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Homo sapiens vacuolar protein sorting 35 homolog (S. cerevisiae) (VPS35), mRNA.


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_018206 Homo sapiens vacuolar protein sorting 35 homolog (S. cerevisiae) (VPS35), mRNA. GenEZ ORF Cloning On-demand $899.00 20

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RefSeq Version NM_018206.4, 156602659
Length 3298 bp
Structure linear
Update Date 17-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens vacuolar protein sorting 35 homolog (S. cerevisiae) (VPS35), mRNA.
Product vacuolar protein sorting-associated protein 35
Comment

Summary: This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008].

RefSeq NP_060676.2
CDS 100..2490
Misc Feature(1)40..42
Misc Feature(2)40..42
Misc Feature(3)118..120
Misc Feature(4)118..120
Misc Feature(5)139..2361
Exon (1)1..102
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (2)103..201
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (3)202..298
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (4)299..422
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (5)423..605
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (6)606..819
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (7)820..903
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (8)904..1013
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (9)1014..1110
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (10)1111..1259
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (11)1260..1467
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (12)1468..1623
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (13)1624..1746
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (14)1747..1926
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (15)1927..2166
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (16)2167..2310
Gene:VPS35
Gene Synonym:MEM3; PARK17
Exon (17)2311..3285
Gene:VPS35
Gene Synonym:MEM3; PARK17
Translation MPTTQQSPQDEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDALKHASNMLGELRTSMLSP KSYYELYMAISDELHYLEVYLTDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVK SFPQSRKDILKDLVEMCRGVQHPLRGLFLRNYLLQCTRNILPDEGEPTDEETTGDISDSM DFVLLNFAEMNKLWVRMQHQGHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERYKQ IVLTGILEQVVNCRDALAQEYLMECIIQVFPDEFHLQTLNPFLRACAELHQNVNVKNIII ALIDRLALFAHREDGPGIPADIKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAMK CYPDRVDYVDKVLETTVEIFNKLNLEHIATSSAVSKELTRLLKIPVDTYNNILTVLKLKH FHPLFEYFDYESRKSMSCYVLSNVLDYNTEIVSQDQVDSIMNLVSTLIQDQPDQPVEDPD PEDFADEQSLVGRFIHLLRSEDPDQQYLILNTARKHFGAGGNQRIRFTLPPLVFAAYQLA FRYKENSKVDDKWEKKCQKIFSFAHQTISALIKAELAELPLRLFLQGALAAGEIGFENHE TVAYEFMSQAFSLYEDEISDSKAQLAAITLIIGTFERMKCFSEENHEPLRTQCALAASKL LKKPDQGRAVSTCAHLFWSGRNTDKNGEELHGGKRVMECLKKALKIANQCMDPSLQVQLF IEILNRYIYFYEKENDAVTIQVLNQLIQKIREDLPNLESSEETEQINKHFHNTLEHLRLR RESPESEGPIYEGLIL
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Position Chain Variation Link
complement(65)-g, c, adbSNP:189775907
complement(66)-g, adbSNP:3743928
complement(71)-g, adbSNP:182309233
complement(188)-dbSNP:
complement(188)-t, adbSNP:145147781
complement(250)-dbSNP:
complement(250)-t, cdbSNP:193077277
complement(259)-g, adbSNP:186122975
complement(270)-t, cdbSNP:183554824
complement(293)-g, adbSNP:11550464
complement(329)-dbSNP:
complement(329)-t, cdbSNP:11550462
complement(344)-g, cdbSNP:188245364
complement(347)-t, adbSNP:12925313
complement(348)-t, adbSNP:12920740
complement(477)-dbSNP:
complement(477)-c, adbSNP:141444850
complement(591)-t, cdbSNP:184863243
complement(609)-dbSNP:
complement(609)-t, cdbSNP:151079367
complement(662)-t, gdbSNP:200388382
complement(685)-g, adbSNP:201098565
complement(703)-t, gdbSNP:79423190
complement(778)-g, adbSNP:142925902
complement(782)-g, cdbSNP:201996601
complement(790..791)-, cdbSNP:35060795
complement(822)-dbSNP:
complement(822)-c, adbSNP:192783364
complement(933)-dbSNP:
complement(933)-g, adbSNP:148572750
complement(1014)-dbSNP:
complement(1014)-t, adbSNP:77133510
complement(1017)-t, adbSNP:145509249
complement(1038)-t, cdbSNP:200578690
complement(1044)-t, adbSNP:144346159
complement(1119)-dbSNP:
complement(1119)-t, cdbSNP:188883365
complement(1141)-t, cdbSNP:140265194
complement(1193)-t, cdbSNP:201593831
complement(1209)-g, adbSNP:113154062
complement(1244)-t, cdbSNP:116254156
complement(1390)-dbSNP:
complement(1390)-t, c, adbSNP:143688112
complement(1391)-t, adbSNP:139200616
complement(1396)-t, gdbSNP:191165923
complement(1416)-g, adbSNP:187425753
complement(1457)-g, adbSNP:17850640
complement(1497)-dbSNP:
