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Homo sapiens calmodulin 1 (phosphorylase kinase, delta) (CALM1), mRNA.


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_006888 Homo sapiens calmodulin 1 (phosphorylase kinase, delta) (CALM1), mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

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RefSeq Version NM_006888.4, 260656023
Length 4268 bp
Structure linear
Update Date 29-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens calmodulin 1 (phosphorylase kinase, delta) (CALM1), mRNA.
Product calmodulin
Comment

Summary: This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].


Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

RefSeq NP_008819.1
CDS 249..698
Misc Feature(1)141..143
Misc Feature(2)249..695
Misc Feature(3)249..695
Misc Feature(4)252..254
Misc Feature(5)282..470
Misc Feature(6)order(309..311,315..317,321..323,342..344,417..419,
Misc Feature(7)312..314
Misc Feature(8)501..689
Misc Feature(9)order(528..530,534..536,540..542,561..563,636..638,
Misc Feature(10)531..533
Misc Feature(11)546..548
Misc Feature(12)546..548
Misc Feature(13)546..548
Misc Feature(14)552..554
Misc Feature(15)594..596
Misc Feature(16)594..596
Misc Feature(17)663..665
Misc Feature(18)663..665
Exon (1)1..251
Gene:CALM1
Gene Synonym:CALML2; caM; CAMI; CPVT4; DD132; PHKD
Exon (2)252..282
Gene:CALM1
Gene Synonym:CALML2; caM; CAMI; CPVT4; DD132; PHKD
Exon (3)283..426
Gene:CALM1
Gene Synonym:CALML2; caM; CAMI; CPVT4; DD132; PHKD
Exon (4)427..533
Gene:CALM1
Gene Synonym:CALML2; caM; CAMI; CPVT4; DD132; PHKD
Exon (5)534..669
Gene:CALM1
Gene Synonym:CALML2; caM; CAMI; CPVT4; DD132; PHKD
Exon (6)670..4256
Gene:CALM1
Gene Synonym:CALML2; caM; CAMI; CPVT4; DD132; PHKD
Translation MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE EVDEMIREADIDGDGQVNYEEFVQMMTAK
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Position Chain Variation Link
31+dbSNP:
31+c, tdbSNP:12885713
45+c, gdbSNP:184206045
46+c, gdbSNP:111249181
76+c, tdbSNP:188359112
81+c, tdbSNP:146545930
85+a, tdbSNP:181001910
88+c, tdbSNP:141007341
97+g, tdbSNP:12886186
158..163+, gcagcgdbSNP:200148015
163+a, gdbSNP:12886342
217+c, tdbSNP:12886083
317+dbSNP:
317+c, tdbSNP:144339242
320+c, tdbSNP:267607278
367+c, tdbSNP:199950662
373+a, tdbSNP:199897752
397+a, gdbSNP:202194260
409+a, tdbSNP:267607276
491+c, tdbSNP:200250055
520+a, gdbSNP:11541171
541+dbSNP:
541+a, gdbSNP:267607277
551+c, tdbSNP:143503733
572+c, tdbSNP:139706811
650+c, tdbSNP:193072150
674+dbSNP:
674+c, tdbSNP:199744595
709+g, tdbSNP:201339726
716+c, tdbSNP:200742588
855+a, gdbSNP:111354847
975+a, gdbSNP:183167213
1115+c, tdbSNP:5871
1219+c, tdbSNP:112958092
1319+a, gdbSNP:187714594
1434+c, tdbSNP:1059285
1472..1473+, ggdbSNP:139060064
1477+c, tdbSNP:199697317
1550..1551+, tdbSNP:35149335
1552..1553+, tdbSNP:71823341
1552+, tdbSNP:71771679
1566..1567+, tdbSNP:199855088
1566..1567+, t, tttdbSNP:56856377
1567+c, g, tdbSNP:111860684
1735+a, cdbSNP:11541170
1736+c, tdbSNP:116646015
1780+a, gdbSNP:1059296
1870+a, gdbSNP:61989066
1872..1873+, aadbSNP:80212837
1872+, adbSNP:11287138
1872+a, gdbSNP:63576962
1873+a, gdbSNP:77928599
1882+a, c, tdbSNP:77916091
1885+a, cdbSNP:78459823
1895+a, cdbSNP:146008731
1980+a, gdbSNP:115723958
1992..1993+, tgdbSNP:202213644
2002+a, tdbSNP:138659409
2048+a, cdbSNP:75951656
2068+c, tdbSNP:192521929
2088+a, gdbSNP:183678923
