Sequence in raw or FASTA format:
Homo sapiens vacuolar protein sorting 35 homolog (S. cerevisiae) (VPS35), mRNA.
| RefSeq Version | NM_018206.4, 156602659 |
| Length | 3298 bp |
| Structure | linear |
| Update Date | 11-MAR-2011 |
| Organism | Homo sapiens (human) |
| Definition | Homo sapiens vacuolar protein sorting 35 homolog (S. cerevisiae) (VPS35), mRNA. |
| Product | vacuolar protein sorting-associated protein 35 |
| Comment | Summary: This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq]. |
| RefSeq | NP_060676.2 |
| CDS | 100..2490 | Exon (1) | 1..102 | Exon (2) | 1..102 | Exon (3) | 103..201 | Exon (4) | 202..298 | Exon (5) | 299..422 | Exon (6) | 423..605 | Exon (7) | 606..819 | Exon (8) | 820..903 | Exon (9) | 904..1013 | Exon (10) | 1014..1110 | Exon (11) | 1111..1259 | Exon (12) | 1260..1467 | Exon (13) | 1468..1623 | Exon (14) | 1624..1746 | Exon (15) | 1747..1926 | Exon (16) | 1927..2166 | Exon (17) | 2167..2310 | Exon (18) | 2311..3285 |
| Translation | MPTTQQSPQDEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDALKHASNMLGELRTSMLSP
KSYYELYMAISDELHYLEVYLTDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVK
SFPQSRKDILKDLVEMCRGVQHPLRGLFLRNYLLQCTRNILPDEGEPTDEETTGDISDSM
DFVLLNFAEMNKLWVRMQHQGHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERYKQ
IVLTGILEQVVNCRDALAQEYLMECIIQVFPDEFHLQTLNPFLRACAELHQNVNVKNIII
ALIDRLALFAHREDGPGIPADIKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAMK
CYPDRVDYVDKVLETTVEIFNKLNLEHIATSSAVSKELTRLLKIPVDTYNNILTVLKLKH
FHPLFEYFDYESRKSMSCYVLSNVLDYNTEIVSQDQVDSIMNLVSTLIQDQPDQPVEDPD
PEDFADEQSLVGRFIHLLRSEDPDQQYLILNTARKHFGAGGNQRIRFTLPPLVFAAYQLA
FRYKENSKVDDKWEKKCQKIFSFAHQTISALIKAELAELPLRLFLQGALAAGEIGFENHE
TVAYEFMSQAFSLYEDEISDSKAQLAAITLIIGTFERMKCFSEENHEPLRTQCALAASKL
LKKPDQGRAVSTCAHLFWSGRNTDKNGEELHGGKRVMECLKKALKIANQCMDPSLQVQLF
IEILNRYIYFYEKENDAVTIQVLNQLIQKIREDLPNLESSEETEQINKHFHNTLEHLRLR
RESPESEGPIYEGLIL
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| Position | Chain | Variation | Link |
| 66 | + | a, g | dbSNP:3743928 |
| 122..123 | + | a, c | dbSNP:11550463 |
| 293 | + | a, g | dbSNP:11550464 |
| 329 | + | c, t | dbSNP:11550462 |
| complement(347) | - | t, a | dbSNP:12925313 |
| complement(348) | - | t, a | dbSNP:12920740 |
| complement(703) | - | t, g | dbSNP:79423190 |
| complement(790..791) | - | , c | dbSNP:35060795 |
| complement(1014) | - | t, a | dbSNP:77133510 |
| complement(1209) | - | g, a | dbSNP:113154062 |
| complement(1244) | - | t, c | dbSNP:116254156 |
| complement(1457) | - | g, a | dbSNP:17850640 |
| complement(1768) | - | t, a | dbSNP:13332463 |
| complement(1904) | - | t, a | dbSNP:34687100 |
| complement(1976) | - | g, a | dbSNP:116797677 |
| 2037 | + | c, t | dbSNP:168745 |
| complement(2362) | - | g, a | dbSNP:76693948 |
| complement(2363) | - | t, g | dbSNP:80303950 |
| complement(2368) | - | g, a | dbSNP:113746010 |
| complement(2444) | - | t, c | dbSNP:117090324 |
| complement(2563) | - | t, c | dbSNP:112747048 |
| complement(2669) | - | t, c | dbSNP:11550461 |
| complement(2748..2749) | - | , t | dbSNP:67124262 |
