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Homo sapiens calcium activated nucleotidase 1 (CANT1), transcript variant 1, mRNA.

Clone ID Definition Vector Stock Status Price *Turnaround time Order
OHu18313 Homo sapiens calcium activated nucleotidase 1 (CANT1), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock $99.00 5-7
OHu18313C Homo sapiens calcium activated nucleotidase 1 (CANT1), transcript variant 1, mRNA. Customized vector In-stock $149.00 5-7

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Sequence Information ORF Nucleotide Sequence
Protein sequence
Vector pcDNA3.1+-DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+-DYK N terminal DYKDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
RefSeq Version NM_138793.3, 229577437
Length 1206 bp
Update Date 02-FEB-2014
Organism Homo sapiens (human)
Definition Homo sapiens calcium activated nucleotidase 1 (CANT1), transcript variant 1, mRNA.
Product soluble calcium-activated nucleotidase 1

Summary: This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene.[provided by RefSeq, Mar 2010].

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

RefSeq NP_620148.1
CDS 496..1701
Misc Feature(1)415..417
Misc Feature(2)628..681
Misc Feature(3)628..681
Misc Feature(4)832..1698
Exon (1)1..154
Gene Synonym:DBQD; SCAN-1; SCAN1; SHAPY
Exon (2)155..1126
Gene Synonym:DBQD; SCAN-1; SCAN1; SHAPY
Exon (3)1127..1330
Gene Synonym:DBQD; SCAN-1; SCAN1; SHAPY
Exon (4)1331..3535
Gene Synonym:DBQD; SCAN-1; SCAN1; SHAPY
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Position Chain Variation Link
complement(62)-t, cdbSNP:12949479
complement(99)-t, gdbSNP:377716176
complement(205)-g, adbSNP:143084065
complement(230)-t, adbSNP:181302869
complement(258)-g, adbSNP:149178778
complement(303)-t, cdbSNP:3744171
complement(481)-g, adbSNP:369606706
complement(483)-g, cdbSNP:375321596
complement(491)-g, adbSNP:373474385
507+g, tdbSNP:11546278
complement(551)-t, cdbSNP:144060377
complement(562)-c, adbSNP:139022430
complement(582)-t, cdbSNP:151134512
complement(598)-t, cdbSNP:199950703
complement(614)-t, cdbSNP:375819727
complement(642)-g, adbSNP:371500993
complement(643)-g, adbSNP:367929269
complement(654)-g, adbSNP:8077024
complement(674)-t, g, cdbSNP:112979829
complement(689)-g, adbSNP:200811852
complement(693)-g, adbSNP:201935694
complement(740)-g, adbSNP:142062082
complement(753)-t, cdbSNP:199762751
complement(764)-g, adbSNP:372736806
complement(768)-g, adbSNP:369008128
complement(782)-g, cdbSNP:375718883
complement(805)-g, adbSNP:200503476
complement(811)-g, adbSNP:372332465
complement(812)-t, cdbSNP:148785781
complement(825)-g, adbSNP:368963278
complement(868)-g, adbSNP:61738470
869+a, gdbSNP:267606702
complement(917)-t, adbSNP:147336056
complement(928)-c, adbSNP:140112462
complement(936)-g, cdbSNP:375790222
complement(954)-g, adbSNP:35290882
complement(972)-t, cdbSNP:149367726
complement(1008)-c, adbSNP:201181440
complement(1017)-g, adbSNP:368203123
complement(1024)-g, adbSNP:375929530
complement(1033)-t, cdbSNP:375322541
complement(1035)-t, cdbSNP:369035083
complement(1051)-t, cdbSNP:199516699
complement(1053)-g, adbSNP:200425171
complement(1065)-g, cdbSNP:376733332
complement(1098)-t, cdbSNP:371849039
complement(1104)-g, adbSNP:200199592
complement(1110)-g, adbSNP:367715703
complement(1147)-c, adbSNP:113155808
complement(1163)-t, cdbSNP:138825464
complement(1166)-g, adbSNP:150181226
complement(1171)-t, cdbSNP:377546036
complement(1191)-t, cdbSNP:374546482
complement(1221)-g, adbSNP:141845435
complement(1230)-t, cdbSNP:138754148
complement(1250)-t, cdbSNP:370801385
complement(1251)-g, adbSNP:376160075
complement(1273)-t, cdbSNP:201092090
complement(1296)-g, adbSNP:138199925
complement(1326)-c, adbSNP:370450411
1391+c, tdbSNP:267606700
1393+c, tdbSNP:267606701
1394+a, gdbSNP:267606699
complement(1431)-g, cdbSNP:372851650
complement(1461)-g, adbSNP:140989921
complement(1462)-t, cdbSNP:9903215
complement(1477)-t, cdbSNP:369108479
complement(1480)-t, cdbSNP:201945398
complement(1487)-g, adbSNP:376495608
complement(1503)-c, adbSNP:201627157
complement(1506)-t, cdbSNP:373142760
complement(1509)-t, cdbSNP:145472081
complement(1520)-t, adbSNP:368950598
complement(1522)-t, cdbSNP:376766039
complement(1551)-t, cdbSNP:3803781
complement(1558)-t, cdbSNP:145516713
1574+a, cdbSNP:387907081
complement(1585)-t, cdbSNP:200161867
complement(1592)-t, cdbSNP:149663607
complement(1607)-g, adbSNP:372631124
complement(1608)-g, adbSNP:372314946
complement(1618)-t, adbSNP:139486406
complement(1626)-g, adbSNP:147738899
complement(1629)-t, cdbSNP:35324359
