2911
Misc Feature(33)2876..2878
Misc Feature(34)3161..3163
Misc Feature(35)3203..3205
Misc Feature(36)3215..3217
Misc Feature(37)3293..3295
Misc Feature(38)3293..3295
Misc Feature(39)3308..3310
Misc Feature(40)3308..3310
Misc Feature(41)3383..3385
Misc Feature(42)3383..3385
Exon (1)1..319
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (2)320..380
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (3)381..698
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (4)699..959
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (5)960..1090
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (6)1091..1262
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (7)1263..1452
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (8)1453..1568
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (9)1569..1695
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (10)1696..1889
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (11)1890..1984
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (12)1985..2117
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (13)2118..2222
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (14)2223..2333
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (15)2334..2487
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (16)2488..2654
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (17)2655..2770
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (18)2771..2893
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (19)2894..3005
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (20)3006..3105
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (21)3106..3211
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (22)3212..3453
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Exon (23)3454..6574
Gene:PDGFRA
Gene Synonym:CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Translation MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS SDLVEDSFL
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Position Chain Variation Link
48+dbSNP:
48+a, gdbSNP:145549583
162+c, tdbSNP:183431225
225..226+, cadbSNP:199818550
226..227+, agdbSNP:113739379
227..228+, gadbSNP:1799767
230+, gdbSNP:55732350
342+a, cdbSNP:138929755
352+a, gdbSNP:200090515
356+c, tdbSNP:375117626
428+dbSNP:
428+a, tdbSNP:200979664
464+c, tdbSNP:149408217
527+a, cdbSNP:143783500
532+c, tdbSNP:35805947
562+c, tdbSNP:143939281
567+a, gdbSNP:36035373
571+c, tdbSNP:200452656
604+a, gdbSNP:112372833
607+a, gdbSNP:140725151
732+dbSNP:
732+c, tdbSNP:373126818
751+a, gdbSNP:112117596
757+g, tdbSNP:201614191
761+g, tdbSNP:376497743
796+c, tdbSNP:376832294
799+a, gdbSNP:150801572
850+c, tdbSNP:374486965
858+a, gdbSNP:139217250
882+c, tdbSNP:367711512
901+a, gdbSNP:267600184
902+a, gdbSNP:267600185
921+a, cdbSNP:200484286
930+c, gdbSNP:149951350
943+c, tdbSNP:2229307
946+a, tdbSNP:377039486
992+dbSNP:
992+c, tdbSNP:139913632
1003+a, gdbSNP:151259376
1069+a, gdbSNP:377699966
1093+dbSNP:
1093+a, gdbSNP:113498710
1109+a, gdbSNP:373234192
1115+c, gdbSNP:376265745
1129+c, tdbSNP:370656660
1132+a, gdbSNP:55966236
