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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


Homo sapiens sprouty-related, EVH1 domain containing 1 (SPRED1), mRNA.


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_152594 Homo sapiens sprouty-related, EVH1 domain containing 1 (SPRED1), mRNA. GenEZ ORF Cloning On-demand $699.00 18

*Business Day

Related Services

RefSeq Version NM_152594.2, 187169267
Length 7255 bp
Structure linear
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Definition Homo sapiens sprouty-related, EVH1 domain containing 1 (SPRED1), mRNA.
Product sprouty-related, EVH1 domain-containing protein 1
Comment

Summary: The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008].


Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.

RefSeq NP_689807.1
CDS 336..1670
Misc Feature(1)210..212
Misc Feature(2)339..341
Misc Feature(3)339..341
Misc Feature(4)372..710
Misc Feature(5)order(399..401,426..428,600..602,606..608)
Misc Feature(6)1329..1619
Exon (1)1..367
Gene:SPRED1
Gene Synonym:hSpred1; NFLS; spred-1
Exon (2)368..542
Gene:SPRED1
Gene Synonym:hSpred1; NFLS; spred-1
Exon (3)543..711
Gene:SPRED1
Gene Synonym:hSpred1; NFLS; spred-1
Exon (4)712..758
Gene:SPRED1
Gene Synonym:hSpred1; NFLS; spred-1
Exon (5)759..917
Gene:SPRED1
Gene Synonym:hSpred1; NFLS; spred-1
Exon (6)918..1019
Gene:SPRED1
Gene Synonym:hSpred1; NFLS; spred-1
Exon (7)1020..7255
Gene:SPRED1
Gene Synonym:hSpred1; NFLS; spred-1
Translation MSEETATSDNDNSYARVRAVVMTRDDSSGGWLPLGGSGLSSVTVFKVPHQEENGCADFFI RGERLRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAI EDISQGCPESKNEAEGADDLQANEEDSSSSLVKDHLFQQETVVTSEPYRSSNIRPSPFED LNARRVYMQSQANQITFGQPGLDIQSRSMEYVQRQISKECGSLKSQNRVPLKSIRHVSFQ DEDEIVRINPRDILIRRYADYRHPDMWKNDLERDDADSSIQFSKPDSKKSDYLYSCGDET KLSSPKDSVVFKTQPSSLKIKKSKRRKEDGERSRCVYCQERFNHEENVRGKCQDAPDPIK RCIYQVSCMLCAESMLYHCMSDSEGDFSDPCSCDTSDDKFCLRWLALVALSFIVPCMCCY VPLRMCHRCGEACGCCGGKHKAAG
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Position Chain Variation Link
4+dbSNP:
4+a, gdbSNP:147075186
92+c, tdbSNP:138385793
243+c, tdbSNP:192699510
285+c, gdbSNP:369369431
324+c, gdbSNP:371200183
361+a, tdbSNP:200157475
365+a, cdbSNP:201692618
395+dbSNP:
395+c, gdbSNP:367745143
405+c, tdbSNP:121434313
459+a, gdbSNP:147204964
466+a, tdbSNP:121434318
483+c, tdbSNP:148646547
512+c, tdbSNP:397517871
525+c, tdbSNP:121434315
526+a, gdbSNP:372205720
546+dbSNP:
546+a, gdbSNP:369150309
626+a, gdbSNP:7182445
641+a, gdbSNP:372791883
684+c, tdbSNP:121434312
688+a, gdbSNP:373381933
723+dbSNP:
723+c, tdbSNP:149883080
752+c, tdbSNP:12148911
781+dbSNP:
781+a, gdbSNP:373384814
800+c, tdbSNP:376944837
846+c, tdbSNP:376527959
870+a, gdbSNP:143121426
896+c, tdbSNP:201335683
898+c, tdbSNP:370735097
899+a, gdbSNP:202092705
900+a, cdbSNP:200142785
922+dbSNP:
922+c, tdbSNP:147474792
942+a, gdbSNP:139897054
954+a, cdbSNP:368660900
968+c, tdbSNP:149991304
972+c, tdbSNP:121434316
975+a, c, tdbSNP:376699107
976+a, gdbSNP:371274407
978+c, g, tdbSNP:121434314
980+a, cdbSNP:144227155
1010+c, tdbSNP:144764225
1020+dbSNP:
1020+g, tdbSNP:201837340
1022+a, cdbSNP:376226762
1037+c, gdbSNP:138553244
1119+a, tdbSNP:121434317
1130+c, tdbSNP:116667267
1156+a, gdbSNP:111363743
1201+a, cdbSNP:372665535
1210+a, gdbSNP:201933663
1222+a, gdbSNP:200974459