2116+, cctdbSNP:67661612
2118+a, cdbSNP:3814846
2125..2126+, ccdbSNP:71461906
2125+c, tdbSNP:61989067
2127..2128+, cdbSNP:200711428
2127+, tdbSNP:71461907
2128+c, tdbSNP:75202062
2142+c, gdbSNP:3814845
2380+a, gdbSNP:141870617
2396+c, tdbSNP:3814844
2540+c, tdbSNP:186848664
2568+c, tdbSNP:35418035
2650+a, cdbSNP:3814843
2662+a, cdbSNP:139692985
2714+a, gdbSNP:192452102
2783+a, gdbSNP:184803743
2824+c, tdbSNP:149760583
2901+a, gdbSNP:189778902
2909+c, tdbSNP:181805019
2916+g, tdbSNP:184371119
2948+g, tdbSNP:189147924
2949+c, tdbSNP:181955035
3049+c, gdbSNP:3179089
3351+c, tdbSNP:184950622
3363..3369+, ataagaadbSNP:200991845
3410+a, cdbSNP:11539544
3435+c, tdbSNP:1058903
3556..3559+, acacdbSNP:150072386
3645+c, gdbSNP:140025082
3678+c, tdbSNP:115172487
3786+a, gdbSNP:145426711
3916+a, gdbSNP:147728175
3975+c, gdbSNP:142500788
3981+c, tdbSNP:144946670
4087+a, cdbSNP:190976650
4090..4091+, gdbSNP:200917629
4161+a, gdbSNP:15414
Gene SymbolCALM1
Gene SynonymCALML2; caM; CAMI; CPVT4; DD132; PHKD
Chromosome14
Locus Map14q32.11
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_006888 Homo sapiens calmodulin 1 (phosphorylase kinase, delta) (CALM1), mRNA. In-stock $248.00 $199.00 10
Title Interplay between calmodulin and phosphatidylinositol 4,5-bisphosphate in Ca2+-induced inactivation of transient receptor potential vanilloid 6 channels .
Author Cao,C., Zakharian,E., Borbiro,I. and Rohacs,T.
Journal J. Biol. Chem. 288 (8), 5278-5290 (2013)
Title 70-kDa heat shock cognate protein hsc70 mediates calmodulin-dependent nuclear import of the sex-determining factor .
Author Kaur,G., Lieu,K.G. and Jans,D.A.
Journal J. Biol. Chem. 288 (6), 4148-4157 (2013)
Title Calmodulin activates neuronal nitric oxide synthase by enabling transitions between conformational states .
Author Salerno,J.C., Ray,K., Poulos,T., Li,H. and Ghosh,D.K.
Journal FEBS Lett. 587 (1), 44-47 (2013)
Title The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function .
Author Ramachandran,P.L., Craig,T.A., Atanasova,E.A., Cui,G., Owen,B.A., Bergen,H.R. III, Mer,G. and Kumar,R.
Journal J. Biol. Chem. 287 (47), 39439-39448 (2012)
Title Structure of the human CALM1 calmodulin gene and identification of two CALM1-related pseudogenes CALM1P1 and CALM1P2 .
Author Rhyner,J.A., Ottiger,M., Wicki,R., Greenwood,T.M. and Strehler,E.E.
Journal Eur. J. Biochem. 225 (1), 71-82 (1994)
Title Study of calmodulin binding to the alternatively spliced C-terminal domain of the plasma membrane Ca2+ pump .
Author Kessler,F., Falchetto,R., Heim,R., Meili,R., Vorherr,T., Strehler,E.E. and Carafoli,E.
Journal Biochemistry 31 (47), 11785-11792 (1992)
Title Insulin-stimulated phosphorylation of calmodulin .
Author Sacks,D.B., Davis,H.W., Crimmins,D.L. and McDonald,J.M.
Journal Biochem. J. 286 (PT 1), 211-216 (1992)
Title Interaction of calmodulin with lactoferrin .
Author de Lillo,A., Tejerina,J.M. and Fierro,J.F.
Journal FEBS Lett. 298 (2-3), 195-198 (1992)
Title Structural organization of the human CaMIII calmodulin gene .
Author Koller,M., Schnyder,B. and Strehler,E.E.
Journal Biochim. Biophys. Acta 1087 (2), 180-189 (1990)
Title Molecular analysis of human and rat calmodulin complementary DNA clones. Evidence for additional active genes in these species .
Author SenGupta,B., Friedberg,F. and Detera-Wadleigh,S.D.
Journal J. Biol. Chem. 262 (34), 16663-16670 (1987)


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