• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


Homo sapiens leucine-rich repeat kinase 2 (LRRK2), mRNA.


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_198578 Homo sapiens leucine-rich repeat kinase 2 (LRRK2), mRNA. GenEZ ORF Cloning On-demand $3749.00 35

*Business Day

Related Services

RefSeq Version NM_198578.3, 171846277
Length 9239 bp
Structure linear
Update Date 21-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens leucine-rich repeat kinase 2 (LRRK2), mRNA.
Product leucine-rich repeat serine/threonine-protein kinase 2
Comment

Summary: This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008].

RefSeq NP_940980.3
CDS 122..7705
Misc Feature(1)23..25
Misc Feature(2)2258..2500
Misc Feature(3)2258..2500
Misc Feature(4)3068..3133
Misc Feature(5)3155..3220
Misc Feature(6)3224..3838
Misc Feature(7)3227..3292
Misc Feature(8)order(3230..3232,3239..3241,3245..3247,3254..3256,
Misc Feature(9)3296..3361
Misc Feature(10)order(3320..3322,3467..3469,3533..3535,3665..3667,
Misc Feature(11)3371..3436
Misc Feature(12)3443..3559
Misc Feature(13)3443..3508
Misc Feature(14)3509..3571
Misc Feature(15)3512..3745
Misc Feature(16)3641..3709
Misc Feature(17)3710..3775
Misc Feature(18)3782..3955
Misc Feature(19)3782..3844
Misc Feature(20)3857..3922
Misc Feature(21)3926..3994
Misc Feature(22)4118..>4507
Misc Feature(23)4121..4642
Misc Feature(24)4142..4165
Misc Feature(25)order(4157..4168,4310..4312,4475..4480,4484..4486,
Misc Feature(26)4223..4225
Misc Feature(27)4235..4243
Misc Feature(28)4301..4312
Misc Feature(29)order(4307..4312,4358..4363)
Misc Feature(30)4475..4486
Misc Feature(31)4586..4594
Misc Feature(32)5771..6505
Misc Feature(33)5774..6517
Misc Feature(34)order(5774..5788,5798..5800,5831..5833,5837..5839,
Misc Feature(35)order(5774..5788,5798..5800,5831..5833,5837..5839,
Misc Feature(36)order(5786..5788,5981..5983,5987..5989,6101..6103,
Misc Feature(37)order(6167..6187,6221..6232)
Misc Feature(38)<6623..7282
Misc Feature(39)order(6632..6634,6644..6646,6665..6670,6701..6706,
Exon (1)1..272
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (2)273..358
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (3)359..468
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (4)469..557
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (5)558..692
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (6)693..827
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (7)828..959
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (8)960..1079
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (9)1080..1222
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (10)1223..1302
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (11)1303..1409
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (12)1410..1539
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (13)1540..1664
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (14)1665..1777
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (15)1778..1922
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (16)1923..2062
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (17)2063..2191
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (18)2192..2362
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (19)2363..2621
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (20)2622..2810
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (21)2811..2929
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (22)2930..2999
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (23)3000..3217
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (24)3218..3468
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (25)3469..3617
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (26)3618..3711
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (27)3712..3898
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (28)3899..4080
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (29)4081..4310
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (30)4311..4438