1261+c, tdbSNP:114636635
1266+c, tdbSNP:375700452
1274+a, gdbSNP:140644874
1279+c, tdbSNP:115440602
1298+a, gdbSNP:369711772
1336+a, gdbSNP:146702985
1341+a, gdbSNP:373477920
1366+a, gdbSNP:376679136
complement(1379)-g, adbSNP:3751526
1413+a, gdbSNP:374685699
1424+a, gdbSNP:140225135
1431+a, gdbSNP:372623722
1443+c, tdbSNP:397517870
1557+g, tdbSNP:150307819
1595+c, tdbSNP:202087411
1608+a, gdbSNP:368307475
1618+a, gdbSNP:369492789
1630+c, tdbSNP:200871227
1718+a, gdbSNP:373694127
1838+c, tdbSNP:192826011
1860+a, gdbSNP:377091058
1896+a, gdbSNP:377201217
1918+c, tdbSNP:16966842
1926+c, tdbSNP:145373657
1991+a, gdbSNP:137920898
2052+c, gdbSNP:13329392
2097+a, tdbSNP:185290497
2205+a, gdbSNP:370660664
2234+a, tdbSNP:373626511
2248..2249+, atdbSNP:147547509
2303+a, gdbSNP:118146919
2332+a, gdbSNP:374443282
2406+a, tdbSNP:188754645
2506+a, gdbSNP:192636064
2613+g, tdbSNP:183715838
2710+a, gdbSNP:115568221
2729..2730+, adbSNP:34079057
2784+g, tdbSNP:141742028
2862+c, tdbSNP:28536719
2864+c, tdbSNP:28576519
2968+a, gdbSNP:376795432
2978+a, gdbSNP:368946709
3041+c, tdbSNP:373111945
3162+g, tdbSNP:199891616
3184+g, tdbSNP:376829790
3327..3330+, ctatdbSNP:146972863
3329..3332+, atctdbSNP:57589132
3329+a, gdbSNP:113071870
3394+a, cdbSNP:1554527
3688+g, tdbSNP:188392935
3713+a, gdbSNP:180946373
3917+a, gdbSNP:118057877
4090+c, tdbSNP:184024152
4156+a, tdbSNP:374589452
4233..4234+, atdbSNP:373432788
4240+c, tdbSNP:111997668
4268+a, cdbSNP:189861748
4281+c, tdbSNP:181716461
4292+a, gdbSNP:138645237
4412+g, tdbSNP:149336440
complement(4456)-g, cdbSNP:147428585
4501+a, gdbSNP:35490364
4523+a, gdbSNP:187134665
4555+a, gdbSNP:79309779
4727+a, gdbSNP:72725362
4781+c, tdbSNP:111766079
4801+c, tdbSNP:373027564
4834+a, gdbSNP:191914374
5065+a, gdbSNP:140749542
5191+a, gdbSNP:11634702
5222+a, gdbSNP:376186397
5230+a, gdbSNP:200294834
5231+a, gdbSNP:181980647
5242+a, gdbSNP:113753698
complement(5261)-t, cdbSNP:147489619
5293+g, tdbSNP:148525432
5298..5299+, adbSNP:375286562
5317+g, tdbSNP:186366365
5368+g, tdbSNP:76527876
5415+a, gdbSNP:142928983
5500+a, gdbSNP:8039150
5562+g, tdbSNP:112221665
5616+a, gdbSNP:8039337
5666+a, gdbSNP:72725364
5712+a, cdbSNP:189589145
5771+a, gdbSNP:182237934
5806..5808+, attdbSNP:369376164
5952..5956+, ggtatdbSNP:372684508
6018+c, tdbSNP:375141692
6042+a, gdbSNP:187788660
6106+a, gdbSNP:191601293
6156+a, gdbSNP:183379085
6332+a, tdbSNP:10852019
complement(6366)-t, cdbSNP:151078068
6367+a, gdbSNP:188784206
6437+c, gdbSNP:141044168
6505+a, tdbSNP:370073425
6602+a, gdbSNP:16966843
6607+a, cdbSNP:143932642
6753..6754+, tdbSNP:141174183
6780+c, tdbSNP:8026118
6805+a, cdbSNP:146871244
6933+a, cdbSNP:78521927
7059+a, gdbSNP:192448813
7068+a, cdbSNP:386449658
7068+g, tdbSNP:115003524
7079+a, gdbSNP:184793714
7130+a, gdbSNP:187951608
7190+c, tdbSNP:140245434
Gene SymbolSPRED1
Gene SynonymhSpred1; NFLS; spred-1
Chromosome15
Locus Map15q14
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_152594 Homo sapiens sprouty-related, EVH1 domain containing 1 (SPRED1), mRNA. On-demand $699.00 18
XM_005254202 PREDICTED: Homo sapiens sprouty-related, EVH1 domain containing 1 (SPRED1), transcript variant X1, mRNA. On-demand $699.00 18
XM_005254203 PREDICTED: Homo sapiens sprouty-related, EVH1 domain containing 1 (SPRED1), transcript variant X2, mRNA. On-demand $549.00 14
