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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


Homo sapiens partner and localizer of BRCA2 (PALB2), mRNA.


Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu25786 Homo sapiens partner and localizer of BRCA2 (PALB2), mRNA. pcDNA3.1+-DYK On-demand $1699.00 25
OHu25786C Homo sapiens partner and localizer of BRCA2 (PALB2), mRNA. Customized vector On-demand $1699.00 25

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Mutation services

Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Data sheet
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
Restriction Sites Hind III- EcoR I
RefSeq Version NM_024675.3, 113722109
Length 3561 bp
Structure linear
Update Date 24-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens partner and localizer of BRCA2 (PALB2), mRNA.
Product partner and localizer of BRCA2
Comment

Summary: This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008].

RefSeq NP_078951.2
CDS 201..3761
Misc Feature(1)75..77
Misc Feature(2)201..1937
Misc Feature(3)201..1937
Misc Feature(4)201..1157
Misc Feature(5)201..800
Misc Feature(6)201..680
Misc Feature(7)375..377
Misc Feature(8)390..392
Misc Feature(9)669..671
Misc Feature(10)1326..1328
Misc Feature(11)1326..1328
Misc Feature(12)1359..1361
Misc Feature(13)1383..1538
Misc Feature(14)2178..2180
Misc Feature(15)2523..3758
Misc Feature(16)2757..3758
Exon (1)1..248
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (2)249..308
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (3)309..411
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (4)412..1884
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (5)1885..2714
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (6)2715..2786
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (7)2787..2948
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (8)2949..3034
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (9)3035..3196
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (10)3197..3313
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (11)3314..3401
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (12)3402..3550
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Exon (13)3551..4058
Gene:PALB2
Gene Synonym:FANCN; PNCA3
Translation MDEPPGKPLSCEEKEKLKEKLAFLKREYSKTLARLQRAQRAEKIKHSIKKTVEEQDCLSQ QDLSPQLKHSEPKNKICVYDKLHIKTHLDEETGEKTSITLDVGPESFNPGDGPGGLPIQR TDDTQEHFPHRVSDPSGEQKQKLPSRRKKQQKRTFISQERDCVFGTDSLRLSGKRLKEQE EISSKNPARSPVTEIRTHLLSLKSELPDSPEPVTEINEDSVLIPPTAQPEKGVDTFLRRP NFTRATTVPLQTLSDSGSSQHLEHIPPKGSSELTTHDLKNIRFTSPVSLEAQGKKMTVST DNLLVNKAISKSGQLPTSSNLEANISCSLNELTYNNLPANENQNLKEQNQTEKSLKSPSD TLDGRNENLQESEILSQPKSLSLEATSPLSAEKHSCTVPEGLLFPAEYYVRTTRSMSNCQ RKVAVEAVIQSHLDVKKKGFKNKNKDASKNLNLSNEETDQSEIRMSGTCTGQPSSRTSQK LLSLTKVSSPAGPTEDNDLSRKAVAQAPGRRYTGKRKSACTPASDHCEPLLPTSSLSIVN RSKEEVTSHKYQHEKLFIQVKGKKSRHQKEDSLSWSNSAYLSLDDDAFTAPFHRDGMLSL KQLLSFLSITDFQLPDEDFGPLKLEKVKSCSEKPVEPFESKMFGERHLKEGSCIFPEELS PKRMDTEMEDLEEDLIVLPGKSHPKRPNSQSQHTKTGLSSSILLYTPLNTVAPDDNDRPT