| complement(2749..2750) | - | , ttt | dbSNP:59370839 |
| complement(2757..2758) | - | , ttt | dbSNP:71852726 |
| complement(2759..2760) | - | , ttt | dbSNP:72524961 |
| 2771 | + | a, c | dbSNP:808078 |
| complement(2772..2773) | - | t, g | dbSNP:71380964 |
| complement(2773) | - | t, g | dbSNP:76901162 |
| 2776 | + | a, t | dbSNP:1053393 |
| complement(3190) | - | t, a | dbSNP:11550460 |
| complement(3241..3242) | - | , a | dbSNP:71378101 |
| complement(3252..3253) | - | , a | dbSNP:34926621 |
| Gene Symbol | VPS35 |
| Gene Synonym | DKFZp434E1211; DKFZp434P1672; FLJ10752; FLJ13588; FLJ20388; MEM3 |
| Chromosome | 16 |
| Locus Map | 16q12 |
| All Transcripts | NM_018206 |
| Title | Vps35 mediates vesicle transport between the mitochondria and peroxisomes . |
| Author | Braschi,E., Goyon,V., Zunino,R., Mohanty,A., Xu,L. and McBride,H.M. |
| Journal | Curr. Biol. 20 (14), 1310-1315 (2010) |
| Title | Retromer-mediated direct sorting is required for proper endosomal recycling of the mammalian iron transporter DMT1 . |
| Author | Tabuchi,M., Yanatori,I., Kawai,Y. and Kishi,F. |
| Journal | J. Cell. Sci. 123 (PT 5), 756-766 (2010) |
| Title | Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5 . |
| Author | Seaman,M.N., Harbour,M.E., Tattersall,D., Read,E. and Bright,N. |
| Journal | J. Cell. Sci. 122 (PT 14), 2371-2382 (2009) |
| Title | GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer . |
| Author | Scott,K.L., Kabbarah,O., Liang,M.C., Ivanova,E., Anagnostou,V., Wu,J., Dhakal,S., Wu,M., Chen,S., Feinberg,T., Huang,J., Saci,A., Widlund,H.R., Fisher,D.E., Xiao,Y., Rimm,D.L., Protopopov,A., Wong,K.K. and Chin,L. |
| Journal | Nature 459 (7250), 1085-1090 (2009) |
| Title | Functional architecture of the retromer cargo-recognition complex . |
| Author | Hierro,A., Rojas,A.L., Rojas,R., Murthy,N., Effantin,G., Kajava,A.V., Steven,A.C., Bonifacino,J.S. and Hurley,J.H. |
| Journal | Nature 449 (7165), 1063-1067 (2007) |
| Title | The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor . |
| Author | Verges,M., Luton,F., Gruber,C., Tiemann,F., Reinders,L.G., Huang,L., Burlingame,A.L., Haft,C.R. and Mostov,K.E. |
| Journal | Nat. Cell Biol. 6 (8), 763-769 (2004) |
| Title | Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21 . |
| Author | Zhang,P., Yu,L., Gao,J., Fu,Q., Dai,F., Zhao,Y., Zheng,L. and Zhao,S. |
| Journal | Genomics 70 (2), 253-257 (2000) |
| Title | Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes . |
| Author | Haft,C.R., de la Luz Sierra,M., Bafford,R., Lesniak,M.A., Barr,V.A. and Taylor,S.I. |
| Journal | Mol. Biol. Cell 11 (12), 4105-4116 (2000) |
| Title | Human homologues of yeast vacuolar protein sorting 29 and 35 . |
| Author | Edgar,A.J. and Polak,J.M. |
| Journal | Biochem. Biophys. Res. Commun. 277 (3), 622-630 (2000) |
| Title | Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . |
| Author | Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and Wiemann,S. |
| Journal | EMBO Rep. 1 (3), 287-292 (2000) |
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