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Homo sapiens pre-B lymphocyte 1 (VPREB1), mRNA.

Clone ID Definition Vector Stock Status Price *Turnaround time Select
OHu18799D Homo sapiens pre-B lymphocyte 1 (VPREB1), mRNA. pcDNA3.1-C-(k)DYK In-stock Starting from $99 5-7
OHu18799C Homo sapiens pre-B lymphocyte 1 (VPREB1), mRNA. Your vector of choice In-stock Starting from $99 5-7
OHu18799M Mutant Clone for Homo sapiens pre-B lymphocyte 1 (VPREB1), mRNA. pcDNA3.1-C-(k)DYK In-stock Starting from $149 Additional 5 days
OHu18799CM Mutant Clone for Homo sapiens pre-B lymphocyte 1 (VPREB1), mRNA. Your vector of choice In-stock Starting from $149 Additional 5 days

*Business Day

Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_007128.2, 18379350
Length 438 bp
Structure linear
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens pre-B lymphocyte 1 (VPREB1), mRNA.
Product immunoglobulin iota chain precursor

Summary: The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. [provided by RefSeq, Oct 2008].

Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

RefSeq NP_009059.1
CDS 27..464
Misc Feature(1)84..149
Misc Feature(2)102..374
Misc Feature(3)114..380
Misc Feature(4)150..194
Misc Feature(5)195..236
Misc Feature(6)237..269
Misc Feature(7)270..371
Exon (1)1..72
Gene Synonym:IGI; IGVPB; VPREB
Exon (2)73..641
Gene Synonym:IGI; IGVPB; VPREB
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Gene SymbolVPREB1
Locus Map22q11.22
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_007128 Homo sapiens pre-B lymphocyte 1 (VPREB1), mRNA. In-stock Starting from $99 5-7
Title VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia .
Author Mangum DS, Downie J, Mason CC, Jahromi MS, Joshi D, Rodic V, Muschen M, Meeker N, Trede N, Frazer JK, Zhou Y, Cheng C, Jeha S, Pui CH, Willman CL, Harvey RC, Hunger SP, Yang JJ, Barnette P, Mullighan CG, Miles RR and Schiffman JD.
Journal Leukemia 28 (1), 216-220 (2014)
Title Genome-wide association study of chronic periodontitis in a general German population .
Author Teumer A, Holtfreter B, Volker U, Petersmann A, Nauck M, Biffar R, Volzke H, Kroemer HK, Meisel P, Homuth G and Kocher T.
Journal J. Clin. Periodontol. 40 (11), 977-985 (2013)
Title The potential role of VPREB1 gene copy number variation in susceptibility to rheumatoid arthritis .
Author Yim SH, Chung YJ, Jin EH, Shim SC, Kim JY, Kim YS, Hu HJ, Shin SH, Pae HO, Zouali M and Chung HT.
Journal Mol. Immunol. 48 (11), 1338-1343 (2011)
Title New genetic associations detected in a host response study to hepatitis B vaccine .
Author Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML and Seielstad M.
Journal Genes Immun. 11 (3), 232-238 (2010)
Title Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening .
Author Wu C, Ma MH, Brown KR, Geisler M, Li L, Tzeng E, Jia CY, Jurisica I and Li SS.
Journal Proteomics 7 (11), 1775-1785 (2007)
Title Molecular components and assembly of mu.surrogate light chain complexes in pre-B cell lines .
Author Ohnishi K and Takemori T.
Journal J. Biol. Chem. 269 (45), 28347-28353 (1994)
Title The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain .
Author Guelpa-Fonlupt V, Bossy D, Alzari P, Fumoux F, Fougereau M and Schiff C.
Journal Mol. Immunol. 31 (14), 1099-1108 (1994)
Title The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface .
Author Tsubata T and Reth M.
Journal J. Exp. Med. 172 (3), 973-976 (1990)
Title Structure and pre-B lymphocyte restricted expression of the VpreB in humans and conservation of its structure in other mammalian species .
Author Bauer SR, Kudo A and Melchers F.
Journal EMBO J. 7 (1), 111-116 (1988)
Title The human Vpre B gene is located on chromosome 22 near a cluster of .
Author Bauer SR, Huebner K, Budarf M, Finan J, Erikson J, Emanuel BS, Nowell PC, Croce CM and Melchers F.
Journal Immunogenetics 28 (5), 328-333 (1988)

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