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Homo sapiens calmodulin 1 (phosphorylase kinase, delta) (CALM1), mRNA.


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_006888 Homo sapiens calmodulin 1 (phosphorylase kinase, delta) (CALM1), mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

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RefSeq Version NM_006888.4, 260656023
Length 4268 bp
Structure linear
Update Date 10-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens calmodulin 1 (phosphorylase kinase, delta) (CALM1), mRNA.
Product calmodulin
Comment

Summary: This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].


Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

RefSeq NP_008819.1
CDS 249..698
Misc Feature(1)141..143
Misc Feature(2)249..695
Misc Feature(3)249..695
Misc Feature(4)252..254
Misc Feature(5)282..470
Misc Feature(6)order(309..311,315..317,321..323,342..344,417..419,
Misc Feature(7)312..314
Misc Feature(8)501..689
Misc Feature(9)order(528..530,534..536,540..542,561..563,636..638,
Misc Feature(10)531..533
Misc Feature(11)546..548
Misc Feature(12)546..548
Misc Feature(13)546..548
Misc Feature(14)552..554
Misc Feature(15)594..596
Misc Feature(16)594..596
Misc Feature(17)663..665
Misc Feature(18)663..665
Exon (1)1..251
Gene:CALM1
Gene Synonym:CALML2; caM; CAMI; CPVT4; DD132; PHKD
Exon (2)252..282
Gene:CALM1
Gene Synonym:CALML2; caM; CAMI; CPVT4; DD132; PHKD
Exon (3)283..426
Gene:CALM1
Gene Synonym:CALML2; caM; CAMI; CPVT4; DD132; PHKD
Exon (4)427..533
Gene:CALM1
Gene Synonym:CALML2; caM; CAMI; CPVT4; DD132; PHKD
Exon (5)534..669
Gene:CALM1
Gene Synonym:CALML2; caM; CAMI; CPVT4; DD132; PHKD
Exon (6)670..4256
Gene:CALM1
Gene Synonym:CALML2; caM; CAMI; CPVT4; DD132; PHKD
Translation MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE EVDEMIREADIDGDGQVNYEEFVQMMTAK
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Position Chain Variation Link
31+dbSNP:
31+c, tdbSNP:12885713
45+c, gdbSNP:184206045
46+c, g, tdbSNP:111249181
76+c, tdbSNP:188359112
81+c, tdbSNP:146545930
85+a, tdbSNP:181001910
88+c, tdbSNP:141007341
97+g, tdbSNP:12886186
158..163+, gcagcgdbSNP:200148015
163+a, gdbSNP:12886342
217+c, tdbSNP:12886083
227+c, tdbSNP:369555148
232+c, tdbSNP:372252650
277+dbSNP:
277+c, tdbSNP:373571763
317+dbSNP:
317+c, tdbSNP:144339242
320+c, tdbSNP:267607278
367+c, tdbSNP:199950662
373+a, tdbSNP:199897752
397+a, gdbSNP:202194260
409+a, tdbSNP:267607276
491+c, tdbSNP:200250055
complement(520)-g, adbSNP:11541171
541+dbSNP:
541+a, gdbSNP:267607277
551+c, tdbSNP:143503733
572+c, tdbSNP:139706811
614+a, gdbSNP:370441016
650+c, tdbSNP:193072150
665+c, tdbSNP:377521523
674+dbSNP:
674+c, tdbSNP:199744595
675+c, gdbSNP:370956572
709+g, tdbSNP:201339726
716+c, tdbSNP:200742588
722+c, tdbSNP:372713000
855+a, gdbSNP:111354847
975+a, gdbSNP:183167213
981+a, tdbSNP:367695382
1026+c, tdbSNP:371446473
1115+c, tdbSNP:5871
1219+c, tdbSNP:112958092
1319+a, gdbSNP:187714594
1434+c, tdbSNP:1059285
1472..1473+, ggdbSNP:139060064
1477+c, tdbSNP:199697317
1551..1552+, tdbSNP:35149335
1551+c, tdbSNP:370254226
1552..1553+, tdbSNP:71823341
1566..1567+, t, tttdbSNP:56856377
1567+c, g, tdbSNP:111860684
complement(1735)-c, adbSNP:11541170
1736+c, tdbSNP:116646015
1780+a, gdbSNP:1059296
1780+a, gdbSNP:386514493
1836..1837+, ttdbSNP:374013990
1842+c, tdbSNP:373356188
1870+a, gdbSNP:61989066
1872+, adbSNP:11287138
1872+a, gdbSNP:63576962
1873+a, gdbSNP:77928599
1881..1882+, aadbSNP:80212837
1881..1882+, aadbSNP:398057371
complement(1882)-, tdbSNP:398026137
1882+a, c, tdbSNP:77916091
1885+a, cdbSNP:78459823
complement(1895)-c, adbSNP:146008731
1980+a, gdbSNP:115723958
1992..1993+, tgdbSNP:202213644
2001+a, gdbSNP:376504500
2002+a, tdbSNP:138659409
2002+a, tdbSNP:386472491
2048+a, cdbSNP:75951656
2068+c, tdbSNP:192521929
2088+a, gdbSNP:183678923