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (31)4439..4657
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (32)4658..4859
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (33)4860..4948
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (34)4949..5136
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (35)5137..5291
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (36)5292..5438
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (37)5439..5630
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (38)5631..5777
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (39)5778..5878
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (40)5879..6069
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (41)6070..6230
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (42)6231..6401
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (43)6402..6502
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (44)6503..6697
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (45)6698..6891
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (46)6892..6964
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (47)6965..7149
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (48)7150..7302
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (49)7303..7511
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (50)7512..7583
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Exon (51)7584..9225
Gene:LRRK2
Gene Synonym:AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Translation MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNI HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM AAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN DIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSA SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQN NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLR SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQ NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIR FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQI RDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA RASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKL RKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVREN QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPK HPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYG CAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHH NSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQ SGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTV KLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRT SQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKE NKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMT AQLGSLKNVMLVLGYNRKNTEGTQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEK MRRTSVE
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Position Chain Variation Link
1+dbSNP:
1+g, tdbSNP:199955454
14+c, gdbSNP:71449755
35+c, tdbSNP:201321281
51+g, tdbSNP:200678517
69+a, tdbSNP:41286472
90+a, gdbSNP:144990030
92+c, gdbSNP:72546314
101+a, gdbSNP:41286470
107+a, gdbSNP:71449756
146+g, tdbSNP:200688492
149+a, gdbSNP:281865040
151..152+, ggdbSNP:67296600
152..153+, gdbSNP:66609848
166+c, tdbSNP:142399623
187+a, gdbSNP:151283507
251+g, tdbSNP:77507662
270+a, gdbSNP:2256408
276+dbSNP:
276+c, tdbSNP:72546335
279+a, gdbSNP:202157354
298+a, tdbSNP:150422099
346+a, gdbSNP:75054132
428+dbSNP:
428+a, cdbSNP:201906467
430+c, gdbSNP:200926937
433+a, tdbSNP:199811736
434+g, tdbSNP:199583240
440+a, gdbSNP:141177841
453+c, tdbSNP:200789262
459+g, tdbSNP:199717383
465+a, cdbSNP:201439315
468+a, gdbSNP:144883021
470+dbSNP:
470+c, tdbSNP:202007707
477+c, tdbSNP:33995463
485+c, tdbSNP:41286468
503+a, gdbSNP:187299177
516+c, tdbSNP:148014807
567+dbSNP:
567+c, gdbSNP:199567598
578+c, tdbSNP:10878245
582+a, gdbSNP:200689827
619+c, tdbSNP:147157307
621+g, tdbSNP:201411683
622+a, gdbSNP:199584795
639+a, gdbSNP:201415714
647+c, gdbSNP:200861326
660+c, gdbSNP:199807643
662+a, tdbSNP:199626351
667+a, gdbSNP:35517158
708+dbSNP:
708+g, tdbSNP:201090840
727+c, tdbSNP:199854074