1133+a, tdbSNP:140245841
1158+c, tdbSNP:142492533
1169+g, tdbSNP:150927351
1209+a, gdbSNP:373948582
1227+c, tdbSNP:200033396
1230+a, cdbSNP:368648130
1231+a, gdbSNP:140632903
1248+c, tdbSNP:139685174
1250+a, gdbSNP:371882159
1270+dbSNP:
1270+g, tdbSNP:4358459
1276+g, tdbSNP:149222227
1298+c, gdbSNP:138296072
1327+c, tdbSNP:142498442
1349+c, tdbSNP:376626935
1350+a, gdbSNP:77524207
1368+g, tdbSNP:78608730
1388+a, cdbSNP:139103850
1430+a, gdbSNP:147982027
1444+a, gdbSNP:143089919
1453+dbSNP:
1453+c, gdbSNP:61735622
1458+a, gdbSNP:41279521
1464+a, tdbSNP:200113704
1466+g, tdbSNP:199827643
1533+a, cdbSNP:397514549
1534+c, tdbSNP:141808456
1591+dbSNP:
1591+a, gdbSNP:375304717
1594+c, tdbSNP:376486197
1608+a, gdbSNP:55865821
1611+c, tdbSNP:61735621
1616+a, gdbSNP:150577828
1620+a, gdbSNP:202072966
1627+a, gdbSNP:374217334
1638+c, tdbSNP:139920579
1650+c, tdbSNP:143344944
1651+a, gdbSNP:56026726
1656+c, tdbSNP:139236922
1706+dbSNP:
1706+a, gdbSNP:267600186
1719+c, gdbSNP:375047532
1721+a, gdbSNP:372990693
1746+g, tdbSNP:201223501
1753+a, gdbSNP:149899465
1756+a, gdbSNP:200309940
1763+c, tdbSNP:35597368
1771+c, g, tdbSNP:144723510
1781+a, gdbSNP:149031291
1825+c, tdbSNP:200434193
1829+a, cdbSNP:369219442
1847+c, tdbSNP:142980928
1883+g, tdbSNP:372546959
1898+dbSNP:
1898+a, tdbSNP:147733970
1909+a, gdbSNP:142562038
1930+a, gdbSNP:146832047
1948+c, tdbSNP:142296477
1951+a, cdbSNP:374603675
1962+c, tdbSNP:181854060
1970+g, tdbSNP:139219072
1975+c, tdbSNP:115085731
1990+dbSNP:
1990+a, gdbSNP:150426218
1995+a, gdbSNP:121908589
2013+a, tdbSNP:121908586
2027..2044+agcccagatggacatgaa, cgcdbSNP:121913271
2028..2042+, gcccagatggacatgdbSNP:121913270
2031+c, tdbSNP:201503614
complement(2032)-t, cdbSNP:1873778
2062+a, gdbSNP:55830582
2069+a, cdbSNP:143003840
2122+dbSNP:
2122+g, tdbSNP:184634858
2140+a, c, gdbSNP:10028020
2153+a, gdbSNP:138740193
2164+a, cdbSNP:372365813
2181+a, gdbSNP:377318745
2222+c, tdbSNP:199902153
2227+dbSNP:
2227+a, gdbSNP:141835121
2291+a, cdbSNP:377159519
2352+dbSNP:
2352+c, tdbSNP:121908587
2380+c, gdbSNP:200719395
2406+a, gdbSNP:371065167
2416+c, tdbSNP:139059344
2483+c, tdbSNP:375434317
2484+a, gdbSNP:367722824
2488+dbSNP:
2488+c, tdbSNP:146251462
2548+a, tdbSNP:139301546
2553+a, gdbSNP:141704268
2561+c, tdbSNP:61735626
2595+c, tdbSNP:139465754
2596+c, tdbSNP:149659832
2613+g, tdbSNP:148654387
2621+c, tdbSNP:34392012
2622+a, gdbSNP:141047712
2626+a, gdbSNP:112489310
2634+a, gdbSNP:61735625
2637+a, tdbSNP:373061721
2648+a, gdbSNP:191808397
2663+dbSNP:
2663+a, gdbSNP:200808048
2752+a, gdbSNP:144920596
2781+dbSNP:
2781+a, gdbSNP:79948560
2801+a, gdbSNP:370600501
2803+c, tdbSNP:2228230
2806+c, gdbSNP:373455487
2852..2857+, agagacdbSNP:121913269
2855..2867+a, gacatcatgcatgdbSNP:121913259
2855..2866+, gacatcatgcatdbSNP:121913261
2855..2863+, gacatcatgdbSNP:121913262
2855..2856+at, gadbSNP:121913264
2855+g, tdbSNP:121913265
2856..2869+acatcatgcatgat, gadbSNP:121913258
2856..2865+acatcatgca, tdbSNP:121913260
2856+a, tdbSNP:121908585
2857..2872+catcatgcatgattcg, ggccdbSNP:121913263
2857..2869+catcatgcatgat, gdbSNP:121913257