TDMCSPAFPILGTTPAFGPQGSYEKASTEVAGRTCCTPQLAHLKDSVCLASDTKQFDSSG SPAKPHTTLQVSGRQGQPTCDCDSVPPGTPPPIESFTFKENQLCRNTCQELHKHSVEQTE TAELPASDSINPGNLQLVSELKNPSGSCSVDVSAMFWERAGCKEPCIITACEDVVSLWKA LDAWQWEKLYTWHFAEVPVLQIVPVPDVYNLVCVALGNLEIREIRALFCSSDDESEKQVL LKSGNIKAVLGLTKRRLVSSSGTLSDQQVEVMTFAEDGGGKENQFLMPPEETILTFAEVQ GMQEALLGTTIMNNIVIWNLKTGQLLKKMHIDDSYQASVCHKAYSEMGLLFIVLSHPCAK ESESLRSPVFQLIVINPKTTLSVGVMLYCLPPGQAGRFLEGDVKDHCAAAILTSGTIAIW DLLLGQCTALLPPVSDQHWSFVKWSGTDSHLLAGQKDGNIFVYHYS
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Position Chain Variation Link
25+dbSNP:
25+g, tdbSNP:180177144
complement(43)-g, cdbSNP:138200248
complement(56)-g, cdbSNP:373698818
93+c, tdbSNP:180177140
complement(152)-t, gdbSNP:376865021
complement(154)-t, cdbSNP:8053188
155+a, gdbSNP:180177141
complement(170)-g, adbSNP:200523571
complement(194)-g, adbSNP:377315640
complement(211)-t, cdbSNP:45619737
complement(213)-g, adbSNP:377085677
complement(223)-g, adbSNP:150390726
complement(237)-t, cdbSNP:373287455
complement(253)-dbSNP:
complement(253)-t, cdbSNP:138789658
272+, gdbSNP:180177142
complement(278)-g, adbSNP:45572434
complement(294)-g, cdbSNP:151316635
complement(300)-g, adbSNP:373483056
complement(301)-c, adbSNP:144944814
complement(304)-g, adbSNP:141047069
complement(309)-dbSNP:
complement(309)-t, g, adbSNP:200048921
complement(310)-t, cdbSNP:202194596
complement(313)-g, adbSNP:371875379
complement(355)-g, adbSNP:373970237
372..375+, ttgtdbSNP:180177143
complement(394)-t, cdbSNP:62625272
396+c, tdbSNP:180177083
429+dbSNP:
429+, tdbSNP:180177084
480+a, gdbSNP:45602040
complement(498)-g, adbSNP:61756147
complement(538)-g, cdbSNP:374425261
complement(539)-t, cdbSNP:376182266
complement(544)-c, adbSNP:145598272
complement(553)-g, adbSNP:370404126
571+c, tdbSNP:45457297
595+, tdbSNP:180177085
complement(600)-t, cdbSNP:139555085
complement(606)-t, adbSNP:144496685
complement(608)-t, adbSNP:112202375
complement(683)-g, cdbSNP:371627753
complement(695)-g, adbSNP:200937538
705+a, cdbSNP:180177086
complement(760)-t, gdbSNP:371582757
complement(790)-g, adbSNP:367945485
818+g, tdbSNP:180177088
complement(819)-g, cdbSNP:374090568
complement(829)-g, adbSNP:57605939
832+a, gdbSNP:180177089
856+a, gdbSNP:45594034
complement(868)-g, adbSNP:150517167
complement(886)-g, cdbSNP:368477874
897+, gdbSNP:180177090
complement(921)-t, cdbSNP:113217267
complement(935)-t, cdbSNP:371612049
951+c, tdbSNP:180177091
957..958+, ctdbSNP:180177092
complement(959)-t, cdbSNP:367842489
965+c, tdbSNP:45465299
968+c, tdbSNP:45487491
complement(973)-t, cdbSNP:371289600
1007+c, tdbSNP:180177093
1031+c, tdbSNP:62625273
complement(1033)-t, adbSNP:200843485
complement(1034)-t, adbSNP:199919863
complement(1040)-g, adbSNP:375258299
1044+a, gdbSNP:45447991
1054+c, tdbSNP:180177094
1056+c, tdbSNP:45585833
1097+c, tdbSNP:180177095
complement(1109)-g, adbSNP:145788619
complement(1118)-g, adbSNP:114428350
complement(1121)-, tdbSNP:202151522
1125+a, gdbSNP:3809683
complement(1126)-c, adbSNP:201588519