Title Deletions of IKZF1 and SPRED1 are associated with poor prognosis in a population-based series of pediatric B-cell precursor acute lymphoblastic leukemia diagnosed between 1992 and 2011 .
Author Olsson L, Castor A, Behrendtz M, Biloglav A, Forestier E, Paulsson
Journal Leukemia 28 (2), 302-310 (2014)
Title MiR-126 promotes coxsackievirus replication by mediating cross-talk of ERK1/2 and Wnt/beta-catenin signal pathways .
Author Ye X, Hemida MG, Qiu Y, Hanson PJ, Zhang HM and Yang D.
Journal Cell. Mol. Life Sci. 70 (23), 4631-4644 (2013)
Title Endothelial microparticle-mediated transfer of MicroRNA-126 promotes vascular endothelial cell repair via SPRED1 and is abrogated in glucose-damaged endothelial microparticles .
Author Jansen F, Yang X, Hoelscher M, Cattelan A, Schmitz T, Proebsting S, Wenzel D, Vosen S, Franklin BS, Fleischmann BK, Nickenig G and Werner N.
Journal Circulation 128 (18), 2026-2038 (2013)
Title Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia .
Author Khor SS, Miyagawa T, Toyoda H, Yamasaki M, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Lin L, Faraco J, Rico T, Honda Y, Honda M, Mignot E and Tokunaga K.
Journal PeerJ 1, E66 (2013)
Title Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease .
Author Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z, Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN, Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A, Boucher G, Brand S, Buning C, Cohain A, Cichon S, D'Amato M, De Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson LR, Franchimont D, Fransen K, Gearry R, Georges M, Gieger C, Glas J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH, Kupcinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W, Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M, Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M, Verspaget HW, De Vos M, Wijmenga C, Wilson DC, Winkelmann J, Xavier RJ, Zeissig S, Zhang B, Zhang CK, Zhao H, Silverberg MS, Annese V, Hakonarson H, Brant SR, Radford-Smith G, Mathew CG, Rioux JD, Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC and Cho JH.
Journal Nature 491 (7422), 119-124 (2012)
Title Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells .
Author Nonami A, Kato R, Taniguchi K, Yoshiga D, Taketomi T, Fukuyama S, Harada M, Sasaki A and Yoshimura A.
Journal J. Biol. Chem. 279 (50), 52543-52551 (2004)
Title Functional proteomics mapping of a human signaling pathway .
Author Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P and Gauthier JM.
Journal Genome Res. 14 (7), 1324-1332 (2004)
Title Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation .
Author Kato R, Nonami A, Taketomi T, Wakioka T, Kuroiwa A, Matsuda Y and Yoshimura A.
Journal Biochem. Biophys. Res. Commun. 302 (4), 767-772 (2003)
Title Spred is a Sprouty-related suppressor of Ras signalling .
Author Wakioka T, Sasaki A, Kato R, Shouda T, Matsumoto A, Miyoshi K, Tsuneoka M, Komiya S, Baron R and Yoshimura A.
Journal Nature 412 (6847), 647-651 (2001)
Title Legius Syndrome .
Author Stevenson,D., Viskochil,D., Mao,R. and Muram-Zborovski,T.
Journal (in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)

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