2858..2869+, atcatgcatgatdbSNP:121913267
2859..2870+, tcatgcatgattdbSNP:121913268
2865..2874+atgattcgaa, cdbSNP:121913266
2867+g, tdbSNP:121908588
2871+c, tdbSNP:377487797
2872+a, gdbSNP:370355869
2884+a, gdbSNP:374372636
2911+dbSNP:
2911+a, gdbSNP:187169233
3010+c, tdbSNP:148970242
3022+c, tdbSNP:143711174
3073+c, gdbSNP:56384252
3091+c, tdbSNP:368291181
3109+dbSNP:
3109+c, tdbSNP:138519829
3110+a, gdbSNP:267600187
3134+a, gdbSNP:111766115
3141+c, tdbSNP:267600188
3142+a, gdbSNP:190260215
3151+a, gdbSNP:182516324
3228+dbSNP:
3228+a, gdbSNP:200042995
3230+c, gdbSNP:140943817
3238+c, tdbSNP:267600189
3261+g, tdbSNP:375104103
3273+a, gdbSNP:368266633
3288+a, gdbSNP:372859148
3296+a, gdbSNP:145019788
3316+c, tdbSNP:138801854
3334+a, gdbSNP:373642812
3335+g, tdbSNP:200676118
3344+a, gdbSNP:56028238
3370+c, tdbSNP:138150216
3429+a, tdbSNP:201874958
3457+dbSNP:
3457+a, gdbSNP:141904599
3486+c, tdbSNP:397514550
3487+a, gdbSNP:55996208
3514+c, gdbSNP:138036141
3522+a, gdbSNP:375050626
3524+a, gdbSNP:369389595
3537+a, gdbSNP:372098007
3541+c, tdbSNP:149498489
3542+a, gdbSNP:376544204
3553+c, tdbSNP:7685117
3559+c, tdbSNP:148629782
3607+a, gdbSNP:148697831
3640+c, tdbSNP:55681376
3652+a, gdbSNP:141346675
3679+a, c, gdbSNP:7680422
3708+g, tdbSNP:147363356
3736..3737+, gdbSNP:35265085
3743+c, tdbSNP:139411764
3765+a, gdbSNP:191352173
3802+a, cdbSNP:145135749
3932+c, tdbSNP:373448060
3938+a, gdbSNP:147581958
3975+a, cdbSNP:3690
4012+a, cdbSNP:75883211
4014..4015+, gdbSNP:34143750
4080+a, cdbSNP:117886200
4106+a, gdbSNP:373134586
4138+a, gdbSNP:115470852
4165+, adbSNP:55684881
4292+a, gdbSNP:117287047
4385+a, gdbSNP:139368669
4433+c, tdbSNP:12511976
4452+a, cdbSNP:181363545
4458+a, gdbSNP:370498526
4594+a, gdbSNP:186210761
4655..4656+, gdbSNP:36157360
4697..4699+, tttdbSNP:138065162
4697..4698+, ttdbSNP:199626687
4697+, tdbSNP:34529347
4710..4712+, tttdbSNP:71200382
4713+a, gdbSNP:202087409
4738+a, gdbSNP:55710909
4766+a, cdbSNP:80118193
5018+a, gdbSNP:190583334
5027+c, gdbSNP:182923160
5030+c, tdbSNP:56288633
5035+a, gdbSNP:376836936
complement(5112)-t, gdbSNP:1565664
5162+c, tdbSNP:145328998
5169+g, tdbSNP:186496962
5240+a, gdbSNP:149228729
5272+a, tdbSNP:374676890
5311+c, tdbSNP:192089590
complement(5344)-t, cdbSNP:74548029
5376+a, gdbSNP:146787407
5379+a, cdbSNP:182602738
5422+a, cdbSNP:187821520
5510+g, tdbSNP:192795307
5540+c, tdbSNP:368579295
5599+c, tdbSNP:183181290
5680+a, gdbSNP:187487079
5701+a, gdbSNP:192159089
5702+c, tdbSNP:56012257
complement(5742)-t, cdbSNP:140479172
5755+a, gdbSNP:145707355
5756+a, gdbSNP:370243026
5848+c, gdbSNP:138354130
5934+a, gdbSNP:140977628
5983..5984+, tgdbSNP:202135569
5988..5989+, gtdbSNP:372137753
5988+g, tdbSNP:10034498
6066+a, gdbSNP:78148538
6097+a, gdbSNP:184179322
6105+c, tdbSNP:149631103
6139+c, tdbSNP:377126983
6147+a, gdbSNP:112690644
6160+a, gdbSNP:138584193
6341+c, tdbSNP:149326950
6474+c, tdbSNP:147418921
Gene SymbolPDGFRA
Gene SynonymCD140A; PDGFR-2; PDGFR2; RHEPDGFRA
Chromosome4
Locus Map4q12
Title A glioma classification scheme based on coexpression modules of .