2089+c, tdbSNP:369307361
complement(2118)-c, adbSNP:3814846
2125..2126+, ccdbSNP:71461906
2125+c, tdbSNP:61989067
2127..2128+, cdbSNP:200711428
2127+, tdbSNP:71461907
2128+c, tdbSNP:75202062
2139+, tdbSNP:398043959
complement(2142)-g, cdbSNP:3814845
2175+a, gdbSNP:373565285
2332+c, tdbSNP:375596643
2380+a, gdbSNP:141870617
complement(2396)-t, cdbSNP:3814844
2537+a, tdbSNP:369706187
2540+c, tdbSNP:186848664
2568+c, tdbSNP:35418035
2647+c, gdbSNP:374437556
complement(2650)-c, adbSNP:3814843
complement(2662)-c, adbSNP:139692985
2714+a, gdbSNP:192452102
2783+a, gdbSNP:184803743
2824+c, tdbSNP:149760583
2834+a, gdbSNP:370139244
2861..2862+, cadbSNP:374154318
2901+a, gdbSNP:189778902
2909+c, tdbSNP:181805019
2916+g, tdbSNP:184371119
2937+a, gdbSNP:367855711
2948+g, tdbSNP:189147924
2949+c, tdbSNP:181955035
3049+c, gdbSNP:3179089
3351+c, tdbSNP:184950622
3363..3369+, ataagaadbSNP:200991845
3410+a, cdbSNP:11539544
3435+c, tdbSNP:1058903
3548+a, gdbSNP:367644606
3556..3559+, acacdbSNP:150072386
3645+c, gdbSNP:140025082
3678+c, tdbSNP:115172487
3786+a, gdbSNP:145426711
3916+a, gdbSNP:147728175
3965+a, gdbSNP:370549807
3975+c, gdbSNP:142500788
3981+c, tdbSNP:144946670
4006+a, tdbSNP:371784290
4087+a, cdbSNP:190976650
4090..4091+, gdbSNP:200917629
4161+a, gdbSNP:15414
Gene SymbolCALM1
Gene SynonymCALML2; caM; CAMI; CPVT4; DD132; PHKD
Chromosome14
Locus Map14q32.11
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_006888 Homo sapiens calmodulin 1 (phosphorylase kinase, delta) (CALM1), mRNA. In-stock $248.00 $199.00 10
XM_006720258 PREDICTED: Homo sapiens calmodulin 1 (phosphorylase kinase, delta) (CALM1), transcript variant X1, mRNA. On-demand $299.00 14
Title Calmodulin-dependent binding to the NHE1 cytosolic tail mediates activation of the Na+/H+ exchanger by Ca2+ and endothelin .
Author Li X, Prins D, Michalak M and Fliegel L.
Journal Am. J. Physiol., Cell Physiol. 305 (11), C1161-C1169 (2013)
Title Calmodulin activation of polo-like kinase 1 is required during mitotic entry .
Author Dai G, Qian Y, Chen J, Meng FL, Pan FY, Shen WG, Zhang SZ, Xue B and Li CJ.
Journal Biochem. Cell Biol. 91 (5), 287-294 (2013)
Title Bruton's tyrosine kinase mediates the synergistic signalling between TLR9 and the B cell receptor by regulating calcium and calmodulin .
Author Kenny EF, Quinn SR, Doyle SL, Vink PM, van Eenennaam H and O'Neill LA.
Journal PLoS ONE 8 (8), E74103 (2013)
Title Structure of the human CALM1 calmodulin gene and identification of two CALM1-related pseudogenes CALM1P1 and CALM1P2 .
Author Rhyner JA, Ottiger M, Wicki R, Greenwood TM and Strehler EE.
Journal Eur. J. Biochem. 225 (1), 71-82 (1994)
Title Catecholaminergic Polymorphic Ventricular Tachycardia .
Author Napolitano,C., Priori,S.G. and Bloise,R.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Title Study of calmodulin binding to the alternatively spliced C-terminal domain of the plasma membrane Ca2+ pump .
Author Kessler F, Falchetto R, Heim R, Meili R, Vorherr T, Strehler EE and Carafoli E.
Journal Biochemistry 31 (47), 11785-11792 (1992)
Title Insulin-stimulated phosphorylation of calmodulin .
Author Sacks DB, Davis HW, Crimmins DL and McDonald JM.
Journal Biochem. J. 286 (PT 1), 211-216 (1992)
Title Interaction of calmodulin with lactoferrin .
Author de Lillo A, Tejerina JM and Fierro JF.
Journal FEBS Lett. 298 (2-3), 195-198 (1992)
Title Structural organization of the human CaMIII calmodulin gene .
Author Koller M, Schnyder B and Strehler EE.
Journal Biochim. Biophys. Acta 1087 (2), 180-189 (1990)
Title Molecular analysis of human and rat calmodulin complementary DNA clones. Evidence for additional active genes in these species .
Author SenGupta B, Friedberg F and Detera-Wadleigh SD.
Journal J. Biol. Chem. 262 (34), 16663-16670 (1987)

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