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Homo sapiens partner and localizer of BRCA2 (PALB2), mRNA.


RefSeq Accession Definition Services Price Order
NM_024675 Homo sapiens partner and localizer of BRCA2 (PALB2), mRNA. ORF Sequence $1246.35
Peptide Services
Antibody Services
Protein Services


RefSeq Version NM_024675.3, 113722109
Length 4069 bp
Structure linear
Update Date 17-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens partner and localizer of BRCA2 (PALB2), mRNA.
Product partner and localizer of BRCA2
Comment

Summary: This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008].

RefSeq NP_078951.2
CDS 201..3761
Misc Feature(1)75..77
Misc Feature(2)201..1157
Misc Feature(3)201..1157
Misc Feature(4)201..800
Misc Feature(5)201..680
Misc Feature(6)375..377
Misc Feature(7)390..392
Misc Feature(8)669..671
Misc Feature(9)1326..1328
Misc Feature(10)1326..1328
Misc Feature(11)1359..1361
Misc Feature(12)2178..2180
Misc Feature(13)2757..3758
Exon (1)1..248
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (2)249..308
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (3)309..411
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (4)412..1884
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (5)1885..2714
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (6)2715..2786
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (7)2787..2948
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (8)2949..3034
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (9)3035..3196
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (10)3197..3313
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (11)3314..3401
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (12)3402..3550
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (13)3551..4058
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Translation MDEPPGKPLSCEEKEKLKEKLAFLKREYSKTLARLQRAQRAEKIKHSIKKTVEEQDCLSQ QDLSPQLKHSEPKNKICVYDKLHIKTHLDEETGEKTSITLDVGPESFNPGDGPGGLPIQR TDDTQEHFPHRVSDPSGEQKQKLPSRRKKQQKRTFISQERDCVFGTDSLRLSGKRLKEQE EISSKNPARSPVTEIRTHLLSLKSELPDSPEPVTEINEDSVLIPPTAQPEKGVDTFLRRP NFTRATTVPLQTLSDSGSSQHLEHIPPKGSSELTTHDLKNIRFTSPVSLEAQGKKMTVST DNLLVNKAISKSGQLPTSSNLEANISCSLNELTYNNLPANENQNLKEQNQTEKSLKSPSD TLDGRNENLQESEILSQPKSLSLEATSPLSAEKHSCTVPEGLLFPAEYYVRTTRSMSNCQ RKVAVEAVIQSHLDVKKKGFKNKNKDASKNLNLSNEETDQSEIRMSGTCTGQPSSRTSQK LLSLTKVSSPAGPTEDNDLSRKAVAQAPGRRYTGKRKSACTPASDHCEPLLPTSSLSIVN RSKEEVTSHKYQHEKLFIQVKGKKSRHQKEDSLSWSNSAYLSLDDDAFTAPFHRDGMLSL KQLLSFLSITDFQLPDEDFGPLKLEKVKSCSEKPVEPFESKMFGERHLKEGSCIFPEELS PKRMDTEMEDLEEDLIVLPGKSHPKRPNSQSQHTKTGLSSSILLYTPLNTVAPDDNDRPT TDMCSPAFPILGTTPAFGPQGSYEKASTEVAGRTCCTPQLAHLKDSVCLASDTKQFDSSG SPAKPHTTLQVSGRQGQPTCDCDSVPPGTPPPIESFTFKENQLCRNTCQELHKHSVEQTE TAELPASDSINPGNLQLVSELKNPSGSCSVDVSAMFWERAGCKEPCIITACEDVVSLWKA LDAWQWEKLYTWHFAEVPVLQIVPVPDVYNLVCVALGNLEIREIRALFCSSDDESEKQVL LKSGNIKAVLGLTKRRLVSSSGTLSDQQVEVMTFAEDGGGKENQFLMPPEETILTFAEVQ GMQEALLGTTIMNNIVIWNLKTGQLLKKMHIDDSYQASVCHKAYSEMGLLFIVLSHPCAK ESESLRSPVFQLIVINPKTTLSVGVMLYCLPPGQAGRFLEGDVKDHCAAAILTSGTIAIW DLLLGQCTALLPPVSDQHWSFVKWSGTDSHLLAGQKDGNIFVYHYS
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Position Chain Variation Link
complement(43)-dbSNP:
complement(43)-g, cdbSNP:138200248
complement(97)-t, cdbSNP:180177140
complement(154)-t, cdbSNP:8053188
complement(155)-g, adbSNP:180177141
complement(170)-g, adbSNP:200523571
complement(211)-t, cdbSNP:45619737
complement(212)-g, adbSNP:145291423
complement(223)-g, adbSNP:150390726
complement(253)-dbSNP:
complement(253)-t, cdbSNP:138789658
complement(272)-, gdbSNP:180177142
complement(278)-g, adbSNP:45572434
complement(294)-g, cdbSNP:151316635
complement(301)-c, adbSNP:144944814
complement(304)-g, adbSNP:141047069
complement(309)-dbSNP:
complement(309)-g, adbSNP:200048921