Author Sun Y, Zhang W, Chen D, Lv Y, Zheng J, Lilljebjorn H, Ran L, Bao Z, Soneson C, Sjogren HO, Salford LG, Ji J, French PJ, Fioretos T, Jiang T and Fan X.
Journal Proc. Natl. Acad. Sci. U.S.A. 111 (9), 3538-3543 (2014)
Title The FIP1L1-PDGFRA fusion gene and the KIT D816V mutation are coexisting in a small subset of myeloid/lymphoid neoplasms with eosinophilia .
Author Schmitt-Graeff AH, Erben P, Schwaab J, Vollmer-Kary B, Metzgeroth G, Sotlar K, Horny HP, Kreipe HH, Fisch P and Reiter A.
Journal Blood 123 (4), 595-597 (2014)
Title A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor alpha .
Author Lei H and Kazlauskas A.
Journal Mol. Cell. Biol. 34 (1), 110-122 (2014)
Title Chromosomal aberrations in primary PDGFRA-mutated gastrointestinal stromal tumors .
Author Schaefer IM, Delfs C, Cameron S, Gunawan B, Agaimy A, Ghadimi BM and Haller F.
Journal Hum. Pathol. 45 (1), 85-97 (2014)
Title Telocytes express PDGFRalpha in the human gastrointestinal tract .
Author Vannucchi MG, Traini C, Manetti M, Ibba-Manneschi L and Faussone-Pellegrini MS.
Journal J. Cell. Mol. Med. 17 (9), 1099-1108 (2013)
Title Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction .
Author Yu JC, Heidaran MA, Pierce JH, Gutkind JS, Lombardi D, Ruggiero M and Aaronson SA.
Journal Mol. Cell. Biol. 11 (7), 3780-3785 (1991)
Title Ligand-induced interaction between alpha- and beta-type platelet-derived growth factor (PDGF) receptors: role of receptor heterodimers in kinase activation .
Author Kanakaraj P, Raj S, Khan SA and Bishayee S.
Journal Biochemistry 30 (7), 1761-1767 (1991)
Title Chromosomal localization of the gene for AA-type platelet-derived growth factor receptor (PDGFRA) in humans and mice .
Author Hsieh CL, Navankasattusas S, Escobedo JA, Williams LT and Francke U.
Journal Cytogenet. Cell Genet. 56 (3-4), 160-163 (1991)
Title Platelet-derived growth factor receptor: current views of the two-subunit model .
Author Hart CE and Bowen-Pope DF.
Journal J. Invest. Dermatol. 94 (6 SUPPL), 53S-57S (1990)
Title An efficient directional cloning system to construct cDNA libraries containing full-length inserts at high frequency .
Author Miki T, Matsui T, Heidaran MA and Aaronson SA.
Journal Gene 83 (1), 137-146 (1989)

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