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Homo sapiens alkaline ceramidase 3 (ACER3), mRNA.


RefSeq Accession Definition Services Price Order
NM_018367 Homo sapiens alkaline ceramidase 3 (ACER3), mRNA. ORF Sequence $233.16
Peptide Services
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Protein Services


RefSeq Version NM_018367.5, 170932466
Length 4387 bp
Structure linear
Update Date 17-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens alkaline ceramidase 3 (ACER3), mRNA.
Product alkaline ceramidase 3
Comment

COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG702017.1, BC049837.1, AF214454.1 and AP000752.4. On Mar 27, 2008 this sequence version replaced gi:141802267.


##Evidence-Data-START## Transcript exon combination :: AF327353.1, AF214454.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025082, ERS025084 [ECO:0000348] ##Evidence-Data-END##

RefSeq NP_060837.3
CDS 105..908
Misc Feature(1)69..71
Misc Feature(2)69..71
Misc Feature(3)126..881
Misc Feature(4)126..881
Misc Feature(5)189..257
Misc Feature(6)291..356
Misc Feature(7)384..437
Misc Feature(8)456..515
Misc Feature(9)543..611
Misc Feature(10)624..692
Misc Feature(11)750..818
Exon (1)1..207
Gene:ACER3
Gene Synonym:APHC; PHCA
Exon (2)208..318
Gene:ACER3
Gene Synonym:APHC; PHCA
Exon (3)319..371
Gene:ACER3
Gene Synonym:APHC; PHCA
Exon (4)372..424
Gene:ACER3
Gene Synonym:APHC; PHCA
Exon (5)425..506
Gene:ACER3
Gene Synonym:APHC; PHCA
Exon (6)507..542
Gene:ACER3
Gene Synonym:APHC; PHCA
Exon (7)543..601
Gene:ACER3
Gene Synonym:APHC; PHCA
Exon (8)602..703
Gene:ACER3
Gene Synonym:APHC; PHCA
Exon (9)704..808
Gene:ACER3
Gene Synonym:APHC; PHCA
Exon (10)809..854
Gene:ACER3
Gene Synonym:APHC; PHCA
Exon (11)855..4387
Gene:ACER3
Gene Synonym:APHC; PHCA
Translation MAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLE KRYIASYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKIKNSVNYH LLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLG IFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRT LYLRYRPKVKFLFGIWPVILFEPLRKH
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Position Chain Variation Link
149+c, tdbSNP:138662843
184+a, tdbSNP:201190641
187+a, cdbSNP:149293091
258+dbSNP:
258+a, gdbSNP:4379869
287+a, gdbSNP:4479014
294+a, gdbSNP:142469431
313+c, tdbSNP:113648802
392+dbSNP:
392+g, tdbSNP:201974871
462+dbSNP:
462+c, tdbSNP:79316237
503+a, cdbSNP:17417894
506+a, gdbSNP:145982324
530+dbSNP:
530+c, tdbSNP:3740767
580+dbSNP:
580+a, gdbSNP:200663793
585+a, cdbSNP:142076622
621+dbSNP:
621+a, gdbSNP:151112611
645+a, gdbSNP:141925215
680+c, tdbSNP:144794891
890+a, gdbSNP:201953460
899+a, gdbSNP:147930782
933+a, gdbSNP:75049780
1046+a, cdbSNP:12786211
1062+a, tdbSNP:6592695
1126+c, tdbSNP:140432815
1171+, adbSNP:201853621
1230+a, gdbSNP:150407670
1561+c, tdbSNP:116435642
1627+c, tdbSNP:191597575
1675+a, gdbSNP:183692122
1747+c, tdbSNP:189592936
1768+g, tdbSNP:181811070
1845+a, gdbSNP:7925774
1981+a, gdbSNP:113193324
2024+a, gdbSNP:186776620
2187+g, tdbSNP:145237694
2275+a, gdbSNP:190086662
2283+a, gdbSNP:591043
2321+c, tdbSNP:1062170
2333+a, tdbSNP:181703509
2392+a, gdbSNP:149171767
2458+a, cdbSNP:200842351
2486+c, tdbSNP:7123496