1128+a, gdbSNP:45561331
complement(1129)-t, cdbSNP:370887726
1150+c, tdbSNP:45548638
complement(1156)-g, adbSNP:200144401
complement(1195)-t, adbSNP:377149139
1199+c, tdbSNP:180177096
complement(1200)-c, adbSNP:202241382
complement(1201)-t, cdbSNP:200620434
1210+c, tdbSNP:45494092
1227+c, tdbSNP:180177097
complement(1242)-t, gdbSNP:375699023
1250..1251+aa, tctdbSNP:180177098
complement(1254)-g, cdbSNP:201035780
1256..1257+, gadbSNP:180177099
complement(1281)-t, cdbSNP:111981798
1319+a, gdbSNP:45623436
complement(1323)-t, gdbSNP:373298267
complement(1356)-t, cdbSNP:148102335
complement(1389)-t, adbSNP:367578415
complement(1394)-t, cdbSNP:61755173
complement(1412)-c, adbSNP:148921082
1440+c, tdbSNP:180177100
1450+a, cdbSNP:45510998
complement(1481)-g, adbSNP:138697796
complement(1511)-t, cdbSNP:190489275
complement(1537)-t, adbSNP:146434474
1548+a, cdbSNP:62625274
complement(1580)-t, cdbSNP:372641262
1599+c, gdbSNP:45602239
complement(1608)-t, cdbSNP:150636811
1619+a, cdbSNP:62625275
complement(1646)-g, cdbSNP:368759893
1670+c, tdbSNP:45612837
1674+a, gdbSNP:45503296
complement(1691)-c, adbSNP:374707677
complement(1692)-c, adbSNP:75023630
complement(1706)-g, cdbSNP:371142570
1717+, adbSNP:180177101
complement(1745)-t, cdbSNP:368503108
complement(1764)-g, adbSNP:373876101
1772+a, gdbSNP:45472400
1778+a, c, g, tdbSNP:45603832
1792+, tdbSNP:180177102
complement(1806)-g, adbSNP:151162255
complement(1810)-g, adbSNP:142103232
complement(1828)-t, cdbSNP:370468259
1833+g, tdbSNP:180177103
complement(1837)-g, adbSNP:148647206
1853+a, tdbSNP:118203997
complement(1855)-t, cdbSNP:375611746
1856+a, gdbSNP:180177104
complement(1859)-g, cdbSNP:370318597
complement(1860)-t, cdbSNP:377486858
1865+a, gdbSNP:45518838
1891+dbSNP:
1891+a, gdbSNP:62625276
complement(1897)-t, cdbSNP:144617793
complement(1898)-g, adbSNP:373141871
complement(1899)-g, adbSNP:370422990
1943+a, gdbSNP:180177105
complement(1987)-t, cdbSNP:187191947
complement(1994)-t, cdbSNP:182494675
complement(2000)-t, cdbSNP:139662375
complement(2010)-g, adbSNP:144015319
complement(2024)-c, adbSNP:374771688
complement(2039)-t, cdbSNP:199682414
complement(2081)-c, adbSNP:139362268
complement(2120)-t, adbSNP:375575311
complement(2135)-t, cdbSNP:141707455
complement(2144)-g, adbSNP:200296117
complement(2167)-g, adbSNP:370360082
complement(2182)-g, adbSNP:71379822
2187+c, tdbSNP:62625277
2214+c, gdbSNP:45532440
complement(2214)-g, cdbSNP:386479502
complement(2227)-g, adbSNP:200875161
complement(2232)-g, adbSNP:376189676
complement(2234)-t, cdbSNP:373796987
complement(2257)-t, cdbSNP:267604470
complement(2267)-t, cdbSNP:371149159
complement(2277)-g, adbSNP:150585579
complement(2335)-g, adbSNP:141458731
2340+a, gdbSNP:45537237
complement(2347)-t, cdbSNP:148335539
2400+a, tdbSNP:45543843
complement(2404)-g, adbSNP:199743500
complement(2408)-t, gdbSNP:369113809
complement(2428)-t, cdbSNP:141749524
2430+a, gdbSNP:62625278
complement(2434)-t, cdbSNP:142343372
complement(2453)-g, adbSNP:138514571
