Sequence in raw or FASTA format:
Homo sapiens growth hormone 1 (GH1), transcript variant 2, mRNA.
|Sequence Information||ORF Nucleotide Sequence
|Vector||pcDNA3.1+-DYK or customized vector|
|Clone information||Clone Map|
|Tag on pcDNA3.1+-DYK||N terminal DYKDDDK tags|
|Restriction Sites||Hind III- EcoR I|
|RefSeq Version||NM_022559.3, 636576918|
|Organism||Homo sapiens (human)|
|Definition||Homo sapiens growth hormone 1 (GH1), transcript variant 2, mRNA.|
|Product||somatotropin isoform 2 precursor|
Summary: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform 1.
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|Gene Synonym||GH; GH-N; GHN; hGH-N; IGHD1B|
|Technical Manual||GenEZ ORF Clone Technical Manual|
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