2561+a, gdbSNP:10793231
2665+a, gdbSNP:143338837
2674+g, tdbSNP:186763379
2684+a, gdbSNP:139284535
2702+a, tdbSNP:143219833
2830+g, tdbSNP:147101885
2850+a, cdbSNP:17135325
2908+a, cdbSNP:138564203
2959+c, tdbSNP:141620887
3037+a, gdbSNP:190024197
3088+c, tdbSNP:182311591
3129+c, tdbSNP:184950227
3158+g, tdbSNP:76526589
3159+a, tdbSNP:117799384
3252+c, gdbSNP:150517190
3295+a, gdbSNP:11540156
3309+a, gdbSNP:190984103
3367+c, tdbSNP:144358416
3384+c, tdbSNP:2826
3408+c, tdbSNP:79522926
3415+a, tdbSNP:139514687
3450..3464+, aaaaaaaaaaaaaaadbSNP:60755151
3450..3451+, adbSNP:60367220
3450+, aaaaaaaaaa, aaaaaaaaaaaaaaadbSNP:10565723
3459+a, gdbSNP:200178452
3464+a, c, gdbSNP:202111355
3470+, aaaagdbSNP:10565724
3474..3478+, gaaaadbSNP:10577848
3542+c, tdbSNP:4944134
3669+g, tdbSNP:112256825
3788+a, gdbSNP:7127936
3799+a, gdbSNP:58717726
3866+a, gdbSNP:7128038
3959+a, gdbSNP:73491478
3967+a, cdbSNP:149282407
3999+c, tdbSNP:146216479
4210+c, tdbSNP:114059496
4219+a, gdbSNP:77668792
4382+c, tdbSNP:6592696
Gene SymbolACER3
Gene SynonymAPHC; PHCA
Chromosome11
Locus Map11q13.5
All Transcripts
RefSeq Accession Definition Sequence Price Select
NM_018367 Homo sapiens alkaline ceramidase 3 (ACER3), mRNA. Full Length $1535.45
ORF Sequence $233.16
Title Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study .
Author Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V., Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
Journal Diabetes Care 33 (10), 2250-2253 (2010)
Title Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis .
Author Hu,W., Xu,R., Sun,W., Szulc,Z.M., Bielawski,J., Obeid,L.M. and Mao,C.
Journal J. Biol. Chem. 285 (11), 7964-7976 (2010)
Title Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip .
Author Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C., Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R., Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A., Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C., Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S., Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N., Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
Journal Am. J. Hum. Genet. 85 (5), 628-642 (2009)
Title Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging .
Author Wheeler,H.E., Metter,E.J., Tanaka,T., Absher,D., Higgins,J., Zahn,J.M., Wilhelmy,J., Davis,R.W., Singleton,A., Myers,R.M., Ferrucci,L. and Kim,S.K.
Journal PLoS Genet. 5 (10), E1000685 (2009)
Title Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate .
Author Mao,C. and Obeid,L.M.
Journal Biochim. Biophys. Acta 1781 (9), 424-434 (2008)
Title hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes .
Author Lamesch,P., Li,N., Milstein,S., Fan,C., Hao,T., Szabo,G., Hu,Z., Venkatesan,K., Bethel,G., Martin,P., Rogers,J., Lawlor,S., McLaren,S., Dricot,A., Borick,H., Cusick,M.E., Vandenhaute,J., Dunham,I., Hill,D.E. and Vidal,M.
Journal Genomics 89 (3), 307-315 (2007)
Title Cloning and characterization of a novel human alkaline ceramidase. .
Author Mao,C., Xu,R., Szulc,Z.M., Bielawska,A., Galadari,S.H. and Obeid,L.M.
Journal J. Biol. Chem. 276 (28), 26577-26588 (2001)

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