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Homo sapiens alkaline ceramidase 3 (ACER3), mRNA.


RefSeq Accession Definition Sequence Price Select
NM_018367 Homo sapiens alkaline ceramidase 3 (ACER3), mRNA. Full Lenth $1535.45
ORF Sequence $233.16


RefSeq Version NM_018367.5, 170932466
Length 4387 bp
Structure linear
Update Date 10-APR-2011
Organism Homo sapiens (human)
Definition Homo sapiens alkaline ceramidase 3 (ACER3), mRNA.
Product alkaline ceramidase 3
Comment

COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG702017.1, BC049837.1, AF214454.1 and AP000752.4. On Mar 27, 2008 this sequence version replaced gi:141802267.

RefSeq NP_060837.3
CDS 105..908
Exon (1)1..207
Exon (2)1..207
Exon (3)208..318
Exon (4)319..371
Exon (5)372..424
Exon (6)425..506
Exon (7)507..542
Exon (8)543..601
Exon (9)602..703
Exon (10)704..808
Exon (11)809..854
Exon (12)855..4387
Translation MAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLE KRYIASYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKIKNSVNYH LLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLG IFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRT LYLRYRPKVKFLFGIWPVILFEPLRKH
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Position Chain Variation Link
258+a, gdbSNP:4379869
287+a, gdbSNP:4479014
313+c, tdbSNP:113648802
462+c, tdbSNP:79316237
complement(530)-t, cdbSNP:3740767
933+a, gdbSNP:75049780
1046+a, cdbSNP:12786211
1062+a, tdbSNP:6592695
1561+c, tdbSNP:116435642
1845+a, gdbSNP:7925774
1981+a, gdbSNP:113193324
complement(2283)-g, adbSNP:591043
2321+c, tdbSNP:1062170
2458+a, cdbSNP:75276480
2486+c, tdbSNP:7123496
2561+a, gdbSNP:10793231
2666+g, tdbSNP:75174180
2850+a, cdbSNP:17135325
3158+g, tdbSNP:76526589
3159+a, tdbSNP:117799384
3295+a, gdbSNP:11540156
3363+a, gdbSNP:80088819
3384+c, tdbSNP:2826
3408+c, tdbSNP:79522926
3450+, aaaaaaaaaaaaaaadbSNP:66637020
3450+, aaaaaaaaaadbSNP:10565723
3459..3473+, aaaaaaaaaaaaaaadbSNP:60755151
3473..3474+, adbSNP:60367220
3474..3478+, gaaaadbSNP:10577848
3479..3483+, gaaaadbSNP:72251358
3480+, aaaagdbSNP:10565724
3542+c, tdbSNP:4944134
3669+g, tdbSNP:112256825
3788+a, gdbSNP:7127936
3799+a, gdbSNP:58717726
3866+a, gdbSNP:7128038
3959+a, gdbSNP:73491478
4210+c, tdbSNP:114059496
4219+a, gdbSNP:77668792
4382+c, tdbSNP:6592696
Gene SymbolACER3
Gene SynonymAPHC; FLJ11238; PHCA
Chromosome11
Locus Map11q13.5
All Transcripts NM_018367
Title Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study .
Author Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V., Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
Journal Diabetes Care 33 (10), 2250-2253 (2010)
Title Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score .
Author Rose,J.E., Behm,F.M., Drgon,T., Johnson,C. and Uhl,G.R.
Journal Mol. Med. 16 (7-8), 247-253 (2010)
Title Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis .
Author Hu,W., Xu,R., Sun,W., Szulc,Z.M., Bielawski,J., Obeid,L.M. and Mao,C.
Journal J. Biol. Chem. 285 (11), 7964-7976 (2010)
Title Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip .
Author Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C., Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R., Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A., Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C., Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S., Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N., Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
Journal Am. J. Hum. Genet. 85 (5), 628-642 (2009)
Title Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging .
Author Wheeler,H.E., Metter,E.J., Tanaka,T., Absher,D., Higgins,J., Zahn,J.M., Wilhelmy,J., Davis,R.W., Singleton,A., Myers,R.M., Ferrucci,L. and Kim,S.K.
Journal PLoS Genet. 5 (10), E1000685 (2009)
Title Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate .
Author Mao,C. and Obeid,L.M.
Journal Biochim. Biophys. Acta 1781 (9), 424-434 (2008)
Title hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes .
Author Lamesch,P., Li,N., Milstein,S., Fan,C., Hao,T., Szabo,G., Hu,Z., Venkatesan,K., Bethel,G., Martin,P., Rogers,J., Lawlor,S., McLaren,S., Dricot,A., Borick,H., Cusick,M.E., Vandenhaute,J., Dunham,I., Hill,D.E. and Vidal,M.
Journal Genomics 89 (3), 307-315 (2007)
Title Cloning and characterization of a novel human alkaline ceramidase. .
Author Mao,C., Xu,R., Szulc,Z.M., Bielawska,A., Galadari,S.H. and Obeid,L.M.
Journal J. Biol. Chem. 276 (28), 26577-26588 (2001)

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