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Homo sapiens TRAF3 interacting protein 2 (TRAF3IP2), transcript variant 2, mRNA.


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_147686 Homo sapiens TRAF3 interacting protein 2 (TRAF3IP2), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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RefSeq Version NM_147686.3, 373938458
Length 6244 bp
Structure linear
Update Date 20-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens TRAF3 interacting protein 2 (TRAF3IP2), transcript variant 2, mRNA.
Product adapter protein CIKS isoform 2
Comment

Summary: This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009].


Transcript Variant: This variant (2) encodes the longest isoform (2).


Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

RefSeq NP_679211.2
CDS 508..2205
Misc Feature(1)496..498
Misc Feature(2)1708..2124
Misc Feature(3)1708..2124
Exon (1)1..499
Gene:TRAF3IP2
Gene Synonym:ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CIKS; PSORS13
Exon (2)500..1336
Gene:TRAF3IP2
Gene Synonym:ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CIKS; PSORS13
Exon (3)1337..1529
Gene:TRAF3IP2
Gene Synonym:ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CIKS; PSORS13
Exon (4)1530..1708
Gene:TRAF3IP2
Gene Synonym:ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CIKS; PSORS13
Exon (5)1709..1797
Gene:TRAF3IP2
Gene Synonym:ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CIKS; PSORS13
Exon (6)1798..1866
Gene:TRAF3IP2
Gene Synonym:ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CIKS; PSORS13
Exon (7)1867..1983
Gene:TRAF3IP2
Gene Synonym:ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CIKS; PSORS13
Exon (8)1984..2058
Gene:TRAF3IP2
Gene Synonym:ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CIKS; PSORS13
Exon (9)2059..6232
Gene:TRAF3IP2
Gene Synonym:ACT1; C6orf2; C6orf4; C6orf5; C6orf6; CIKS; PSORS13
Translation MNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDF SQAHSTLKLANHQRPVSRQVTCLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASES VVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSLGGSQEMVQR PQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFE PQRYPACAQMLPPNLSPHAPWNYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLP GASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNRAGAPGESLE CPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVN FLLVNGFQTAIDIFEDRIRGIDIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDED EHGLHTKYIHRMMQIEFIKQGSMNFRFIPVLFPNAKKEHVPTWLQNTHVYSWPKNKKNIL LRLLREEEYVAPPRGPLPTLQVVPL
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Position Chain Variation Link
complement(238)-dbSNP:
complement(238)-g, adbSNP:78707591
complement(513)-t, cdbSNP:1127423
complement(515)-t, cdbSNP:148778036
complement(535)-t, cdbSNP:33980500
complement(611..612)-, ggtdbSNP:142054894
complement(623)-g, adbSNP:200469044
complement(636)-t, gdbSNP:199642555
complement(678)-g, adbSNP:144366791
complement(679)-t, cdbSNP:201280730
complement(698)-t, gdbSNP:149246847
complement(727)-g, adbSNP:13190932
complement(728)-t, cdbSNP:149247775
complement(739)-g, cdbSNP:73764462
complement(744)-g, cdbSNP:150601696
complement(758)-t, cdbSNP:141777182
complement(766)-t, cdbSNP:138172773
complement(788)-t, cdbSNP:61756667