complement(310)-t, cdbSNP:202194596
complement(394)-t, cdbSNP:62625272
complement(396)-t, cdbSNP:180177083
complement(429)-dbSNP:
complement(429)-, tdbSNP:180177084
complement(480)-g, adbSNP:45602040
complement(498)-g, adbSNP:61756147
complement(544)-c, adbSNP:145598272
complement(571)-t, cdbSNP:45457297
complement(595)-, tdbSNP:180177085
complement(600)-t, cdbSNP:139555085
complement(606)-t, adbSNP:144496685
complement(608)-t, adbSNP:112202375
complement(695)-g, adbSNP:200937538
complement(705)-c, adbSNP:180177086
complement(818)-t, gdbSNP:180177088
complement(829)-g, adbSNP:57605939
complement(832)-g, adbSNP:180177089
complement(856)-g, adbSNP:45594034
complement(868)-g, adbSNP:150517167
complement(897)-, gdbSNP:180177090
complement(921)-t, cdbSNP:113217267
complement(951)-t, cdbSNP:180177091
complement(965)-t, cdbSNP:45465299
complement(968)-t, cdbSNP:45487491
complement(1007)-t, cdbSNP:180177093
complement(1031)-t, cdbSNP:62625273
complement(1033)-t, adbSNP:200843485
complement(1034)-t, adbSNP:199919863
complement(1044)-g, adbSNP:45447991
complement(1054)-t, cdbSNP:180177094
complement(1056)-t, cdbSNP:45585833
complement(1097)-t, cdbSNP:180177095
complement(1109)-g, adbSNP:145788619
complement(1118)-g, adbSNP:114428350
complement(1121)-, tdbSNP:202151522
complement(1125)-g, adbSNP:3809683
complement(1126)-c, adbSNP:201588519
complement(1128)-g, adbSNP:45561331
complement(1150)-t, cdbSNP:45548638
complement(1156)-g, adbSNP:200144401
complement(1199)-t, cdbSNP:180177096
complement(1200)-c, adbSNP:202241382
complement(1201)-t, cdbSNP:200620434
complement(1227)-t, cdbSNP:180177097
complement(1250..1251)-tct, aadbSNP:180177098
complement(1254)-g, cdbSNP:201035780
complement(1256..1257)-, gadbSNP:180177099
complement(1281)-t, cdbSNP:111981798
complement(1319)-g, adbSNP:45623436
complement(1356)-t, cdbSNP:148102335
complement(1394)-t, cdbSNP:61755173
complement(1412)-c, adbSNP:148921082
complement(1440)-t, cdbSNP:180177100
complement(1450)-c, adbSNP:45510998
complement(1481)-g, adbSNP:138697796
complement(1511)-t, cdbSNP:190489275
complement(1537)-t, adbSNP:146434474
complement(1543)-t, cdbSNP:142628513
complement(1548)-c, adbSNP:62625274
complement(1599)-g, cdbSNP:45602239
complement(1608)-t, cdbSNP:150636811
complement(1619)-c, adbSNP:62625275
complement(1670)-t, cdbSNP:45612837
complement(1674)-g, adbSNP:45503296
complement(1692)-c, adbSNP:75023630
complement(1772)-g, adbSNP:45472400
complement(1778)-t, g, c, adbSNP:45603832
complement(1792)-, tdbSNP:180177102
complement(1806)-g, adbSNP:151162255
complement(1810)-g, adbSNP:142103232
complement(1833)-t, gdbSNP:180177103
complement(1837)-g, adbSNP:148647206
complement(1853)-t, adbSNP:118203997
complement(1856)-g, adbSNP:180177104
complement(1865)-g, adbSNP:45518838
complement(1876)-t, g, adbSNP:152451
complement(1891)-dbSNP:
complement(1891)-g, adbSNP:62625276
complement(1897)-t, cdbSNP:144617793
complement(1943)-g, adbSNP:180177105
complement(1987)-t, cdbSNP:187191947
complement(1994)-t, cdbSNP:182494675
complement(2000)-t, cdbSNP:139662375
complement(2010)-g, adbSNP:144015319
complement(2039)-t, cdbSNP:199682414
complement(2081)-c, adbSNP:139362268
complement(2123)-t, cdbSNP:146276404
complement(2135)-t, cdbSNP:141707455
complement(2144)-g, adbSNP:200296117
complement(2182)-g, adbSNP:71379822
complement(2187)-t, cdbSNP:62625277
complement(2214)-g, cdbSNP:45532440
complement(2227)-g, adbSNP:200875161
complement(2277)-g, adbSNP:150585579
complement(2282)-t, cdbSNP:150569240
complement(2335)-g, adbSNP:141458731
complement(2340)-g, adbSNP:45537237
complement(2347)-t, cdbSNP:148335539
complement(2365)-t, cdbSNP:146355383
complement(2400)-t, adbSNP:45543843
complement(2404)-g, adbSNP:199743500
complement(2428)-t, cdbSNP:141749524
