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Homo sapiens POU class 3 homeobox 3 (POU3F3), mRNA.

RefSeq Accession Definition Services Price Order
NM_006236 Homo sapiens POU class 3 homeobox 3 (POU3F3), mRNA. ORF Sequence $435.87
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RefSeq Version NM_006236.1, 5453935
Length 1503 bp
Structure linear
Update Date 24-MAR-2012
Organism Homo sapiens (human)
Definition Homo sapiens POU class 3 homeobox 3 (POU3F3), mRNA.
Product POU domain, class 3, transcription factor 3

Summary: POU3F3 is a member of the class III POU family of transcription factors (see POU3F1; MIM 602479) that are expressed in the central nervous system. The POU domain in these proteins is required for high affinity binding to octamer DNA sequences (summarized by Sumiyama et al., 1996 [PubMed 8703082]).[supplied by OMIM, Jul 2010].

RefSeq NP_006227.1
CDS 1..1503
Misc Feature(1)940..1164
Misc Feature(2)940..1164
Misc Feature(3)1219..1392
Misc Feature(4)order(1219..1233,1237..1239,1288..1290,1306..1308,
Misc Feature(5)order(1225..1227,1234..1236,1354..1356,1363..1368,
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Position Chain Variation Link
87+c, tdbSNP:186512421
360+g, tdbSNP:191591917
972+a, gdbSNP:182992623
1173+c, tdbSNP:199565525
1179+c, tdbSNP:140419524
1187+c, gdbSNP:146486201
1200+c, tdbSNP:143105467
1206+a, gdbSNP:140129722
1215+c, gdbSNP:137877846
1347+a, gdbSNP:147315122
1473+a, tdbSNP:202016096
Gene SymbolPOU3F3
Gene SynonymBRN1; OTF8
Locus Map2q12.1
All Transcripts
RefSeq Accession Definition Sequence Price Select
NM_006236 Homo sapiens POU class 3 homeobox 3 (POU3F3), mRNA. Full Length $435.87
ORF Sequence $435.87
Title The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors .
Author Wissmuller,S., Kosian,T., Wolf,M., Finzsch,M. and Wegner,M.
Journal Nucleic Acids Res. 34 (6), 1735-1744 (2006)
Title Cooperative function of POU proteins and SOX proteins in glial cells .
Author Kuhlbrodt,K., Herbarth,B., Sock,E., Enderich,J., Hermans-Borgmeyer,I. and Wegner,M.
Journal J. Biol. Chem. 273 (26), 16050-16057 (1998)
Title Human class III POU genes, POU3F1 and POU3F3, map to chromosomes 1p34.1 and 3p14.2 .
Author Sumiyama,K., Washio-Watanabe,K., Ono,T., Yoshida,M.C., Hayakawa,T. and Ueda,S.
Journal Mamm. Genome 9 (2), 180-181 (1998)
Title The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U .
Author Malik,K.F., Jaffe,H., Brady,J. and Young,W.S. III.
Journal Brain Res. Mol. Brain Res. 45 (1), 99-107 (1997)
Title Class III POU genes: generation of homopolymeric amino acid repeats under GC pressure in mammals .
Author Sumiyama,K., Washio-Watanabe,K., Saitou,N., Hayakawa,T. and Ueda,S.
Journal J. Mol. Evol. 43 (3), 170-178 (1996)
Title Expression of a large family of POU-domain regulatory genes in mammalian brain development .
Author He,X., Treacy,M.N., Simmons,D.M., Ingraham,H.A., Swanson,L.W. and Rosenfeld,M.G.
Journal Nature 340 (6228), 35-41 (1989)

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