732+a, tdbSNP:140300473
745+a, g, tdbSNP:111655870
753+c, tdbSNP:112794616
754+c, gdbSNP:199915040
804+c, gdbSNP:56108242
812+c, tdbSNP:201332859
834+dbSNP:
834+a, tdbSNP:28365216
847+c, tdbSNP:201803678
857+a, cdbSNP:150050676
871+c, tdbSNP:139971538
877+c, tdbSNP:200006488
897+a, cdbSNP:199557665
905+a, gdbSNP:182233369
923+c, gdbSNP:201298800
946+a, c, tdbSNP:72546315
955+a, gdbSNP:199626996
977+dbSNP:
977+c, gdbSNP:200437744
988+c, tdbSNP:17490713
989+a, gdbSNP:201159244
992+a, gdbSNP:199981482
1010+a, gdbSNP:199552001
1014+c, tdbSNP:281865059
1015+c, tdbSNP:57355477
1035+a, cdbSNP:201334964
1057+g, tdbSNP:41286466
1121+dbSNP:
1121+a, gdbSNP:78501232
1129+a, gdbSNP:199981130
1147+a, gdbSNP:201322917
1167+g, tdbSNP:200680138
1176+, cdbSNP:36016791
1185+a, gdbSNP:146562427
1194+c, tdbSNP:141262110
1198+g, tdbSNP:201546601
1209+a, gdbSNP:72546336
1213+a, gdbSNP:200462425
1216+c, tdbSNP:144975499
1217+a, gdbSNP:113065049
1228+dbSNP:
1228+c, tdbSNP:201261152
1229+a, gdbSNP:200189771
1238+a, gdbSNP:202170315
1253+c, tdbSNP:200870486
1256+a, gdbSNP:201171722
1261+c, tdbSNP:200440892
1275+a, gdbSNP:201929195
1313+dbSNP:
1313+c, tdbSNP:146765799
1330+c, tdbSNP:200920379
1355+a, gdbSNP:200043889
1376+a, gdbSNP:201457113
1377+c, tdbSNP:34594498
1378+a, gdbSNP:200357353
1391+a, gdbSNP:202171494
1426+dbSNP:
1426+a, gdbSNP:71653637
1431+c, tdbSNP:200035812
1444+a, gdbSNP:201439614
1494+c, tdbSNP:200308266
1504+c, tdbSNP:35847451
1508..1509+, gdbSNP:150246989
1510+g, tdbSNP:79656150
1553+dbSNP:
1553+a, gdbSNP:56001713
1585+a, tdbSNP:75711334
1594+g, tdbSNP:200955457
1598+c, tdbSNP:199954611
1614+c, tdbSNP:201629713
1632+c, tdbSNP:201333920
1633+a, gdbSNP:200022961
1637+c, tdbSNP:150368439
1638+a, gdbSNP:202009639
1641+c, gdbSNP:200618023
1663..1664+, gdbSNP:34090008
1682+dbSNP:
1682+a, gdbSNP:35328937
1736+a, cdbSNP:200634016
1737+a, gdbSNP:55968234
1751+a, gdbSNP:79996249
1774+c, gdbSNP:7308720
1782+c, tdbSNP:149499327
1795+a, gdbSNP:77424631
1861+a, tdbSNP:145906734
1863+c, tdbSNP:202191866
1866+c, tdbSNP:79299560
1938+dbSNP:
1938+a, gdbSNP:138717506
1943+a, cdbSNP:201131172
1946+c, gdbSNP:142717718
1957+c, tdbSNP:201593147
1968+a, gdbSNP:281865042
1976+g, tdbSNP:55987538
1995+a, gdbSNP:200787476
2026+a, gdbSNP:200024343
2040+a, cdbSNP:202013032
2063+dbSNP:
2063+g, tdbSNP:76943330
2108+c, tdbSNP:78154388
2119+c, gdbSNP:200421434
2143+a, cdbSNP:72546319
2146+a, gdbSNP:201162329
2159+a, tdbSNP:148395944
2166+a, gdbSNP:190631149
2167+a, tdbSNP:199987713
2177+c, tdbSNP:202039763
2213+dbSNP:
2213+c, tdbSNP:201326926
2218+c, tdbSNP:200680745
2241+a, gdbSNP:199843822
2242+c, tdbSNP:201548169
2244..2245+, adbSNP:35611877
2245+a, tdbSNP:141585121
2248+a, cdbSNP:200697712
2250+a, gdbSNP:150894657
2255+a, gdbSNP:199566791
2258+c, gdbSNP:201532214
2268+c, tdbSNP:281865043
2269+a, gdbSNP:200459681
2272+c, tdbSNP:199614089
2280+a, gdbSNP:71653639
2288+a, gdbSNP:10878307
2293+a, gdbSNP:180861646
2310+c, tdbSNP:202172700
2312+c, tdbSNP:201126499
2333+a, gdbSNP:144393152
2350+g, tdbSNP:200425243
2367+dbSNP:
2367+a, gdbSNP:200867751
2383+a, tdbSNP:199929255
2385+c, tdbSNP:34410987
2392+a, gdbSNP:200848928
2413+c, tdbSNP:190597533
2420+c, tdbSNP:201823680
2421+a, gdbSNP:200861727
2443+a, gdbSNP:146103273
2449+a, gdbSNP:201443306
2452+, adbSNP:66818984
2452+a, tdbSNP:200312137
2457+c, tdbSNP:199585357
2460+a, gdbSNP:201537658
2491+c, tdbSNP:200463556
2499+g, tdbSNP:35173587
2500+a, gdbSNP:200235844
2501+c, tdbSNP:143619089
2506+c, tdbSNP:201177991
2535+g, tdbSNP:145719951
2549+a, gdbSNP:72546337
2602+c, tdbSNP:76890302
2603+a, tdbSNP:200251719
2624+dbSNP:
2624+a, gdbSNP:200557762
2628+c, tdbSNP:201806052
2629+a, gdbSNP:148920013
2662+c, g, tdbSNP:77692505
2666+a, gdbSNP:201935073
2673+c, tdbSNP:200700326
2681+a, gdbSNP:199610116
2703+a, gdbSNP:201419877
2715+c, tdbSNP:142700458
2723+g, tdbSNP:199815424
2732+a, gdbSNP:281865044
2733+a, gdbSNP:201505363
2736+g, tdbSNP:200280257
2794+c, tdbSNP:201622949
2818+dbSNP:
2818+a, cdbSNP:148113070
2835+a, tdbSNP:140851697
2868+g, tdbSNP:202244316
