Homo sapiens triple functional domain (PTPRF interacting) (TRIO), mRNA.
| RefSeq Version | NM_007118.2, 45439358 |
| Length | 10244 bp |
| Structure | linear |
| Update Date | 11-MAR-2011 |
| Organism | Homo sapiens (human) |
| Definition | Homo sapiens triple functional domain (PTPRF interacting) (TRIO), mRNA. |
| Product | triple functional domain protein |
| Comment | COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BF058117.1, BC035585.1, U42390.1, AI478154.1, BQ691537.1, AF091395.1, BC017268.2 and BQ009698.1. On or before Jun 11, 2008 this sequence version replaced gi:169168483, gi:169167724, gi:169167541, gi:6005921. |
| RefSeq | NP_009049.2 |
| CDS | 7..9300 | Exon (1) | 1..163 | Exon (2) | 1..163 | Exon (3) | 164..238 | Exon (4) | 239..353 | Exon (5) | 354..546 | Exon (6) | 547..1059 | Exon (7) | 1060..1182 | Exon (8) | 1183..1374 | Exon (9) | 1375..1506 | Exon (10) | 1507..1737 | Exon (11) | 1738..1860 | Exon (12) | 1861..2052 | Exon (13) | 2053..2222 | Exon (14) | 2223..2397 | Exon (15) | 2398..2593 | Exon (16) | 2594..2760 | Exon (17) | 2761..2880 | Exon (18) | 2881..3072 | Exon (19) | 3073..3222 | Exon (20) | 3223..3337 | Exon (21) | 3338..3453 | Exon (22) | 3454..3576 | Exon (23) | 3577..3771 | Exon (24) | 3772..3887 | Exon (25) | 3888..3954 | Exon (26) | 3955..4064 | Exon (27) | 4065..4134 | Exon (28) | 4135..4224 | Exon (29) | 4225..4317 | Exon (30) | 4318..4429 | Exon (31) | 4430..4620 | Exon (32) | 4621..4722 | Exon (33) | 4723..4865 | Exon (34) | 4866..4965 | Exon (35) | 4966..5209 | Exon (36) | 5210..5502 | Exon (37) | 5503..5673 | Exon (38) | 5674..5769 | Exon (39) | 5770..5918 | Exon (40) | 5919..5985 | Exon (41) | 5986..6089 | Exon (42) | 6090..6159 | Exon (43) | 6160..6249 | Exon (44) | 6250..6342 | Exon (45) | 6343..6393 | Exon (46) | 6394..6471 | Exon (47) | 6472..6663 | Exon (48) | 6664..6841 | Exon (49) | 6842..7638 | Exon (50) | 7639..7886 | Exon (51) | 7887..8025 | Exon (52) | 8026..8053 | Exon (53) | 8054..8216 | Exon (54) | 8217..8338 | Exon (55) | 8339..8417 | Exon (56) | 8418..8618 | Exon (57) | 8619..8757 | Exon (58) | 8758..10227 |
| Translation | MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRKNDEM
KAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPSEEVC
KRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFE
TNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDI
LAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSESFPKKNSGSG
NADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNK
GLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIR
QIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLPSELQDL
EDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV
IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSL
HRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAHQLEDRIQDFV
RRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQTT
LQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKI
KLELFLQLRIFERDAIDIISDLESWNDELSQQMNDFDTEDLTIAEQRLQHHADKALTMNN
LTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHR
KHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKT
HQSALQVQQKAEAMLQANHYDMDMIRDCAEKVASHWQQLMLKMEDRLKLVNASVAFYKTS
EQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRN
ADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQY
VVFERSAKQALEWIHDNGEFYLSTHTSTGSSIQHTQELLKEHEEFQITAKQTKERVKLLI
QLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSLQ
LDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLW
EMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKF
QMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELL
TCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTL
IRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVG
RTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGRR
DGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRRG
QTVEVLERPHDKPDWCLVRTTDRSPAAEGLVPCGSLCIAHSRSSMEMEGIFNHKDSLSVS
SNDASPPASVASLQPHMIGAQSSPGPKRPGNTLRKWLTSPVRRLSSGKADGHVKKLAHKH
KKSREVRKSADAGSQKDSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEEG
EEGADAVPLPPPMAIQQHSLLQPDSQDDKASSRLLVRPTSSETPSAAELVSAIEELVKSK
MALEDRPSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVET
ERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLED
PEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIKP
VQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVA
QGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKV
SCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEINQILENQRNFLNAL
TSPIEYQRNHSGGGGGGGSGGSGGGGGSGGGGAPSGGSGHSGGPSSCGGAPSTSRSRPSR
IPQPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLPPPGAAPEAGPSAPSRRPPGADAE
GSEREAEPIPKMKVLESPRKGAANASGSSPDAPAKDARASLGTLPLGKPRAGAASPLNSP
LSSAVPSLGKEPFPPSSPLQKGGSFWSSIPASPASRPGSFTFPGDSDSLQRQTPRHAAPG
KDTDRMSTCSSASEQSVQSTQSNGSESSSSSNISTMLVTHDYTAVKEDEINVYQGEVVQI
LASNQQNMFLVFRAATDQCPAAEGWIPGFVLGHTSAVIVENPDGTLKKSTSWHTALRLRK
KSEKKDKDGKREGKLENGYRKSREGLSNKVSVKLLNPNYIYDVPPEFVIPLSEVTCETGE
TVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEATLKIVGVTTEDDGIYTCI
AVNDMGSASSSASLRVLGPGMDGIMVTWKDNFDSFYSEVAELGRGRFSVVKKCDQKGTKR
AVATKFVNKKLMKRDQVTHELGILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLDC
VVRWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPENILVDESLAKPTIKLADFGDA
VQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEET
CLNICRLDFSFPDDYFKGVSQKAKEFVCFLLQEDPAKRPSAALALQEQWLQAGNGRSTGV
LDTSRLTSFIERRKHQNDVRPIRSIKNFLQSRLLPRV
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| Gene Symbol | TRIO |
| Gene Synonym | ARHGEF23; FLJ42780; tgat |
| Chromosome | 5 |
| Locus Map | 5p15.2 |
| All Transcripts | NM_007118 |
| Title | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . |
| Author | Rose,J.E., Behm,F.M., Drgon,T., Johnson,C. and Uhl,G.R. |
| Journal | Mol. Med. 16 (7-8), 247-253 (2010) |
| Title | Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India . |
| Author | Chattopadhyay,I., Singh,A., Phukan,R., Purkayastha,J., Kataki,A., Mahanta,J., Saxena,S. and Kapur,S. |
| Journal | Mutat. Res. 696 (2), 130-138 (2010) |
| Title | Mutation of ARHGAP9 in patients with coronary spastic angina . |
| Author | Takefuji,M., Asano,H., Mori,K., Amano,M., Kato,K., Watanabe,T., Morita,Y., Katsumi,A., Itoh,T., Takenawa,T., Hirashiki,A., Izawa,H., Nagata,K., Hirayama,H., Takatsu,F., Naoe,T., Yokota,M. and Kaibuchi,K. |
| Journal | J. Hum. Genet. 55 (1), 42-49 (2010) |
| Title | Assembly of high order G alpha q-effector complexes with RGS proteins . |
| Author | Shankaranarayanan,A., Thal,D.M., Tesmer,V.M., Roman,D.L., Neubig,R.R., Kozasa,T. and Tesmer,J.J. |
| Journal | J. Biol. Chem. 283 (50), 34923-34934 (2008) |
| Title | The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma . |
| Author | Salhia,B., Tran,N.L., Chan,A., Wolf,A., Nakada,M., Rutka,F., Ennis,M., McDonough,W.S., Berens,M.E., Symons,M. and Rutka,J.T. |
| Journal | Am. J. Pathol. 173 (6), 1828-1838 (2008) |
| Title | The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain . |
| Author | Medley,Q.G., Serra-Pages,C., Iannotti,E., Seipel,K., Tang,M., O'Brien,S.P. and Streuli,M. |
| Journal | J. Biol. Chem. 275 (46), 36116-36123 (2000) |
| Title | Trio amino-terminal guanine nucleotide exchange factor domain expression promotes actin cytoskeleton reorganization, cell migration and anchorage-independent cell growth . |
| Author | Seipel,K., Medley,Q.G., Kedersha,N.L., Zhang,X.A., O'Brien,S.P., Serra-Pages,C., Hemler,M.E. and Streuli,M. |
| Journal | J. Cell. Sci. 112 (PT 12), 1825-1834 (1999) |
| Title | NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio . |
| Author | Liu,X., Wang,H., Eberstadt,M., Schnuchel,A., Olejniczak,E.T., Meadows,R.P., Schkeryantz,J.M., Janowick,D.A., Harlan,J.E., Harris,E.A., Staunton,D.E. and Fesik,S.W. |
| Journal | Cell 95 (2), 269-277 (1998) |
| Title | Assignment of TRIO, the Trio gene (PTPRF interacting) to human chromosome bands 5p 15.1-->p 14 by in situ hybridization . |
| Author | Taviaux,S., Diriong,S., Bellanger,J.M., Streuli,M. and Debant,A. |
| Journal | Cytogenet. Cell Genet. 76 (1-2), 107-108 (1997) |
| Title | The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains . |
| Author | Debant,A., Serra-Pages,C., Seipel,K., O'Brien,S., Tang,M., Park,S.H. and Streuli,M. |
| Journal | Proc. Natl. Acad. Sci. U.S.A. 93 (11), 5466-5471 (1996) |
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