complement(1497)-t, cdbSNP:150810185
complement(1579)-t, adbSNP:141253289
complement(1669)-dbSNP:
complement(1669)-g, adbSNP:184277092
complement(1768)-dbSNP:
complement(1768)-t, adbSNP:13332463
complement(1882)-t, cdbSNP:201566773
complement(1894)-g, cdbSNP:148255605
complement(1902)-t, cdbSNP:145679337
complement(1904)-t, adbSNP:34687100
complement(1908)-t, adbSNP:142063738
complement(1957)-dbSNP:
complement(1957)-t, cdbSNP:188286943
complement(1976)-g, adbSNP:201998902
complement(1980)-g, adbSNP:138794859
complement(2011)-t, adbSNP:144997996
complement(2037)-t, cdbSNP:168745
complement(2044)-g, adbSNP:145406665
complement(2160)-g, cdbSNP:188831675
complement(2167)-dbSNP:
complement(2167)-t, gdbSNP:150494360
complement(2221)-t, gdbSNP:199940967
complement(2244)-t, cdbSNP:145033509
complement(2248)-t, cdbSNP:184960717
complement(2340)-dbSNP:
complement(2340)-g, adbSNP:140543776
complement(2362)-g, adbSNP:76693948
complement(2363)-t, gdbSNP:80303950
complement(2368)-g, adbSNP:113746010
complement(2419)-t, gdbSNP:192419029
complement(2445)-t, cdbSNP:181292654
complement(2454)-t, gdbSNP:151308268
complement(2460)-t, cdbSNP:184968916
complement(2492)-t, cdbSNP:200195623
complement(2497)-t, cdbSNP:183923278
complement(2498)-t, cdbSNP:188654478
complement(2501)-t, cdbSNP:189948577
complement(2546)-g, adbSNP:185420432
complement(2563)-t, cdbSNP:112747048
complement(2669)-t, cdbSNP:11550461
complement(2748..2749)-, t, tttdbSNP:67124262
complement(2749..2750)-, t, tt, ttt, ttttdbSNP:59370839
complement(2769..2770)-, tttdbSNP:71852726
complement(2771)-c, adbSNP:808078
complement(2772..2773)-t, gdbSNP:71380964
complement(2773)-t, gdbSNP:199765664
complement(2776)-t, adbSNP:1053393
complement(2779)-g, adbSNP:145606241
complement(2912)-t, gdbSNP:181198454
complement(2944)-g, adbSNP:188743379
complement(3190)-t, adbSNP:11550460
complement(3251..3252)-, adbSNP:71378101
complement(3252..3253)-, adbSNP:34926621
complement(3254)-g, adbSNP:183646374
Gene SymbolVPS35
Gene SynonymMEM3; PARK17
Chromosome16
Locus Map16q12
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_018206 Homo sapiens vacuolar protein sorting 35 homolog (S. cerevisiae) (VPS35), mRNA. On-demand $899.00 20
Title Frequency of the D620N mutation in VPS35 in Parkinson disease .
Author Kumar,K.R., Weissbach,A., Heldmann,M., Kasten,M., Tunc,S., Sue,C.M., Svetel,M., Kostic,V.S., Segura-Aguilar,J., Ramirez,A., Simon,D.K., Vieregge,P., Munte,T.F., Hagenah,J., Klein,C. and Lohmann,K.
Journal Arch. Neurol. 69 (10), 1360-1364 (2012)
Title VPS35 mutation in Japanese patients with typical Parkinson's disease .
Author Ando,M., Funayama,M., Li,Y., Kashihara,K., Murakami,Y., Ishizu,N., Toyoda,C., Noguchi,K., Hashimoto,T., Nakano,N., Sasaki,R., Kokubo,Y., Kuzuhara,S., Ogaki,K., Yamashita,C., Yoshino,H., Hatano,T., Tomiyama,H. and Hattori,N.
Journal Mov. Disord. 27 (11), 1413-1417 (2012)
Title Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer .
Author Jia,D., Gomez,T.S., Billadeau,D.D. and Rosen,M.K.
Journal Mol. Biol. Cell 23 (12), 2352-2361 (2012)
Title Vacuolar protein sorting 35 Asp620Asn mutation is rare in the ethnic Chinese population with Parkinson's disease .
Author Zhang,Y., Chen,S., Xiao,Q., Cao,L., Liu,J., Rong,T.Y., Ma,J.F., Wang,G., Wang,Y. and Chen,S.D.
Journal Parkinsonism Relat. Disord. 18 (5), 638-640 (2012)
Title Identification of VPS35 mutations replicated in French families with Parkinson disease .
Author Lesage,S., Condroyer,C., Klebe,S., Honore,A., Tison,F., Brefel-Courbon,C., Durr,A. and Brice,A.
Journal Neurology 78 (18), 1449-1450 (2012)
Title The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor .
Author Verges,M., Luton,F., Gruber,C., Tiemann,F., Reinders,L.G., Huang,L., Burlingame,A.L., Haft,C.R. and Mostov,K.E.
Journal Nat. Cell Biol. 6 (8), 763-769 (2004)
Title Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21 .
Author Zhang,P., Yu,L., Gao,J., Fu,Q., Dai,F., Zhao,Y., Zheng,L. and Zhao,S.
Journal Genomics 70 (2), 253-257 (2000)
Title Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes .
Author Haft,C.R., de la Luz Sierra,M., Bafford,R., Lesniak,M.A., Barr,V.A. and Taylor,S.I.
Journal Mol. Biol. Cell 11 (12), 4105-4116 (2000)
Title Human homologues of yeast vacuolar protein sorting 29 and 35 .
Author Edgar,A.J. and Polak,J.M.
Journal Biochem. Biophys. Res. Commun. 277 (3), 622-630 (2000)
Title Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing .
Author Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and Wiemann,S.
Journal EMBO Rep. 1 (3), 287-292 (2000)


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