complement(2456)-t, cdbSNP:147120218
2457+c, tdbSNP:180177110
complement(2474)-g, adbSNP:183322618
complement(2489)-g, cdbSNP:373478248
2523+c, tdbSNP:180177111
2528+a, c, tdbSNP:45508997
complement(2529)-t, cdbSNP:148026749
complement(2560)-g, adbSNP:201042302
complement(2565)-g, adbSNP:145805054
complement(2579)-g, adbSNP:377626805
2586+g, tdbSNP:180177112
2593..2594+, ctdbSNP:180177113
complement(2594)-t, adbSNP:61756018
complement(2611)-g, adbSNP:149836639
2617+c, tdbSNP:45464991
complement(2642)-t, cdbSNP:140776736
complement(2653)-g, adbSNP:370908330
complement(2674)-g, cdbSNP:146218439
2721+dbSNP:
2721+, adbSNP:180177116
complement(2721)-t, cdbSNP:368990417
complement(2731)-c, adbSNP:375713631
2759+c, tdbSNP:180177115
complement(2761)-t, cdbSNP:146455175
2790+dbSNP:
2790+c, tdbSNP:45568339
2797+a, gdbSNP:62625279
2807+a, c, tdbSNP:45542234
complement(2808)-g, cdbSNP:376641234
2845+a, gdbSNP:45486906
2860+g, tdbSNP:45550935
2861+a, cdbSNP:180177120
complement(2873)-g, c, adbSNP:78179744
2874+a, gdbSNP:45476495
2886..2887+, tdbSNP:180177121
2918+a, gdbSNP:180177122
2920+a, gdbSNP:45504298
2932+c, tdbSNP:180177123
complement(2942)-g, adbSNP:115759702
complement(2943)-t, cdbSNP:374736398
2961+dbSNP:
2961+c, tdbSNP:180177124
complement(2963)-g, cdbSNP:372931676
2973+c, gdbSNP:180177125
2980+a, tdbSNP:62625280
2994+a, gdbSNP:45624036
complement(3000)-t, cdbSNP:370243279
3016+g, tdbSNP:45478192
complement(3031)-c, adbSNP:201817103
3040+dbSNP:
3040+c, tdbSNP:45464500
complement(3041)-t, gdbSNP:45525135
complement(3051)-g, adbSNP:149522412
complement(3055)-t, adbSNP:373280855
complement(3061)-t, cdbSNP:375942535
complement(3081)-g, adbSNP:61755166
complement(3103)-g, cdbSNP:369132015
3120..3121+, aadbSNP:180177126
complement(3153)-g, adbSNP:139726856
3162+c, tdbSNP:118203999
complement(3178)-g, adbSNP:61756146
3182..3183+, tdbSNP:180177127
3193+a, gdbSNP:45551636
3224+dbSNP:
3224+c, tdbSNP:180177130
3226+, cdbSNP:180177131
complement(3244)-g, adbSNP:367840862
complement(3254)-g, cdbSNP:183489969
complement(3256)-g, adbSNP:376619846
complement(3261)-t, cdbSNP:143808171
3313+a, gdbSNP:180177132
3316+dbSNP:
3316+, adbSNP:180177133
complement(3328)-g, cdbSNP:377713277
complement(3346)-g, adbSNP:138273800
complement(3379)-t, cdbSNP:116967702
complement(3425)-dbSNP:
complement(3425)-t, adbSNP:202222149
complement(3449)-g, cdbSNP:147045425
3451+c, tdbSNP:62625271
complement(3452)-t, cdbSNP:141570833
3455+a, gdbSNP:45486891
complement(3457)-t, cdbSNP:146377793
3478+c, tdbSNP:45616636
3486+a, gdbSNP:62625281
3494..3498+, gacgadbSNP:180177134
complement(3496)-g, adbSNP:142132127
3497+a, gdbSNP:45565738
3500+g, tdbSNP:45516100
complement(3507)-t, cdbSNP:201657283
complement(3510)-c, adbSNP:188254555
complement(3520)-g, adbSNP:149194681
3523+, adbSNP:180177135
3562+dbSNP:
3562+a, gdbSNP:62625282
complement(3566)-g, adbSNP:373783514
complement(3573)-c, adbSNP:146444298
3618+g, tdbSNP:62625283
complement(3627)-g, adbSNP:368694141
3628+a, tdbSNP:62625284
3633+c, gdbSNP:180177137
