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Homo sapiens vacuolar protein sorting 35 homolog (S. cerevisiae) (VPS35), mRNA.


Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu18510 Homo sapiens vacuolar protein sorting 35 homolog (S. cerevisiae) (VPS35), mRNA. pcDNA3.1+-DYK On-demand $279.00 12-14
OHu18510C Homo sapiens vacuolar protein sorting 35 homolog (S. cerevisiae) (VPS35), mRNA. Customized vector On-demand $329.00 12-14

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Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_018206.4, 156602659
Length 2391 bp
Structure linear
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens vacuolar protein sorting 35 homolog (S. cerevisiae) (VPS35), mRNA.
Product vacuolar protein sorting-associated protein 35
Comment

Summary: This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008].

RefSeq NP_060676.2
CDS 100..2490
Misc Feature(1)40..42
Misc Feature(2)40..42
Misc Feature(3)118..120
Misc Feature(4)118..120
Misc Feature(5)139..2361
Exon (1)1..102
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (2)103..201
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (3)202..298
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (4)299..422
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (5)423..605
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (6)606..819
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (7)820..903
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (8)904..1013
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (9)1014..1110
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (10)1111..1259
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (11)1260..1467
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (12)1468..1623
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (13)1624..1746
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (14)1747..1926
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (15)1927..2166
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (16)2167..2310
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (17)2311..3285
Gene:VPS35
Gene Synonym:MEM3; PARK17
Translation MPTTQQSPQDEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDALKHASNMLGELRTSMLSP KSYYELYMAISDELHYLEVYLTDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVK SFPQSRKDILKDLVEMCRGVQHPLRGLFLRNYLLQCTRNILPDEGEPTDEETTGDISDSM DFVLLNFAEMNKLWVRMQHQGHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERYKQ IVLTGILEQVVNCRDALAQEYLMECIIQVFPDEFHLQTLNPFLRACAELHQNVNVKNIII ALIDRLALFAHREDGPGIPADIKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAMK CYPDRVDYVDKVLETTVEIFNKLNLEHIATSSAVSKELTRLLKIPVDTYNNILTVLKLKH FHPLFEYFDYESRKSMSCYVLSNVLDYNTEIVSQDQVDSIMNLVSTLIQDQPDQPVEDPD PEDFADEQSLVGRFIHLLRSEDPDQQYLILNTARKHFGAGGNQRIRFTLPPLVFAAYQLA FRYKENSKVDDKWEKKCQKIFSFAHQTISALIKAELAELPLRLFLQGALAAGEIGFENHE TVAYEFMSQAFSLYEDEISDSKAQLAAITLIIGTFERMKCFSEENHEPLRTQCALAASKL LKKPDQGRAVSTCAHLFWSGRNTDKNGEELHGGKRVMECLKKALKIANQCMDPSLQVQLF IEILNRYIYFYEKENDAVTIQVLNQLIQKIREDLPNLESSEETEQINKHFHNTLEHLRLR RESPESEGPIYEGLIL
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Position Chain Variation Link
complement(65..66)-g, adbSNP:398122321
complement(65)-g, c, adbSNP:189775907
66+a, gdbSNP:3743928
complement(71)-g, adbSNP:182309233