complement(2430)-g, adbSNP:62625278
complement(2434)-t, cdbSNP:142343372
complement(2453)-g, adbSNP:138514571
complement(2456)-t, cdbSNP:147120218
complement(2457)-t, cdbSNP:180177110
complement(2474)-g, adbSNP:183322618
complement(2523)-t, cdbSNP:180177111
complement(2528)-t, c, adbSNP:45508997
complement(2529)-t, cdbSNP:148026749
complement(2560)-g, adbSNP:201042302
complement(2565)-g, adbSNP:145805054
complement(2586)-t, gdbSNP:180177112
complement(2594)-t, adbSNP:61756018
complement(2611)-g, adbSNP:149836639
complement(2617)-t, cdbSNP:45464991
complement(2642)-t, cdbSNP:140776736
complement(2674)-g, cdbSNP:146218439
complement(2721)-dbSNP:
complement(2721)-, adbSNP:180177116
complement(2759)-t, cdbSNP:180177115
complement(2761)-t, cdbSNP:146455175
complement(2790)-dbSNP:
complement(2790)-t, cdbSNP:45568339
complement(2797)-g, adbSNP:62625279
complement(2807)-t, c, adbSNP:45542234
complement(2845)-g, adbSNP:45486906
complement(2860)-t, gdbSNP:45550935
complement(2861)-c, adbSNP:180177120
complement(2873)-g, c, adbSNP:78179744
complement(2874)-g, adbSNP:45476495
complement(2918)-g, adbSNP:180177122
complement(2920)-g, adbSNP:45504298
complement(2932)-t, cdbSNP:180177123
complement(2942)-g, adbSNP:115759702
complement(2961)-dbSNP:
complement(2961)-t, cdbSNP:180177124
complement(2973)-g, cdbSNP:180177125
complement(2980)-t, adbSNP:62625280
complement(2994)-g, adbSNP:45624036
complement(3016)-t, gdbSNP:45478192
complement(3031)-c, adbSNP:201817103
complement(3040)-dbSNP:
complement(3040)-t, cdbSNP:45464500
complement(3041)-t, gdbSNP:45525135
complement(3051)-g, adbSNP:149522412
complement(3081)-g, adbSNP:61755166
complement(3153)-g, adbSNP:139726856
complement(3162)-t, cdbSNP:118203999
complement(3178)-g, adbSNP:61756146
complement(3193)-g, adbSNP:45551636
complement(3224)-dbSNP:
complement(3224)-t, cdbSNP:180177130
complement(3226)-, cdbSNP:180177131
complement(3254)-g, cdbSNP:183489969
complement(3261)-t, cdbSNP:143808171
complement(3313)-g, adbSNP:180177132
complement(3316)-dbSNP:
complement(3316)-, adbSNP:180177133
complement(3346)-g, adbSNP:138273800
complement(3379)-t, cdbSNP:116967702
complement(3425)-dbSNP:
complement(3425)-t, adbSNP:202222149
complement(3449)-g, cdbSNP:147045425
complement(3451)-t, cdbSNP:62625271
complement(3452)-g, cdbSNP:141570833
complement(3455)-g, adbSNP:45486891
complement(3457)-t, cdbSNP:146377793
complement(3478)-t, cdbSNP:45616636
complement(3486)-g, adbSNP:62625281
complement(3496)-g, adbSNP:142132127
complement(3497)-g, adbSNP:45565738
3500+g, tdbSNP:45516100
complement(3507)-t, cdbSNP:201657283
complement(3510)-c, adbSNP:188254555
complement(3520)-g, adbSNP:149194681
3523+, adbSNP:180177135
complement(3562)-dbSNP:
complement(3562)-g, adbSNP:62625282
complement(3573)-c, adbSNP:146444298
complement(3618)-t, gdbSNP:62625283
complement(3628)-t, adbSNP:62625284
complement(3633)-g, cdbSNP:180177137
complement(3649)-t, gdbSNP:45566737
complement(3673)-g, adbSNP:45505500
complement(3687)-t, cdbSNP:145369260
complement(3697)-, gdbSNP:180177138
complement(3708)-g, adbSNP:200283306
complement(3718)-g, adbSNP:146659762
complement(3739)-t, cdbSNP:180177139
complement(3749)-g, cdbSNP:118203998
complement(3819..3820)-, cdbSNP:34411226
complement(3836)-t, cdbSNP:189962793
complement(3858)-t, gdbSNP:185410736
complement(3993)-c, adbSNP:180748355
Gene SymbolPALB2
Gene SynonymFANCN; PNCA3
Chromosome16
Locus Map16p12.2
All Transcripts
RefSeq Accession Definition Sequence Price Select
NM_024675 Homo sapiens partner and localizer of BRCA2 (PALB2), mRNA. Full Length $1424.15
ORF Sequence $1246.35
Title Contribution of the PALB2 c.2323C>T [p.Q775X] founder mutation in well-defined breast and/or ovarian cancer families and unselected ovarian cancer cases of French Canadian descent .