3649+g, tdbSNP:45566737
3673+a, gdbSNP:45505500
complement(3683)-g, adbSNP:372686500
complement(3687)-t, cdbSNP:145369260
3695+a, gdbSNP:45439097
3697+, gdbSNP:180177138
complement(3708)-g, adbSNP:200283306
complement(3718)-g, adbSNP:146659762
3739+c, tdbSNP:180177139
3749+c, gdbSNP:118203998
complement(3818..3819)-, cdbSNP:34411226
complement(3836)-t, cdbSNP:189962793
complement(3858)-t, gdbSNP:185410736
complement(3993)-c, adbSNP:180748355
Gene SymbolPALB2
Gene SynonymFANCN; PNCA3
Chromosome16
Locus Map16p12.2
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_024675 Homo sapiens partner and localizer of BRCA2 (PALB2), mRNA. On-demand $1699.00 25
Title Compensatory functions and interdependency of the DNA-binding domain of BRCA2 with the BRCA1-PALB2-BRCA2 complex .
Author Al Abo M, Dejsuphong D, Hirota K, Yonetani Y, Yamazoe M, Kurumizaka
Journal Cancer Res. 74 (3), 797-807 (2014)
Title Low prevalence of germline PALB2 mutations in Australian triple-negative breast cancer .
Author Wong-Brown MW, Avery-Kiejda KA, Bowden NA and Scott RJ.
Journal Int. J. Cancer 134 (2), 301-305 (2014)
Title Analysis of PALB2 gene in BRCA1/BRCA2 negative Spanish hereditary breast/ovarian cancer families with pancreatic cancer cases .
Author Blanco A, de la Hoya M, Osorio A, Diez O, Miramar MD, Infante M, Martinez-Bouzas C, Torres A, Lasa A, Llort G, Brunet J, Grana B, Perez Segura P, Garcia MJ, Gutierrez-Enriquez S, Carracedo A, Tejada MI, Velasco EA, Calvo MT, Balmana J, Benitez J, Caldes T and Vega A.
Journal PLoS ONE 8 (7), E67538 (2013)
Title BRCA and pancreatic cancer .
Author Brennan GT, Relias V and Saif MW.
Journal JOP 14 (4), 325-328 (2013)
Title Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer .
Author Reid S, Schindler D, Hanenberg H, Barker K, Hanks S, Kalb R, Neveling K, Kelly P, Seal S, Freund M, Wurm M, Batish SD, Lach FP, Yetgin S, Neitzel H, Ariffin H, Tischkowitz M, Mathew CG, Auerbach
Journal Nat. Genet. 39 (2), 162-164 (2007)
Title PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene .
Author Rahman N, Seal S, Thompson D, Kelly P, Renwick A, Elliott A, Reid S, Spanova K, Barfoot R, Chagtai T, Jayatilake H, McGuffog L, Hanks S, Evans DG, Eccles D, Easton DF and Stratton MR.
Journal Nat. Genet. 39 (2), 165-167 (2007)
Title Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2 .
Author Xia B, Sheng Q, Nakanishi K, Ohashi A, Wu J, Christ N, Liu X, Jasin M, Couch FJ and Livingston DM.
Journal Mol. Cell 22 (6), 719-729 (2006)
Title Large-scale characterization of HeLa cell nuclear phosphoproteins .
Author Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC and Gygi SP.
Journal Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)
Title Esophageal Atresia/Tracheoesophageal Fistula Overview .
Author Scott,D.A.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Title Fanconi Anemia .
Author Alter,B.P. and Kupfer,G.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)

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