complement(155)-dbSNP:
complement(155)-g, cdbSNP:370411054
complement(188)-t, adbSNP:145147781
complement(250)-dbSNP:
complement(250)-t, cdbSNP:193077277
complement(259)-g, adbSNP:186122975
complement(268)-t, cdbSNP:375285388
complement(270)-t, cdbSNP:183554824
293+a, gdbSNP:11550464
complement(293)-g, adbSNP:386519058
329+dbSNP:
329+c, tdbSNP:11550462
complement(344)-g, cdbSNP:188245364
complement(347)-t, adbSNP:12925313
complement(348)-t, adbSNP:12920740
complement(384)-g, adbSNP:375122817
complement(477)-dbSNP:
complement(477)-c, adbSNP:141444850
complement(481)-t, cdbSNP:375986040
complement(580)-g, adbSNP:370380458
complement(591)-t, cdbSNP:184863243
complement(649)-dbSNP:
complement(649)-g, adbSNP:373346821
complement(662)-t, gdbSNP:200388382
complement(685)-g, adbSNP:201098565
703+g, tdbSNP:79423190
complement(709)-t, gdbSNP:369424393
complement(777)-g, adbSNP:376845827
complement(778)-g, adbSNP:142925902
complement(782)-g, cdbSNP:201996601
complement(790..791)-, cdbSNP:35060795
complement(822)-dbSNP:
complement(822)-c, adbSNP:192783364
complement(847)-t, cdbSNP:375809380
complement(933)-dbSNP:
complement(933)-g, adbSNP:148572750
complement(1013)-t, cdbSNP:371218680
complement(1014)-dbSNP:
complement(1014)-t, adbSNP:77133510
complement(1038)-t, cdbSNP:200578690
complement(1044)-t, adbSNP:144346159
complement(1119)-dbSNP:
complement(1119)-t, cdbSNP:188883365
complement(1141)-t, cdbSNP:140265194
complement(1193)-t, cdbSNP:201593831
complement(1209)-g, adbSNP:113154062
complement(1244)-t, cdbSNP:116254156
complement(1354)-dbSNP:
complement(1354)-t, adbSNP:370055356
complement(1361)-t, adbSNP:375087873
complement(1367)-g, adbSNP:373075116
complement(1389)-g, adbSNP:368876504
complement(1390)-t, c, adbSNP:143688112
complement(1391)-t, adbSNP:139200616
complement(1396)-t, gdbSNP:191165923
complement(1416)-g, adbSNP:187425753
complement(1426)-t, cdbSNP:376209552
complement(1457)-g, adbSNP:17850640
complement(1477)-dbSNP:
complement(1477)-t, cdbSNP:367611000
complement(1497)-t, cdbSNP:150810185
complement(1515)-t, adbSNP:374074473
complement(1519)-g, cdbSNP:370401767
complement(1525)-c, adbSNP:376308396
complement(1526)-g, adbSNP:373113084
complement(1579)-t, adbSNP:141253289
complement(1602)-t, cdbSNP:267604550
complement(1632)-dbSNP:
complement(1632)-g, adbSNP:373955385
complement(1669)-g, adbSNP:184277092
1675+c, tdbSNP:398124658
complement(1690)-g, adbSNP:369196817
complement(1701)-g, adbSNP:376718984
complement(1768)-dbSNP:
complement(1768)-t, adbSNP:13332463
complement(1802)-g, adbSNP:376786968
complement(1882)-t, cdbSNP:201566773
complement(1894)-g, cdbSNP:148255605
complement(1902)-t, cdbSNP:145679337
complement(1904)-t, adbSNP:34687100
complement(1908)-t, adbSNP:142063738
complement(1957)-dbSNP:
complement(1957)-t, cdbSNP:188286943
complement(1976)-g, adbSNP:201998902
complement(1980)-g, adbSNP:138794859
complement(2011)-t, adbSNP:144997996
2037+c, tdbSNP:168745
complement(2044)-g, adbSNP:145406665
complement(2106)-g, adbSNP:376700700
complement(2121)-t, cdbSNP:375643041
complement(2160)-g, cdbSNP:188831675
complement(2167)-dbSNP:
complement(2167)-t, gdbSNP:150494360
complement(2221)-t, gdbSNP:199940967
complement(2222)-t, cdbSNP:375501847
complement(2244)-t, cdbSNP:145033509