complement(947)-g, adbSNP:141508826
complement(1045)-g, adbSNP:141283234
complement(1073)-t, cdbSNP:138401155
complement(1087)-t, cdbSNP:147059564
complement(1148)-t, cdbSNP:181942095
complement(1156)-t, gdbSNP:139282334
complement(1164)-g, adbSNP:189180850
complement(1168)-t, cdbSNP:145697646
complement(1198)-g, adbSNP:149860754
complement(1254)-t, cdbSNP:141106401
complement(1265)-g, cdbSNP:146627823
complement(1326)-g, cdbSNP:144405088
complement(1376)-dbSNP:
complement(1376)-c, adbSNP:200074354
complement(1400)-t, gdbSNP:139657171
complement(1464)-t, gdbSNP:146226365
complement(1476)-c, adbSNP:1043730
complement(1488)-g, adbSNP:112036127
complement(1512)-t, cdbSNP:117922343
complement(1514)-t, cdbSNP:200547309
complement(1527)-g, adbSNP:200703649
complement(1565)-dbSNP:
complement(1565)-t, cdbSNP:148619849
complement(1571)-g, adbSNP:143865750
complement(1652)-g, adbSNP:149449506
complement(1691)-t, cdbSNP:139767840
complement(1708)-g, adbSNP:147420020
complement(1740)-dbSNP:
complement(1740)-t, adbSNP:61757647
complement(1753)-g, cdbSNP:200053958
complement(1829)-dbSNP:
complement(1829)-g, adbSNP:138824557
complement(1844)-t, gdbSNP:11540679
complement(1851)-g, cdbSNP:200991285
complement(1852)-g, adbSNP:200246882
complement(1872)-dbSNP:
complement(1872)-g, adbSNP:200213270
complement(1914)-g, adbSNP:150436455
complement(1924)-t, cdbSNP:111815306
complement(1941)-g, adbSNP:144166946
complement(1942)-t, cdbSNP:149504543
complement(1947)-c, adbSNP:141459820
complement(2090)-dbSNP:
complement(2090)-t, cdbSNP:202090066
complement(2121)-g, adbSNP:186097801
complement(2131)-g, adbSNP:148316010
complement(2199)-g, cdbSNP:143248990
complement(2397)-g, adbSNP:138485893
complement(2452)-t, cdbSNP:181849404
complement(2508)-g, adbSNP:57533271
complement(2727)-g, adbSNP:9487669
complement(2762)-c, adbSNP:190544260
complement(2814..2815)-, ctdbSNP:57931464
complement(2815..2816)-, ctdbSNP:67783055
complement(2816..2817)-, ctdbSNP:77609240
complement(2890)-t, cdbSNP:9384797
complement(3016)-g, adbSNP:140677458
complement(3085)-t, cdbSNP:56410656
complement(3107)-g, cdbSNP:151268687
complement(3154)-g, adbSNP:192431256
complement(3234)-t, cdbSNP:11153297
complement(3314)-t, cdbSNP:142369053
complement(3612)-t, cdbSNP:149136178
complement(3683)-g, adbSNP:145220678
complement(3699..3700)-, tdbSNP:144962646
complement(3816)-g, adbSNP:188240738
complement(4109)-t, cdbSNP:183487901
complement(4185)-, tdbSNP:34755165
complement(4225)-g, adbSNP:114806915
complement(4428)-g, adbSNP:191696872
complement(4436)-t, gdbSNP:187010950
complement(4451)-g, adbSNP:201800803
complement(4559)-t, cdbSNP:149985533
complement(4603..4609)-, cctatagdbSNP:201818157
complement(4757)-g, adbSNP:183607050
complement(4871..4872)-, gttdbSNP:34539212
complement(4874..4875)-, gttdbSNP:201372735
complement(4885)-t, cdbSNP:41289894
complement(5126)-g, adbSNP:193081739
complement(5190)-g, adbSNP:926241
complement(5198)-g, adbSNP:111496051
complement(5250)-g, adbSNP:188896539
complement(5303)-c, adbSNP:184152004
complement(5360)-g, adbSNP:147436836
complement(5395..5396)-, gtdbSNP:146668280
complement(5416)-g, adbSNP:190908201
complement(5489)-, a, aa, aaaadbSNP:35557081
complement(5506..5507)-, a, aadbSNP:66883611
complement(5507)-, adbSNP:35454154
complement(5507)-, aa, aaaadbSNP:71722158