2879+a, gdbSNP:201184634
2882+a, gdbSNP:145926545
2890+c, gdbSNP:58559150
2892+a, gdbSNP:200795874
2895+a, gdbSNP:201810995
2908+a, gdbSNP:72547970
2910+a, gdbSNP:281865045
2951+dbSNP:
2951+g, tdbSNP:17519916
2952+a, tdbSNP:202241468
2964+a, gdbSNP:200442352
2965+, adbSNP:35344809
2965+a, gdbSNP:201165146
2978+c, tdbSNP:7966550
2985+c, tdbSNP:189460764
3001+dbSNP:
3001+g, tdbSNP:199847386
3004+a, c, gdbSNP:199606289
3027+a, gdbSNP:200577947
3036+a, gdbSNP:201718451
3039+a, gdbSNP:75148313
3051+c, tdbSNP:200171409
3060+a, gdbSNP:113160317
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Gene SymbolLRRK2
Gene SynonymAURA17; DARDARIN; PARK8; RIPK7; ROCO2
Chromosome12
Locus Map12q12
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_198578 Homo sapiens leucine-rich repeat kinase 2 (LRRK2), mRNA. On-demand $3749.00 35
Title Olfaction and imaging biomarkers in premotor LRRK2 G2019S-associated Parkinson disease .
Author Sierra,M., Sanchez-Juan,P., Martinez-Rodriguez,M.I., Gonzalez-Aramburu,I., Garcia-Gorostiaga,I., Quirce,M.R., Palacio,E., Carril,J.M., Berciano,J., Combarros,O. and Infante,J.
Journal Neurology 80 (7), 621-626 (2013)
Title Cerebral pathological and compensatory mechanisms in the premotor phase of leucine-rich repeat kinase 2 parkinsonism .
Author van Nuenen,B.F., Helmich,R.C., Ferraye,M., Thaler,A., Hendler,T., Orr-Urtreger,A., Mirelman,A., Bressman,S., Marder,K.S., Giladi,N., van de Warrenburg,B.P., Bloem,B.R. and Toni,I.
Journal Brain 135 (PT 12), 3687-3698 (2012)
Title Progressive degeneration of human neural stem cells caused by pathogenic LRRK2 .
Author Liu,G.H., Qu,J., Suzuki,K., Nivet,E., Li,M., Montserrat,N., Yi,F., Xu,X., Ruiz,S., Zhang,W., Wagner,U., Kim,A., Ren,B., Li,Y., Goebl,A., Kim,J., Soligalla,R.D., Dubova,I., Thompson,J., Yates,J. III, Esteban,C.R., Sancho-Martinez,I. and Izpisua Belmonte,J.C.
Journal Nature 491 (7425), 603-607 (2012)
Title [The absence of the common LRRK2 G2019S mutation in 120 young onset Hungarian Parkinon's disease patients] .
Author Balicza,P., Bereznai,B., Takats,A., Klivenyi,P., Dibo,G., Hidasi,E., Balogh,I. and Molnar,M.J.
Journal Ideggyogy Sz 65 (7-8), 239-242 (2012)
Title Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations .
Author Trancikova,A., Mamais,A., Webber,P.J., Stafa,K., Tsika,E., Glauser,L., West,A.B., Bandopadhyay,R. and Moore,D.J.
Journal PLoS ONE 7 (10), E47784 (2012)
Title Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology .
Author Zimprich,A., Biskup,S., Leitner,P., Lichtner,P., Farrer,M., Lincoln,S., Kachergus,J., Hulihan,M., Uitti,R.J., Calne,D.B., Stoessl,A.J., Pfeiffer,R.F., Patenge,N., Carbajal,I.C., Vieregge,P., Asmus,F., Muller-Myhsok,B., Dickson,D.W., Meitinger,T., Strom,T.M., Wszolek,Z.K. and Gasser,T.
Journal Neuron 44 (4), 601-607 (2004)
Title Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease .
Author Paisan-Ruiz,C., Jain,S., Evans,E.W., Gilks,W.P., Simon,J., van der Brug,M., Lopez de Munain,A., Aparicio,S., Gil,A.M., Khan,N., Johnson,J., Martinez,J.R., Nicholl,D., Carrera,I.M., Pena,A.S., de Silva,R., Lees,A., Marti-Masso,J.F., Perez-Tur,J., Wood,N.W. and Singleton,A.B.
Journal Neuron 44 (4), 595-600 (2004)
Title The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval .
Author Zimprich,A., Muller-Myhsok,B., Farrer,M., Leitner,P., Sharma,M., Hulihan,M., Lockhart,P., Strongosky,A., Kachergus,J., Calne,D.B., Stoessl,J., Uitti,R.J., Pfeiffer,R.F., Trenkwalder,C., Homann,N., Ott,E., Wenzel,K., Asmus,F., Hardy,J., Wszolek,Z. and Gasser,T.
Journal Am. J. Hum. Genet. 74 (1), 11-19 (2004)
Title Identifying novel transcripts and novel genes in the human genome by using novel SAGE tags .
Author Chen,J., Sun,M., Lee,S., Zhou,G., Rowley,J.D. and Wang,S.M.
Journal Proc. Natl. Acad. Sci. U.S.A. 99 (19), 12257-12262 (2002)
Title A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1 .
Author Funayama,M., Hasegawa,K., Kowa,H., Saito,M., Tsuji,S. and Obata,F.
Journal Ann. Neurol. 51 (3), 296-301 (2002)


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