complement(1647)-g, cdbSNP:145794847
complement(1652)-g, adbSNP:369580248
complement(1660)-t, cdbSNP:376981421
complement(1667)-t, cdbSNP:34082669
complement(1671)-g, adbSNP:147501831
complement(1710)-t, cdbSNP:190867364
complement(1722)-g, adbSNP:368175077
complement(1790)-t, cdbSNP:146866436
complement(1799)-g, adbSNP:142460586
complement(1858)-t, cdbSNP:117904862
complement(1900)-g, adbSNP:369845406
complement(2128)-t, adbSNP:185468461
complement(2146)-t, cdbSNP:149131650
complement(2271)-t, cdbSNP:8079368
complement(2287)-g, cdbSNP:201955120
complement(2294)-t, cdbSNP:113992271
complement(2365)-g, adbSNP:79189369
complement(2372)-g, adbSNP:114125762
complement(2397)-c, adbSNP:149991908
complement(2401)-g, adbSNP:376540900
complement(2486)-g, adbSNP:374029495
complement(2506)-t, cdbSNP:370978997
complement(2519)-g, adbSNP:376745661
complement(2530)-t, cdbSNP:115856545
complement(2545)-g, adbSNP:371226687
2548+c, tdbSNP:11891
complement(2635)-g, adbSNP:180869519
complement(2665)-t, cdbSNP:75126416
complement(2692)-g, adbSNP:189700956
complement(2699)-c, adbSNP:78037898
complement(2733)-c, adbSNP:139951975
complement(2757)-g, adbSNP:77565945
complement(2758)-g, cdbSNP:112529550
complement(2771)-t, cdbSNP:368558655
complement(2794)-g, adbSNP:8078860
complement(2850)-g, adbSNP:114706748
complement(2868)-t, cdbSNP:186436891
complement(2879)-t, gdbSNP:181138576
complement(2933)-t, gdbSNP:35308608
complement(3077)-g, cdbSNP:139673784
complement(3113)-t, cdbSNP:190318927
complement(3114)-t, cdbSNP:373877717
3141+a, gdbSNP:4861
complement(3177)-t, cdbSNP:73999357
complement(3433)-g, adbSNP:184171534
3438+g, tdbSNP:1127654
complement(3485)-g, adbSNP:14791
complement(3495)-c, adbSNP:192546263
Gene SymbolCANT1
Gene SynonymDBQD; SCAN-1; SCAN1; SHAPY
Locus Map17q25.3
Title Further delineation of CANT1 phenotypic spectrum and demonstration of its role in proteoglycan synthesis .
Author Nizon M, Huber C, De Leonardis F, Merrina R, Forlino A, Fradin M, Tuysuz B, Abu-Libdeh BY, Alanay Y, Albrecht B, Al-Gazali L, Basaran SY, Clayton-Smith J, Desir J, Gill H, Greally MT, Koparir E, van Maarle MC, MacKay S, Mortier G, Morton J, Sillence D, Vilain C, Young I, Zerres K, Le Merrer M, Munnich A, Le Goff C, Rossi A and Cormier-Daire V.
Journal Hum. Mutat. 33 (8), 1261-1266 (2012)
Title Desbuquois dysplasia type I and fetal hydrops due to novel mutations in the CANT1 gene .
Author Laccone F, Schoner K, Krabichler B, Kluge B, Schwerdtfeger R, Schulze B, Zschocke J and Rehder H.
Journal Eur. J. Hum. Genet. 19 (11), 1133-1137 (2011)
Title A founder mutation of CANT1 common in Korean and Japanese Desbuquois dysplasia .
Author Dai J, Kim OH, Cho TJ, Miyake N, Song HR, Karasugi T, Sakazume S, Ikema M, Matsui Y, Nagai T, Matsumoto N, Ohashi H, Kamatani N, Nishimura G, Furuichi T, Takahashi A and Ikegawa S.
Journal J. Hum. Genet. 56 (5), 398-400 (2011)
Title The androgen-regulated Calcium-Activated Nucleotidase 1 (CANT1) is commonly overexpressed in prostate cancer and is tumor-biologically relevant in vitro .
Author Gerhardt J, Steinbrech C, Buchi O, Behnke S, Bohnert A, Fritzsche F, Liewen H, Stenner F, Wild P, Hermanns T, Muntener M, Dietel M, Jung K, Stephan C and Kristiansen G.
Journal Am. J. Pathol. 178 (4), 1847-1860 (2011)
Title Structure and protein design of a human platelet function inhibitor .
Author Dai J, Liu J, Deng Y, Smith TM and Lu M.
Journal Cell 116 (5), 649-659 (2004)
Title Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways .
Author Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H and Sugano S.
Journal Oncogene 22 (21), 3307-3318 (2003)
Title Homozygosity mapping of a Desbuquois dysplasia locus to chromosome 17q25.3 .
Author Faivre L, Le Merrer M, Al-Gazali LI, Ausems MG, Bitoun P, Bacq D, Maroteaux P, Munnich A and Cormier-Daire V.
Journal J. Med. Genet. 40 (4), 282-284 (2003)
Title Bacterial expression and characterization of a novel, soluble, calcium-binding, and calcium-activated human nucleotidase .
Author Murphy DM, Ivanenkov VV and Kirley TL.
Journal Biochemistry 42 (8), 2412-2421 (2003)
Title Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase .
Author Failer BU, Braun N and Zimmermann H.
Journal J. Biol. Chem. 277 (40), 36978-36986 (2002)
Title Cloning, expression, and characterization of a soluble calcium-activated nucleotidase, a human enzyme belonging to a new family of extracellular nucleotidases .
Author Smith TM, Hicks-Berger CA, Kim S and Kirley TL.
Journal Arch. Biochem. Biophys. 406 (1), 105-115 (2002)

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