complement(5750)-t, gdbSNP:79219929
complement(5769)-t, cdbSNP:185339622
complement(5802)-c, adbSNP:182094502
complement(5828)-t, cdbSNP:10484479
complement(5850)-t, adbSNP:190424035
complement(5894)-g, adbSNP:186483827
complement(5968)-t, cdbSNP:181857341
complement(5998)-t, cdbSNP:150533032
complement(6007)-g, adbSNP:190151980
complement(6109)-g, adbSNP:75432622
complement(6214)-t, gdbSNP:112217872
Gene SymbolTRAF3IP2
Gene SynonymACT1; C6orf2; C6orf4; C6orf5; C6orf6; CIKS; PSORS13
Chromosome6
Locus Map6q21
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_001164281 Homo sapiens TRAF3 interacting protein 2 (TRAF3IP2), transcript variant 3, mRNA. On-demand $699.00 18
NM_001164283 Homo sapiens TRAF3 interacting protein 2 (TRAF3IP2), transcript variant 5, mRNA. On-demand $299.00 14
NM_147686 Homo sapiens TRAF3 interacting protein 2 (TRAF3IP2), transcript variant 2, mRNA. On-demand $699.00 18
Title IL-17 receptor adaptor protein Act1/CIKS plays an evolutionarily conserved role in antiviral signaling .
Author Ryzhakov,G., Blazek,K., Lai,C.C. and Udalova,I.A.
Journal J. Immunol. 189 (10), 4852-4858 (2012)
Title TRAF6-dependent Act1 phosphorylation by the IkappaB kinase-related kinases suppresses interleukin-17-induced NF-kappaB activation .
Author Qu,F., Gao,H., Zhu,S., Shi,P., Zhang,Y., Liu,Y., Jallal,B., Yao,Y., Shi,Y. and Qian,Y.
Journal Mol. Cell. Biol. 32 (19), 3925-3937 (2012)
Title CIKS/Act1-mediated signaling by IL-17 cytokines in context: implications for how a CIKS gene variant may predispose to psoriasis .
Author Sonder,S.U., Paun,A., Ha,H.L., Johnson,P.F. and Siebenlist,U.
Journal J. Immunol. 188 (12), 5906-5914 (2012)
Title Persistent stimulation with interleukin-17 desensitizes cells through SCFbeta-TrCP-mediated degradation of Act1 .
Author Shi,P., Zhu,S., Lin,Y., Liu,Y., Liu,Y., Chen,Z., Shi,Y. and Qian,Y.
Journal Sci Signal 4 (197), RA73 (2011)
Title The expression of the receptor for advanced glycation end-products (RAGE) in RA-FLS is induced by IL-17 via Act-1 .
Author Heo,Y.J., Oh,H.J., Jung,Y.O., Cho,M.L., Lee,S.Y., Yu,J.G., Park,M.K., Kim,H.R., Lee,S.H., Park,S.H. and Kim,H.Y.
Journal Arthritis Res. Ther. 13 (4), R113 (2011)
Title Identification of alternatively spliced Act1 and implications for its roles in oncogenesis .
Author Xia,Y.F., Li,Y.D., Li,X. and Geng,J.G.
Journal Biochem. Biophys. Res. Commun. 296 (2), 406-412 (2002)
Title Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells .
Author Qian,Y., Zhao,Z., Jiang,Z. and Li,X.
Journal Proc. Natl. Acad. Sci. U.S.A. 99 (14), 9386-9391 (2002)
Title CIKS, a connection to Ikappa B kinase and stress-activated protein kinase .
Author Leonardi,A., Chariot,A., Claudio,E., Cunningham,K. and Siebenlist,U.
Journal Proc. Natl. Acad. Sci. U.S.A. 97 (19), 10494-10499 (2000)
Title Act1, an NF-kappa B-activating protein .
Author Li,X., Commane,M., Nie,H., Hua,X., Chatterjee-Kishore,M., Wald,D., Haag,M. and Stark,G.R.
Journal Proc. Natl. Acad. Sci. U.S.A. 97 (19), 10489-10493 (2000)
Title Cloning and characterization of two overlapping genes in a subregion at 6q21 involved in replicative senescence and schizophrenia .
Author Morelli,C., Magnanini,C., Mungall,A.J., Negrini,M. and Barbanti-Brodano,G.
Journal Gene 252 (1-2), 217-225 (2000)


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