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Homo sapiens paired related homeobox 2 (PRRX2), mRNA.

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_016307 Homo sapiens paired related homeobox 2 (PRRX2), mRNA. GenEZ ORF Cloning On-demand $TBD TBD

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RefSeq Version NM_016307.3, 38505203
Length 1327 bp
Structure linear
Update Date 18-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens paired related homeobox 2 (PRRX2), mRNA.
Product paired mesoderm homeobox protein 2

Summary: The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq, Jul 2008].

##Evidence-Data-START## Transcript exon combination :: BC014645.1, AF061970.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

RefSeq NP_057391.1
CDS 228..989
Misc Feature(1)552..716
Misc Feature(2)552..716
Misc Feature(3)order(552..554,558..560,609..611,627..629,666..668,
Misc Feature(4)order(555..557,675..677,684..689,696..698)
Misc Feature(5)906..962
Misc Feature(6)915..956
Exon (1)1..486
Gene Synonym:PMX2; PRX2
Exon (2)487..674
Gene Synonym:PMX2; PRX2
Exon (3)675..853
Gene Synonym:PMX2; PRX2
Exon (4)854..1311
Gene Synonym:PMX2; PRX2
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Position Chain Variation Link
77+a, cdbSNP:115147301
524+a, gdbSNP:35865713
530+a, gdbSNP:201665194
534+a, cdbSNP:201179051
539+c, gdbSNP:149764500
632+a, gdbSNP:199887986
660+c, gdbSNP:202114136
741+c, gdbSNP:145779250
742+c, gdbSNP:140591214
745+c, tdbSNP:144448846
746+a, gdbSNP:146603979
793+c, tdbSNP:141327412
810+c, gdbSNP:143393943
814+a, gdbSNP:201217720
823+a, cdbSNP:148368723
829+c, gdbSNP:140111310
883+c, tdbSNP:150293718
923+c, tdbSNP:138042846
933+c, tdbSNP:202233874
934+a, gdbSNP:201083423
944+c, tdbSNP:200632042
979+c, tdbSNP:143523637
1001+a, cdbSNP:28428946
1035+a, gdbSNP:116237845
1090+a, gdbSNP:142417382
1123+c, gdbSNP:2241898
1140+c, tdbSNP:1051445
1151+c, gdbSNP:28441121
1256+g, tdbSNP:73627671
1300..1301+, a, tdbSNP:36093277
1307+c, tdbSNP:10988483
Gene SymbolPRRX2
Gene SynonymPMX2; PRX2
Locus Map9q34.1
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_016307 Homo sapiens paired related homeobox 2 (PRRX2), mRNA. On-demand TBD TBD
Title Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study .
Author Nagy,P., Karton,A., Betz,A., Peskin,A.V., Pace,P., O'Reilly,R.J., Hampton,M.B., Radom,L. and Winterbourn,C.C.
Journal J. Biol. Chem. 286 (20), 18048-18055 (2011)
Title Web-based, participant-driven studies yield novel genetic associations for common traits .
Author Eriksson,N., Macpherson,J.M., Tung,J.Y., Hon,L.S., Naughton,B., Saxonov,S., Avey,L., Wojcicki,A., Pe'er,I. and Mountain,J.
Journal PLoS Genet. 6 (6), E1000993 (2010)
Title Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia .
Author Jugessur,A., Shi,M., Gjessing,H.K., Lie,R.T., Wilcox,A.J., Weinberg,C.R., Christensen,K., Boyles,A.L., Daack-Hirsch,S., Nguyen,T.T., Christiansen,L., Lidral,A.C. and Murray,J.C.
Journal PLoS ONE 5 (7), E11493 (2010)
Title Oxidation of Prx2 and phosphorylation of GRP58 by angiotensin II in human coronary smooth muscle cells identified by 2D-DIGE analysis .
Author Tokutomi,Y., Araki,N., Kataoka,K., Yamamoto,E. and Kim-Mitsuyama,S.
Journal Biochem. Biophys. Res. Commun. 364 (4), 822-830 (2007)
Title The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors .
Author Wissmuller,S., Kosian,T., Wolf,M., Finzsch,M. and Wegner,M.
Journal Nucleic Acids Res. 34 (6), 1735-1744 (2006)
Title A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia .
Author Gervais,C., Mauvieux,L., Perrusson,N., Helias,C., Struski,S., Leymarie,V., Lioure,B. and Lessard,M.
Journal Leukemia 19 (1), 145-148 (2005)
Title GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein .
Author Scott,K.K., Norris,R.A., Potter,S.S., Norrington,D.W., Baybo,M.A., Hicklin,D.M. and Kern,M.J.
Journal DNA Cell Biol. 22 (2), 95-105 (2003)
Title Regulation of vascular smooth muscle cell growth and adhesion by paired-related homeobox genes .
Author Jones,F.S., McKean,D.M., Meech,R., Edelman,D.B., Oakey,R.J. and Jones,P.L.
Journal Chest 121 (3 SUPPL), 89S-90S (2002)
Title Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome .
Author Norris,R.A., Scott,K.K., Moore,C.S., Stetten,G., Brown,C.R., Jabs,E.W., Wulfsberg,E.A., Yu,J. and Kern,M.J.
Journal Mamm. Genome 11 (11), 1000-1005 (2000)
Title Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds .
Author Stelnicki,E.J., Arbeit,J., Cass,D.L., Saner,C., Harrison,M. and Largman,C.
Journal J. Invest. Dermatol. 111 (1), 57-63 (1998)

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