complement(2248)-t, cdbSNP:184960717
complement(2280)-g, adbSNP:369831560
complement(2340)-dbSNP:
complement(2340)-g, adbSNP:140543776
complement(2362)-g, adbSNP:76693948
complement(2363)-t, gdbSNP:80303950
complement(2368)-g, adbSNP:113746010
complement(2386)-t, cdbSNP:370966099
complement(2419)-t, gdbSNP:192419029
complement(2445)-t, cdbSNP:181292654
complement(2460)-t, cdbSNP:184968916
complement(2492)-t, cdbSNP:200195623
complement(2497)-t, cdbSNP:183923278
complement(2498)-t, cdbSNP:188654478
complement(2501)-t, cdbSNP:189948577
complement(2546)-g, adbSNP:185420432
complement(2563)-t, cdbSNP:112747048
2669+c, tdbSNP:11550461
complement(2749..2750)-, t, tt, ttt, ttttdbSNP:59370839
complement(2751..2752)-, tttdbSNP:71852726
2771+a, cdbSNP:808078
complement(2771)-, gdbSNP:373111906
complement(2772..2773)-, tttdbSNP:369756092
complement(2772..2773)-t, gdbSNP:71380964
complement(2773)-t, gdbSNP:199765664
2776+a, tdbSNP:1053393
complement(2777..2778)-, ttdbSNP:369068093
complement(2779)-g, adbSNP:145606241
complement(2912)-t, gdbSNP:181198454
complement(2944)-g, adbSNP:188743379
complement(3190)-t, adbSNP:11550460
complement(3251..3252)-, adbSNP:34926621
complement(3254)-g, adbSNP:183646374
Gene SymbolVPS35
Gene SynonymMEM3; PARK17
Chromosome16
Locus Map16q12
Title VPS35 and EIF4G1 mutations are rare in Parkinson's disease among Indians .
Author Sudhaman S, Behari M, Govindappa ST, Muthane UB, Juyal RC and Thelma BK.
Journal Neurobiol. Aging 34 (10), 2442 (2013)
Title VPS35 Asp620Asn and EIF4G1 Arg1205His mutations are rare in Parkinson disease from southwest China .
Author Chen Y, Chen K, Song W, Chen X, Cao B, Huang R, Zhao B, Guo X, Burgunder J, Li J and Shang HF.
Journal Neurobiol. Aging 34 (6), 1709 (2013)
Title The VPS35 gene and Parkinson's disease .
Author Deng H, Gao K and Jankovic J.
Journal Mov. Disord. 28 (5), 569-575 (2013)
Title Whole exome sequencing of rare variants in EIF4G1 and VPS35 in Parkinson disease .
Author Nuytemans K, Bademci G, Inchausti V, Dressen A, Kinnamon DD, Mehta A, Wang L, Zuchner S, Beecham GW, Martin ER, Scott WK and Vance JM.
Journal Neurology 80 (11), 982-989 (2013)
Title Pathogenic mutation in VPS35 impairs its protection against MPP(+) cytotoxicity .
Author Bi F, Li F, Huang C and Zhou H.
Journal Int. J. Biol. Sci. 9 (2), 149-155 (2013)
Title Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21 .
Author Zhang P, Yu L, Gao J, Fu Q, Dai F, Zhao Y, Zheng L and Zhao S.
Journal Genomics 70 (2), 253-257 (2000)
Title Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes .
Author Haft CR, de la Luz Sierra M, Bafford R, Lesniak MA, Barr VA and Taylor SI.
Journal Mol. Biol. Cell 11 (12), 4105-4116 (2000)
Title Human homologues of yeast vacuolar protein sorting 29 and 35 .
Author Edgar AJ and Polak JM.
Journal Biochem. Biophys. Res. Commun. 277 (3), 622-630 (2000)
Title Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing .
Author Simpson JC, Wellenreuther R, Poustka A, Pepperkok R and Wiemann S.
Journal EMBO Rep. 1 (3), 287-292 (2000)
Title Parkinson Disease Overview .
Author Farlow,J., Pankratz,N.D., Wojcieszek,J. and Foroud,T.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)

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