Author Tischkowitz,M., Sabbaghian,N., Hamel,N., Pouchet,C., Foulkes,W.D., Mes-Masson,A.M., Provencher,D.M. and Tonin,P.N.
Journal BMC Med. Genet. 14, 5 (2013)
Title PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function .
Author Ma,J., Cai,H., Wu,T., Sobhian,B., Huo,Y., Alcivar,A., Mehta,M., Cheung,K.L., Ganesan,S., Kong,A.N., Zhang,D.D. and Xia,B.
Journal Mol. Cell. Biol. 32 (8), 1506-1517 (2012)
Title Rare germline mutations in PALB2 and breast cancer risk: a population-based study .
Author Tischkowitz,M., Capanu,M., Sabbaghian,N., Li,L., Liang,X., Vallee,M.P., Tavtigian,S.V., Concannon,P., Foulkes,W.D., Bernstein,L., Bernstein,J.L. and Begg,C.B.
Journal Hum. Mutat. 33 (4), 674-680 (2012)
Title Hereditary breast cancer: beyond BRCA genetic analysis; PALB2 emerges .
Author Poumpouridou,N. and Kroupis,C.
Journal Clin. Chem. Lab. Med. 50 (3), 423-434 (2012)
Title Mutation analysis of BRCA1, BRCA2, PALB2 and BRD7 in a hospital-based series of German patients with triple-negative breast cancer .
Author Pern,F., Bogdanova,N., Schurmann,P., Lin,M., Ay,A., Langer,F., Hillemanns,P., Christiansen,H., Park-Simon,T.W. and Dork,T.
Journal PLoS ONE 7 (10), E47993 (2012)
Title Fanconi anemia is associated with a defect in the BRCA2 partner PALB2 .
Author Xia,B., Dorsman,J.C., Ameziane,N., de Vries,Y., Rooimans,M.A., Sheng,Q., Pals,G., Errami,A., Gluckman,E., Llera,J., Wang,W., Livingston,D.M., Joenje,H. and de Winter,J.P.
Journal Nat. Genet. 39 (2), 159-161 (2007)
Title Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer .
Author Reid,S., Schindler,D., Hanenberg,H., Barker,K., Hanks,S., Kalb,R., Neveling,K., Kelly,P., Seal,S., Freund,M., Wurm,M., Batish,S.D., Lach,F.P., Yetgin,S., Neitzel,H., Ariffin,H., Tischkowitz,M., Mathew,C.G., Auerbach,A.D. and Rahman,N.
Journal Nat. Genet. 39 (2), 162-164 (2007)
Title PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene .
Author Rahman,N., Seal,S., Thompson,D., Kelly,P., Renwick,A., Elliott,A., Reid,S., Spanova,K., Barfoot,R., Chagtai,T., Jayatilake,H., McGuffog,L., Hanks,S., Evans,D.G., Eccles,D., Easton,D.F. and Stratton,M.R.
Journal Nat. Genet. 39 (2), 165-167 (2007)
Title Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2 .
Author Xia,B., Sheng,Q., Nakanishi,K., Ohashi,A., Wu,J., Christ,N., Liu,X., Jasin,M., Couch,F.J. and Livingston,D.M.
Journal Mol. Cell 22 (6), 719-729 (2006)
Title Large-scale characterization of HeLa cell nuclear phosphoproteins .
Author Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E., Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
Journal Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)

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